Keywords: cell death; donor lung treatment; primary graft dysfunction; inflammation; necrostatin-1;
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Keywords: Necroptosis; Smac mimetic; Cell death; Pancreatic carcinoma; IAP proteins; cIAP; cellular IAP; FADD; Fas-associated protein with death domain; FCS; fetal calf serum; GAPDH; anti-glyceraldehyde 3-phosphate dehydrogenase; IAP; inhibitor of apoptosis; MLKL;
Keywords: AIF; apoptosis-inducing factor; BSO; Buthionine sulfoximine; CAM; chorioallantoic membrane; cIAP; cellular inhibitor of apoptosis; DR5; death receptor-5; ENDOG; endonuclease G; ER; endoplasmatic reticulum; FCS; fetal calf serum; HBV; hepatitis B virus; HC
Keywords: 4-PBA; 4-phenylbutyrate; CC3; cleaved Caspase-3; CXCR4; chemokine (C-X-C motif) receptor 4; DMEM; Dulbecco's modified Eagle medium; EDTA; ethylenediaminetetraacetic acid; EM; electronic microscopic; ER; endoplasmic reticulum; FBS; fetal bovine serum; GR
Keywords: Glucocorticoid; Osteoporosis; Necrostatin-1; Necroptosis; Caspase-8;
Keywords: RIP1; receptor interacting protein 1; RIP3; receptor interacting protein3; SKN; shikonin; TNFα; tumor necrosis factor alpha; ROS; reactive oxygen species; Nec-1; necrostatin-1; zVAD; benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone; Shikonin; Progr
Necroptosis in 3-chloro-1, 2-propanediol (3-MCPD)-dipalmitate-induced acute kidney injury in vivo and its repression by miR-223-3p
Keywords: 3-MCPD; 3-chloro-1,2-propanediol; 3â²UTR; 3â² un-translated region; AKI; acute kidney injury; BMD10; Benchmark doses; BMDL10; BMD Lower Confidence Limit; BW; body weight; CXCl; chemokine (C-X-C motif) ligand; DE; differentially expressed; DR6; death rec
RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway
Keywords: 3-MA; 3-methyladenine; AO; Acridine Orange; DMEM; Dulbecco's Modified Eagle's Medium; GFAP; glial fibrillary acidic protein; HRP; horseradish peroxidase; LC3 II; light chain 3 II; LDH; lactate dehydrogenase; LMP; lysosomal membrane permeability; MAP2; mic
High-mobility group box 1 protein-mediated necroptosis contributes to dasatinib-induced cardiotoxicity
Keywords: HMGB1; high mobility group box 1; CML; chronic myelogenous leukemia; Ph+ALL; Philadelphia chromosome positive acute lymphoblastic leukemia; RIP1; receptor-interacting protein kinase 1; RIP3; receptor-interacting protein kinase 3; MLKL; mixed lineage kinas
Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells
Keywords: ÎÏ; mitochondrial membrane potential; AA; antimycin A; CI; complex I or NADH:Ubiquinone oxidoreductase; CIII; complex III or Ubiquinol-cytochrome c oxidoreductase; CsA; cyclosporin A; ETC; electron transport chain; Fer-1; ferrostatin-1; HEt; hydroethidi
Neuroprotective Effects of DTIO, A Novel Analog of Nec-1, in Acute and Chronic Stages After Ischemic Stroke
Keywords: BSA; bovine serum albumin; CBF; cerebral blood flow; CSPGs; chondroitin sulfate proteoglycans; DTIO; 5-(3â²,5â²-dimethoxybenzal)-2-thio-imidazole-4-ketone; ELISA; enzyme-linked immunosorbent assay; GFAP; glial fibrillary acidic protein; HT22; hippocampa
A novel RIPK1 inhibitor that prevents retinal degeneration in a rat glaucoma model
Keywords: CH; chemical hypoxia; CHX; cycloheximide; Cpd27; compound 27; DAPI; 4,6-diamidino-2-phenylindole; GCL; ganglion cell layer; H2O2; hydrogen peroxide; MNNG; 1-methyl-3-nitro-1 nitrosoguanidine; Nec-1; necrostatin-1; OGD; oxygen glucose deprivation; PI; prop
