Neurosteroids: Endogenous allosteric modulators of GABAA receptors
Keywords: GABAA receptor; Neurosteroid; Tonic conductance; Extrasynaptic receptors; Inhibitory neurotransmission
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Sex differences in acute ethanol withdrawal severity after adrenalectomy and gonadectomy in Withdrawal Seizure-Prone and Withdrawal Seizure-Resistant mice
Keywords: GABA; Progesterone; Corticosterone; Neurosteroid; Convulsions; Alcohol
Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation in Npc1−/− mouse brain
Keywords: ALLO, allopregnanolone; GABA, gamma-aminobutyric acid; GFAP, glial fibrillary acidic protein; LC3, microtubule-associated protein 1 light chain 3; PXR, pregnane X receptorCathepsin; Glia; LC3; Lipid; Neurosteroid; Myelination
Expression levels of the α4 subunit of the GABAA receptor in differentiated neuroblastoma cells are correlated with GABA-gated current
Keywords: GABA; Alpha-4; Chloride current; Neurosteroid; Pregnanolone; Benzodiazepine inverse agonist; Depolarization; Bumetanide
Puberty, steroids and GABAA receptor plasticity
Keywords: Pregnanolone; Allopregnanolone; Puberty; GABAA receptor; Neurosteroid; Stress; Chloride; Anxiety; Tonic current; CA1 hippocampus; Steroid withdrawal
Pregnenolone sulfate modulation of N-methyl-d-aspartate receptors is phosphorylation dependent
Keywords: N-methyl-d-aspartate receptor; hypothermia; neurosteroid; patch-clamp recording; phosphorylation; dephosphorylation; DMSO; dimethyl sulfoxide; ECS; extracellular solution; EDTA; ethylenediamine-N,N,Nâ²,Nâ²-tetraacetic acid; EGTA; ethylene glycol-bis-(β
The role of neurosteroids in the pathophysiology and treatment of catamenial epilepsy
Keywords: Epilepsy; Neurosteroid; Allopregnanolone; THDOC; Androstanediol; GABA-A receptor; Progesterone withdrawal; Menstrual cycle; Ganaxolone
Neurosteroids allosterically modulate the ion pore of the NMDA receptor consisting of NR1/NR2B but not NR1/NR2A
Keywords: Neurosteroid; NMDA receptor; NR2B subunit; Pregnenolone; Pregnanolone; Ifenprodil; Allosteric modulation; MK-801; Hippocampus; Receptor binding; Kinetics; Ion channel; CHO; Nanomolar; Pregnenolone sulphate; Pregnanolone sulphate
Parity and estrogen-administration alter affective behavior of ovariectomized rats
Keywords: Estrogen; Hippocampus; Neurosteroid; Affect; Reproductive experience;
Assessment of neuroactive steroid formation in diabetic rat spinal cord using high-performance liquid chromatography and continuous flow scintillation detection
Keywords: Diabetes; HPLC; Neuroprotection; Neurosteroid; Pulse-chase; Spinal cord; Steroids and the nervous system;
Fast non-genomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms
Keywords: Spinal cord; Neurosteroid; Progesterone; Allopregnanolone; Mechanical allodynia; Thermal heat hyperalgesia; GABAA receptor; Glycine receptor; Carrageenan; Inflammatory pain; Spinal inhibition;
Treatments for spinal cord injury: Is there hope in neurosteroids?
