کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5906082 | 1159947 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression profiles of key transcription factors involved in lipid metabolism in Beijing-You chickens
ترجمه فارسی عنوان
پروفایل های بیان کننده عوامل رونویسی کلیدی در متابولیسم لیپید در جوجه های پکن شما
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کلمات کلیدی
SREBP1MCEmRNAGLMPPARαPPARγC/EBPα - C / EBPαc/ebpβ - c / ebpβanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceIMF - صندوق بین المللی پولTranscription factors - عوامل رونویسیLipid metabolism - متابولیسم لیپیدGeneralized linear model - مدل خطی تعمیمیافتهsterol regulatory element-binding protein 1 - پروتئین اتصال دهنده عصاره استرول 1Intramuscular fat - چربی داخل عضلانیMitotic clonal expansion - گسترش کلونال متیوتیکperoxisome proliferator-activated receptor γ - گیرنده پروتئین کننده پروکسیوم فعال γperoxisome proliferator-activated receptor α - گیرنده پروتئینی فعال پروکسایزوم α
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
چکیده انگلیسی
Intramuscular fat (IMF) is a crucial factor for the meat quality of chickens. With the aim of studying the molecular mechanisms underlying IMF deposition in chickens, the expression profiles of five candidate transcription factors involved in lipid metabolism in several tissues were examined in Beijing-You (BJY) chickens at five ages (0, 4, 8, 14 and 20 wk). Results showed that accumulation of IMF in breast (IMFbr), thigh (IMFth) and abdominal fat weight increased significantly (P < 0.01) after 8 wk. Accumulation of both IMFbr and IMFth from 8 to 14 wk exceeded that from 14 to 20 wk; IMFth was 4-7 times of IMFbr. As for the expression profiles of key transcription factors: 1) expression of C/EBPα and PPARγ in abdominal fat was significantly higher than that in breast and thigh muscles at all ages. The expression of C/EBPα was positively correlated with PPARγ in both breast and thigh muscles, which indicated that both C/EBPα and PPARγ promoted fat deposition and might act through a unified pathway; 2) the expression of SREBP-1 in 0, 4, and 8 wk in thigh muscle was significantly higher than that in breast; 3) expression of C/EBPβ at 4 and 8 wk was significantly higher than that at 14 and 20 wk; and it was positively correlated with IMFth and IMFbr from 0 to 8 wk; 4) expression of PPARα in breast and thigh muscles was significantly higher than that in abdominal fat. Taken together, all five transcription factors studied play roles in lipid metabolism in chickens with C/EBPα and PPARγ being important effectors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 537, Issue 1, 1 March 2014, Pages 120-125
Journal: Gene - Volume 537, Issue 1, 1 March 2014, Pages 120-125
نویسندگان
R.Q. Fu, R.R. Liu, G.P. Zhao, M.Q. Zheng, J.L. Chen, J. Wen,