Metabolic profiling on the effect of 2,2â²,4,4â²-tetrabromodiphenyl ether (BDE-47) in MCF-7Â cells
Keywords: Metabolomics; BDE-47; NADPH; ROS; Breast cancer;
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Human cytochrome P450 expression in bacteria: Whole-cell high-throughput activity assay for CYP1A2, 2A6 and 3A4
Keywords: ACN; acetonitrile; C7H; coumarin 7-hydroxylation; CPR; NADPH cytochrome P450 oxidoreductase; CYB5; cytochrome b5; CYP; microsomal cytochrome P450 monooxygenases; DBF; dibenzyl-fluorescein; DBODF; dibenzylfluorescein O-debenzylation; DMSO; dimethyl sulfoxi
Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment
Keywords: AKR; aldo-keto reductase; CDK; cyclin-dependent kinase; CI; combination index; Dau; daunorubicin; Dau-ol; daunorubicinol; DOX; doxorubicin; DMSO; dimethyl sulfoxide; Fa; fraction affected; HCT116-AKR1C3; cells transfected with pCI_AKR1C3; HCT116-EV; cells
Dual roles of different redox forms of complement factor H in protecting against age related macular degeneration
Keywords: CFH; Complement Factor H; AMD; Age related macular degeneration; BM; Bruch's membrane; β2GPI; Beta-2-Glycoprotein I; TRX-1; Thioredoxin-1; TRX-R; Thioredoxin-1 reductase; NADPH; Nicotinamide adenine dinucleotide phosphate; MAA; Malondialdehyde acetaldehy
Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5
Keywords: Cotinine; Triglyceride; Metabolism; Oxidative stress; Reactive oxygen species; CYP2A6; 3-NT; nitrotyrosine adducts; ADH; alcohol dehydrogenase; ALD; alcoholic liver disease; ALDH; acetaldehyde dehydrogenase; ALT; alanine transaminase; COH; coumarin 7-hydr
In vitro/in vivo antioxidant and hepatoprotective potential of defatted extract and flavonoids isolated from Astragalus spruneri Boiss. (Fabaceae)
Keywords: Astragalus spruneri; Isolated rat liver microsomes; Hepatocytes; Antioxidant activity; Cytoprotection; AA; ascorbic acid; CAT; catalase; EAS; defatted extract from A. spruneri; GSH; reduced glutathione; LDH; lactate dehydrogenase; LPO; lipid peroxidation;
In vitro antiglycating effect and in vivo neuroprotective activity of Trigonelline in d-galactose induced cognitive impairment
Keywords: Aβ; amyloid beta; AChE; acetyl cholinesterase; AD; Alzheimer's disease; AG; aminoguanidine; AGEs; advanced glycation end products; ANOVA; analysis of variance; AU; arbitrary units; BSA; bovine serum albumin; d-gal; d-galactose; DNP; Donepezil; GSH; red
In-vitro metabolism, CYP profiling and metabolite identification of E- and Z- guggulsterone, a potent hypolipidmic agent
Keywords: 1-ABZT; 1-aminobenzotriazole; CYP450; cytochrome P450; HLM; human liver microsomes; IS; internal standard; LC-MS/MS; liquid chromatography-tandem mass spectrometry; NADPH; reduced form of nicotinamide adenine dinucleotide phosphate; HPLC; high-performan
Ginger (Zingiber officinale Roscoe) for the treatment and prevention of necrotizing enterocolitis
Keywords: DAB; Diaminobenzidine tetrahydrochloride; ET-1; Endothelin-1; ETA; Endothelin receptor type A; ETB; Endothelin receptor type B; GSH; Reduced glutathione; GSH-PX; Glutathione peroxidase; IL-1β; Interleukin 1 beta; IL-6; Interleukin 6; IQR; Interquartile r
Glucocorticoids induce apoptosis and matrix metalloproteinase-13 expression in chondrocytes through the NOX4/ROS/p38 MAPK pathway
Keywords: Dex; dexamethasone; ROS; reactive oxygen species; NOX; NADPH oxidase; MAPK; mitogen-activated protein kinase; MMP; metalloproteinase; GCs; glucocorticoids; GR; glucocorticoid receptor; OA; osteoarthritis; RA; rheumatoid arthritis; NADPH; nicotinamide aden
TIGAR inhibits ischemia/reperfusion-induced inflammatory response of astrocytes
