کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3069672 1580692 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology
چکیده انگلیسی

Tau pathology is encountered in many neurodegenerative disorders known as tauopathies, including Alzheimer's disease. Physical activity is a lifestyle factor affecting processes crucial for memory and synaptic plasticity. Whether long-term voluntary exercise has an impact on Tau pathology and its pathophysiological consequences is currently unknown. To address this question, we investigated the effects of long-term voluntary exercise in the THY-Tau22 transgenic model of Alzheimer's disease-like Tau pathology, characterized by the progressive development of Tau pathology, cholinergic alterations and subsequent memory impairments. Three-month-old THY-Tau22 mice and wild-type littermates were assigned to standard housing or housing supplemented with a running wheel. After 9 months of exercise, mice were evaluated for memory performance and examined for hippocampal Tau pathology, cholinergic defects, inflammation and genes related to cholesterol metabolism. Exercise prevented memory alterations in THY-Tau22 mice. This was accompanied by a decrease in hippocampal Tau pathology and a prevention of the loss of expression of choline acetyltransferase within the medial septum. Whereas the expression of most cholesterol-related genes remained unchanged in the hippocampus of running THY-Tau22 mice, we observed a significant upregulation in mRNA levels of NPC1 and NPC2, genes involved in cholesterol trafficking from the lysosomes. Our data support the view that long-term voluntary physical exercise is an effective strategy capable of mitigating Tau pathology and its pathophysiological consequences.


► Long-term voluntary exercise prevents the development of memory impairment in a transgenic model of AD-like Tau pathology.
► Long-term voluntary exercise reduces hippocampal Tau pathology and loss of ChAT expression in the medial septum.
► Beneficial effects are associated with an increased mRNA expression of NPC1 and NPC2.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 43, Issue 2, August 2011, Pages 486–494
نویسندگان
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