Keywords: Feeding management; Fatty liver; Light control; Nutritional stress; Steatosis; FA; fatty acids; TG; triglyceride; NEFA; non-esterified free fatty acids; VLDL; very low-density lipoprotein; CP; crude protein; Fabp1; fatty acid binding protein 1; Srebp1; st
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Keywords: Srebp1; Sterol regulatory element binding protein 1; Cd36; Cluster of differentiation 36; Ppar; Peroxisomal proliferator-activated receptor; Ucp2; Uncoupling protein 2; Socs3; STAT-induced suppressor of cytokine signaling 3; Fatp2/5; Fatty acid transporte
Keywords: EDC; endocrine disrupting chemical; PCB; polychlorobiphenyl; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; BPA; bisphenol A; ER; estrogen receptor; EST; estrogen sulfotransferase; HFHS; high-fat high-sucrose; DEHP; Di-[2-ethylhexyl]-phthalate; GTT; glucose t
Keywords: T2DM; type 2 diabetes mellitus; MetS; metabolic syndrome; IR; insulin resistance; HMW; high molecular weight; AMPK; 5Ⲡadenosine monophosphate activated protein kinase; AdipoR; adiponectin receptor; PPARγ; peroxisome proliferator activated receptor γ;
Keywords: Dihydrocapsiate; HFD; Obesity; Glucose intolerance; Hepatic steatosis; ACOX1; Acyl-CoA oxidase 1; ADIPO; adiponectin; AIN; American Institute of Nutrition; ANOVA; 1-way analysis of variance; BAT; brown adipose tissue; BMI; body mass index; C/EBPβ; CCAAT/
Keywords: ACC; acetyl-CoA carboxylase; ALDOA; aldolase A; AIs; aromatase inhibitors; AMPK; AMP-activated protein kinase; BC; breast cancer; CML; chronic myelogenous leukemia; CT; computed tomography; CPT1; carnitine palmitoyltransferase 1; CRC; colorectal cancer; 2
Keywords: Pancreatic cancer; MIA PaCa-2Â cells; SREBP1; Fatostatin; PF429242; Lipid metabolism;
Keywords: Aromatase; Cyp19; SREBP1; Steatosis; PPARα; Testosterone;
Keywords: ACO; Acyl-CoA oxidase; ATGL; Adipose triglyceride lipase; CPT1; Carnitine palmitoyltransferase 1; FAS; Fatty acid synthase; FAT/CD36; Fatty acid translocase/cluster of differentiation 36; GLUT; Glucose transporter; LPL; Lipoprotein lipase; PFK; Phosphofru
Keywords: ACACA; acetyl-coenzyme A carboxylase alpha; ACTB; actin beta; CAT; catalase; CD36; cluster of differentiation 36; CON; control diet; DM; dry matter; FASN; fatty acid synthase; FM; flax meal; FMD; flax meal diet; FO; flax oil; GAPDH; glyceraldehyde-3-phosp
Keywords: AA; arachidonic acid; Aβ; fibrillar β-amyloid; ACC; acetyl-CoA carboxylase; Akt; protein kinase B; APP; amyloid precursor protein; ASAH2; neutral ceramidase; BA; benzyl alcohol; BBB; blood-brain-barrier; BMI; body mass index; BPM; bis(monoacylglycero)
Keywords: AbFW; abdominal fat weight; ADD-1; adipocyte determination and differentiation-dependent factor 1; ANOVA; analysis of variance; BJY; Beijing-You; C/EBPα; CCAAT/enhancer-binding protein factors α; C/EBPβ; CCAAT/enhancer-binding protein factors β; GLM;
Keywords: CRBN; cereblon; I-R; ischemia-reperfusion; WT; wild-type; KO; knockout; AMPK; AMP-activated protein kinase; ACC; acetyl-CoA carboxylase; PARP1; poly (ADP-ribose) polymerase 1; AICAR; 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside; A-769662; a no
Keywords: SREBP1; Sterol regulatory element-binding protein-1; FAS; Fatty acid synthase; CPT1A; Carnitine palmitoyltransferase IA; CPT1B; Carnitine palmitoyltransferase IB; TG; Triglyceride; Triglycerides; PGC-1α; Mitochondrial fusion; Autophagy; Aging;
Keywords: ABC; ATP-binding cassette; AE2 (SLC4A2); anion exchanger 2; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ALP; alkaline phosphatase; ASBT (SLC10A2); apical sodium-dependent bile acid transporter; ASCOM; activating signal cointegrator-
Liver kinase B1 induces browning phenotype in 3â¯T3-L1 adipocytes
