Phylogeny and evolution of the cholesterol transporter NPC1 in insects
Keywords: Niemann-Pick type C1; Phylogenetic analysis; Sterol absorption;
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Dataset in support of the generation of Niemann-Pick disease Type C1 patient-specific iPS cell lines carrying the novel NPC1 mutation c.1180T>C or the prevalent c.3182T>C mutation - Analysis of pluripotency and neuronal differentiation
Keywords: Induced pluripotent stem cells; Niemann-Pick Type C1; Neuronal differentiation;
Cytochrome b561, copper, β-cleaved amyloid precursor protein and niemann-pick C1 protein are involved in ascorbate-induced release and membrane penetration of heparan sulfate from endosomal S-nitrosylated glypican-1
Keywords: Aβ; amyloid β peptide; anMan; anhydromannose; APP; amyloid precursor protein; β-CTF; C-terminal fragment of APP generated by β-cleavage; γ-CTF; C-terminal fragment of APP generated by γ-cleavage; CYB561A3; A3 variant of cytochrome b561; GAG; glycosa
Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlrâ/â mice
Keywords: Macrophages/monocytes; Antibodies; Oxidized lipids; Cholesterol/metabolism; Vascular biology; oxLDL; oxidized LDL; Ldlrâ/â; LDL receptor knockout; NPC1; Niemann-Pick Type C1; CVD; cardiovascular disease; PC; phosphorylcholine; NPC1mut; NPC1 mutant; tp
NPC1, intracellular cholesterol trafficking and atherosclerosis
Keywords: NPC1; Niemann-Pick type C1; LE/LY; late endosome/lysosome; LDL; low-density lipoprotein; LDL-C; LDL-cholesterol; ER; endoplasmic reticulum; SSD; sterol-sensing domain; NTD; N-terminal domain; apoE; apolipoprotein E; LXR; liver X receptor; OSBP; oxysterolÂ
A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells
Keywords: Liver Disease; Mouse Model; Dyslipidemia; Lipopolysaccharide; AcLDL; acetyl low-density lipoprotein; ALT; alanine aminotransferase; Bambi; BMP and activin membrane-bound inhibitor; BDL; bile duct ligation; CCl4; carbon tetrachloride; CE; cholesterol ester
Leaky synapses: Regulation of spontaneous neurotransmission in central synapses
Keywords: spontaneous neurotransmission; synaptic vesicle recycling; SNARE; miniature synaptic transmission; synaptotagmin; cholesterol; HRP; horseradish peroxidase; MCD; methyl-β-cyclodextrin; NMJ; neuromuscular junction; NPC1; Niemann-Pick type C1; RRP; readily
Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases
Keywords: neurodegeneration; mitochondria; oxidative damage; Huntington's disease; Friedreich ataxia; xeroderma pigmentosum; BDNF; brain-derived neurotrophic factor; CREB; cyclic AMP response element-binding protein; cybrid; cytoplasmic hybrid; FRDA; Friedreich a