کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11015208 | 1788350 | 2019 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Liver kinase B1 induces browning phenotype in 3â¯T3-L1 adipocytes
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کلمات کلیدی
Sirt1TMEM26PPARγ coactivator-1αPRDM16SREBP1sirtuin1HSLLPLCPT1PGC-1αAMPKBATLKB1PPARγC/EBPα - C / EBPαUcp1 - UCP1White adipose tissue - بافت چربی سفیدbrown adipose tissue - بافت چربی قهوه ایAnti-obesity - ضد چاقیhormone-sensitive lipase - لیپاز حساس به هورمونLipoprotein lipase - لیپو پروتئین لیپازSterol regulatory element binding protein 1 - پروتئین اتصال دهنده عصاره استریل 1uncoupling protein 1 - پروتئین جدا سازی 1transmembrane protein 26 - پروتئین غشایی 26adenosine monophosphate-activated protein kinase - پروتئین کیناز فعال شده با آدنوزین مونوفسفاتperilipin - پریلیپینWAT - چیPLIN - کاملliver kinase B1 - کیناز کیناز B1peroxisome proliferator-activated receptor γ - گیرنده پروتئین کننده پروکسیوم فعال γ
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Induction of brown adipocytes in white adipose tissue is a promising therapy for combating human obesity and its associated disorders. Liver kinase B1 (LKB1) is a tumor inhibitor and metabolic modulator. Recent data suggest that LKB1 is necessary for adipogenesis, but its role in the browning of white adipocytes remains unknown. The objective of this study was to reveal the effect of LKB1 on browning. In our study, we showed that overexpression of LKB1 in 3â¯T3-L1 adipocytes up-regulated the expression of brown adipocyte markers, including UCP1, PGC-1α, Cidea, and PRDM16, and beige-cell-specific genes, such as CD137 and Tmem26. It was possible that the expression of UCP1 and other beige markers was increased by activation of PPARγ, resulting in the browning of 3â¯T3-L1 preadipocytes. The browning effect was abolished by a PPARγ inhibitor (GW9662). Moreover, these effects were dramatically abrogated by silencing of LKB1. Additionally, LKB1 decreased the expression levels of adipogenesis proteins (C/EBPα and SREBP1) and up-regulated lipid catabolism protein, perilipin (PLIN). In summary, the study suggested that LKB1 induces the browning of white adipocytes, in addition to promoting lipid metabolism. Therefore, LKB1 may be a helpful therapeutic candidate for treating obesity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 682, 15 January 2019, Pages 33-41
Journal: Gene - Volume 682, 15 January 2019, Pages 33-41
نویسندگان
Pengjiao Xi, Jie Xue, Zhaoxia Wu, Haomin Wang, Jie Han, Huimin Liang, Derun Tian,