Keywords: LKB1; Liver kinase B1; WAT; white adipose tissue; BAT; brown adipose tissue; UCP1; uncoupling protein 1; AMPK; adenosine monophosphate-activated protein kinase; PPARγ; Peroxisome proliferator-activated receptor γ; PGC-1α; PPARγ coactivator-1α; PRDM16
Sterol regulatory element binding protein 1 trans-activates 25-hydroxy vitamin D3 24-hydroxylase gene expression in renal proximal tubular cells
Keywords: Vitamin D; CYP24A1; SREBP1; Thyroid hormone; Transcriptional regulation;
Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration
Keywords: Small molecule screening; PGC-1a; PGC-1alpha; PGC-1alpha1; Protein stabilization; UCP1; Mitochondrial respiration; Brown adipose tissue; C/EBP; CCAAT-enhancer-binding proteins; FCCP; carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone; HEK; human embryon
Zhiheshouwu ethanol extract induces intrinsic apoptosis and reduces unsaturated fatty acids via SREBP1 pathway in hepatocellular carcinoma cells
Keywords: Zhiheshouwu ethanol extract; Hepatocellular carcinoma; Intrinsic apoptosis; SREBP1;
ApoE is a major determinant of hepatic bile acid homeostasis in mice
Keywords: ApoE; apolipoprotein E; BA; bile acid; HCHF; high-cholesterol/high-fat liver; Lrh; receptor homolog-1; Srebp1; sterol regulatory element-binding protein; Shp; small heterodimer partner; MCA; muricholic acid; CDCA; chenodeoxycholic acid; MRM; multiple reac
Evolution, regulation, and function of porcine selenogenome
Keywords: ACC; acetyl CoA carboxylase; AKT; protein kinase B; Cys; cysteine; DIO1; type 1 iodothyronine deiodinase; ER; endoplasmic reticulum; FAS; fatty acid synthase; FOXO1; forkhead box protein O1; GPX; glutathione peroxidase; INSR; insulin receptor; MIEN; migra
Loss of DJ-1 promotes browning of white adipose tissue in diet-induced obese mice
Keywords: ACC; acyl-CoA carboxylase; Actb; beta-actin encoding gene; AMPK; AMP-activated protein kinase; ATG; autophagy-related protein; ATGL; adipose triglyceride lipase; ATP5B; ATP synthase subunit beta; β3-AR; beta 3 adrenergic receptor; C/EBPα; CCAAT/enhancer
Adipocytes spectrum - From homeostasia to obesity and its associated pathology
Keywords: Acrp30 (AdipoQ); adiponectin gene; AdipoR; adiponectin receptor; AGE; angiotensinogen; ALP; alkaline phosphatase; Ang II; angiotensin II; Angptl2; angiopoietin-like protein-2; Aqp7; aquaporin-7; aP2; adipocyte-specific fatty acid binding protein 2 gene; A
Elevated sterol regulatory elementary binding protein 1 and GluA2 levels in the hippocampal nuclear fraction of Genetic Absence Epilepsy Rats from Strasbourg
Keywords: Absence epilepsy; GAERS; Nuclear translocation; SREBP1; GluA2; Pro-cell death signaling;
Original ArticleLipid quantification by Raman microspectroscopy as a potential biomarker in prostate cancer
Keywords: Prostate cancer; Raman microspectroscopy; Lipogenesis; TRAMP; Biomarker; FASN; fatty acid synthase; ACC; acetyl Co-A carboxylase; SREBP1; sterol regulatory element binding protein 1; TRAMP; transgenic adenocarcinoma of the mouse prostate; PCa; prostate ca
Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver
Keywords: ACC; acetyl CoA carboxylase; ApoB; apolipoprotein B; COX-1; cytochrome c oxidase subunit 1; CPT1-l; carnitine palmitoyltrasnferase; FAS; fatty acid synthase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GCLC; glutamate-cysteine ligase catalytic; GCL
Sphingolipids and glycerophospholipids - The “ying and yang” of lipotoxicity in metabolic diseases
Keywords: AA; arachidonic acid; AKT; RAC-alpha serine/threonine-protein kinase; CCTα; choline-phosphate cytidylyltransferase A; CERK; Ceramide Kinase; C1P; ceramide-1-phosphate; CerS; ceramide synthase; CERT; ceramide transport protein; HDL; high-density lipoprote
Nanoformulated copper/zinc superoxide dismutase exerts differential effects on glucose vs lipid homeostasis depending on the diet composition possibly via altered AMPK signaling
Keywords: ACC; Acetyl-coA carboxylase; ACOX1; Acyl-CoA oxidase1; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; DTSSP; 3,3â²-Dithiobis (sulfosuccinimidylpropionate); FABP1; Fatty acid binding protein 1; FASN; Fatty acid synthase; FCCP; Carbonyl c
BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells
Keywords: Annexin V; FITC-conjugated annexinV; BCA; bicinchoninic acid; BNIP3; Bcl2/adenovirus E1B 19Â kDa protein-interacting protein 3; CBP; CREB-binding protein; CCCP; carbonyl cyanide m-chlorophenyl hydrazine; CHIP; chromatin immunoprecipitation; CHOP; CCAAT-en
Steroidogenic acute regulatory protein (StAR) overexpression attenuates HFD-induced hepatic steatosis and insulin resistance
Keywords: StAR; steroidogenic acute regulatory protein; NAFLD; non-alcoholic fatty liver disease; HFD; high-fat diet; DMEM; Dulbecco's Modified Eagle Medium; PBS; phosphate buffered solution; FBS; fetal bovine serum; ITS-X; insulin-transferrin-selenium-ethanolamine
Molecular aspects of lipid metabolism, digestibility and antioxidant status of Atlantic bluefin tuna (T. thynnus L.) larvae during first feeding
Keywords: ABT; Atlantic bluefin tuna; aco; acyl coA oxidase; alp; alkaline phosphatase; amy; amylase; anpep; amino peptidase; ARA; arachidonic acid (20:4n-6); bal1; bile salt activated lipase 1; bal2; bile salt activated lipase 2; C; free cholesterol; cat; catalase
Sodium sulfite promotes the assembly and secretion of very low-density lipoprotein in HL-7702 hepatocytes
Keywords: TG; triglyceride; VLDL; very low-density lipoprotein; apoB100; apolipoprotein B100; ELISA; enzyme-linked immunosorbent assay; CPT1; carnitine palmitoyl transferase 1; SREBP1; sterol regulatory element binding protein-1; MTP; microsomal triglyceride transf
NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1
Keywords: NS5ATP6; FGF21; miR-577; SIRT1; SREBP1;
Vitamin A deficiency suppresses high fructose-induced triglyceride synthesis and elevates resolvin D1 levels
Keywords: NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; HFSC; high fructose corn syrup; ALT; alanine aminotransferase; AST; aspartate aminotransferase; RBP4; retinol binding protein 4; FGF21; fibroblast growth factor 21; CRP; C-reac
Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-α-lipoic acid, in human hepatocellular carcinoma cells
Keywords: ACC; acetyl-CoA carboxylase; Akt; protein kinase B; AMPK; AMP-activated protein kinase; apoB; apolipoprotein B; apoE; apolipoprotein E; CPT1α; carnitine palmitoyltransferase 1α; DGAT1; diacylglycerol O-acyltransferase 1; DGAT2; diacylglycerol O-acyltran
Transcriptional regulation analysis of FAM3A gene and its effect on adipocyte differentiation
Keywords: FAM3A; family with sequence similarity 3, member A; G6PD; glucose-6-phosphate dehydrogenase; PPARG(2); peroxisome proliferator-activated receptor gamma(2); C/EBPα; CCAAT/enhancer binding protein alpha; C/EBPβ(C/EBPβbeta); CCAAT/enhancer binding protein
An SOD1 deficiency enhances lipid droplet accumulation in the fasted mouse liver by aborting lipophagy
Keywords: Fasting; Lipophagy; Liver steatosis; Oxidative stress; Superoxide dismutase; ACC; acetyl CoA-carboxylase; ALT; alanine aminotransferase; apoB; apolipoprotein B; BSA; bovine serum albumin; ER; endoplasmic reticulum; FAS; fatty acid synthase; GLU; glucose;
Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis
Keywords: Acox1; acyl-CoA oxidase 1, palmitoyl; Agpat6; 1-acylglycerol-3-phosphate O-acyltransferase 6; Ash1l; absent, small, or homeotic-like 1 L; BPA; bisphenol A; BW; body weight; Cebpα; CCAAT/enhancer binding protein (C/EBP), alpha; Cebpβ or C/EBPβ; CCAAT/e
JAZF1 can regulate the expression of lipid metabolic genes and inhibit lipid accumulation in adipocytes
Keywords: JAZF1; TAK1; SREBP1; Adipocytes; 3T3-L1; Lipid accumulation
Deletion of PARP-2 induces hepatic cholesterol accumulation and decrease in HDL levels
Keywords: ABCA1; adenosine triphosphate-binding cassette transporter A1; ACACA; cetyl-CoA carboxylase alpha; ACLY; ATP citrate lyase; ACOX2; acyl-CoA oxidase 2; ARTD2; ADP-ribosyl transferase diphtheria toxin-like 2; cyp51A1; cytochrome P450, family 51 subfamily A,
A key role of the mitochondrial citrate carrier (SLC25A1) in TNFα- and IFNγ-triggered inflammation
Keywords: acetyl-CoA; acetyl-coenzyme A; ChIP; chromatin immunoprecipitation; CHX; cycloheximide; CIC; mitochondrial citrate carrier; CNFASB; 4-chloro-3-{[(3-nitrophenyl)amino]sulfonyl}benzoic acid; DAN; 2,3-diaminonaphthalene; FOXA1; forkhead-box A1; GAS; IFNγ-ac
Liquid fructose downregulates Sirt1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells
Keywords: ACO; acyl-CoA oxydase; AMPK; AMP-activated protein kinase; APRT; adenosyl phosphoribosyl transferase); ACC; acetyl-CoA carboxylase); ChREBP; carbohydrate response element binding protein; CYP4A1; cytochrome P450 4A1; FAS; fatty acid synthase; Foxa2; forkh
Deletion of SIRT1 From Hepatocytes in Mice Disrupts Lipin-1 Signaling and Aggravates Alcoholic Fatty Liver
Keywords: Alcoholic Fatty Liver; Lipid Metabolism; Inflammation; Signal Transduction; AH; alcoholic hepatitis; ALD; alcoholic liver disease; mRNA; messenger RNA; NFATc4; nuclear factor of activated T cells c4; PGC; peroxisome proliferator-activated receptor co-fact
The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue
Keywords: aP2; fatty acid binding protein 4; ATGL; adipose triacylglycerol lipase; BMI; body mass index; CGI-58; α/β-hydrolase domain containing 5; CNI; calcineurin inhibitor; CsA; cyclosporin A; DGAT1; diglyceride acyltransferase 1; FAS; fatty acid synthase; FFA
Identification and functional characterization of human glycerol-3-phosphate acyltransferase 1 gene promoters
Keywords: Glycerol-3-phosphate acyltransferase 1; Promoter; Human; Liver-enriched transcription factors; SREBP1
Loss of toll-like receptor 3 function improves glucose tolerance and reduces liver steatosis in obese mice
Keywords: EMT; epithelial-mesenchymal transition; FDR; false discovery rate; FFA; free fatty acids; G6P; glucose-6-phosphotase; GcK; glucokinase; GO; gene ontology; GTT; glucose tolerance test; HDL-C; high-density lipoprotein cholesterol; HFD; high fat diet; HOMA
Platelet lysate suppresses the expression of lipocalin-type prostaglandin D2 synthase that positively controls adipogenic differentiation of human mesenchymal stromal cells
Keywords: L-PGDS; Lipocalin-type prostaglandin D2 synthase; MSCs; Mesenchymal stromal cells; PL; Platelet lysate; FCS; Fetal calf serum; PPARγ; Peroxisome proliferator-activated receptor gamma; CEBPα; CCAAT/enhancer binding protein alpha; FABP4; Fatty acid bindin
Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide
Keywords: ALS; Neuronal excitotoxicity; SREBP1; Insig-1; Neuroprotection;
Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins
Keywords: Lamin; SREBP1; Nuclear envelope; Lipodystrophy; Progeria
Nuclear Receptors as New Perspective for the Management of Liver Diseases
Keywords: BSEP (ABCB11); bile salt export pump; CAR (NR1I3); constitutive androstane receptor; ERα (NR3A1); estrogen receptor alpha; FXR (NR1H4); farnesoid X receptor/bile acid receptor; HSC; hepatic stellate cells; NAFLD; nonalcoholic fatty liver disease; NASH; n