Keywords: NAC، N-acetyl-L-cysteine; CD, carbon dot; AuNP, citrate–gold nanoparticle; r-CDs, raw carbon dots; p-CDs, passivated carbon dots; f-CDs, functionalized carbon dots; PEG, polyethylene glycol; NAC, N-acetyl-l-cysteine; MWCNTs, multiwalled carbon nanotubes; DIC, diisopropylcarbodiimi
مقالات ISI NAC، N-acetyl-L-cysteine (ترجمه نشده)
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Keywords: NAC، N-acetyl-L-cysteine; H2DCF-DA, 2′,7′-dichlorodihydrofluorescein diacetate; DHE, dihydroethidium; HSPG, heparan sulfate proteoglycans; NAC, N-acetyl-L-cysteine; PI3K, phosphatidylinositol 3-kinase; PEI, polyethylenimine; rAAV, recombinant adeno-associated virus; ROS, reactive
Keywords: NAC، N-acetyl-L-cysteine; NSCLC; CCRT; Vinorelbine; JNK; CeramideNSCLC, non-small cell lung cancer; CCRT, concurrent chemoradiotherapy; VNR, vinorelbine; JNK, c-Jun N-terminal kinase; CT, chemotherapy; RT, radiotherapy; NAC, N-acetyl-L-cysteine
ZT-25, a new vacuolar H+-ATPase inhibitor, induces apoptosis and protective autophagy through ROS generation in HepG2 cells
Keywords: NAC، N-acetyl-L-cysteine; V-ATPases, vacuolar H+-ATPases; MMP, mitochondrial membrane potential; CQ, chloroquine; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; 3-MA, 3-methyladenine; NAC, N-acetyl-L-cysteine; DMEM, Dulbecco's modified eagle medium; DCFH-DA, 2
Blue light irradiation-induced oxidative stress in vivo via ROS generation in rat gingival tissue
Keywords: NAC، N-acetyl-L-cysteine; ESR, electron spin resonance; FAD, flavin adenine dinucleotide; GSH, glutathione; GSSG, glutathione oxidized disulfide form; HEV, high-energy visible; LED, light-emitting diode; MDA, malondialdehyde; NAC, N-acetyl-l-cysteine; QTH, quartz tungsten halogen;
Toxic effects of n-3 polyunsaturated fatty acids in human lung A549 cells
Keywords: NAC، N-acetyl-L-cysteine; PUFAs, Polyunsaturated Fatty Acids; EPA, Eicosapentaenoic Acid (20:5); DHA, Docosahexaenoic Acid (22:6); 3-MA, 3-Methyladenine; NAC, N-acetyl-l-cysteine; ROS, reactive oxygen speciesEicosapentaenoic acid; Docosahexaenoic acid; A549 lung cancer cells; Oxid
Protective effect of antioxidants on DNA damage in leukocytes from X-linked adrenoleukodystrophy patients
Keywords: NAC، N-acetyl-L-cysteine; AMN, adrenomieloneuropathy; C22:0, docosanoic acid; C24:0, tetracosanoic acid; C26:0, hexacosanoic acid; CCER, childhood cerebral form; DCFH-DA, dihydrodichlorofluorescein diacetate; IEM, inborn error of metabolism; NAC, N-acetyl-l-cysteine; PBS, phosfate
Ligand-independent activation of aryl hydrocarbon receptor signaling in PCB3-quinone treated HaCaT human keratinocytes
Keywords: NAC، N-acetyl-L-cysteine; 4-ClBQ, 1-(4-Chlorophenyl)-benzo-2,5-quinone; AhR, aryl hydrocarbon receptor; ARNT, aryl hydrocarbon receptor nuclear translocator; CYP1A1, cytochrome P4501A1; NAC, N-acetyl-l-cysteine; PCB3, 4-monochlorobiphenyl; PCB77, 3,3′,4,4′-tetrachlorobiphenyl; PCB
Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling
Keywords: NAC، N-acetyl-L-cysteine; BaP, benzo[a]pyrene; ROS, reactive oxygen species; ERK, extracellular signal-regulated kinases; NAC, N-acetyl-l-cysteine; PAHs, polycyclic aromatic hydrocarbons; MMP9, matrix metalloproteinases 9; BPDE, benzo(a)pyrene diolepoxideBenzo[a]pyrene; ROS; ERK;
