Keywords: N هیدروکسی بنزوتریازول; Biphalin; Opioid receptors; MOR/DOR/KOR agonist; Synergistic analgesic effect; Cyclic peptides; Acm; acetamidomethyl; ACN; acetonitrile; BBB; blood brain barrier; Boc; t-butyloxycarbonyl; BOP; (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluoro
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Keywords: N هیدروکسی بنزوتریازول; BBB; blood brain barrier; BK; bradykinin; Boc; t-butyloxycarbonyl; BR; bradykinin receptor; CNS; central nervous system; DALKD; [des-Arg10, Leu9]-kallidin; DIPEA; diisopropylethylamine; DMF; N,N-dimethylformamide; Dyn A; dynorphin A; Fmoc; fluorenylmethyl
Keywords: N هیدروکسی بنزوتریازول; CD; circular dichroism; CPE; cytopathic effect; DMF; dimethylformamide; FBS; fetal bovine serum; Fmoc; 9-fluorenylmethoxycarbonyl; HBTU; O-benzotriazole-N,N,Nâ²,Nâ²-tetramethyl-uronium-hexafluorophosphate; HOBt; N-hydroxybenzotriazole; HPLC; high perfor
Keywords: N هیدروکسی بنزوتریازول; Boc; t-butyloxycarbonyl; Boc-Lys(Boc)-Osu; Nα,Nε-di-Boc-l-lysine hydroxysuccinimide ester; BSA; bovine serum albumin; Cbz; carboxybenzyl; CLRs; C-type lectin receptors; CRD; carbohydrate-recognition domain; Con A; Concanavaline A; DBU; 1,8-diazabicyclo[
Keywords: N هیدروکسی بنزوتریازول; Pro-apoptotic agents; Anticancer agents; Cyclic peptides; Peptidomimetics; Nur77; Tubulin; Bcl-2; NMR studies; Molecular modeling; Confocal microscopy; FACS analysis; ADT; AutoDock Tools; COSY; correlation spectroscopy; DBU; 1,8-Diazabicyclo[5.4.0]undec-7
Keywords: N هیدروکسی بنزوتریازول; Ac; acetyl; ACTH; adrenocorticotropic hormone; Alloc; allyloxycarbonyl; Boc; t-butoxycarbonyl; BSA; bovine serum albumin; DIC; N,Nâ²,-diisopropylcarbodiimide; DIEA; diisopropylethylamine; DMEM; Dulbecco's Modified Eagle Medium; DMF; N,N-dimethylformami
Keywords: N هیدروکسی بنزوتریازول; Peptidomimetic boronates; Proteasome inhibitors; Docking studies; ChT-L; chymotrypsin-like; T-L; trypsin-like; PGPH; post-glutamyl peptide hydrolyzing; DMSO; dimethyl sulfoxide; DMF; dimethylformamide; Pd2(dba)3; tris(benzylideneacetone)dipalladium; EDC;
Design, synthesis and pharmacological evaluation of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-arylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamides as potent Hsp90 inhibitors
Keywords: N هیدروکسی بنزوتریازول; Hsp90 inhibitors; CETSA; Molecular dynamics simulation; Apoptosis; IKK; (R)-Tic; (R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; GA; geldanamycin; BnBr; Benzyl bromide; CETSA; cellular thermal shift assay; DMEM; Dulbecco's modified Eagle's medium; R
Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease
Keywords: N هیدروکسی بنزوتریازول; PK; pharmacokinetics; DMF; N,N,-dimethylfornamide; DCM; dichloromethane; CDI; carbonyl diimidazole; TLC; thin layer chromatography; EDCI; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; HOBt; N-hydroxybenzotriazole; DIEA; diisopropylethylamine; DTT; dithio
Insights into amyloid-like aggregation of H2 region of the C-terminal domain of nucleophosmin
Keywords: N هیدروکسی بنزوتریازول; TIS; Triisopropylsilane; TFA; Trifluoroacetic acid; DMF; Dimethylformamide; HBTU; 1-H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-Hexafluorophosphate(1-),3 oxide; HOBt; N-hydroxybenzotriazole; DIEA; Di-isopropylethylamine; Fmoc; Fluorenylmethoxycarbo
Bivalent SIRT1 inhibitors
Keywords: N هیدروکسی بنزوتریازول; β-NAD+; β-nicotinamide adenine dinucleotide; NAM; nicotinamide; 2â²-O-AADPR; 2â²-O-acyl-ADP-ribose; RP-HPLC; reversed-phase high performance liquid chromatography; HRMS; high-resolution mass spectrometry; EDC-MeI; 1-(3-dimethylaminopropyl)-3-ethylcarb
Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups
Keywords: N هیدروکسی بنزوتریازول; S1P1 receptor agonist; Immunomodulator; Lymphocyte count; Aminomethyl pyridine; Aminomethyl benzene; Aminomethyl thiophene; Phototoxicity; BuLi; n-butyl lithium; CC; column chromatography; DCM; dichloromethane; DIPEA; diisopropylethylamine; DEAD; diethyl
Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors
Keywords: N هیدروکسی بنزوتریازول; BK; bradykinin; BR; bradykinin receptor; CNS; central nervous system; DALKD; [des-Arg10,Leu9]-kallidin; DIPEA; diisopropylethylamine; DMF; N,N-dimethylformamide; Dyn A; dynorphin A; HR MS; high resolution mass spectroscopy; Fmoc; 9-fluorenylmethoxycarbony
A total synthesis of a highly N-methylated cyclodepsipeptide [2S,3S-Hmp]-aureobasidin L using solid-phase methods
Keywords: N هیدروکسی بنزوتریازول; Aureobasidin; N-Methylated cyclodepsipeptide; Depsidipeptide; Fmoc-based solid-phase peptide synthesis; Boc; tert-butyloxycarbonyl; BTC; bis-(trichloromethyl)-carbonate; 13C NMR; carbon-13 nuclear magnetic resonance; COSY; correlation spectroscopy; DBU; 1
G-quadruplex DNA recognition by nucleophosmin: New insights from protein dissection
Keywords: N هیدروکسی بنزوتریازول; TIS; Triisopropylsilane; TFA; Trifluoroacetic acid; DMF; Dimethylformamide; DCM; Dichloromethane; HBTU; 1-H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-hexafluorophosphate(1-), 3 oxide; HOBt; N-hydroxybenzotriazole; DIEA; Di-isopropylethylamine; Fmoc
A new class of aggregation inhibitor of amyloid-β peptide based on an O-acyl isopeptide
Keywords: N هیدروکسی بنزوتریازول; Aβ; amyloid β peptide; AD; Alzheimer's disease; DIC; N,Nâ²-diisopropylcarbodiimide; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; FAM; carboxyfluorescein; HOBt; N-hydroxybenzotriazole; HPLC; high-performance liquid chromatography; kDa; kiloda
Design, synthesis and evaluation of antimicrobial activity of N-terminal modified Leucocin A analogues
Keywords: N هیدروکسی بنزوتریازول; AMP; antimicrobial peptide; CD; circular dichroism; DIC; 1,3-diisopropylcarbodiimide; Fmoc; 9-fluorenylmethyloxycarbonyl; HOBt; N-hydroxybenzotriazole; RP-HPLC; reversed phase high performance liquid chromatography; LAB; lactic acid bacteria; LeuA; Leucoc
The pro-apoptotic action of new analogs of the insect gonadoinhibiting peptide Neb-colloostatin: Synthesis and structure-activity studies
Keywords: N هیدروکسی بنزوتریازول; Ach; 1-aminocyclohexane-1-carboxylic acid; Acp; 1-aminocyclopentane-1-carboxylic acid; CD; circular dichroism; DMF; dimethylformamide; EDT; 1,2-ethanedithiol; Fmoc; 9-fluorenylmethoxycarbonyl; HBTU; O-benzotriazole-N,N,Nâ²,Nâ²-tetramethyl-uronium-hexafl
Discovery of pyrazole as C-terminus of selective BACE1 inhibitors
Keywords: N هیدروکسی بنزوتریازول; Alzheimer's disease; BACE1; C-terminus; Click chemistry; In situ screening assay; Pyrazole; EDCl; N-(3-dimethylaminopropyl)-Nâ²-ethylcarbodiimide hydrochloride; HOBt; N-hydroxybenzotriazole; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; E
Linear and cyclic glycopeptide as HIV protease inhibitors
Keywords: N هیدروکسی بنزوتریازول; HIV-1 protease; Linear and cyclic glycopeptides; Solid and solution peptide synthesis; Molecular docking; AIDS; acquired immunodeficiency syndrome; CTC; 2-chlorotrityl chloride; DCM; dichloromethane; DIPEA; N,N-diisopropyl ethylamine; DMF; N,N-dimethylfor
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling
Keywords: N هیدروکسی بنزوتریازول; Smo; smoothened; Hh; hedgehog; Ptc; patched; Shh; sonic hedgehog; β arr2; β-arrestin2; β arr2-GFP; β-arrestin2-green fluorescent protein chimera; Gli; glioma-associated oncogene; GPCR; G-protein-coupled receptor; V2R; vasopressin2 receptor; HTS; high-
TAT-mediated photochemical internalization results in cell killing by causing the release of calcium into the cytosol of cells
Keywords: N هیدروکسی بنزوتریازول; TMR; carboxytetramethylrhodamine; CPP; cell-penetrating peptide; TAT; trans-activator of transcription; TM-PCI; TMR-TAT mediated photochemical internalization; RBC; red blood cell; PDT; photodynamic therapy; DMF; dimethylformamide; DCM; dichloromethane; T
Biological and conformational evaluation of angiotensin II lactam bridge containing analogues
Keywords: N هیدروکسی بنزوتریازول; AAA; Amino acid analysis; ACN; Acetonitrile; AII; angiotensin II; BOP; (Benzotriazol-1-yl-oxy)tris(dimethylamino)phosphonium hexafluorophosphate; BSA; bovine serum albumin; CD; Circular Dichroism; CE; Capillary Electrophoresis; CHO; Chinese hamster ovary;
High content analysis to determine cytotoxicity of the antimicrobial peptide, melittin and selected structural analogs
Keywords: N هیدروکسی بنزوتریازول; HBTU; O-benzotriazole-N,N,Nâ²,Nâ²-tetramethyl-uronium-hexafluoro-phosphate; PyBOPb; enzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate; HOBt; N-hydroxybenzotriazole; DIEA; N,Nâ²-diisopropylethylamine; MBHA; 4-methylbenzhydrylamine;
Separation of fluorinated amino acids and oligopeptides from their non-fluorinated counterparts using high-performance liquid chromatography
Keywords: N هیدروکسی بنزوتریازول; Cys; cysteine; DCM; dichloromethane; DIC; N,Nâ²-diisopropylcarbodiimide; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; EtOH; ethanol; F%wt; fluorine weight percentage in an analyte or a solvent; Fmoc; fluorenylmethoxycarbonyl; HFIP; hexaf
Solid-phase peptide head-to-side chain cyclodimerization: Discovery of C2-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors
Keywords: N هیدروکسی بنزوتریازول; All; allyl; AgRP; Agouti-related protein; ASIP; agouti-signaling protein; Boc; tert-butyloxycarbonyl; Fmoc; fluorenylmethoxycarbonyl; CH3CN; acetonitrile; Cl-HOBt; 1-hydroxy-6-chlorobenzotriazole; DCM; dichloromethane; DIPEA; diisopropylethylamine; DMF; N
Evaluation of new leptin fragments on food intake and body weight of normal rats
Keywords: N هیدروکسی بنزوتریازول; 2-Cl-Z; 2-chloro-benzyloxycarbonyl; AAA; amino acid analysis; BOP; benzotriazol-1-yl-oxy-tris(dimethylamino) phosphonium hexafluorophosphate; Bzl; benzyl; CD; circular dichroism; CH3CN; acetonitrile; CHO; Formyl; CSF; Cerebrospinal fluid; DCM; dichloromet
Synthesis and preliminary physical applications of a rhodamin-biotin phosphatidylethanolamine, an easy attainable lipid double probe
Keywords: N هیدروکسی بنزوتریازول; Boc; tertio-butyloxycarbonyl; DBU; 1,8-diazabicyclo[5,4,0]undec-7-ene; DHB; 2,5-dihydroxybenzoic acid; DIEA; diisopropyl ethyl amine; DMAP; 4-N,N-dimethylaminopyridine; DMF; N,N-dimethylformamide; DSPE; distearyl-phosphatidylethanolamine; Fmoc; 9-fluoreny
Hemolytic activity of new linear surfactin analogs in relation to their physico-chemical properties
Keywords: N هیدروکسی بنزوتریازول; CHCA; α-cyano 4-hydroxy cinnamic acid; CMC; critical micellar concentration; DCM; dichloromethane; DIEA; di-isopropyl ethylamine; DMSO; dimethyl sulfoxide; HC50; concentration inducing 50% of hemolysis; HOBt; n-hydroxybenzotriazole; NMP; N-methyl-pyrroli