کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341054 | 1295821 | 2009 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Leaky synapses: Regulation of spontaneous neurotransmission in central synapses
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کلمات کلیدی
HRPTTXNMJNiemann-Pick Type C1SNARERRPMCDNPC1Neuromuscular junction - اتصال عصبی عضلانیSynaptic vesicle recycling - بازیافت مجدد سیناپتیس vesiclereadily releasable pool - به راحتی استخر آزادtetrodotoxin - تترو دوتوکسین Synaptotagmin - سیناپتوتاگمینmethyl-β-cyclodextrin - متیل-β-سیکلوکودکسترینHorseradish peroxidase - پراکسیداز هوررادیشcholesterol - کلسترولsoluble N-ethylmaleimide-sensitive factor attachment protein receptor - گیرنده پروتئین دلبستگی حساس به پروتئین محلول N-ethylmaleimide
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The mechanisms underlying spontaneous neurotransmitter release are not well understood. Under physiological as well as pathophysiological circumstances, spontaneous fusion events can set the concentration of ambient levels of neurotransmitter within the synaptic cleft and in the extracellular milieu. In the brain, unregulated release of excitatory neurotransmitters, exacerbated during pathological conditions such as stroke, can lead to neuronal damage and death. In addition, recent findings suggest that under physiological circumstances spontaneous release events can trigger postsynaptic signaling events independent of evoked neurotransmitter release. Therefore, elucidation of mechanisms underlying spontaneous neurotransmission may help us better understand the functional significance of this form of release and provide tools for its selective manipulation. For instance, our recent investigations indicate that the level of cholesterol in the synapse plays a critical role in limiting spontaneous synaptic vesicle fusion. Therefore, alterations in synaptic cholesterol metabolism can be a critical determinant of glutamatergic neurotransmission at rest. This article aims to provide a closer look into our current understanding of the mechanisms underlying spontaneous neurotransmission and the signaling triggered by these unitary release events.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 158, Issue 1, 12 January 2009, Pages 177-188
Journal: Neuroscience - Volume 158, Issue 1, 12 January 2009, Pages 177-188
نویسندگان
C.R. Wasser, E.T. Kavalali,