Spiruchostatin A and B, novel histone deacetylase inhibitors, induce apoptosis through reactive oxygen species-mitochondria pathway in human lymphoma U937 cells
Keywords: NAC، N-acetyl-L-cysteine; SP-A, Spiruchostatin A; SP-B, Spiruchostatin B; ROS, reactive oxygen species; HDAC, histone deacetylase; MMP, mitochondrial membrane potential; NAC, N-acetyl-l-cysteine; FITC, fluorescein isothiocyanate; HATs, histone acetyltransferases; HDACi, histone de
Lactate regulates myogenesis in C2C12 myoblasts in vitro
Keywords: NAC، N-acetyl-L-cysteine; La, lactate; ROS, reactive oxygen species; DM, differentiation medium; AA, ascorbic acid (vitamin C); NAc, N-Acetyl-l-cysteine; LA, linolenic acid; SC, satellite cell; Pax7, paired box transcription factor 7; Myf5, myogenic factor 5; MyoD, myogenic determ
The role of oxidized ATM in the regulation of oxidative stress-induced energy metabolism reprogramming of CAFs
Keywords: NAC، N-acetyl-L-cysteine; ATM, ataxia-telangiectasia mutated protein kinase; CAFs, cancer-associated fibroblasts; DSB, double strand breaks; EMR, energy metabolism reprogramming; HIF1, hypoxia inducible factor 1; NAC, N-acetyl-L-cysteine; NF, normal fibroblasts; OP, oxidative phos
Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells
Keywords: NAC، N-acetyl-L-cysteine; CRC, colorectal carcinoma; 5-FU, 5-fluorouracil; UA, ursolic acid; MSI, microsatellite instability; JNK, c-jun N-terminal kinase; MAPK, mitogen-activated protein kinase; NAC, N-acetyl-l-cysteine; STS, staurosporine; TUNEL, TdT-mediated dUTP nick end label
Superoxide generated by pyrogallol reduces highly water-soluble tetrazolium salt to produce a soluble formazan: A simple assay for measuring superoxide anion radical scavenging activities of biological and abiological samples
Keywords: NAC، N-acetyl-L-cysteine; O2−, superoxide anion radical; NBT, nitroblue tetrazolium; pyrogallol, 1,2,3-trihydroxybenzene; WST-1, 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium sodium salt; SOD, superoxide dismutase; NAC, N-acetyl-l-cysteine; ROS, reactive
Cytotoxic effects of incense particles in relation to oxidative stress, the cell cycle and F-actin assembly
Keywords: NAC، N-acetyl-L-cysteine; BG, background; DCFH, 2′,7′-dichlorodohydrofluorescin; DCFH-DA, 2′,7′-dichlorodohydrofluorescin diacetate; DCF, 2′,7′-dichlorefluorescin; DMSO, dimethyl sulfoxide; GSH, glutathione; GSSG, glutathione disulfide; NAC, N-acetyl-l-cysteine; PM, particulate ma
Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats
Keywords: NAC، N-acetyl-L-cysteine; apocynin, 4′-hydroxy-3′-methoxyacetophenone; BD1047, N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide; CCI, chronic constriction injury; NAC, N-acetyl-l-cysteine; NADPH oxidase, nicotinamide adenine dinucleotide phosphat
Somatic alterations in mitochondrial DNA produce changes in cell growth and metabolism supporting a tumorigenic phenotype
Keywords: NAC، N-acetyl-L-cysteine; mtDNA, mitochondrial DNA; UV, Ultraviolet; ROS, Reactive Oxidative Species; DCFH2-DA, 2′, 7-dichlorodihydrofluorescein diacetate; NAC, N-acetyl-L-cysteine; Vit E, vitamin E; Mito C, Mitomycin C; ATP, Adenosine Triphosphate; OXPHOS, oxidative phosphorylati
