Keywords: NICD، دامنه درونی سلول Notch; NSCs, neural stem cells; TBI, traumatic brain injury; mNSS, modified neurological severity scores; NICD, Notch intracellular domain; VEGF, vascular endothelial growth factor; BDNF, brain-derived neurotrophic factor; GFAP, glial fibrillary acidic protein;
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Keywords: NICD، دامنه درونی سلول Notch; DAVID, Database for Annotation, Visualization, and Integrated Discovery; ELISA, enzyme-linked immunosorbent assay; FDR, false discovery rate; GO, gene ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; NICD, Notch intracellular domain; PCR, polymera
Keywords: NICD، دامنه درونی سلول Notch; hFOB, human fetal osteoblast; CRD, carbohydrate recognition-binding domain; ALP, alkaline phosphatase; pNPP, p-nitrophenol phosphate substrate; NICD, Notch intracellular domain; β-GP, β-glycerophosphate; AA, ascorbic acid; 1,25-(OH)2D3, 1α-25-dihydroxycho
Keywords: NICD، دامنه درونی سلول Notch; Notch; γ-secretase complex; Insulin resistance2DOG, 2-Deoxy-glucose; DBZ, Dibenzazepine; GSI, γ-secretase inhibitor; NICD, Notch intracellular domain; Rbp-Jκ, Recombination signal binding protein-Jκ; T2D, Type 2 diabetes
Lingo-1 shRNA and Notch signaling inhibitor DAPT promote differentiation of neural stem/progenitor cells into neurons
Keywords: NICD، دامنه درونی سلول Notch; NSC, neural stem cell; SCI, spinal cord injury; DAPT, N-[N-(3, 5-difluorophenacetyl)-1-alanyl]-S-phenylglycinet-butylester; NICD, Notch intracellular domain; DMSO, dimethyl sulfoxide; OMgp, oligodendrocyte myelin glycoprotein; GFP, green fluorescent prote
Downregulated protein O-fucosyl transferase 1 (Pofut1) expression exerts antiproliferative and antiadhesive effects on hepatocytes by inhibiting Notch signalling
Keywords: NICD، دامنه درونی سلول Notch; Notch1; Pofut1; EGFHCC, Hepatocellular carcinoma; Pofut1, Protein O-fucosyl transferase 1; HCC, Hepatocellular carcinoma; EGF(R), Epidermal growth factor (receptor); NICD, Notch intracellular domain; RBP-Jk, Recombination binding protein for immunoglobuli
The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells
Keywords: NICD، دامنه درونی سلول Notch; ECs, endothelial cells; γSI, gamma-secretase inhibitor; SMCs, smooth muscle cells; NICD, Notch intracellular domain; MOI, multiplicity of infectionEndothelial cells; Inflammation; ADAM10; Notch pathway
Caveolin-1 promote astroglial differentiation of neural stem/progenitor cells through modulating Notch1/NICD and Hes1 expressions
Keywords: NICD، دامنه درونی سلول Notch; Cav-1, caveolin-1; Cav-1 KO mice, caveolin-1 knockout mice; Cav-2, caveolin-2; NPCs, neural progenitor cells; GFAP, glial fibrillary acidic protein; NICD, notch intracellular domain; Hes1, hairy enhancer of split 1; siRNA, small interfering RNA; Con P, Ca
Esco2 promotes neuronal differentiation by repressing Notch signaling
Keywords: NICD، دامنه درونی سلول Notch; NICD, Notch intracellular domain; RBS, Roberts–SC phocomelia; CdLS, Cornelia de Lange syndrome; NPCs, neural progenitor cells; PLL, poly-l-lysine; PMSF, phenylmethylsulfonyl fluoride; DTT, dithiothreitol; ChIP, Chromatin immunoprecipitation; DAPI, 4′,6-di
The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity
Keywords: NICD، دامنه درونی سلول Notch; Dll, delta-like; NICD, Notch intracellular domain; RIP, regulated intramembrane proteolysis; NRR, negative regulatory region; CMP, common myeloid progenitor; HSC, hematopoietic stem cell; CLP, common lymphoid progenitorA disintegrin and metalloproteinase
Numb modulates intestinal epithelial cells toward goblet cell phenotype by inhibiting the Notch signaling pathway
Keywords: NICD، دامنه درونی سلول Notch; NICD, Notch intracellular domain; PBS, phosphate buffered saline; PTB, amino-terminal phosphotyrosine-binding domain; PRR, carboxyl-terminal praline rich regionNumb; Intestine; Epithelium; Notch signaling; MUC2; Goblet cell
Activating Notch signaling post-SCI modulates angiogenesis in penumbral vascular beds but does not improve hindlimb locomotor recovery