Keywords: TIGAR; Astrocytes; NADPH; NF-κB; Inflammation; Stroke;
Kinetics and thermodynamics of the thermal inactivation and chaperone assisted folding of zebrafish dihydrofolate reductase
Keywords: Zebrafish dihydrofolate reductase; Thermal inactivation of zDHFR; Kinetics and thermodynamics of thermal denaturation; GroEL-ES and minichaperone assisted folding of zDHFR; Fluorescence and CD spectroscopy of zDHFR; zDHFR; Zebrafish Dihydrofolate reductas
Genetic and metabolic engineering for microbial production of poly-γ-glutamic acid
Keywords: Biopolymers; Glutamic acid; Pathway engineering; Poly-γ-glutamic acid; Recombinant producers; AI-2; autoinducer AI-2; AmtB; ammonium transporter; CscB; sucrose permease; CodY; a global regulator protein; CwlO; cell wall d/l-endopeptidase; d-AAT; d-amino
Insights into the functional properties of the marneral oxidase CYP71A16 from Arabidopsis thaliana
Keywords: P450; cytochrome P450 monooxygenase; CPR; cytochrome P450 reductase; LB; lysogeny broth (medium); TB; terrific broth (medium); IPTG; isopropyl-β-d-thiogalactopyranoside; GC/MS; gas chromatography coupled with mass spectrometry; HPLC; high performance liq
Catalytic modulation of human cytochromes P450 17A1 and P450 11B2 by phospholipid
Keywords: CYP17A1; cytochrome P450 17A1; CYP11B1; cytochrome P450 11B1; CYP11B2; cytochrome P450 11B2; POR; cytochrome P450-oxidoreductase; 12:0 PC (DLPC); 1,2-dioleoyl-sn-glycero-3-phosphocholine; 14:0 PC; 1,2-dimyristoyl-sn-glycero-3-phosphocholine; 16:0 PC; 1,2-
Cholemic nephropathy - Historical notes and novel perspectives
Keywords: AKI; acute kidney injury; CBDL; common bile duct ligation; CKD; chronic kidney disease; CN; cholemic nephropathy; FXR; farnesoid X receptor; GFR; glomerular filtration rate; IL-18; interleukin 18; iNOS; inducible nitric oxide synthase; KDIGO; Kidney Disea
The proinflammatory effects of macrophage-derived NADPH oxidase function in autoimmune diabetes
Keywords: ABIS; All Babies in Southwest Sweden study; APC; Antigen presenting cells; Arg-1; Arginase 1; CB3; Coxsackievirus strain B3; CB4; Coxsackievirus strain B4; CGD; Chronic granulomatous disease; CSF-1; Colony-stimulating factor 1; AISY; Diabetes Autoimmunity
In vitro and in vivo metabolic activation of rhein and characterization of glutathione conjugates derived from rhein
Keywords: CE; collision energy; DMSO; dimethyl sulfoxide; DP; declustering potential; RH; rhein; EPI; enhanced product ion; GSH; glutathione; IDA; information-dependent acquisition; LC-MS/MS; liquid chromatography-tandem mass spectrometry; MRM; multiple-reaction mo
Brazil nut improves the oxidative metabolism of superoxide-hydrogen peroxide chemically-imbalanced human fibroblasts in a nutrigenomic manner
Keywords: Val16Ala-SOD2 polymorphism; Selenium; Seleno-L-methionine; Paraquat; MnTBAP; Nutrigenomic effect; Ala; alanine; BN; Brazil nut; BNs; Brazil nuts; BNAE; Brazil nut aqueous extract; CAT; catalase (E.C. 1.11.1.6); DCFH-DA; 2â²,7â²-Dichlorodihydrofluorescei
ROS signalling in the biology of cancer
Keywords: AEJ; alternative end joining; ALL; acute lymphoblastic leukaemia; AML; acute myeloid leukaemia; Apaf-1; apoptotic protein activating factor 1; APL; acute promyelocytic leukaemia; ASK1; apoptosis signal regulating kinase 1; Bcr-Abl; breakpoint cluster-Abel
N-acetylcysteine supplementation increases exercise performance and reduces oxidative stress only in individuals with low levels of glutathione
Keywords: GPx; glutathione peroxidase; GSH; reduced glutathione; GSSG; oxidized glutathione; GR; glutathione reductase; H2O2; hydrogen peroxide; LOH; lipid alcohols; LOOH; lipid hydroperoxides; NADP+; oxidized form of nicotinamide adenine dinucleotide phosphate; NA
NADPH oxidase 4 and endothelial nitric oxide synthase contribute to endothelial dysfunction mediated by histone methylations in metabolic memory
Keywords: APO; apocynin; BSP; bisulfite sequencing PCR; ChIP; chromatin immunoprecipitation; CM-H2DCFDA; 5-(and-6)-chloromethyl-2â²,7â²dichlorodihydrofluorescein diacetate, acetylester; DAF-FM; 4-amino-5-methylamino-2,7-difluorofluorescein diacetate; DANï¼2; 3-d
NADPH-dependent and -independent disulfide reductase systems
Keywords: Ahp; alkyl hydroperoxide reductase; APS; 5'-adenylylsulfate; BSO; buthionine sulfoximine; CoA; coenzyme A; Cys; cysteine; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; FTR; ferredoxin-thioredoxin reductase; Gpx; glutathione peroxida
G protein-coupled estrogen receptor (GPER) deficiency induces cardiac remodeling through oxidative stress
Keywords: 4-HNE; 4 hydroxynonenal; apoE; apolipoprotein E; AWTed; anterior wall thickness at end diastole; Ccl5; ligand 5; C-C motif; chemokine; CoQ10; ubiquinone; FS; fractional shortening; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GPX; glutathione peroxida
Cytochrome P450 mediated metabolic activation of chrysophanol
Keywords: CE; collision energy; DDQ; 2,3-dichloro-5,6-dicyano-1,4-benzoquinone; DMSO; dimethyl sulfoxide; DP; declustering potential; EPI; enhanced product ion; GSH; glutathione; IDA; information-dependent acquisition; LC-MS/MS; liquid chromatography-tandem mass sp
Molecular determinants of PPARγ partial agonism and related in silico/in vivo studies of natural saponins as potential type 2 diabetes modulators
Keywords: Type 2 diabetes; Saponins; PPARγ; Partial agonists; Pharmacophore; Docking; CAT; catalase; GSH; reduced glutathione; HB; hydrogen bond; MDA; malondialdehyde; NADPH; beta-nicotinamide adenine dinucleotide 2â²-phosphate; PDB; Protein Data Bank; PPARγ;
Lysine production from the sugar alcohol mannitol: Design of the cell factory Corynebacterium glutamicum SEA-3 through integrated analysis and engineering of metabolic pathway fluxes
Keywords: Metabolic flux analysis; 13C; Elementary flux mode; Fructokinase; Glyceraldehyde 3-phosphate dehydrogenase; NADPH; Lysine; Oxidative pentose phosphate pathway; Fructose; Seaweed; Macroalgae; Biomass;
ROS-dependent signalling pathways in plants and algae exposed to high light: Comparisons with other eukaryotes
Keywords: ABA; abscisic acid; ABC; ATP binding cassette; ADP + Pi; adenosine diphosphate and inorganic phosphate; AOX; alternative oxidase; APX; ascorbate peroxidase; ATP; adenosine triphosphate; AQP; aquaporin; b6f; Cytochrome b6f complex; CysP; peroxidatic cystei
Lysine as a heme iron ligand: A property common to three truncated hemoglobins from Chlamydomonas reinhardtii
Keywords: 2-over-2 hemoglobin; Heme reduction potential; Nitric oxide dioxygenase; Nuclear magnetic resonance; 1D; one-dimensional; CtrHb; heme domain of Chlamydomonas eugametos LI637 hemoglobin; DEAE; diethylaminoethyl; DQF-COSY; double-quantum filtered correlatio
Sialic acid-binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β2-integrin-dependent function in human eosinophils
Keywords: Eosinophil; Siglec-8; β2-integrin; apoptosis; phosphoproteomics; reduced nicotinamide adenine dinucleotide phosphate oxidase (NADPH); p38; c-Jun N-terminal kinase (JNK); Akt; DAPI; 4â²-6-Diamidino-2-pheynlindole dihydrochloride; DAVID; Database for Anno
Neutralization of TNFR-1 and TNFR-2 modulates S. aureus induced septic arthritis by regulating the levels of pro inflammatory and anti inflammatory cytokines during the progression of the disease
