کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5512902 | 1540626 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver
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کلمات کلیدی
GCLMNLRP3NQO1apoBACCGCLCsuccinate dehydrogenase subunit ASREBP2IL-1βNAD(P)H:quinone oxidoreductase-1COX-1SCAPICAM-1GAPDHSREBP1FASNrf2GstANAFLDSREBP1ckeap1 - buy1MPO - DFONFκB - NFKBApolipoprotein B - آپولیپوپروتئین Bacetyl coA carboxylase - استیل کولا کربوکسیلازfatty acid synthase - اسید چرب سنتازNLRP3 inflammasome - التهاب NLRP3Interleukin-1 beta - اینترلوکین-1 بتاCytochrome C oxidase subunit 1 - زیرسایت اکسیداز سیتوکروم C 1nuclear factor (erythroid-derived 2)-like 2 - فاکتور هسته ای (erythroid-derived 2) -like 2Nuclear factor-kappa B - فاکتور هسته ای-کاپا BFructose - فروکتوز Intercellular adhesion molecule 1 - مولکول چسبندگی بین سلولی 1myeloperoxidase - میلوپراکسیداز sterol regulatory element-binding protein 1 - پروتئین اتصال دهنده عصاره استرول 1srebp cleavage-activating protein - پروتئین فعال کننده پروتئین Srebpsterol regulatory element-binding protein 2 - پروتئین متصل کننده عصاره استرول 2Kelch-like ECH-associated protein 1 - پروتئین مرتبط با ECH کلچ 1nod-like receptor protein 3 - پروتئین گیرنده مانند گربه 3saturated fat - چربی های اشباع شدهglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Therefore, the aim of our study was to investigate the dissimilar effects of these two dietary components on selected proinflammatory and antioxidant pathways in the liver of C57BL/6 mice fed a standard (SD), a 45% saturated fat (HFAT) or a 60% fructose (HFRT) diet for 12 weeks. HFAT diet evoked systemic metabolic alterations and overweight, not observed in HFRT mice. However, HFRT mice had a greater hepatic triglyceride deposition with increased ratio of triacylglycerols containing the palmitic acid compared to HFAT, as assessed by liquid chromatography-mass spectrometry analysis. This effect is due to the higher activation of the SCAP/SREBP1c lipogenic pathway by HFRT feeding. In addition, we found inhibition of Keap1/Nrf2 antioxidant signaling and more robust stimulation of the Nlrp3 inflammasome pathway in the livers of HFRT-fed mice when compared with HFAT-fed mice, which is consistent with the recent finding that palmitate and SREBP1c are implicated in hepatic oxidative stress and inflammation. These effects were associated with increased hepatic inflammation, as confirmed by high expression of markers of leukocyte infiltration in the HFRT group. Thus, we hypothesize an amplifying loop among lipogenesis, palmitate, Nrf2 and Nlrp3 that leads to a higher risk of NAFLD progression to NASH in a high-fructose diet compared to a high-saturated fat intake.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 42, April 2017, Pages 160-171
Journal: The Journal of Nutritional Biochemistry - Volume 42, April 2017, Pages 160-171
نویسندگان
Debora Nigro, Francesca Menotti, Alessia S. Cento, Loredana Serpe, Fausto Chiazza, Federica Dal Bello, Francesco Romaniello, Claudio Medana, Massimo Collino, Manuela Aragno, Raffaella Mastrocola,