دانلود مقالات ISI درباره AICD، دامنه درون سلولی APP + ترجمه فارسی

فسفولیلاسیون پروتئین پیونده دهنده پروتئین پیش ساز آمیکوئید Fe65 در واکنش به تمایز نورون

Phosphorylation of Fe65 amyloid precursor protein-binding protein in response to neuronal differentiation

Keywords: AICD، دامنه درون سلولی APP; Aβ, amyloid-β; AD, Alzheimers’ disease; AICD, APP intracellular domain; APP, amyloid precursor protein; ATM/ATR, ataxia telangiectasia mutated/ataxia-telangiectasia-and Rad3-related; BCA, bicinchoninic acid; CHO, Chinese hamster ovary; CPI, complete prote

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Sox2 functionally interacts with βAPP, the βAPP intracellular domain and ADAM10 at a transcriptional level in human cells

Keywords: AICD، دامنه درون سلولی APP; AD, Alzheimer’s disease; Aβ, amyloid-β peptide; ADAM, a disintegrin and metalloprotease; AICD, APP intracellular domain; BACE1, beta-site APP cleaving enzyme 1; EDTA, ethylenediaminetetraacetic acid; FBS, fetal bovine serum; HEK, human embryonic kidney; H

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stages

Keywords: AICD، دامنه درون سلولی APP; Aβ, amyloid-β; ABC, avidin–biotin peroxidase complex; AD, Alzheimer’s disease; AICD, APP intracellular domain; ANOVA, analysis of variance; APP, amyloid precursor protein; BACE1, β-site APP-cleaving enzyme 1; EDTA, ethylenediaminetetraacetic acid; FAD, fa

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing

Keywords: AICD، دامنه درون سلولی APP; Aβ, β-amyloid peptide; AD, Alzheimer’s disease; APP, amyloid precursor protein; AICD, APP intracellular domain; sAPPα, soluble APPα; sAPPβ, soluble APPβ; CHO, chinese hamster ovary; CTF, C-terminal fragment; DAPT, N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Ca2+ dysregulation in the endoplasmic reticulum related to Alzheimer’s disease: A review on experimental progress and computational modeling

Keywords: AICD، دامنه درون سلولی APP; AD, Alzheimer’s disease; AICD, APP intracellular domain; APP, amyloid precursor protein; Aβ, amyloid-β; CALHM1, Ca2+ homeostasis modulator 1; CICR, Ca2+-induced Ca2+ release; CLI, command-line interface; DAG, diacyl glycerol; ER, endoplasmic reticulum; FA

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Toward the structure of presenilin/γ-secretase and presenilin homologs

Keywords: AICD، دامنه درون سلولی APP; Aβ, amyloid β-protein; AICD, APP intracellular domain; APP, amyloid β-protein precursor; CTF, C-terminal fragment; i-CLiP, intramembrane-cleaving protease; mmPSH, Methanoculleus marisnigri JR1 presenilin homolog; NTF, N-terminal fragment; PS1, presenilin-

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein

Keywords: AICD، دامنه درون سلولی APP; Aβ, Amyloid β-peptide; AICD, APP intracellular domain; APP, Amyloid-β Precursor Protein; BACE, beta-site APP cleaving enzyme; DCM, dichloromethane; DMSO, dimethylsulfoxide; ESI, electrospray ionization; EtOAc, ethyl acetate; FBS, fetal bovine serum; GSAP,

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

GDNF, NGF and BDNF as therapeutic options for neurodegeneration

Keywords: AICD، دامنه درون سلولی APP; AAV2, adeno-associated viral vector; AD, Alzheimer's disease; ADAMs, a disintegrin and metalloprotease enzyme family; ALS, Amyotrophic lateral sclerosis; AICD, APP intracellular domain; apoE, apolipoprotein E; APP, amyloid precursor protein; BACE, beta-si

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2013 سفارش ترجمه

Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production

Keywords: AICD، دامنه درون سلولی APP; Aβ, amyloid β-peptide; ACN, acetonitrile; AD, Alzheimer disease; AICD, APP intracellular domain; APP, Aβ precursor protein; FA, formic acid; GCB, γ-secretase inhibitor coupled to biotin via a cleavable linker; GSAPs, γ-secretase associated proteins; IP, i

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

In vitro screening on amyloid precursor protein modulation of plants used in Ayurvedic and Traditional Chinese medicine for memory improvement