Keywords: NICD، دامنه درونی سلول Notch; SCI, Spinal cord injury; ECs, endothelial cells; NICD, Notch intracellular domain; Jag, Jagged; Dll, Delta-like ligand; Hes, Hairy/Enhancer of Split; dpi, days post-injury; N1 Ab, anti-Notch1 antibody; Jag1-Fc, Jagged1-Fc chimeric protein; LEA, Lycopersic
Notch signaling and Notch signaling modifiers
Keywords: NICD، دامنه درونی سلول Notch; DSL, Delta, Serrate, LAG-2 family; T-ALL, T cell acute lymphoblastic leukemia; CADASIL, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy; NICD, Notch intracellular domain; CSL, CBF1 Su(H) LAG-1; EGF, epidermal gro
Mapping the Deltex-Binding Surface on the Notch Ankyrin Domain Using Analytical Ultracentrifugation
Keywords: NICD، دامنه درونی سلول Notch; Dx, Deltex; NICD, Notch intracellular domain; AUC, analytical ultracentrifugation; MASLS, multi-angle static light scattering; SA model, self-association model; SA+ID model, self-association, incompetent dimer model; MBP, maltose binding proteinNotch sign
Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells
Keywords: NICD، دامنه درونی سلول Notch; NICD, Notch intracellular domain; Dll, Delta-likeAtoh1; Dll1; MUC2; Goblet cell; Notch signaling
14-3-3σ controls corneal epithelial cell proliferation and differentiation through the Notch signaling pathway
Keywords: NICD، دامنه درونی سلول Notch; TA, transient amplifying; K5, keratin-5; K14, keratin-14; K3, cytokeratin-3; K12, keratin-12; NICD, Notch intracellular domain; RBP1, retinol binding protein 1; WT, wild type; Er, repeated epilation; PFA, paraformaldehyde; BrdU, 5-bromo-2′-deoxyuridine; D
Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling
Keywords: NICD، دامنه درونی سلول Notch; 2-AG, 2-arachidonyl glycerol; AEA, anandamide; APH-1, anterior pharynx defective protein 1; BrdU, bromodeoxy uridine; DAPI, 4′,6-diamidino-2-phenylindole; NICD, notch intracellular domain; Pen-2, presenilin enhancer 2; SEM, standard error of the mean; shR
γ-Secretase in biology and medicine
Keywords: NICD، دامنه درونی سلول Notch; Aβ, amyloid-β protein; APP, amyloid β-protein precursor; AICD, APP intracellular domain; CSF, cerebral spinal fluid; COX, cyclooxygenase; CTF, C-terminal fragment of presenilin; NICD, Notch intracellular domain; NSAIDs, non-steroidal anti-inflammatory dru
Intercellular exchange of proteins: The immune cell habit of sharing
Keywords: NICD، دامنه درونی سلول Notch; APC, antigen-presenting cell; GFP, green fluorescent protein; IS, immunological synapse; MHC, major histocompatibility complex; NECD, Notch extracellular domain; NICD, Notch intracellular domain; NK, natural killer; PM, plasma membrane; RasGAP, RasGTPase-
Down-regulation of Notch-dependent transcription by Akt in vitro
Keywords: NICD، دامنه درونی سلول Notch; NICD, Notch intracellular domain; dnAkt, dominant negative Akt; HDAC, histone deacetylase; TSA, trichostatin A; SMRT, silencing mediator of retinoid and thyroid hormone receptors; GSK3β, glycogen synthase kinase 3βAkt; NICD; Notch; Transcription
Functional role of Notch signaling in the developing and postnatal heart
Keywords: NICD، دامنه درونی سلول Notch; RAM, RBP-JK-associated module; CSL, CBF-1-Suppressor of hairless-Lag-1; DSL, Delta-Serrate-Lag-2; NICD, Notch intracellular domain; EMT, epithelial–mesenchymal transition; AV, atrioventricular; ES, embryonic stemNotch; Jagged; Delta-like; Heart; Cardiac s
γ-Secretase Inhibitors Enhance Taxane-Induced Mitotic Arrest and Apoptosis in Colon Cancer Cells
Keywords: NICD، دامنه درونی سلول Notch; APC, adenomatous polyposis coli; cdk, cyclin-dependent kinase; CPT, camptothecin; DAPT, N-[N-(3,5-difluorophenacetyl-l-alanyl)-S-phenylglycine]-t-butyl ester; FBS, fetal bovine serum; 5-FU, 5-fluorouracil; NICD, Notch intracellular domain; RT-PCR, reverse
Multiple functions of Notch signaling in self-renewing organs and cancer
Keywords: NICD، دامنه درونی سلول Notch; NICD, Notch intracellular domain; BM, bone marrow; HSC, hematopoietic stem cell; AGM, aorta-gonad-mesonephreos; TA cells, transient amplifying cells; Hes, hairy enhancer of split; FoBs, follicular B cells; MzBs, marginal zone B cells; T-ALL, T cell acute