Keywords: ANOVA; analysis of variance; CFU; colony forming unit; CIA; collagen-induced arthritis; CPCSEA; committee for the purpose of control and supervision of experiments on animals; Cyt C; cytochrome C; DMSO; dimethyl sulfoxide; DPI; days post infection; EDTA;
Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice
Keywords: CREBH; PPARα; Liver Injury; Mouse Model; Steatohepatitis; AHF; atherogenic high-fat; ALT; alanine aminotransferase; AST; aspartate aminotransferase; CREBH; hepatocyte-specific cAMP-responsive element binding protein; DECR; 2,4 dienoyl-coA reductase; FAO;
The 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3â²,4â²-methylenedioxyphenyl]-coumarin downmodulates the FcγR- and CR-mediated oxidative metabolism and elastase release in human neutrophils: Possible mechanisms underlying inhibition of the formation a
Keywords: ABAH; 4-aminobenzoic acid hydrazide; ANOVA; analysis of variance; CL-luc; lucigenin-enhanced chemiluminescence; CL-lum; luminol-enhanced chemiluminescence; CR; complement receptor; DAPI; 4',6-diamidino-2-phenylindole dihydrochloride; DMSO; dimethyl sulfox
H2S and polysulfide metabolism: Conventional and unconventional pathways
Keywords: α-KB; α-ketobutyrate; α-KG; α-ketoglutarate; AdoMet; S-adenosyl-l-methionine; AOX; alternative oxidase; AOA; Aminooxyacetate; BCA; β-cyanoalanine; BKCa; large-conductance Ca2+-dependent K+ channels; BPA; bovine pulmonary arteries; CBS; cystathionine
Enhancing NADPH regeneration and increasing hydroxylation efficiency with P450 monooxygenase through strengthening expression of glucose-6-phosphate dehydrogenase in industrial filamentous fungi
Keywords: Rhizopus nigricans; NADPH; 16α, 17-epoxyprogesterone; Glucose-6-phosphate dehydrogenase;
The ADMA/DDAH/NO pathway in human vein endothelial cells exposed to arsenite
Keywords: ADMA; asymmetric dimethylarginine; NO; nitric oxide; NOx; nitric oxide stable metabolites; NOSe; nitric oxide synthase endothelial; DDAH; dimethylarginine dimethylaminohydrolase; PRMT; protein-arginine methyltransferase; NADPH; oxidase NOx-4; HUVEC; human
Positron emission tomography-computed tomography and 4-hydroxynonenal-histidine immunohistochemistry reveal differential onset of lipid peroxidation in primary lung cancer and in pulmonary metastasis of remote malignancies
Keywords: PET-CT; Positron Emission Tomography-Computed Tomography; 4-HNE; 4-hydroxynonenal; 18F-FDG; 18-fluorodeoxyglucose; SPN; solitary pulmonary nodule; LDHA; Lactate dehydrogenase A; SUV; standardized uptake value; ROS; reactive oxygen species; RNS; reactive n
All-trans retinal levels and formation of lipofuscin precursors after bleaching in rod photoreceptors from wild type and Abca4-/- mice
Keywords: Photoreceptor; Retinal; Retinol; NADPH; ABCA4; Lipofuscin; Fluorescence;
Characterization of ethoxyresorufin O-deethylase activity (EROD) in oyster Crassostrea brasiliana
Keywords: 7-ER; 7-ethoxyresorufin; AHRs; aryl hydrocarbon receptors; ANF; α-naphthoflavone; CYP; cytochrome p450; DMSO; dimethyl sulfoxide; DTT; dl-dithiothreitol; ELP; ellipticine; EROD; 7-ethoxyresorufin O-deethylase activity; FRF; furafylline; NADH; β-nicotina
Myeloperoxidase, asymmetric dimethyl-arginine and the renin-angiotensin-aldosterone-system in cardiovascular risk patients: Cross-sectional findings from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study
Keywords: CVD; cardiovascular disease; CAD; coronary artery disease; CRP; C-reactive protein; MPO; myeloperoxidase; HOCL; hypochlorus acid; NO; nitric oxide; NOS; nitric oxide synthase; ADMA; asymmetrical dimethyl-arginine; ROS; reactive oxygen species; DDAH; dimet