Necrostatin-1 protects hippocampal neurons against ischemia/reperfusion injury via the RIP3/DAXX signaling pathway in rats
Keywords: I/R; ischemia/reperfusion; RIP3; receptor-interacting protein 3; DAXX; death-associated protein; Nec-1; necrostatin-1; HE; hematoxylin and eosin; PML-NBs; promyelocytic leukemia protein-nuclear bodies; FADD; fas-associated with death domain protein; DMSO;
Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion
Keywords: AA; Antimycin A; ALL; Allopurinol; ASK1; Apoptosis-signaling kinase 1; DCFH2-DA; 5-(6)-carboxy-2â², 7â²-dichlorodihydrofluorescein diacetate; DPI; Diphenyleneiodonium; ERK; Extracellular signal regulated kinase; H2O2; Hydrogen peroxide; JNK; c-Jun-N-ter
Cisplatin-induced necroptosis in TNFα dependent and independent pathways
Keywords: RIP; receptor-interacting protein; MLKL; mixed lineage kinase domain-like protein; CypD; cyclophilin-D; ROS; reactive oxygen species; mPTP; mitochondrial permeability transition pore; TNFα; tumor necrosis factor α; CaMKII; Ca2 +-calmodulin-dependent pr
Necrostatin-1 protects against oleic acid-induced acute respiratory distress syndrome in rats
Keywords: ARDS; Necroptosis; Inflammation; Necrostatin-1;
Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing
Keywords: Rottlerin; AMPK; mTOR; 4EBP-1; Autophagy; Protein synthesis; RPMI; Roswell Park Memorial Institute (RPMI); Becl-1; beclin-1; AMPK; AMP-activated protein kinase; ACC; acetyl-CoA carboxylase; mTOR; mammalian target of rapamycin; raptor; regulatory-associate
Necroptosis: an alternative cell death program defending against cancer
Keywords: AIF; apoptosis-inducing factor; ALL; acute lymphoblastic leukemia; cIAP; cellular inhibitor of apoptosis protein; CLL; chronic lymphocytic leukemia; CYLD; cylindromatosis; DAMPs; Damage Associated Molecular Patterns; DCs; dendritic cells; Drp1; dynamin-re
Diarachidonoylphosphoethanolamine induces necrosis/necroptosis of malignant pleural mesothelioma cells
Keywords: DAPE; 1,2-diarachidonoyl-sn-glycero-3-phosphoethanolamine; MPM; malignant pleural mesothelioma; PI; propidium iodide; AV; annexin V; Nec-1; necrostatin-1; ROS; reactive oxygen species; MPT; mitochondrial permeability transition; CypD; cyclophilin D; CsA;
24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8
Keywords: 24S-OHC; 24(S)-hydroxycholesterol; ACAT1; acyl-CoA:cholesterol acyltransferase 1; AD; Alzheimer's disease; cIAP; cellular inhibitor of apoptosis protein; CYP46A1; cholesterol 24-hydroxylase; JurkatCas8â/â; caspase-8-deficient Jurkat; LDH; lactate de
Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells
Keywords: Apoptosis; Necrosis; Necrostatin-1; RIP1; AIF; PARP-1;
Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury
Keywords: Global cerebral ischemia; Necrostatin-1; Nuclear translocation; Programmed necrosis; Receptor-interacting protein 3
Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells
Keywords: Apoptosis; Smac; Leukemia; Necroptosis; AML; acute myeloid leukemia; CI; combination index; cIAP; cellular inhibitor of apoptosis protein; FACS; fluorescence-activated cell-sorting analysis; FCS; fetal calf serum; FLT3; Fms-like tyrosine kinase 3; FSC/SSC
The role of RIP3 mediated necroptosis in ouabain-induced spiral ganglion neurons injuries
