Research reportRole of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction
Keywords: Finasteride; Metyrapone; Cocaine; Neurosteroid; Bicuculline; GABA;
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The neurosteroid allopregnanolone impairs object memory and contextual fear memory in male C57BL/6J mice
Keywords: Learning; Memory; Hippocampus; Neurosteroid; Novelty; Object recognition; Fear conditioning; Context;
CommentarySlc10A4 - what do we know about the function of this “secret ligand carrier” protein?
Keywords: Synaptic vesicles; Epilepsy; Alzheimer's and Parkinson's disease; Schizophrenia and addiction; Transporter; Neurosteroid;
ReviewGABAA receptor modulation: Potential to deliver novel pain medicines?
Keywords: Allodynia; Benzodiazepine; Disinhibition; Hyperalgesia; Neuropathic; Neurosteroid;
Genome–brain–behavior interdependencies as a framework to understand hormone effects on learned behavior
Keywords: Genome; Hormone; Songbird; Behavior; Neuropeptide; Neurosteroid
A clinical/translational perspective: Can a developmental hormone play a role in the treatment of traumatic brain injury?
Keywords: Progesterone; Neuroprotection; Traumatic brain injury; Neurosteroid
Effects of water restriction on reproductive physiology and affiliative behavior in an opportunistically-breeding and monogamous songbird, the zebra finch
Keywords: Affiliation; Corticosterone; DHEA; Estradiol; Monogamy; Neurosteroid; Pair bond; Sex difference; Song; Testosterone
Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease
Keywords: Vitamin D; Brain; Development; Degeneration; Neurosteroid; Vitamin D deficiency; Neuroprotection; Psychiatric disease
Involvement of the neurosteroid 7α-hydroxypregnenolone in the courtship behavior of the male newt Cynops pyrrhogaster
Keywords: Newt; Courtship; Behavior; Neurosteroid; 7α-hydroxypregnenolone; Dopamine;
Steroid sulfatase-deficient mice exhibit endophenotypes relevant to Attention Deficit Hyperactivity Disorder
Keywords: Anxiety; Basal forebrain; COUMATE; Dehydroepiandrosterone sulfate; Locomotor activity; Neurosteroid;
Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration
Keywords: Neurosteroid; Lickometer; Alcohol; Extrasynaptic; GABAA receptors;
Effects of koumine, an alkaloid of Gelsemium elegans Benth., on inflammatory and neuropathic pain models and possible mechanism with allopregnanolone
Keywords: CCI; chronic constriction injury; CFA; complete Freund's adjuvant; HPLC-MS; High Performance Liquid Chromatography-Mass Spectrometry; MWL; mechanical withdrawal latency; SNL; spinal nerve ligation; TWL; thermal withdrawal latency; Gelsemium elegans Be
11β-Hydroxylase inhibitors protect against seizures in mice by increasing endogenous neurosteroid synthesis
Keywords: Neurosteroid; Allotetrahydrodeoxycorticosterone; Steroid 11β-hydroxylase (CYP11B1) inhibitor; Metyrapone; Etomidate; FinasterideTHDOC, allotetrahydrodeoxycorticosterone
Effects of 7-keto dehydroepiandrosterone on voluntary ethanol intake in male rats
Keywords: DHEA; 7-keto DHEA; Neurosteroid; GABAA receptor; Ethanol intake; Rats;
Progesterone in the treatment of acute traumatic brain injury: a clinical perspective and update
Keywords: progesterone; neuroprotection; traumatic brain injury; neurosteroid; clinical trials; pharmacotherapyCNS, central nervous system; DRS, Disability Rating Scale; GOS, Glasgow Outcome Scale; GSC, Glasgow Coma Scale; HRT, hormone replacement therapies; MPA, m
The pharmacokinetics and pharmacodynamics of the injectable anaesthetic alfaxalone in the horse
Keywords: alfaxalone; alfaxan; anaesthetic; horse; neurosteroid; pharmacokinetic;
