دانلود مقالات ISI درباره Npc1 + ترجمه فارسی

اثر نشاسته بر خواص مکانیکی و ریز ساختار پنیر های فرآوری شده با انواع مختلف ساختارهای شبکه کازئین

Effects of starches on the mechanical properties and microstructure of processed cheeses with different types of casein network structures

Keywords: Processed cheese; Pre-cooked cheese; Starch; Microstructure; Mechanical property; TS; tapioca starch; PS; potato starch; PC1; pre-cooked cheese produced at 1000 rpm, 10 min; PC2; pre-cooked cheese produced at 1000 rpm, 30 min; NPC1; processed cheese a

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

با استفاده از پارامترهای ترمودینامیکی برای کالیبره کردن دوز واکنش مکانیکی برای عفونت میزبان توسط یک ویروس

Using thermodynamic parameters to calibrate a mechanistic dose-response for infection of a host by a virus

Keywords: Dose-response; Virus; Entropy; Enthalpy; Mucin; Asp; aspartate; Cr; host cell receptor; CRD; carbohydrate-recognition domain; EBOV; Zaire ebolavirus; G; Gibbs free energy; ΔGa; change in Gibbs free energy on association of virus and cell; GI; gastrointes

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

ترکیبی از داروهای ترکیبی به طور موثر انسانی ویروس ابولا را مسدود می کند

Synergistic drug combination effectively blocks Ebola virus infection

Keywords: Ebola treatment; Ebola prevention; Drug combination; Drug repurposing; Polypharmacology; EBOV; Ebola virus; NPC1; Niemann Pick C1 protein; IC50; half-maximum inhibitory concentrations;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

اسپیگیلوپیدوز های عصبی: لیپیدهای غشاء و پروتئین های فعال کننده اسپینگولیپید، کاتابولیسم اسپینگولیپید لیزوزوم را تنظیم می کنند

Neuronal sphingolipidoses: Membrane lipids and sphingolipid activator proteins regulate lysosomal sphingolipid catabolism

Keywords: Cholesterol transfer of NPC2; Regulation of acid sphingomyelinase; Tay Sachs disease; Regulation of ganglioside catabolism; Lipid modifiers; ASM; acid sphingomyelinase; BMP; bis(monoacylglycero)-phosphate; CAD; cationic amphiphilic drug; DOPC; dioleoyl-l-

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2016 سفارش ترجمه

تعریف مکانیسم مولکولی برای قاچاق داخل سلولی و سرنوشت میسلی کوپلیمر بلوک و اجزای آن

Elucidating the molecular mechanism for the intracellular trafficking and fate of block copolymer micelles and their components

Keywords: Block copolymer micelles; Intracellular trafficking; Intermembrane transport; NPC1; ORP2; ABCB1;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Improvement of impaired electrical activity in NPC1 mutant cortical neurons upon DHPG stimulation detected by micro-electrode array

Keywords: NPC1; Cortical neuron; MEA; Electrical activity; Group I mGluRs; DHPG;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes

Keywords: Anx; annexin; AnxA8ins; siRNA-insensitive AnxA8; Ctrl; control; GFP; green fluorescent protein; IPTG; isopropyl-β-d-thiogalactose; LDL; low-density lipoprotein; LEL; late endosomes/lysosomes; NPC1; Niemann Pick disease type C1; PM; plasma membrane; PNS;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Part A: Temporal and dose-dependent transcriptional responses in the liver of fathead minnows following short term exposure to the polycyclic aromatic hydrocarbon phenanthrene

Keywords: SREBF1; sterol regulatory element binding transcription factor 1; FASN; fatty acid synthase; HSD17B12; hydroxysteroid (17-beta) dehydrogenase 12; ACACA; acetyl-CoA carboxylase alpha; CYB5A; cytochrome b5 type A (microsomal); SLC27A4; solute carrier family

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

Part B: Morphometric and transcriptomic responses to sub-chronic exposure to the polycyclic aromatic hydrocarbon phenanthrene in the fathead minnow (Pimephales promelas)

Keywords: PNPLA2; patatin-like phospholipase domain containing 2; APOE; apolipoprotein E; NPC1; Niemann-Pick disease, type C1; LCAT; lecithin-cholesterol acyltransferase; DGAT1; diacylglycerol O-acyltransferase 1; LRP1; low density lipoprotein-related protein 1 (al

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

Novel cyclo-peptides inhibit Ebola pseudotyped virus entry by targeting primed GP protein

Keywords: Ebola virus; Primed GP; Entry inhibitor; Antiviral screening; BLI; Docking; EBOV; Ebola virus; GPcl; primed EBOV glycoprotein; NPC1; Niemann-Pick C1; IC50; 50% inhibitory concentration; BLI; Bio-layer Interferometry; MD; molecular dynamic; MM/GBSA; Molecu

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

Niemann-Pick C2 protein regulates sterol transport between plasma membrane and late endosomes in human fibroblasts

Keywords: ACAT; acyl Coenzyme A acyl transferase; Alexa647-Tf; Alexa647-tagged transferrin; 13C3-cholesterol; cholesterol with heavy carbon (C13) at position 3; CHO; Chinese Hamster Ovarian; ER; endoplasmic reticulum; D; diffusion coefficient; DHE; dehydroergostero

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein

Keywords: Niemann-Pick disease type C; NPC1; Non-steroidal pharmacological chaperone; Structure-activity relationships;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

The cholesterol transport inhibitor U18666A inhibits type I feline coronavirus infection

Keywords: Feline coronavirus; Cholesterol; U18666A; Histone deacetylase inhibitor; NPC1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Cytochrome b561, copper, β-cleaved amyloid precursor protein and niemann-pick C1 protein are involved in ascorbate-induced release and membrane penetration of heparan sulfate from endosomal S-nitrosylated glypican-1

Keywords: Aβ; amyloid β peptide; anMan; anhydromannose; APP; amyloid precursor protein; β-CTF; C-terminal fragment of APP generated by β-cleavage; γ-CTF; C-terminal fragment of APP generated by γ-cleavage; CYB561A3; A3 variant of cytochrome b561; GAG; glycosa

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Decreased calcium flux in Niemann-Pick type C1 patient-specific iPSC-derived neurons due to higher amount of calcium-impermeable AMPA receptors

Keywords: NPC1; GluA2; AMPA; Calcium; Patch clamp; Fura2; iPSC derived neurons;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Macrophage miRNAs in atherosclerosis

Keywords: miRNA; microRNA; anti-miR; anti-microRNA; apo; apolipoprotein; SREBP; sterol response element binding protein; HDL; high density lipoprotein; LDL; low density lipoprotein; VLDL; very low density lipoprotein; ABC; ATP-binding cassette transporter; NPC1; Ni

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr−/− mice

Keywords: Macrophages/monocytes; Antibodies; Oxidized lipids; Cholesterol/metabolism; Vascular biology; oxLDL; oxidized LDL; Ldlr−/−; LDL receptor knockout; NPC1; Niemann-Pick Type C1; CVD; cardiovascular disease; PC; phosphorylcholine; NPC1mut; NPC1 mutant; tp

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Research ArticleTransgenic overexpression of Niemann-Pick C2 protein promotes cholesterol gallstone formation in mice

Keywords: NPC2; Niemann-Pick C2; NPC1; Niemann-Pick C1; NPC2(h/h); Niemann-Pick C2-deficient hypomorph mice; ABCG5/G8; adenosine triphosphate-binding cassettes G5 and G8; ConA; Concanavalin A; Npc2.Tg; Niemann-Pick C2 transgenic mice; PCR; polymerase chain reacti

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Extensive macrophage accumulation in young and old Niemann-Pick C1 model mice involves the alternative, M2, activation pathway and inhibition of macrophage apoptosis

Keywords: BAL; bronchoalveolar lavage; ELISA; enzyme-liked immunosorbent assay; GFAP; glial fibrillary acid protein; GM-CSF; granulocyte macrophage colony-stimulating factor; H & E; hematoxylin and eosin; HPBCD; hydroxypropyl-beta-cyclodextrin; NPC1; Niemann-Pick

