Keywords: بیماری های نوروژنیک; Extracellular alpha-synuclein; Oxidative stress; “Prion-like” protein transmission; Nitric oxide; Mitochondria dysfunction; Neurodegenerative diseases; OH; hydroxyl radicals; AD; Alzheimer's disease; ASN; α-synuclein; Aβ; amyloid β; CaN; calcineu
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Keywords: بیماری های نوروژنیک; 2DG; 2-Deoxy-D-glucose; 2-ME; 2-methoxyestradiol; 3NP; 3-nitropropionic acid; ASK1; apoptosis signal-regulating kinase 1; Atg; autophagy-related gene; ATM; ataxia-telangiectasia mutated; Bif-1; Bax-interacting factor-1; BNIP3; Bcl-2/E1B interacting protei
Keywords: بیماری های نوروژنیک; Neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; Infection; Incretins; GLP-1; Liraglutide;
Keywords: بیماری های نوروژنیک; Unbiased longitudinal image processing; Diffusion tensor imaging; Neurodegenerative diseases; Reliability and precision; Within-subject template;
Keywords: بیماری های نوروژنیک; Glutamate; Neurodegenerative diseases; Excitotoxicity; Oxidative stress; Mitochondrial dysfunction; Calcium overload; Therapeutics;
Keywords: بیماری های نوروژنیک; Parkinson's disease; Huntington's disease; Neurodegenerative diseases; Mitochondrial dysfunction; Creatine; Co-Q10; PGC-1α; Sirtuins;
Keywords: بیماری های نوروژنیک; Neurogenesis; Neuroprotective agents; Neurodegenerative diseases; Aminopropyl carbazole; Neural stem cells;
Keywords: بیماری های نوروژنیک; PD; Parkinson's disease; AD; Alzheimer's disease; HD; Huntington's Disease; ALS; Amyotrophic Lateral Sclerosis; TAR DNA; binding protein TDP-43; TCA; tricarboxylic acid cycle; ROS; reactive oxygen species; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydrod
Keywords: بیماری های نوروژنیک; Asteraceae; Echinacea angustifolia; Echinacea purpurea; HeLa; Human vein epithelial cells; Neurodegenerative diseases
Keywords: بیماری های نوروژنیک; BPA; Insulin signaling; Glucose transporters; Neurodegenerative diseases; Mice
Keywords: بیماری های نوروژنیک; Cyanotoxins; Low doses; Apoptosis; Inflammation; Brain cells; Neurodegenerative diseases
Keywords: بیماری های نوروژنیک; Iron; Neurodegenerative diseases; Chelation
Multiple-step, one-pot synthesis of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates and their corresponding ethyl esters
Keywords: بیماری های نوروژنیک; Autophagy; Lanthionine ketimine; Neurodegenerative diseases; ALS; Alzheimer's; Cysteine; Phosphonate; Arbuzov;
The frequency of the C9orf72 expansion in a Brazilian population
Keywords: بیماری های نوروژنیک; C9orf72; G4C2 repeat expansion; Amyotrophic lateral sclerosis; Frontotemporal dementia; Neurodegenerative diseases; Frequency;
Resistin destroys mitochondrial biogenesis by inhibiting the PGC-1α/ NRF1/TFAM signaling pathway
Keywords: بیماری های نوروژنیک; Mitochondrial biogenesis; Resistin; Peroxisome proliferator activator receptor gamma-coactivator 1α (PGC-1α); mtDNA; Neurodegenerative diseases;
Dual channel LSTM based multi-feature extraction in gait for diagnosis of Neurodegenerative diseases
Keywords: بیماری های نوروژنیک; Neurodegenerative diseases; Diagnosis; Gait disorders; Time series; Force series; Dual channel LSTM;
Design of epigallocatechin gallate loaded PLGA/PF127 nanoparticles and their effect upon an oxidative stress model
Keywords: بیماری های نوروژنیک; Epigallocatechin gallate; PF127; PLGA; Nanoparticles; Neurodegenerative diseases;
Myxobacterial natural products: An under-valued source of products for drug discovery for neurological disorders
Keywords: بیماری های نوروژنیک; Drug discovery; Neurodegenerative diseases; Natural products; Myxobacteria;
Orphan G protein-coupled receptors: The role in CNS disorders
Keywords: بیماری های نوروژنیک; Orphan GPCR; Anxiety; Depression; Seizure; Neurodegenerative diseases; Brain; Fatty acids;
Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease
Keywords: بیماری های نوروژنیک; AChE; acetylcholine esterase; AD; Alzheimer's disease; AP1; activator protein 1; APP; amyloid precursor protein; Aβ; amyloid beta; BACE1; β-site of APP cleaving enzyme; Bax; Bcl-2-associated X protein; BBB; blood-brain barrier; Bcl-2; B-cell lymphoma
Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration?