Diallyl trisulfide attenuated n-hexane induced neurotoxicity in rats by modulating P450 enzymes
Keywords: n-Hexane; Diallyl trisulfide; Neurotoxicology; CYP450; 2,5-Hexanedione; Pyrrole adducts; DATS; diallyl trisulfide; 2,5-HD; 2,5-hexanedione; 2,5-DMP; 2,5-dimethylpyrrole; CYP; cytochromes; NADPH; nicotinamide adenine dinucleotide phosphate; FID; flame ioni
The self-sufficient CYP102 family enzyme, Krac9955, from Ktedonobacter racemifer DSM44963 acts as an alkyl- and alkyloxy-benzoic acid hydroxylase
Keywords: Cytochrome P450 enzymes; Monooxygenases; Fatty acid oxidation; Ktedonobacter; Alkylbenzoic acids; Alkyloxybenzoic acids; BSTFA; N,O-Bis(trimethylsilyl)trifluoroacetamide; CYP; cytochrome P450 enzyme; DEAE; diethylaminoethanol; DMSO; dimethyl sulfoxide; EM
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis
Keywords: Atherosclerosis; CVD; Sirtuin; SIRT1; SIRT3; SIRT6; Oxidative stress; Lipid metabolism; ABC; Adenosine triphosphate binding cassette; ABCG; ABC sub-family G member; ADP; Adenosine diphosphate; AMPK; Adenosine monophosphate-activated protein kinase; eNOS;
Enzymatic reduction of hydrogen peroxide on Polypogon australis plants grown in a copper mining liquid waste
Keywords: MLW; mining liquid waste; ROS; reactive oxygen species; CAT; catalases; APX; ascorbate peroxidases; GPX; glutathione peroxidases; G-POD; guaiacol peroxidases; PRX; peroxiredoxins; TRX-dp PRX; thioredoxin-dependent peroxiredoxins; GR; glutathione reductase
Prenatal high sucrose intake affected learning and memory of aged rat offspring with abnormal oxidative stress and NMDARs/Wnt signaling in the hippocampus
Keywords: AD; Alzheimer's disease; DKK1; Dickkopf-related protein 1; FINS; fasting plasma insulin; HS; high sucrose; FPG; fasting plasma glucose concentration; FZD; Frizzled; Homa-IR; insulin resistance index; LRP5/6; low-density lipoprotein-related protein recep
Conversion of NOX2 into a constitutive enzyme in vitro and in living cells, after its binding with a chimera of the regulatory subunits
Keywords: AA; all-cis-Arachidonic Acid; CCCP; carbonyl cyanide 3-chlorophenyl hydrazone; CGD; Chronic Granulomatous Disease; cyt c; cytochrome c; cyt b558; flavocytochrome b558; DPI; Diphenylene Iodonium; DISCO; Dichroism, Imaging and mass Spectrometry for Chemical
Temporal changes of oxidative stress markers in Escherichia coli K1-induced experimental meningitis in a neonatal rat model
Keywords: BBB; Blood brain barrier; BDNF; Brain derived neurotrophic factor; CAT; Catalase; CFU; Colony-forming unit; DCIP; Dichloroindophenol; DNPH; Dinitrophenylhidrazine; EDTA; Ethylenediaminetetraacetic acid; H2O2; Hydrogen Peroxide; ip; Intra peritoneal; MDA;
Enhanced performance of the methylerythritol phosphate pathway by manipulation of redox reactions relevant to IspC, IspG, and IspH
Keywords: MEP pathway; Isoprenoid; Escherichia coli; Fe-S cluster protein; NADPH;
Research PaperEffects of chlorine dioxide fumigation on redox balancing potential of antioxidative ascorbate-glutathione cycle in 'Daw' longan fruit during storage
Keywords: Redox status; Ascorbate; Glutathione; NADPH; Chlorine dioxide; Dimocarpus longan;
Candidate cytochrome P450 genes for ethoxyresorufin O-deethylase activity in oyster Crassostrea gigas
Keywords: ANF; α-naphthoflavone; CTZ; clotrimazole; CYP1; cytochrome P450 1; DMSO; dimethyl sulfoxide; DTT; DL-dithiothreitol; ELP; ellipticine; EROD; ethoxyresorufin O-deethylase activity; FRF; furafylline; NADH; β-nicotinamide adenine dinucleotide reduced; NADP