Aggressive interactions differentially modulate local and systemic levels of corticosterone and DHEA in a wild songbird
Keywords: Aggression; Brain; Dehydroepiandrosterone; Liver; Muscle; Neurosteroid; Season; Stress; Territory; Testosterone;
Vitamin D in fetal brain development
Keywords: Brain; Development; Neurosteroid; Vitamin D deficiency
Multiple effects of allopregnanolone on GABAergic responses in single hippocampal CA3 pyramidal neurons
Keywords: Neurosteroid; Allopregnanolone; Cl− conductance; GABAA receptors; Hippocampus; Patch clamp
Localization of brain 5α-reductase messenger RNA in mice selectively bred for high chronic alcohol withdrawal severity
Keywords: Ethanol; Neurosteroid; GABA; Convulsion; In situ hybridization
Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence
Keywords: neurosteroid; neuroactive steroid; pregnenolone; allopregnanolone; schizophreniaCNS, central nervous system; CSF, cerebrospinal fluid; HPA, hypothalamic–pituitary–adrenal; PTSD, post-traumatic stress disorder; TBI, traumatic brain injury
Divergent mechanisms for trophic actions of estrogens in the brain and peripheral tissues
Keywords: Aging; Estropause; Menopause; Progesterone; Neurosteroid; Estrogen receptor;
Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice
Keywords: Affect; Learning; Memory; Stress; Neurosteroid; Autism spectrum disorder; Allopregnanolone; Corticosterone
Allosteric modulation of the NMDA receptor by neurosteroids in rat brain and the impact of long term morphine administration
Keywords: NMDA receptor; Neurosteroid; Morphine; Allosteric modulation; Hippocampus; Hypothalamus; Tolerance; NMDA; N-methyl-d-aspartate; NR2B; NMDA receptor subunit 2B; PS; pregnenolone sulfate; DHEAS; dehydroepiandrosterone sulfate; 3α5βS; pregnanolone sulfate;
Association of the aromatase gene with Alzheimer's disease in women
Keywords: CYP19A1; Indel; Microsatellite; SNP; Linkage disequilibrium; Menopause; Neurosteroid
Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity
Keywords: GABAA receptor; Neurosteroid; PS; THDOC; Direct activation; Spontaneous opening
Synthesis and GABAA receptor activity of A-homo analogues of neuroactive steroids
Keywords: A-homopregnane; Neurosteroid; γ-Aminobutyric acid; GABAA receptor
Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model
Keywords: Ganaxolone; Neurosteroid; Clonazepam; GABAA receptor; Amygdala kindling; Epilepsy
Progesterone reduces hyperactivity of female and male dopamine transporter knockout mice
Keywords: Estrogen; Hippocampus; Neurosteroid; Affect; Reproductive experience
Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration
Keywords: Intranasal; Neurosteroid; Pregnenolone; Progesterone; Memory; Anxiety
Disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis
Keywords: Progesterone; Epileptogenesis; Kindling; Disease-modifying; Neurosteroid; Progesterone receptor; SeizureP, progesterone; PR, progesterone receptor; PRKO, PR knockout; WT, wild-type; AED, antiepileptic drug; TBI, traumatic brain injury; AD, afterdischarge;
Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects
Keywords: Alzheimer's disease; temporal cortex; allopregnanolone; DHEA; pregnenolone; neurosteroid; postmortem
Aggressive interactions rapidly increase androgen synthesis in the brain during the non-breeding season
Keywords: 3beta-HSD; Aggression; Androstenedione; Aromatase; Challenge hypothesis; Coenzyme; Cofactor; DHEA; Estradiol; Estrogens; Intracrine; NAD+; Neurosteroid; Song sparrow; Songbird; Testosterone
17β-Estradiol levels in male zebra finch brain: Combining Palkovits punch and an ultrasensitive radioimmunoassay
