کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5684941 | 1597922 | 2017 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nanoformulated copper/zinc superoxide dismutase exerts differential effects on glucose vs lipid homeostasis depending on the diet composition possibly via altered AMPK signaling
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کلمات کلیدی
ACCDTSSPPCXPCK2HK2SREBP1FABP1OCRLPLPLLGLUT4GLUT1SOD1FCCPACOX1GTTAMPKTBARSPTTHEPES4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid - 4- (2-Hydroxyethyl) piperazine-1-ethanesulfonic acidAMP-activated protein kinase - AMP-پروتئین کیناز فعال شده استAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPinsulin tolerance test - آزمون تحمل انسولینpyruvate tolerance test - آزمون تحمل پیرواتacetyl-CoA carboxylase - استیل کروکسی سیلازfatty acid synthase - اسید چرب سنتازITT - اینجاglucose tolerance test - تست تحمل گلوکزsuperoxide dismutase 1 - سوپر اکسید دیسموتاز 1Fasn - فسادLipoprotein lipase - لیپو پروتئین لیپازthiobarbituric acid reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکOxygen consumption rate - میزان مصرف اکسیژنGlucose transporter type 4 - نوع حمل گلوکز 4hexokinase 2 - هگزوکیناز 2sterol regulatory element-binding protein 1 - پروتئین اتصال دهنده عصاره استرول 1fatty acid binding protein 1 - پروتئین مرتبط با اسید چرب 1polyethylene glycol - پلی اتیلن گلیکولPoly-l-lysine - پلی-لیزینPEG - پلیاتیلن گلیکول pyruvate carboxylase - پیرووات کربوکسیلازcarbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone - کربونیل سیانید 4- (trifluoromethoxy) phenylhydrazone
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Evidence suggests that superoxide dismutase 1 (SOD1) promotes glucose vs lipid metabolism depending on the diet type. We recently reported that nanoformulated SOD1 (Nano) improved lipid metabolism without altering glucose homeostasis in high-fat (HF) diet-fed mice. Here, we sought to determine the effects and potential mechanisms of Nano in modulating glucose and lipid homeostasis in mice fed a normal chow diet (CD) vs HF diet. Mice were fed a CD or a HF diet (45%) for 10Â wk and injected with Nano once every 2 days for 15 days. The fasting glucose level was lower (PÂ <Â 0.05) in CDÂ +Â Nano-treated mice compared to control. Conversely, blood glucose was not altered but serum triglycerides were lower in HFÂ +Â Nano-treated mice. Genes involved in fatty acid synthesis were reduced by Nano in the skeletal muscle of CD but not of HF diet-fed mice. Adenosine monophosphate-activated protein kinase (AMPK), which promotes both glucose and lipid metabolism depending on the fuel availability, is activated by Nano in CD-fed mice. Moreover, Nano increased phosphorylation of ACC, a downstream target of AMPK, in both CD and HF diet-fed mice. Nano increased mitochondrial respiration in C2C12 myocytes in the presence of glucose or fatty acid, and this effect is inhibited by Compound C, an AMPK inhibitor. Our data suggest that Nano promotes glucose and lipid metabolism in CD and HF diet-fed mice, respectively, and this effect is mediated partly via AMPK signaling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Translational Research - Volume 188, October 2017, Pages 10-26
Journal: Translational Research - Volume 188, October 2017, Pages 10-26
نویسندگان
Gopalakrishnan Natarajan, Curtis Perriotte-Olson, Fatema Bhinderwala, Robert Powers, Cyrus V. Desouza, Geoffrey A. Talmon, Jiang Yuhang, Matthew C. Zimmerman, Alexander V. Kabanov, Viswanathan Saraswathi,