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Chylomicron remnant model emulsions induce intracellular cholesterol accumulation and cell death due to lysosomal destabilization

Keywords: ACAT; acyl CoA:cholesterol acyltransferase; ac-LDL; acetylated LDL; apoE; apolipoprotein E; BSA; bovine serum albumin; CE; esterified cholesterol; DMEM; Dulbecco's modified Eagle's medium; ER; endoplasmic reticulum; FBS; fetal bovine serum; HSPGs; heparan

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

In silico assessment of phosphorylation and O-β-GlcNAcylation sites in human NPC1 protein critical for Ebola virus entry

Keywords: Ebola; NPC1; Post translational modification; In silico;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2015 سفارش ترجمه

Structure-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein

Keywords: Niemann-Pick disease type C; NPC1; Pharmacological chaperone; Oxysterol; Structure-activity relationships;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells

Keywords: Aβ; amyloid beta peptide; AD; Alzheimer's disease; ADAM; A disintegrin and metalloproteinase; APOE; apolipoprotein E; APP; amyloid precursor protein; BACE1; beta-secretase; CHO; Chinese hamster ovary; CTF; C-terminal fragment; DN; dominant negative; FA

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

NPC1, intracellular cholesterol trafficking and atherosclerosis

Keywords: NPC1; Niemann-Pick type C1; LE/LY; late endosome/lysosome; LDL; low-density lipoprotein; LDL-C; LDL-cholesterol; ER; endoplasmic reticulum; SSD; sterol-sensing domain; NTD; N-terminal domain; apoE; apolipoprotein E; LXR; liver X receptor; OSBP; oxysterolÂ

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Impact of the loss of caveolin-1 on lung mass and cholesterol metabolism in mice with and without the lysosomal cholesterol transporter, Niemann-Pick type C1

Keywords: ABCA1; ATP binding cassette transporter A1; ABCG1; ATP binding cassette transporter G1; bw; body weight; Cav-1; Caveolin-1; EC; esterified cholesterol; CYP27A1; sterol-27 hydroxylase; FVB; Friend Leukemia Virus; LAL; lysosomal acid lipase; Npc1; Niemannâ€

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1

Keywords: Lloviu virus; Ebola; Filovirus; Viral entry; Viral membrane fusion; Viral glycoprotein; Endosomal cysteine proteases; Viral receptor; Niemann-Pick C1; NPC1; Cuevavirus; Filoviridae;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Bidirectional links between Alzheimer's disease and Niemann-Pick type C disease

Keywords: Alzheimer's disease; Amyloid-β; Niemann-Pick type C disease; NPC1; Tau; Cholesterol; Lipids;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Identification of mutation in NPC2 by exome sequencing results in diagnosis of Niemann-Pick disease type C

Keywords: NPC; Niemann-Pick type C; NPC1; NPC1 gene; NPC2; NPC2 gene; SMPD1; sphingomyelin phosphodiesterase 1 gene; LDL; low density lipoprotein; HGMD; The Human Gene Mutation Database; ALS; amyotrophic lateral sclerosis; DTR; deep tendon reflex; MRI; magnetic r

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Niemann-Pick C1-Like 1 and cholesterol uptake

Keywords: NPC1L1; Niemann-Pick C1-Like 1; LDL; low-density lipoprotein; PM; plasma membrane; ERC; endocytic recycling compartment; NTD; N-terminal domain; NFC; NPC1L1-Flotillin-Cholesterol; NPC1L1; Cholesterol absorption; Ezetimibe; NPC1; Flotillin; Lipid raf

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Dancing with the sterols: Critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis

Keywords: ABC; ATP Binding Cassette; AICAR; Aminoimidazole Carboxamide Ribonucleotide; ApoE; Apolipoprotein E; ApoER2; ApoE receptor 2 (LRP8); AR; Androgen Receptor; BAC; Bacterial Artificial Chromosome; CETP; Cholesterol Ester Transfer Protein; eNOS; endothelial N