Keywords: Spinal cord injury; Neurosteroid; DHEA; Sonic-hedgehog; Methylprednisolone; Drug development; Motor recovery; Bladder control
Neurosteroids 3β, 20 (R/S)-pregnandiols decrease offset rate of the GABA-site activation at the recombinant GABAA receptor
Keywords: GABAA receptor; GABA; Neurosteroid; Onset/offset rate; Pregnenolone sulfate
Analysis of steroids in songbird plasma and brain by coupling solid phase extraction to radioimmunoassay
Keywords: Corticosterone; Dehydroepiandrosterone; DHEA; Estradiol; Neurosteroid; Songbird; RIA; EIA; Song sparrow; European starling; Zebra finch; Avian; Yolk; Bird; Chicken; Stress; Hormone; C18; Sample preparation; Steroid extraction; Lipid
Endogenous steroid production in the spinal cord and potential involvement in neuropathic pain modulation
Keywords: Neurosteroid; Nociception; Pain; Sensory system; Spinal cord
Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice
Keywords: AC-5216; Anxiolytic effect; Translocator protein (18 kDa) (TSPO); Peripheral benzodiazepine receptor (PBR); Mitochondrial benzodiazepine receptor (MBR); Neurosteroid; Trilostane; Finasteride; Picrotoxin; Social interaction; Mice
Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3α,5α-THP formation in the midbrain ventral tegmental area
Keywords: Neurosteroid; Biosynthesis; Non-genomic; GABAA receptors; Homeostasis
Persistence of tolerance to the anaesthetic effect of allopregnanolone in male rats
Keywords: GABAA receptor (Gamma-aminobutyric acid A); In situ hybridisation; Neurosteroid; Burst suppression threshold; Allopregnanolone tolerance
Neurosteroid dehydroepiandrosterone sulphate inhibits persistent sodium currents in rat medial prefrontal cortex via activation of sigma-1 receptors
Keywords: Neurosteroid; Dehydroepiandrosterone sulphate; Medial prefrontal cortex; Whole-cell patch clamp; Persistent sodium currents; Sigma-1 receptors; Gi protein; Protein kinase C; Excitability; Chemical inhibition of mitochondria
Sex differences in DHEA and estradiol during development in a wild songbird: Jugular versus brachial plasma
Keywords: 3beta-HSD; Aromatase; Avian; Bird; Brain; Dehydroepiandrosterone; Estrogen; European starling; Nestling; Neurosteroid; Ontogeny; Sex difference; Sexual differentiation; Song; Testosterone; Zebra finch
3β-HSD activates DHEA in the songbird brain
Keywords: 3β-HSD; Adrenal; Aggression; Aromatase; Brain; DHEA; Estrogen; Neurosteroid; Season; Song; Sparrow; Stress; Testosterone; Zebra finch
Decreased anticonvulsant efficacy of allopregnanolone during ethanol withdrawal in female Withdrawal Seizure-Prone vs. Withdrawal Seizure-Resistant mice
Keywords: Alcohol; Convulsions; Neurosteroid; Pentylenetetrazol; Selected lines; GABAA receptors;
Neuroprogesterone: Key to estrogen positive feedback?
Keywords: Estrogen positive feedback; Progesterone receptor; Neurosteroids; Neurosteroid; Lordosis; Membrane estrogen receptor; mGluR1a; Calcium; Brain; Luteinizing hormone; Astrocytes; Glial; LH; Reproduction; 3beta-HSD; Estradiol; Rapid; Non-genomic; Hypothalamus
The biological activity of 3α-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury
Keywords: Allodynia; Neuropathy; Neurobiology of pain; Neurosteroid; Sciatic nerve constriction; Spinal cord; Steroid and neural disease
Brain transcriptomics in response to β-naphthoflavone treatment in rainbow trout: The role of aryl hydrocarbon receptor signaling
Keywords: Fish; Oncorhynchus mykiss; Cortisol; Stress response; Neurosteroid; Endocrine disruption; Steroidogenesis; Heat shock proteins; Sex steroids; PCBs;
The membrane-associated progesterone-binding protein 25-Dx: Expression, cellular localization and up-regulation after brain and spinal cord injuries
Keywords: Progesterone; Neuroprotection; Membrane receptor; 25-Dx; Neurosteroid; TBI
Ethanol intake patterns in female mice: Influence of allopregnanolone and the inhibition of its synthesis
Keywords: Alcohol; Self-administration; Lickometer; Neurosteroid; GABA; Finasteride;
Novel mechanisms for neuroendocrine regulation of aggression
Keywords: Allopregnanolone; Brain; DHEA; Estrogen; Hamster; Melatonin; Neurosteroid; Songbird; Stress; Testosterone - KT
Steroid requirements for regulation of the α4 subunit of the GABAA receptor in an in vitro model
Keywords: Pregnanolone; Neurosteroid; Estradiol; GABAA receptor; α4; IMR-32 cells; Nerve growth factor; GABA
Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: A role for NMDA receptors
Keywords: Allopregnanolone; Amygdala; Neurosteroid; GABAA; NMDA; Patch clamp;