Keywords: AICD، دامنه درون سلولی APP; AD, Alzheimer's disease; Aβ, β-amyloid peptide; APP, amyloid-β precursor protein; ADAMs, a disintegrin and metalloproteinases; sAPP, α soluble APP; AICD, APP intracellular domain; BACE1, beta-site APP cleaving enzyme1; sAPPβ, β soluble APP; BBB, blood–bra

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Nuclear signalling by membrane protein intracellular domains: The AICD enigma

Keywords: AICD، دامنه درون سلولی APP; Aβ, amyloid β-peptide; AD, Alzheimer's disease; ADAM, a disintegrin and metalloprotease; AICD, APP intracellular domain; APP, amyloid precursor protein; GSAP, γ-secretase activating protein; HDAC, histone deacetylase; IDE, insulin-degrading enzyme; KPI, K

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

In vitro modelling of Alzheimer's disease: Degeneration and cell death induced by viral delivery of amyloid and tau

Keywords: AICD، دامنه درون سلولی APP; AD, Alzheimer's disease; AdV, adenovirus; AICD, APP intracellular domain; APP, amyloid precursor protein; Aβ, amyloid beta; BACE1, beta-site APP cleaving enzyme 1; βCTF, beta-C-terminal fragment (of APP); BI, beta-secretase inhibitor; C99, C-terminal frag

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

γ-Secretase in biology and medicine

Keywords: AICD، دامنه درون سلولی APP; Aβ, amyloid-β protein; APP, amyloid β-protein precursor; AICD, APP intracellular domain; CSF, cerebral spinal fluid; COX, cyclooxygenase; CTF, C-terminal fragment of presenilin; NICD, Notch intracellular domain; NSAIDs, non-steroidal anti-inflammatory dru

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

In vitro reconstitution of γ-secretase activity using yeast microsomes

Keywords: AICD، دامنه درون سلولی APP; Aβ, amyloid β peptides; APP, amyloid precursor protein; AICD, APP intracellular domain; Aph-1, anterior pharynx-1; CTF, carboxyl-terminal fragment; PS, presenilin; NCT, nicastrin; Pen-2, presenilin enhancer-2; wt, wildtype; PC, phosphatidyl choline; CHAPS

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

Keywords: AICD، دامنه درون سلولی APP; aa, amino acids; AD, Alzheimer's disease; APP, amyloid precursor protein; AICD, APP intracellular domain; Aβ, β-amyloid; APLP1,2, amyloid precursor protein-like 1,2; BACE, β-secretase aspartyl protease cleaving enzyme; CTF, C-terminal fragment; FAD, famil

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

Stable insertion of Alzheimer Aβ peptide into the ER membrane strongly correlates with its length

Keywords: AICD، دامنه درون سلولی APP; AD, Alzheimer’s disease; Aβ, amyloid β-peptide; APP, amyloid β-protein precursor; AICD, APP intracellular domain; CTF, C-terminal fragment; TM, transmembrane; p3, 3 kDa product; ER, endoplasmic reticulum; Lep, leader peptidaseAmyloid β-protein precursor;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

The Alzheimer's disease-associated γ-secretase complex: Functional domains in the presenilin 1 protein

Keywords: AICD، دامنه درون سلولی APP; AD, Alzheimer's disease; APP, amyloid β-precursor protein; Aβ, Amyloid β-peptide; PS, presenilin; TM, transmembrane; AICD, APP intracellular domain; NTF, N-terminal fragment; CTF, C-terminal fragment; RIP, regulated intramembrane proteolysis; I-CliP, intr

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

The role of intracellular amyloid β in Alzheimer's disease

Keywords: AICD، دامنه درون سلولی APP; 3xTg-AD, triple-transgenic model; α7AchR, α7 nicotinic acetylcholine receptors; Aβ, amyloid β peptide; Aβ*56, 56 kDa Aβ oligomer; AD, Alzheimer's disease; ADDLs, Aβ-derived diffusible ligands; AICD, APP intracellular domain; APP, amyloid precursor protein

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Blocking the cleavage at midportion between γ- and ε-sites remarkably suppresses the generation of amyloid β-protein

Keywords: AICD، دامنه درون سلولی APP; Aβ, amyloid β-protein; AD, Alzheimer’s disease; APP, β-amyloid precursor protein; AICD, APP intracellular domain; βCTF, β-carboxyl-terminal fragment; CHO, Chinese hamster ovary; mt, mutant; PS, presenilin; TMD, transmembrane domain; TOF MS, time-of-flight

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه