کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2203245 | 1100427 | 2009 | 6 صفحه PDF | دانلود رایگان |
γ-Secretase is a membrane-embedded proteolytic complex composed of presenilin and three other subunits. The γ-secretase complex generates the amyloid β-peptide of Alzheimer's disease but also plays important roles in normal physiology, especially in signaling from the Notch receptor. How this hydrolytic enzyme works in a hydrophobic environment is largely unanswered, but mutagenesis and chemical probes have offered insight. γ-Secretase is an important therapeutic target, although mechanism-based toxicity presents a serious obstacle. Agents that lower amyloid β-peptide production while leaving important normal functions of γ-secretase intact are promising therapeutic leads. Inhibition of Notch signaling by γ-secretase inhibitors, which is undesirable for the prevention or treatment of Alzheimer's disease, may be beneficial for the treatment of a variety of cancers.
Journal: Seminars in Cell & Developmental Biology - Volume 20, Issue 2, April 2009, Pages 219–224