Keywords: بیماری های نوروژنیک; Neurodegenerative diseases; mTOR; omega-3; Docosahexaenoic acid; Eicosapentaenoic acid;
La infusión intracerebroventricular prolongada de lÃquido cefalorraquÃdeo procedente de pacientes con esclerosis lateral amiotrófica provoca cambios histológicos en el cerebro y la médula espinal de la rata similares a los hallados en la enfermedad
Keywords: بیماری های نوروژنیک; Esclerosis lateral amiotrófica; Modelo experimental ELA; Periferina; TDP-43; Enfermedades neurodegenerativas; Citotoxicidad; Amyotrophic lateral sclerosis; ALS experimental model; Peripherin; TDP-43; Neurodegenerative diseases; Cytotoxicity;
An inorganic overview of natural Aβ fragments: Copper(II) and zinc(II)-mediated pathways
Keywords: بیماری های نوروژنیک; Metal ions; Alzheimer's disease; Neurodegenerative diseases; Aβ-degrading enzyme; Metallostasis;
Scavenger Receptor-A deficiency impairs immune response of microglia and astrocytes potentiating Alzheimer's disease pathophysiology
Keywords: بیماری های نوروژنیک; Aging; Beta-amyloid plaques; Glial cells; Neurodegenerative diseases; Neuroinflammation; Scavenger receptor;
Role of autophagy in environmental neurotoxicity
Keywords: بیماری های نوروژنیک; Autophagy; Neurotoxicity; Neurodegenerative diseases; Environmental contaminants;
Differential protein expression of hippocampal cells associated with heavy metals (Pb, As, and MeHg) neurotoxicity: Deepening into the molecular mechanism of neurodegenerative diseases
Keywords: بیماری های نوروژنیک; Metal exposure; Proteomics; Pathway visualization; Neurodegenerative diseases; AD; Alzheimer's disease; APP; Amyloid precursor protein; Aβ; Amyloid-beta; CAM; Calmodulin; ETC; Electron transport chain; GAD; glutamate decarboxylase; Glu; Glutamate; GO; Ge
3D neural tissue models: From spheroids to bioprinting
Keywords: بیماری های نوروژنیک; 3D printing; Nerve regeneration; Neurons; Glial cells; Traumatic nerve injuries; Neurodegenerative diseases;
Novel indanone derivatives as MAO B/H3R dual-targeting ligands for treatment of Parkinson's disease
Keywords: بیماری های نوروژنیک; Multi-targeting; Neurodegenerative diseases; Histamine H3 receptor antagonist; Monoamine oxidase inhibitor; Neurotransmitter dysregulation; Parkinson's disease; AChE; acetylcholinesterase; anal. calc.; elementary analysis calculated; BuChE; butyrylcholine
A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities
Keywords: بیماری های نوروژنیک; Ubiquilin; Drosophila; Neurons; Proteostasis; Neurodegenerative diseases; Locomotion; Learning; Memory;
The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases
Keywords: بیماری های نوروژنیک; α-Crystallins; Neurodegenerative diseases; Neuroprotection; Gene regulation; Aβ; β-amyloid peptides; AD; Alzheimer's disease; ALS; Amyotrophic lateral sclerosis; AxD; Alexander's disease; CNS; Central nervous system; EAE; experimental autoimmune enceph
Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions
Keywords: بیماری های نوروژنیک; antioxidant; ginsenosides; neurodegenerative diseases; Panax ginseng;
Application of the gene editing tool, CRISPR-Cas9, for treating neurodegenerative diseases
Keywords: بیماری های نوروژنیک; Genetic engineering; Gene mutation; Gene editing; DNA repair; Neurodegenerative diseases;
3D human brain cell models: New frontiers in disease understanding and drug discovery for neurodegenerative diseases
Keywords: بیماری های نوروژنیک; 3D culture; iPSC; Organoid; Co-culture; Microfluidics; Neurodegenerative diseases;
Cooperativity between different tRNA modifications and their modification pathways
Keywords: بیماری های نوروژنیک; tRNA modifications; Elongator; Neurodegenerative diseases; Anticodon stem and loop; Yeast; Cross talk;
Mesenchymal stem cell-mediated immunomodulation in cell therapy of neurodegenerative diseases
Keywords: بیماری های نوروژنیک; Mesenchymal stem cells; neurodegenerative diseases; immunomodulation; microglia; T cells;
The effect of tDCS on functional connectivity in primary progressive aphasia