Enhanced antitumor activity of vitamin C via p53 in Cancer cells
Keywords: NAC، N-acetyl-L-cysteine; NAC, N-acetyl-l-cysteine; CHX, cycloheximide; DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; ELISA, enzyme-linked immunosorbent assay; IP, immunoprecipitation; ip, intraperitoneal; PBS
Biotransformation of geniposide by human intestinal microflora on cytotoxicity against HepG2 cells
Keywords: NAC، N-acetyl-L-cysteine; IM, intestinal microflora; GS, geniposide; GN, genipin; NAC, N-acetyl-l-cysteine; ROS, reactive oxygen species; DAPI, 4,6-diamidino-2-phenylindoleIntestinal microflora; Geniposide; Genipin; Metabolism; Cytotoxicity
Protein kinase C stimulates human B cell activating factor gene expression through reactive oxygen species-dependent c-Fos in THP-1 pro-monocytic cells
Keywords: NAC، N-acetyl-L-cysteine; BAFF, B cell activating factor belongs to TNF-α family; ROS, reactive oxygen species; FBS, fetal bovine serum; NAC, N-acetyl-L-cysteine; DCF-DA, 2′,7′-Dichlorodihydrofluorescein diacetate; PMA, phorbol 12-myristate 13-acetate; IOM, ionomycinhBAFF; Promote
Conditionally immortalised neural stem cells promote functional recovery and brain plasticity after transient focal cerebral ischaemia in mice
Keywords: NAC، N-acetyl-L-cysteine; MHP36, Maudsley hippocampal murine neural stem cell line clone 36; MCAO, transient middle cerebral artery occlusion; CBF, cerebral blood flow; NAC, N-acetyl-l-cysteine; MAP-2, microtubule-associated protein 2; GFAP, glial fibrillary acidic protein; CNPase
Arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-Jun
Keywords: NAC، N-acetyl-L-cysteine; arsenite; p53; c-Jun; MEKK1; nutlin-3; neuroblastomaEGFP, enhanced green fluorescence protein; JNK, c-Jun N-terminal protein kinases; MDM2, mouse double minute; NAC, N-acetyl-L-cysteine
Chemical, spectroscopic characterization, DFT studies and initial pharmacological assays of a silver(I) complex with N-acetyl-l-cysteine
Keywords: NAC، N-acetyl-L-cysteine; NAC, N-acetyl-l-cysteine; SSNMR, solid-state nuclear magnetic resonance; NMR, nuclear magnetic resonance; IR, infrared; Ag–NAC, silver complex with N-acetyl-l-cysteine; MIC, minimal inhibitory concentration; CP/MAS, cross polarization/magic angle spinning
Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53
Keywords: NAC، N-acetyl-L-cysteine; Ginsenoside; Apoptosis; ROS; NF-κB; AntioxidantDCF, 2,7-dichlorofluorescein; H2DCFDA, 5-(and-6)-chloromethyl-2′7′-dichlorodihydrofluorescein diacetate acetyl ester; NAC, N-acetyl-l-cysteine; PCD, programmed cell death; ROS, reactive oxygen species
Oxidative stress is implicated in arsenic-induced neural tube defects in chick embryos
Keywords: NAC، N-acetyl-L-cysteine; SA, sodium arsenite; NTDs, neural tube defects; NAC, N-acetyl-l-cysteine; ROS, reactive oxygen species; SOD, superoxide dismutase; GPX, glutathione peroxidase; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; 5-mec, 5-mecthylcystidineSodium arsenit
The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury