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells

Keywords: Alzheimer's disease; APP; BACE1; Cholesterol; Endocytosis; NPC1;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells

Keywords: Liver Disease; Mouse Model; Dyslipidemia; Lipopolysaccharide; AcLDL; acetyl low-density lipoprotein; ALT; alanine aminotransferase; Bambi; BMP and activin membrane-bound inhibitor; BDL; bile duct ligation; CCl4; carbon tetrachloride; CE; cholesterol ester

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2012 سفارش ترجمه

Lysosomal Ca2+ homeostasis: Role in pathogenesis of lysosomal storage diseases

Keywords: Lysosomal calcium; Lysosomal storage disease; Niemann-Pick; NPC1; Mucolipidosis type IV; MLIV; NAADP

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Npc1 deficiency in the C57BL/6J genetic background enhances Niemann–Pick disease type C spleen pathology

Keywords: NPC, Niemann–Pick type C; NPC1, Niemann–Pick C1 proteinNiemann–Pick type C disease; NPC1; Cholesterol; Liver; Spleen

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Neuroinflammatory and oxidative stress phenomena in MPS IIIA mouse model: The positive effect of long-term aspirin treatment

Keywords: MPS IIIA; Mucopolysaccharidosis (MPS) type IIIA, Sanfilippo disease type A; LSD; Lysosomal storage diseases; GAGs; Glycosaminoglycans; CNS; Central nervous system; GFAP; Glial fibrillary acidic protein; NSAIDs; Nonsteroidal anti-inflammatory drugs; PCR; P

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology

Keywords: Alzheimer's disease; Exercise; Tauopathies; THY-Tau22; Transgenic model; NPC1

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesis

Keywords: NPC1; Spermatogenesis; Individualization; Drosophila; Sterols;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Annexin A6-Linking Ca2+ signaling with cholesterol transport

Keywords: AA; arachidonic acid; AnxA; annexin group A; BCC; breast cancer cells; cav-1; caveolin-1; cPLA2; cytoplasmic phospholipase A2; CHO; Chinese Hamster Ovary; DRM; detergent resistant membranes; EGFR; epidermal growth factor receptor; eNOS; endothelial nitric

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts

Keywords: Alzheimer’s disease; Amyloid-β; APP; Cholesterol; Lipid rafts; Niemann Pick type C disease; NPC1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

br regulates the expression of the ecdysone biosynthesis gene npc1

Keywords: npc1; br; Ecdysone; Ring gland; Drosophila

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Cholesterol involvement in the pathogenesis of neurodegenerative diseases

Keywords: Cholesterol transport; Cholesterol binding protein; Niemann–Pick disease; NPC1; NPC2

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

New functions of cholesterol binding proteins

Keywords: Cholesterol binding protein; LXR; NPC1; Mechanisms

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Leaky synapses: Regulation of spontaneous neurotransmission in central synapses

Keywords: spontaneous neurotransmission; synaptic vesicle recycling; SNARE; miniature synaptic transmission; synaptotagmin; cholesterol; HRP; horseradish peroxidase; MCD; methyl-β-cyclodextrin; NMJ; neuromuscular junction; NPC1; Niemann-Pick type C1; RRP; readily

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2009 سفارش ترجمه

Human NPC1L1 and NPC1 can functionally substitute for the ncr genes to promote reproductive development in C. elegans

Keywords: NPC1L1; NPC1; NCR genes; Ezetimibe; Dauer

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Niemann–Pick type C disease: Novel NPC1 mutations and characterization of the concomitant acid sphingomyelinase deficiency

Keywords: Niemann–Pick type C disease; NPC1; Acid sphingomyelinase; Cholesterol

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Niemann-Pick C disease: Use of denaturing high performance liquid chromatography for the detection of NPC1 and NPC2 genetic variations and impact on management of patients and families

Keywords: Niemann-Pick disease; NPC2; NPC1; Denaturing high-performance liquid chromatography; DHPLC; Mutation detection;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه