Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide

► Insig-1 is markedly degraded in spinal cords of G93A tg mice and ALS patients. ► Spinal cord degradation of Insig-1 is associated with SREBP1 activation in G93A mice and human ALS. ► Mouse spinal neuron excitotoxicity is blocked by SREBP1 peptide inhibitor Indip.