Keywords: Steroid; Estrogens; Songbird; Aromatase; Solid phase extraction; Neurosteroid; Testosterone; NCM; Fadrozole; Song; Hippocampus
Birdsong and the neural production of steroids
Keywords: Aromatase; Estrogen; Testosterone; Androgen; Neurosteroid; Song system; Songbird
Corticosterone and cortisol binding sites in plasma, immune organs and brain of developing zebra finches: Intracellular and membrane-associated receptors
Keywords: Avian; Bird; Bursa of Fabricius; CBG; Cerebellum; Diencephalon; Glucocorticoid; GR; Immunosteroid; Liver; Mineralocorticoid; MR; Neurosteroid; Non-genomic; Songbird; Spleen; Stress; Telencephalon; Thymus;
Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking- and withdrawal-related behaviors
Keywords: Neurosteroid; Ethanol; C57BL/6 mice; Self-administration; Lickometer; Reinstatement; Finasteride; Gonadectomy; Adrenalectomy; Handling-induced convulsions
The role of dehydroepiandrosterone (DHEA) in drug-seeking behavior
Keywords: Addiction; AMPA; Cocaine; DHEA; DHEA-S; GABA; Glutamate; Neurosteroid; NMDA; Sigma receptor
Estrogen action: A historic perspective on the implications of considering alternative approaches
Keywords: Estradiol; Estrogen receptor; Trophic; α-fetoprotein; Breast cancer; Neurosteroid
Selective regulation of 3α-hydroxysteroid oxido-reductase expression in dorsal root ganglion neurons: A possible mechanism to cope with peripheral nerve injury-induced chronic pain
Keywords: Cellular target for analgesics; Dorsal root ganglion; Neuropathic pain; Neurosteroid; Peripheral nerve constriction;
Social isolation stimulates hippocampal estradiol synthesis
Keywords: Estradiol; Hippocampus; Neurosteroid; Social isolation; P450arom; StAR; Real-time RT-PCR; Molecular psychology;
Pregnenolone protects the PC-12 cell line against amyloid beta peptide toxicity but its sulfate ester does not
Keywords: Pregnenolone; Pregnenolone sulfate; Amyloid beta; Neurotoxicity; Alzheimer’s disease; Neurosteroid
Discovery of neurosteroid glucuronides in mouse brain
Keywords: Neuroactive steroid; Neurosteroid; Glucuronidation; Glucuronide; Liquid chromatography-mass spectrometry;
Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3α-reduced neurosteroids
Keywords: Nociception; Neuropathic pain; Neurosteroid; Peripheral benzodiazepine receptor; Mitochondria; Allodynia; Hyperalgesia; Allopregnanolone;
17β-Nitro-5α-androstan-3α-ol and its 3β-methyl derivative: Neurosteroid analogs with potent anticonvulsant and anxiolytic activities
Keywords: Neurosteroid; Allopregnanolone; GABAA receptor; Anticonvulsant; Anxiolytic; Bioisostere
The influence of the membrane on neurosteroid actions at GABAA receptors
Keywords: Anesthetic; GABAA; Lipophilic; Neurosteroid; Inhibition; Excitability
Progesterone can enhance consolidation and/or performance in spatial, object and working memory tasks in Long–Evans rats
Keywords: cognition; learning; Long–Evans rat; memory; neurosteroid; progesterone; progestogen; Rattus norvegicus
Evidence for a key role of steroids in the modulation of pain
Keywords: Analgesia; Neurosteroid; Nociception; Pain; Peripheral neuropathy; Steroidogenic enzyme
The inhibition of female rabbit sexual behavior by progesterone: Progesterone receptor-dependent and-independent effects
Keywords: Progesterone; Progesterone receptor; Neurosteroid; Chlormadinone acetate; RU486; Attractivity; Receptivity; Aggression; Female sexual behavior
Neurosteroid Replacement Therapy for Catamenial Epilepsy
Keywords: Catamenial epilepsy; progesterone; neurosteroid; allopregnanolone; ganaxolone; GABAA receptor;