کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10800982 | 1054720 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hemolytic activity of new linear surfactin analogs in relation to their physico-chemical properties
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کلمات کلیدی
CMCDIEAHC50NMPTBTUHOBtTX-100RBCTFADCMN-methyl-pyrrolidone2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborateRed blood cells - سلولهای قرمز خونDMSO - DMSON-hydroxybenzotriazole - N هیدروکسی بنزوتریازولCHCA - آنها می خواهندTrifluoroacetic acid - اسید TrifluoroaceticTriton X-100 - تریتون X-100 Dichloromethane - دیکلورمتانDimethyl sulfoxide - دیمتیل سولفواکسیدSurfactin - سورفاکتینCritical micellar concentration - غلظت میکرولیکی بحرانیHemolysis - همولیز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
New linear analogs of surfactin have been synthesized. Their physico-chemical parameters were determined. The results indicate that these linear products show surface activities although they are lowered compared to those of cyclic compounds. The hemolytic activities have also been assayed. In contrast with cyclic surfactins, no significant hemolysis occurs for the linear products in the range of concentrations tested. Moreover, a protective effect against Triton X-100 induced hemolysis has been highlighted for linear surfactins. The concentration at which this protective effect happens is correlated directly to the CMC, and inversely to the acyl chain length of the product. In a hypotonic medium, analogs having a long acyl chain tend to increase the hemolysis, meanwhile the product with the shortest chain tends to decrease it.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - General Subjects - Volume 1726, Issue 1, 30 October 2005, Pages 87-95
Journal: Biochimica et Biophysica Acta (BBA) - General Subjects - Volume 1726, Issue 1, 30 October 2005, Pages 87-95
نویسندگان
Samuel Dufour, Magali Deleu, Katherine Nott, Bernard Wathelet, Philippe Thonart, Michel Paquot,