Keywords: بیماری های نوروژنیک; Primary progressive aphasia (PPA); Transcranial direct current stimulation (tDCS); Resting-state fMRI (rsfMRI); Functional connectivity; Neurodegenerative diseases;
Non-viral delivery of an optogenetic tool into cells with self-healing hydrogel
Keywords: بیماری های نوروژنیک; Self-healing hydrogel; Optogenetics; Bacteriorhodopsin; Neurodegenerative diseases;
Caenorhabditis elegans as a model system for target identification and drug screening against neurodegenerative diseases
Keywords: بیماری های نوروژنیک; Amyloid; Neurodegenerative diseases; Animal model; C. elegans; Drug screening; Target identification;
Targeting ERK signaling pathway by polyphenols as novel therapeutic strategy for neurodegeneration
Keywords: بیماری های نوروژنیک; Neurodegenerative diseases; Flavonoids; Natural products; MAPK; ERK; MEK/ERK;
Development of novel amide-derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a key modification
Keywords: بیماری های نوروژنیک; Dyrk1A; Neurodegenerative diseases; Cyclopropyl amide; SF3b1 phosphorylation; CNS penetration;
Neuroprotection afforded by circadian regulation of intracellular glutathione levels: A key role for miRNAs
Keywords: بیماری های نوروژنیک; Circadian rhythms; Glutathione; Neurodegenerative diseases; microRNA; miR-96-5p; EAAC1;
Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study
Keywords: بیماری های نوروژنیک; Functional brain connectivity; Resting-state EEG rhythms; Neurodegenerative diseases; Dementia; Alzheimer's disease; Parkinson's disease; Dementia with Lewy bodies;
Indirubin derivatives protect against endoplasmic reticulum stress-induced cytotoxicity and down-regulate CHOP levels in HT22 cells
Keywords: بیماری های نوروژنیک; Indirubin; Endoplasmic reticulum stress; CHOP; HT22 cells; Neurodegenerative diseases;
N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1δ/ε inhibitors: Synthesis, biological evaluation and molecular modeling studies
Keywords: بیماری های نوروژنیک; Quinazolines; Protein kinases; Casein kinase 1δ/ε; MTT assay; Neurodegenerative diseases; Cancer;
Effects of Gardenia jasminoides extracts on cognition and innate immune response in an adult Drosophila model of Alzheimer's disease
Keywords: بیماری های نوروژنیک; Gardenoside; Geniposide; Crocin; Inflammation; Memory; Gardenia jasminoides; Neurodegenerative diseases;
Tetrahydroxy stilbene glycoside (TSG) antagonizes Aβ-induced hippocampal neuron injury by suppressing mitochondrial dysfunction via Nrf2-dependent HO-1 pathway
Keywords: بیماری های نوروژنیک; TSG; tetrahydroxy stilbene glycoside; Aβ; amyloid-beta peptide; AD; Alzheimer's disease; PD; Parkinson's disease; ND; neurodegenerative diseases; LDH; lactate dehydrogenase; ÎÏm; mitochondrial membrane potential; FBS; fetal bovine serum; ROS; react
Bioassay-guided fractionation of ethyl acetate extract from Armillaria mellea attenuates inflammatory response in lipopolysaccharide (LPS) stimulated BV-2 microglia
Keywords: بیماری های نوروژنیک; Armillaria mellea; Neuroinflammation; BV-2 microglia; Neurodegenerative diseases; Anti-inflammation; A. mellea; Armillaria mellea; LPS; lipopolysaccharide; Fr; fraction; pre-HPLC; preparative high performance liquid chromatography; MS; mass spectrometry;
Nanoparticle standards for immuno-based quantitation of α-synuclein oligomers in diagnostics of Parkinson's disease and other synucleinopathies
Keywords: بیماری های نوروژنیک; Parkinson's disease; α-Synuclein; Diagnostic biomarker; Surface-based fluorescence intensity distribution analysis (sFIDA); Silica nanoparticles (SiNaPs); Automation; Protein aggregates; Neurodegenerative diseases;
Research articleChronic sleep fragmentation exacerbates amyloid β deposition in Alzheimer's disease model mice
Keywords: بیماری های نوروژنیک; Sleep disturbance; Sleep fragmentation; Alzheimer's disease; Amyloid β; Neurodegenerative diseases;
Attenuation of H2O2-induced neuronal cell damage by piceatannol
Keywords: بیماری های نوروژنیک; Piceatannol; Hydrogen peroxide; Glutathione peroxidase; Polyphenols; Antioxidant; Neurodegenerative diseases;