Keywords: SGN; spiral ganglion neuron; RIP3; receptor-interacting protein 3; Nec-1; necrostatin-1; ABR; auditory brain-stem response; Z-VAD; N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone; Spiral ganglion neuron injury; Ouabain; Necroptosis; Nec-1; RIP3; Z-VAD;
Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3
Keywords: Actb; β-Actin; cIAP; Cellular Inhibitor of Apoptosis Protein; Ctx; Cortex; CYLD; Cylindromatosis; DG; Dentate Gyrus; DISC; Death Inducing Signaling Complex; DR; Death Receptor; FADD; Fas-associated Protein with Death Domain; Gapdh; Glyceraldehyde 3-phosp
Sexual dimorphism in BDNF signaling after neonatal hypoxia-ischemia and treatment with necrostatin-1
Keywords: ANOVA; analysis of variance; BDNF; brain-derived neurotrophic factor; E2; estradiol; ELISA; enzyme-linked immunosorbent assay; ER; estrogen receptor; ERE; estrogen response element; FL.TrkB; full-length TrkB; HI; hypoxia-ischemia; nec-1; necrostatin-1;
Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: The impact of cell differentiation state
Keywords: ACPT-I; LY354740; VU0361737; (S)-3,4-DCPG; AZ12216052; AMN082; Necrostatin-1; [3H]MPP(+) uptake; mGluR II/III expression6-OHDA, 6-hydroxydopamine; DAT, dopamine transporter; FBS, fetal bovine serum; GABA, γ-aminobutyric acid; GPCRs, G-protein-coupled rece
Sorafenib overcomes the chemoresistance in HBx-expressing hepatocellular carcinoma cells through down-regulation of HBx protein stability and suppresses HBV gene expression
Keywords: 3-MA; 3-methyladenine; AIF; apoptosis-inducing factor; BAF; Bafilomycin A1; CQ; Chloroquine; HBV; Hepatitis B virus; HBx; Hepatitis B virus X; HCC; Hepatocellular carcinoma; IFNα; interferon alpha; LC3II; dynein light chain 3; MMP; mitochondrial membrane
Necroptosis, in vivo detection in experimental disease models
Keywords: (AD); Alzheimer's disease; (AKI); acute kidney injury; (CLP); cecal ligation and puncture; (CypD); cyclophilin D; (ConA); Concanavalin-A; (DAI); DNA-dependent activator of IFN-regulatory factors; (DAMPs); damage-associated molecular patterns; (HMGB1); hig
Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation
Keywords: BHA; butylated hydroxyanisole; cIAP1; cellular inhibitor of apoptosis protein-1; FADD; Fas-associated protein with death domain; Nec-1; necrostatin-1; RIPK1; receptor-interacting serine-threonine kinase 1; TNF; tumor necrosis factor; TRADD; TNF receptor
Differential effects of caspase inhibitors on TNF-induced necroptosis
Keywords: CHX, cycloheximide; PI, propidium iodide; PBS-T, PBS with 0.1% Tween 20Apoptosis; Necroptosis; Necrostatin-1; Z-VAD-fmk; Z-Asp-CH2-DCB; Z-DEVD-fmk
Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway
Keywords: Bak; Bcl-2 antagonist/killer; Bax; Bcl-2-associated X protein; FADD; Fas-associated death domain; FAM3B; family with sequence similarity 3, member B; LDH; lactate dehydrogenase; MTT; 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; Nec-1; ne
Discrimination between primary necrosis and apoptosis by necrostatin-1 in Annexin V-positive/propidium iodide-negative cells
Keywords: PI, propidium iodide; CHX, cycloheximide; zVAD, z-VAD-fmkApoptosis; Necrosis; Annexin V; Necrostatin-1; RIP1
Attenuation of cadmium-induced necrotic cell death by necrostatin-1: Potential necrostatin-1 acting sites
Keywords: Necrostatin-1; Cadmium; Necrosis; Mitochondria; RIP1; NF-κB
Necroptosis contributes to the NMDA-induced excitotoxicity in rat's cultured cortical neurons
Keywords: Necroptosis; Necrostatin-1; N-methyl-d-aspartate; Excitotoxicity; Calcium;