Self-administration of 3α-androstanediol increases locomotion and analgesia and decreases aggressive behavior of male hamsters
Keywords: Non-genomic; Neurosteroid; Anabolic–androgenic androgens; Reward; Reinforcement
Fluctuations in brain concentrations of neurosteroids are not associated to changes in gephyrin levels
Keywords: Gephyrin; GABAA receptor; Pregnancy; Oral contraceptive; Neurosteroid; Rat
The progesterone metabolite allopregnanolone potentiates GABAA receptor-mediated inhibition of 5-HT neuronal activity
Keywords: Electrophysiology; Neurosteroid; Rat; Serotonin; Slice
Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice
Keywords: Animal model; Alcohol intake; Operant; Neurosteroid; Reinforcement; Lickometer; Drinking patterns; Locomotor activity;
Activities of 3β-HSD and aromatase in slices of developing and adult zebra finch brain
Keywords: Songbird; Neurosteroid; Neurosteroidogenesis; Estrogen; DHEA
Neurosteroids in child and adolescent psychopathology
Keywords: Adolescents; Neurosteroid; Neurodevelopment; Psychopathology; Treatment
Neurosteroid dehydroepiandrosterone sulfate enhances spontaneous glutamate release in rat prelimbic cortex through activation of dopamine D1 and sigma-1 receptor
Keywords: Neurosteroid; Dehydroepiandrosterone sulfate; Prelimbic cortex; Glutamate release; D1 receptor; Sigma-1 receptor
Analysis of clinical symptomatology, extrapyramidal symptoms and neurocognitive dysfunction following dehydroepiandrosterone (DHEA) administration in olanzapine treated schizophrenia patients: A randomized, double-blind placebo controlled trial
Keywords: Dehydroepiandrosterone; DHEA; Neurosteroid; Psychosis; Schizophrenia; Olanzapine
Progestins influence motivation, reward, conditioning, stress, and/or response to drugs of abuse
Keywords: Neurosteroid; Non-genomic; GABAA; D1 receptors; NMDA rececptor; Anxiety; Affect; Learning; Cocaine; Progesterone; 3α,5α-THP
Neurosteroid modulation of synaptic and extrasynaptic GABAA receptors
Keywords: GABAA receptor; Neurosteroid; Inhibitory synaptic transmission; Tonic current; Extrasynaptic receptors3α,5α-THP, 5α-pregnan-3α-ol-20-one; 3α,5α-THDOC, 5α-pregnan-3α,21-diol-20-one; 3α,5β-THP, 5β-pregnan-3α-ol-20-one; 5α-DHP, 5α-dihydroprogesterone; CGC, c
Neurosteroid regulation of GABAA receptors: Focus on the α4 and δ subunits
Keywords: GABAA receptor; Alpha-4; Delta; Neurosteroid; Allopregnanolone; Pregnanolone; THP; GABA; Hippocampus; Anxiety; Panic; Premenstrual syndrome; Premenstrual dysphoric disorder; Puberty; Mood3α,5α-THP, 3α-OH-5α-pregnan-20-one (allopregnanolone); 3α,5β-THP, 3α
Mechanisms of neurosteroid interactions with GABAA receptors
Keywords: GABA; Neurosteroid; Anesthesia; Enantiomer; Electrophysiology; Photoaffinity label3α5αP, (3α,5α)-3-hydroxypregnan-20-one; 3α5βP, (3α,5β)-3-hydroxypregnan-20-one; 17PA, (3α,5α)-17-phenylandrost-16-en-3-ol; ACN, (3α,5α,17β)-3-hydroxyandrostane-17-carbonitri
Effects of neurosteroid 3α-hydroxy-5α-pregnan-20-one on ethanol-mediated paired-pulse depression of population spikes in the CA1 region of rat hippocampal slices
Keywords: Paired pulse dissociation; Paired pulse depression; Ethanol; Hippocampus; Neurosteroid
Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy
Keywords: Epileptogenesis; Status epilepticus; Glia; Hippocampus; Neurosteroid; Pilocarpine
Expression of heteromeric glycine receptor-channels in rat spinal cultures and inhibition by neuroactive steroids
Keywords: Glycine receptors of spinal cord culture; Protein and mRNA expression; Neurosteroid; Electrophysiology; Alphaxalone; Betaxalone; Tropisetron
Plasticité de l'inhibition spinale et symptômes douloureux chez l'animal
Keywords: moelle épinière; nociception; GABA; glycine; homéostasie chlorure; prostaglandine E2; neurostéroïde; désinhibition spinale; spinal cord; nociception; GABA; Glycine; chloride homeostasis; prostaglandin E2; neurosteroid; spinal disinhibition;
Androstenetriol improves survival in a rodent model of traumatic shock
Keywords: Androstenetriol; Trauma; Hemorrhagic shock; Neurosteroid
The Neurosteroid Allopregnanolone Is Reduced in Prefrontal Cortex in Alzheimer’s Disease
Keywords: allopregnanolone; Alzheimer’s disease; dehydroepiandrosterone; neurosteroid; postmortem; prefrontal cortex
Neurosteroid modulation of recombinant rat α5β2γ2L and α1β2γ2L GABAA receptors in Xenopus oocyte
Keywords: Neurosteroid; GABAA receptor; α1-subunit; α5-subunit; Xenopus oocyte
Intradermal pregnenolone sulfate attenuates capsaicin-induced nociception in rats
Keywords: Neurosteroid; Pregnenolone sulfate; Capsaicin receptor; Opioid; Cannabinoid; Nociception