The pro-apoptotic action of new analogs of the insect gonadoinhibiting peptide Neb-colloostatin: Synthesis and structure-activity studies

- 15 new analogs of Neb-colloostatin were evaluated for pro-apoptotic activity in Tenebrio molitor.
- Some analogs strongly induce apoptosis in cells in vivo.
- Neb-colloostatin analogs with pro-apoptotic properties in insects adopt unordered structures.
- The structure-activity relationship of Neb-colloostatin is discussed.