Matrine suppresses AGE-induced HAEC injury by inhibiting ROS-mediated NRLP3 inflammasome activation
Keywords: التهاب NLRP3; Matrine; AGEs; HAECs; NLRP3 inflammasome;
مقالات ISI التهاب NLRP3 (ترجمه نشده)
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Air pollution is associated with the development of atherosclerosis via the cooperation of CD36 and NLRP3 inflammasome in ApoE-/- mice
Keywords: التهاب NLRP3; Fine particulate matter; Atherosclerosis; NLRP3 inflammasome;
Procyanidin B2 protects rats from paraquat-induced acute lung injury by inhibiting NLRP3 inflammasome activation
Keywords: التهاب NLRP3; Paraquat poisoning; Procyanidin B2; Acute lung injury; NLRP3 inflammasome; Oxidative stress;
Leptospira interrogans infection leads to IL-1β and IL-18 secretion from a human macrophage cell line through reactive oxygen species and cathepsin B mediated-NLRP3 inflammasome activation
Keywords: التهاب NLRP3; Leptospira interrogans; Macrophages; NLRP3 inflammasome; IL-1β and IL-18;
Inhibition of the NLRP3 inflammasome attenuates foam cell formation of THP-1 macrophages by suppressing ox-LDL uptake and promoting cholesterol efflux
Keywords: التهاب NLRP3; NLRP3 inflammasome; Foam cell formation; Macrophage; Atherosclerosis;
Long Noncoding RNA SNHG1 Promotes Neuroinflammation in Parkinson's Disease via Regulating miR-7/NLRP3 Pathway
Keywords: التهاب NLRP3; lncRNAs; long noncoding RNAs; LPS; lipopolysaccharide; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NLRP3; nod-like receptor protein 3; PD; Parkinson's disease; SNHG1; small nucleolar RNA host gene 1; SNpc; substantia nigra pars compacta; TNF; tu
Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome
Keywords: التهاب NLRP3; Astragaloside IV; Cycloastragenol; Cardiac fibrosis; NLRP3 inflammasome;
The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation
Keywords: التهاب NLRP3; SGK1; serum-glucocorticoid regulated kinase 1; Ang II; Angiotension II; IL; interleukin; TGF-β; transforming growth factor-β; CTGF; connective tissue growth factor; TNF-α; tumor necrosis factor-α; IFN-γ; Interferon-γ; ASC; apoptosis associated speck
NLRP3 inflammasome inhibition attenuates silica-induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells
Keywords: التهاب NLRP3; NLRP3 inflammasome; Epithelial to mesenchymal transition; Silica;
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway
Keywords: التهاب NLRP3; AhR; aryl hydrocarbon receptor; ARNT; ah receptor nuclear translocator protein; ATP; adenosine triphosphate; ASC; apoptosis-associated speck-like protein containing CARD; BMDM; bone marrow-derived macrophage; BSA; bovine serum albumin; Caspase-1; cysteiny
AlCl3 inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production through suppressing NF-κB signaling pathway in murine peritoneal macrophages
Keywords: التهاب NLRP3; Aluminium chloride; Murine peritoneal macrophages; NLRP3 inflammasome; IL-1β generation; NF-κB signaling pathway;
Hepatocyte-specific deletion of IL1-RI attenuates liver injury by blocking IL-1 driven autoinflammation
Keywords: التهاب NLRP3; Interleukin-1; Interleukin-1 receptor type 1; Acute liver failure; Acute-on-chronic liver failure; Therapy; Liver disease; Inflammation; Neutrophils; NLRP3 inflammasome; Caspase 1; Pyroptosis; NF-κB; JNK; TLR4; TNF-α;
The NLRP3 inflammasome: Role in metabolic disorders and regulation by metabolic pathways
Keywords: التهاب NLRP3; NLRP3 inflammasome; Metabolic disorder; Metabolic pathway; IL-1β; IL-18;
Ozone protects the rat lung from ischemia-reperfusion injury by attenuating NLRP3-mediated inflammation, enhancing Nrf2 antioxidant activity and inhibiting apoptosis
Keywords: التهاب NLRP3; Ozone oxidative preconditioning; Lung ischemia-reperfusion injury; Nrf2 expression; NLRP3 inflammasome; Oxidative stress; Apoptosis;
Flavonoids interfere with NLRP3 inflammasome activation
Keywords: التهاب NLRP3; Flavonoid; NLRP3 inflammasome; Syk; Pyk2; Monosodium urate crystal;
Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells
Keywords: التهاب NLRP3; AS; atherosclerosis; CVD; cardiovascular diseases; ROS; reactive oxygen species; HUVECs; human umbilical vein endothelial cells; LPS; lipopolysaccharide; MTT; 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazo- lium bromide; DMSO; dimethyl sulfoxide; NAC;
Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis
Keywords: التهاب NLRP3; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BUN; blood urea nitrogen; BW; body weight; BG; blood glucose; DCFDA; dichlorodihydrofluorescein diacetate; DN; diabetic nephropathy; ECL; enhanced chemiluminescence; EM; electron microscopy;
Baicalin ameliorates chronic unpredictable mild stress-induced depressive behavior: Involving the inhibition of NLRP3 inflammasome activation in rat prefrontal cortex
Keywords: التهاب NLRP3; Baicalin; Chronic unpredictable mild stress; Antidepressant; NLRP3 inflammasome; IL-1β;
Research articleAstragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms
Keywords: التهاب NLRP3; Astragaloside IV; Cerebral ischemia and reperfusion; Cognitive impairments; TLR4 signaling pathway; NLRP3 inflammasome; Microglial activation;
Role of the NLRP3 inflammasome in a model of acute burn-induced pain
Keywords: التهاب NLRP3; BL; baseline; ICE; interleukin-1 converting enzyme; IL; interleukin; PWF; paw withdrawal force; SEM; standard error of the mean; wt; wild type; NLRP3 inflammasome; Caspase-1; Interleukin-1β; Burns; Mouse model; Pain;
Induction of heme oxygenas-1 attenuates NLRP3 inflammasome activation in lipopolysaccharide-induced mastitis in mice
Keywords: التهاب NLRP3; Mastitis; LPS; NLRP3 inflammasome; TXNIP; HO-1;
Puerarin inhibits amyloid β-induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS-dependent oxidative and endoplasmic reticulum stresses
Keywords: التهاب NLRP3; Puerarin; Amyloid β1-40; NLRP3 inflammasome; Retinal pigment epithelial; Reactive oxygen species;
Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages
Keywords: التهاب NLRP3; CO; Glycolysis; NLRP3 inflammasome; Macrophages;
Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction
Keywords: التهاب NLRP3; Resveratrol; Sirt1; Autophagy; NLRP3 inflammasome; Neuroprotection; Ischemia-reperfusion;
A new mechanism of inhibition of IL-1β secretion by celastrol through the NLRP3 inflammasome pathway
Keywords: التهاب NLRP3; Celastrol; Anti-inflammatory effects; NLRP3 inflammasome; IL-1β;
Original articleComparative effects of schisandrin A, B, and C on Propionibacterium acnes-induced, NLRP3 inflammasome activation-mediated IL-1β secretion and pyroptosis
Keywords: التهاب NLRP3; Schisandrin; Anti-inflammatory; Propionibacterium acnes; NLRP3 inflammasome; Pyroptosis; Caspase-1;
Research reportNLRP3 gene knockout blocks NF-κB and MAPK signaling pathway in CUMS-induced depression mouse model
Keywords: التهاب NLRP3; NLRP3 inflammasome; Knockout; Interleukin-1β; Depression; Stress; Inflammation;
Rutin protects endothelial dysfunction by disturbing Nox4 and ROS-sensitive NLRP3 inflammasome
Keywords: التهاب NLRP3; Rutin; High glucose; Endothelial dysfunction; Nox4; ROS; NLRP3 inflammasome;
NLRP3 inflammasome activation mediates fatigue-like behaviors in mice via neuroinflammation
Keywords: التهاب NLRP3; CFS; chronic fatigue syndrome; IL-1β; interleukin-1β; KO; knockout; LPS; lipopolysaccharide; MDA; malondialdehyde; PFC; prefrontal cortex; ROS; reactive oxygen species; NLRP3 inflammasome; fatigue; IL-1β;
MD-2 regulates LPS-induced NLRP3 inflammasome activation and IL-1beta secretion by a MyD88/NF-κB-dependent pathway in alveolar macrophages cell line
Keywords: التهاب NLRP3; MD-2; NLRP3 inflammasome; NF-κB; Alveolar macrophages cell line; LPS;
Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse
Keywords: التهاب NLRP3; P2X7 receptor; NLRP3 inflammasome; Caspase-3; Ischemic stroke; Neuronal apoptosis;
Protective effects of wedelolactone on dextran sodium sulfate induced murine colitis partly through inhibiting the NLRP3 inflammasome activation via AMPK signaling
Keywords: التهاب NLRP3; WEL; wedelolactone; DSS; dextran sulfate sodium; UC; ulcerative colitis; COX-2; cyclooxygenase-2; iNOS; Inducible nitric oxide synthase; MAPK; mitogen activated protein kinase; DAI; disease activity index; MPO; myeloperoxidase; AP; alkaline phosphatase; I
Esculentoside A exerts anti-inflammatory activity in microglial cells
Keywords: التهاب NLRP3; Esculentoside A; Neuroinflammation; NF-κB p65; NLRP3 inflammasome; Microglia cells;
Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling
Keywords: التهاب NLRP3; Rhapontin; Inflammation; Intestinal barrier; NLRP3 inflammasome; SIRT1;
Therapeutic efficacy of carboxyamidotriazole on 2,4,6-trinitrobenzene sulfonic acid-induced colitis model is associated with the inhibition of NLRP3 inflammasome and NF-κB activation
Keywords: التهاب NLRP3; Carboxyamidotriazole; Inflammatory bowel disease; TNBS rat colitis; NLRP3 inflammasome; NF-κB;
Structure activity relationships of engineered nanomaterials in inducing NLRP3 inflammasome activation and chronic lung fibrosis
Keywords: التهاب NLRP3; Engineered nanomaterial (ENM); NLRP3 inflammasome; Lung fibrosis; Structure activity relationship (SAR); Chronic lung toxicity;
Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway
Keywords: التهاب NLRP3; Irisin; NLRP3 inflammasome; Oxidative stress; Oxygen-glucose deprivation (OGD); Ischemic stroke;
Phagolysosome acidification is required for silica and engineered nanoparticle-induced lysosome membrane permeabilization and resultant NLRP3 inflammasome activity
Keywords: التهاب NLRP3; NLRP3 Inflammasome; MWCNT; TNB; Silica; Lysosome membrane permeabilization;
Sinigrin inhibits production of inflammatory mediators by suppressing NF-κB/MAPK pathways or NLRP3 inflammasome activation in macrophages
Keywords: التهاب NLRP3; 2-Propenyl glucosinolate; Inflammation; NLRP3 inflammasome; NF-κB/MAPK; Macrophage;
Research articleEffect of betaine on hepatic insulin resistance through FOXO1-induced NLRP3 inflammasome
Keywords: التهاب NLRP3; Betaine; FOXO1; NLRP3 inflammasome; Insulin resistance; Oxidative stress; TXNIP;
TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2â²,4,4â²-tetrabromodiphenyl ether (BDE-47)-treated mice
Keywords: التهاب NLRP3; Polybrominated diphenyl ethers; NLRP3 inflammasome; TDP-43; Parkin; Cognitive impairment;
Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver
Keywords: التهاب NLRP3; ACC; acetyl CoA carboxylase; ApoB; apolipoprotein B; COX-1; cytochrome c oxidase subunit 1; CPT1-l; carnitine palmitoyltrasnferase; FAS; fatty acid synthase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GCLC; glutamate-cysteine ligase catalytic; GCL
A novel mechanism of diabetic vascular endothelial dysfunction: Hypoadiponectinemia-induced NLRP3 inflammasome activation
Keywords: التهاب NLRP3; Adiponectin; Endothelial cells; NLRP3 inflammasome; Oxidative/nitrative stress; Type 2 diabetic mellitus;
Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway
Keywords: التهاب NLRP3; Senescence; IL-1β; NLRP3 inflammasome; ROS; TXNIP;
Structural characterization and macrophage immunomodulatory activity of a novel polysaccharide from Smilax glabra Roxb.
Keywords: التهاب NLRP3; Smilax glabra Roxb.; Polysaccharide; Structure; Immunomodulatory activity; NLRP3 inflammasome;
The NLRP3 inflammasome modulates sleep and NREM sleep delta power induced by spontaneous wakefulness, sleep deprivation and lipopolysaccharide
Keywords: التهاب NLRP3; Sleep deprivation; NLRP3 inflammasome; Interleukin-1 beta; Caspase-1; EEG delta power; Inflammation; Lipopolysaccharide; Cortex;
NLRP3 inflammasome activation in mesenchymal stem cells inhibits osteogenic differentiation and enhances adipogenic differentiation
Keywords: التهاب NLRP3; Mesenchymal stem cell; NLRP3 inflammasome; Osteoporosis; Adipogenesis; Osteogenesis;
ROS/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia
Keywords: التهاب NLRP3; ICH; Thrombin; ROS/TXNIP pathway; NLRP3 inflammasome; Apoptosis;
A mechanistic insight into curcumin modulation of the IL-1β secretion and NLRP3 S-glutathionylation induced by needle-like cationic cellulose nanocrystals in myeloid cells
Keywords: التهاب NLRP3; Curcumin; NLRP3 inflammasome; IL-1β; S-glutathionylation; Nanomaterials; Cellulose nanocrystals; AP-1; activator protein-1; ASC; apoptosis-associated speck-like protein containing a CARD; CNC-AEMA2; cellulose nanocrystals-grafted-poly(N-aminoethylmethacr
Conditioned medium from persistently RSV-infected macrophages alters transcriptional profile and inflammatory response of non-infected macrophages
Keywords: التهاب NLRP3; Respiratory syncytial virus; Viral persistence; Transcriptome; Microarray; NLRP3 inflammasome; Conditioned medium;