Keywords: NAC، N-acetyl-L-cysteine; GSH, reduced glutathione; GSSG, oxidized glutathione; GCL, glutamate-cysteine ligase; GR, glutathione reductase; GPx, glutathione peroxidase; GST, glutathione-S-transferase; NAC, N-acetyl-l-cysteine; ROS, reactive oxygen species; DILI, drug-induced liver
ROS/Epac1-mediated Rap1/NF-kappaB activation is required for the expression of BAFF in Raw264.7 murine macrophages
Keywords: NAC، N-acetyl-L-cysteine; BAFF, B cell activating factor belongs to TNF-α family; cAMP, cyclic adenine monophosphate; Epac, cAMP-responsive guanine nucleotide exchange factor; FBS, fetal bovine serum; LPS, lipopolysaccharide; ROS, reactive oxygen species; NAC, N-acetyl-L-cysteine;
A novel parthenin analog exhibits anti-cancer activity: Activation of apoptotic signaling events through robust NO formation in human leukemia HL-60 cells
Keywords: NAC، N-acetyl-L-cysteine; AIF, apoptosis inducing factor; AML, acute myeloid leukemia; DR4, death receptor 4; DR5, death receptor 5; DRP-1, dynamin related protein-1; GSH, glutathione reduced; iNOS, inducible nitric oxide synthase; NAC, N-acetyl-l-cysteine; NF-κB, nuclear factor-k
Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway
Keywords: NAC، N-acetyl-L-cysteine; ISA, irciniastatin A; JNK, c-Jun N-terminal kinase; NAC, N-acetyl-l-cysteine; ROS, reactive oxygen speciesIrciniastatin A; Ribotoxic stress; Apoptosis; Caspase-8; JNK
Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite
Keywords: NAC، N-acetyl-L-cysteine; trans-resveratrol, trans-3, 4′,5-trihydroxystilbene; SIN-1, 5-amino-3-(4-morpholinyl)-1,2,3-oxadiazolium chloride; BSA, bovine serum albumin; NAC, N-acetyl-l-cysteine; FBS, fetal bovine serum; DMEM, Dulbecco's Modified Eagles Medium; ROS, reactive oxygen
Knock-out of metacaspase and/or cytochrome c results in the activation of a ROS-independent acetic acid-induced programmed cell death pathway in yeast
Keywords: NAC، N-acetyl-L-cysteine; Yeast; Programmed cell death; Reactive oxygen species; N-Acetyl-l-cysteine; Cytochrome c; YCA1ROS, reactive oxygen species; AA, acetic acid; PCD, programmed cell death; AA-PCD, acetic acid-induced programmed cell death; NAC, N-acetyl-l-cysteine; wt, wild
NADPH oxidase is involved in protein kinase CKII down-regulation-mediated senescence through elevation of the level of reactive oxygen species in human colon cancer cells
Keywords: NAC، N-acetyl-L-cysteine; CKII, protein kinase CKII (also known as casein kinase II); DCF, dichlorofluorescein; DHE, dihydroethidium; DRB, 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole; ETH, ethidium; FBS, fetal bovine serum; NAC, N-acetyl-l-cysteine; NOX, NADPH oxidase; PBS, phos
LPS-induced iNOS expression in Bv-2 cells is suppressed by an oxidative mechanism acting on the JNK pathway—A potential role for neuroprotection
Keywords: NAC، N-acetyl-L-cysteine; LPS, lipopolysaccharide; NAC, N-acetyl-L-cysteine; NOS, nitric oxide synthase; RNS, reactive nitrogen species; ROS, reactive oxygen species; TLR4, Toll-like receptor 4; NO, nitric oxide; NO2−, nitrite; ∙ O2−, superoxide anion; ONOO−, peroxynitriteMicrogli
Cannabidiol induced a contrasting pro-apoptotic effect between freshly isolated and precultured human monocytes
Keywords: NAC، N-acetyl-L-cysteine; CBD, cannabidiol; CMF-DA, 5-chloromethylfluorescein diacetate; FBS, fetal bovine serum; GSH, glutathione; HO, heme oxygenase; NA, naïve; NAC, N-acetyl-L-cysteine; O.D., optical density; PBMC, peripheral blood mononuclear cells; PBS, phosphate-buffered sal
An oxidative environment promotes growth of Mycobacterium abscessus
Keywords: NAC، N-acetyl-L-cysteine; MnTE-2-PyP, manganese(II) meso-tetrakis-(N-methylpyridinium-2-yl) porphyrin; NAC, N-acetyl-l-cysteine; NTM, nontuberculous mycobacteria; PMA, phorbol 12-myristate 13-acetate; CFU, colony-forming units; SOD, superoxide dismutase; GPx, glutathione peroxidas
Responsiveness of human monocyte-derived dendritic cells to thimerosal and mercury derivatives
Keywords: NAC، N-acetyl-L-cysteine; DCs, dendritic cells; mono-DCs, DCs derived from monocytes; NAC, N-acetyl-l-cysteine; ROS, reactive oxygen species; TSA, thiosalicylic acidHuman dendritic cells; Oxidative stress; Reactive oxygen species; Thimerosal; Mercury derivatives
IL-8 production by macrophages is synergistically enhanced when cigarette smoke is combined with TNF-α
Keywords: NAC، N-acetyl-L-cysteine; CSM, cigarette smoke medium; BALF, bronchoalveolar lavage fluid; COPD, chronic obstructive pulmonary disease; IκB, inhibitory IκB; GSH, glutathione; MDMs, monocyte-derived macrophages; NAC, N-acetyl-l-cysteine; ROS, reactive oxygen species; SODs, Superoxi
Sensitization effect of thimerosal is mediated in vitro via reactive oxygen species and calcium signaling
Keywords: NAC، N-acetyl-L-cysteine; TSA, thiosalicylic acid; DCs, dendritic cells; NAC, N-acetyl-l-cysteine; ROS, reactive oxygen species; GSH, reduced glutathione; GSSG, oxidized glutathioneThimerosal; U937 activation; Reactive oxygen species; Calcium influx; Mitochondrial membrane potenti
Antioxidants potentiate American ginseng-induced killing of colorectal cancer cells
Keywords: NAC، N-acetyl-L-cysteine; DCF, 2,7-dichlorofluorescein; H2DCFDA, 5-(and-6)-chloromethyl-2′7′-dichlorodihydrofluorescein diacetate acetyl ester; MMP, mitochondrial membrane potential; NAC, N-acetyl-L-cysteine; ROS, reactive oxygen species; S4h, hour-steamed American ginseng root ex
Alternative cell death of Apaf1-deficient neural progenitor cells induced by withdrawal of EGF or insulin
Keywords: NAC، N-acetyl-L-cysteine; Apaf1, apoptotic protease activating factor 1; NPCs, neural progenitor cells; ROS, reactive oxygen species; EGF, epidermal growth factor; CNS, central nervous system; NAC, N-acetyl-L-cysteine; GFP, green fluorescent protein; LC3, microtubule-associated pr
Involvement of ROS in chlorogenic acid-induced apoptosis of Bcr-Abl+ CML cells
Keywords: NAC، N-acetyl-L-cysteine; ROS, reactive oxygen species; CML, chronic myeloid leukemia; NAC, N-acetyl-l-cysteine; JC-1, 5,5′-6,6′-tetracholoro-1,1′-3,3′-tetraethylbenzimidazolylcarbocyanine iodide; DCFH-DA, 2′,7′-dichlorodihydrofluorescein diacetate; DHE, dihydroethidium; JNK, c-Ju
Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro
Keywords: NAC، N-acetyl-L-cysteine; ROS, reactive oxygen species; CSC, cigarette smoke condensate; NAC, N-acetyl-L-cysteine; DSB, double strand break; FISH, fluorescence in situ hybridization; TercKO, telomerase RNA knockout miceSmoke; Telomere; Oxidative stress; Mouse; Embryo
A novel role for vitamin B12: Cobalamins are intracellular antioxidants in vitro
Keywords: NAC، N-acetyl-L-cysteine; AdoCbl, adenosylcobalamin; CNCbl, cyanocobalamin; DCFH-DA, dichlorofluorescin diacetate; GSH, glutathione; GSCbl, glutathionylcobalamin; Hcy, homocysteine; HOCbl, hydroxocobalamin; MeCbl, methylcobalamin; NAC, N-acetyl-l-cysteine; NACCbl, N-acetyl-l-cyste
Mechanisms of growth inhibition in keratinocytes by mercurio-substituted 4′,5′-dihydropsoralens
Keywords: NAC، N-acetyl-L-cysteine; TMP, 4,5′,8-trimethylpsoralen; H2TMP, 4,8-dimethyl-5′-methyl-4′,5′-dihydropsoralen; Iodomercurio-H2TMP, 4,8-dimethyl-5′-iodomercuriomethyl-4′,5′-dihydropsoralen; NAc, N-acetyl-l-cysteine; UVA, ultraviolet light A (320–400 nm); TCA, trichloroacetic acid; B
Apoptosis signal-regulating kinase (ASK)-1 mediates apoptosis through activation of JNK1 following engagement of membrane immunoglobulin
Keywords: NAC، N-acetyl-L-cysteine; mIg, membrane Ig; ASK, apoptosis signal-regulating kinase; ROS, reactive oxygen species; H2O2, hydrogen peroxide; ΔΨm, mitochondrial membrane potential; NAC, N-acetyl-l-cysteine; DCFDA, dichlorodihydrofluorescein diacetate; PI, propidium iodideB cells; Ap
Tumor necrosis factor (TNF)-α-induced IL-8 expression in gastric epithelial cells: Role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1
Keywords: NAC، N-acetyl-L-cysteine; AP-1, activator protein-1; ENA-78, epithelial cell-derived neutrophil-activating protein-78; Gro-α, growth-related oncogene-α; IL, interleukin; MIP-3α, macrophage inflammatory protein-3α; NAC, N-acetyl-l-cysteine; NF-κB, nuclear factor-κB; Ref-1, redox fa
Mutations in the C. elegans Succinate Dehydrogenase Iron–Sulfur Subunit Promote Superoxide Generation and Premature Aging
Keywords: NAC، N-acetyl-L-cysteine; DCPIP, dichlorophenol indophenol; DHE, dihydroethidium; FUdR, 5-fluoro-2′-deoxyuridine; GPDH, glycerol phosphate dehydrogenase; MRC, mitochondrial respiratory chain; NAC, N-acetyl-l-cysteine; NGM, nematode growth medium; PGL, paraganglioma; PHEO, pheochro
Role of nitric oxide and nuclear factor-κB in the CYP2E1 potentiation of tumor necrosis factor α hepatotoxicity in mice
Keywords: NAC، N-acetyl-L-cysteine; TNF, tumor necrosis factor; CYP2E1, cytochrome P4502E1; PY, pyrazole; 1400W, N-(3-aminomethyl)benzylacetamindine; NAC, N-acetyl-l-cysteine; MAPK, mitogen-activated protein kinase; 3-NT, 3-nitrotyrosine; ALT, alanine aminotransferase; AST, aspartate aminot
Regenerative capacity of neural precursors in the adult mammalian brain is under the control of p53
Keywords: NAC، N-acetyl-L-cysteine; DB, denatonium benzoate; DG, dentate gyrus; FISEL, fluorescence in situ end labeling; GFAP, glial fibrillary acidic protein; NeuN, neuron-specific nuclear protein; NAC, N-acetyl-l-cysteine; NS, neurosphere; NSCs, neural stem/progenitor cells; NT, nontrans
Ramifications of a redox switch within a normal cell: Its absence in a cancer cell
Keywords: NAC، N-acetyl-L-cysteine; HIF-1, hypoxia-inducible factor-1; NAC, N-acetyl-L-cysteine; RMCP, redox model of cell proliferation; Trx, thioredoxin.Cell cycle; Intracellular redox potential; Cancer; Warburg effect; Apoptosis; Aneuploidy; Uncontrolled proliferation