Keywords: NLS، سیگنال محلی سازی هسته ای; AML, acute myeloid leukemia; CRM1, Chromosomal Region Maintenance 1; GST, glutathione S-transferase; MBP, maltose binding protein; NES, nuclear export signal; NLS, nuclear localization signal; NPM1, nucleophosmin; NPMc+, cytoplasmic nucleophosmin; scFv, s
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Keywords: NLS، سیگنال محلی سازی هسته ای; CLSM, confocal laser scanning microscopy; EGFP, enhanced green fluorescent protein; RFP, red fluorescent protein; NLS, nuclear localization signal; NOS, nucleolar localization signal; NES, nuclear export signal; HIV, human immunodeficiency virus type 1; H
Keywords: NLS، سیگنال محلی سازی هسته ای; PAK1; Tyrosyl phosphorylation; Prolactin; EstrogenE2, 17β-estradiol; EGF, epidermal growth factor; JAK2, Janus kinase 2; NLS, nuclear localization signal; PAK, p21-activated serine–threonine kinase; PRL, prolactin; pTyr, phosphorylated on tyrosines; Tyr,
Identification of nuclear localization signal within goldfish Tgf2 transposase
Keywords: NLS، سیگنال محلی سازی هسته ای; NLS, nuclear localization signal; hAT, Hobo/Activator/Tam3; Tgf2, transposon of goldfish; Tgf2TPase, Tgf2 transposase; L-Tgf2TP, full-length Tgf2TPase; Tgf2TP△120N, N-terminal truncated Tgf2TPase; Tgf2TP△31C and Tgf2TP△16C, C-terminal truncated Tgf2TPase;
Unmasking a novel disease gene NEO1 associated with autism spectrum disorders by a hemizygous deletion on chromosome 15 and a functional polymorphism
Keywords: NLS، سیگنال محلی سازی هسته ای; ASD, autism spectrum disorders; bp, base pair; CGH, comparative genomic hybridization; DAPI, 4′6-diamidino-2-phenylindone; GFP, green fluorescent protein; Mb, megabase pair; NeICD, neogenin intracellular domain; NLS, nuclear localization signal; LMB, lept
In silico identification of BESS-DC genes and expression analysis in the silkworm, Bombyx mori
Keywords: NLS، سیگنال محلی سازی هسته ای; BESS, BEAF32 (Boundary element associated factor 32), Su(var)3–7 and Stonewall; BESS-DC, BESS-domain containing; MADF, myb/SANT-like domain in Adf-1; NLS, nuclear localization signal; NES, nuclear export signal; HP 1, heterochromatin protein 1; qRT-PCR, q
Structure, expression and functions of MTA genes
Keywords: NLS، سیگنال محلی سازی هسته ای; MTA, metastasis associated proteins; NuRD, nucleosome remodeling and histone deacetylase;; BAH, Bromo-Adjacent Homology; ELM2, egl-27 and MTA1 homology; SANT, SWI, ADA2, N-CoR, TFIIIB-B; NLS, nuclear localization signal; PTM, post-translational modificati
Molecular identification and functional characterisation of the interferon regulatory factor 1 in the blunt snout bream (Megalobrama amblycephala)
Keywords: NLS، سیگنال محلی سازی هسته ای; MaIRF1; Aeromonas hydrophila; Cloning; ExpressionMaIRF1, Megalobrama amblycephala interferon regulatory factor 1; aa, amino acid; IFN, interferon; nt, nucleotide; hpi, hours post injection; NLS, nuclear localization signal; DBD, DNA-binding domain; IAD, I
Molecular Mechanism of HIV-1 Vpr for Binding to Importin-α
Keywords: NLS، سیگنال محلی سازی هسته ای; Vpr, viral protein R; HIV-1, human immunodeficiency virus type 1; NLS, nuclear localization signal; h-importin-α1, human importin-α1; IBB, importin-β-binding; ARM, armadillo; GST, glutathione S-transferase; ITC, isothermal titration calorimetry; DLS, dyna
EF-hand domains are involved in the differential cellular distribution of dystrophin Dp40
Keywords: NLS، سیگنال محلی سازی هسته ای; NGF, nerve growth factor; DMD, duchenne muscular dystrophy; NLS, nuclear localization signal; DAP, dystrophin-associated proteinsDystrophin Dp40; EF-hands; Subcellular localization; β-dystroglycan; PC12 cells; Site-directed mutagenesis
The cytoplasmic and nuclear populations of the eukaryote tRNA-isopentenyl transferase have distinct functions with implications in human cancer
Keywords: NLS، سیگنال محلی سازی هسته ای; tRNA, transfer RNA; TRIT1, tRNA isopentenyl transferase 1; i6A37, N6-(isopentenyl) adenosine; DMAPP, dimethylallyl pyrophosphate; NLS, nuclear localization signal; ORF, open reading frames; tgm, tRNA gene-mediated; pol II, RNA polymerase II; pol III, RNA
NEIL1 p.Gln282Stop variant is predominantly localized in the cytoplasm and exhibits reduced activity in suppressing mutations
Keywords: NLS، سیگنال محلی سازی هسته ای; DAPI, 4′,6-diamidino-2-phenylindole; GO, glucose oxidase; HGVD, Human Genetic Variation Database; HPRT, hypoxanthine phosphoribosyltransferase; MAF, mutation annotation format; MAP, MUTYH-associated polyposis; NLS, nuclear localization signal; RNA-seq, RN
Structure and Mechanism of Dimer–Monomer Transition of a Plant Poly(A)-Binding Protein upon RNA Interaction: Insights into Its Poly(A) Tail Assembly
Keywords: NLS، سیگنال محلی سازی هسته ای; PABP, poly(A)-binding protein; RRM, RNA recognition motif; NLS, nuclear localization signal; HSQC, heteronuclear single quantum coherence; NOE, nuclear Overhauser enhancement; 3D, three-dimensional; SAXS, small-angle X-ray scattering; EDTA, ethylenediamin
Nuclear export of the influenza virus ribonucleoprotein complex: Interaction of Hsc70 with viral proteins M1 and NS2
Keywords: NLS، سیگنال محلی سازی هسته ای; Kd, dissociation constant; HA, hemagglutinin; Hsc70, heat shock cognate 70; NA, neuraminidase; NES, nuclear export signal; NLS, nuclear localization signal; vRNP, viral ribonucleoprotein complexDissociation constant; Hsc70; Influenza virus; M1; NS2; Nucle
The long N-terminus of the C. elegans DNA repair enzyme APN-1 targets the protein to the nucleus of a heterologous system
Keywords: NLS، سیگنال محلی سازی هسته ای; AP sites, apurinic/apyrimidinic sites; Endo IV, endonuclease IV; MMS, methyl methane sulfonate; NLS, nuclear localization signal; PAGE, polyacrylamide gel electrophoresis; PCR, polymerase chain reaction; SDS, sodium dodecyl sulfateAP endonuclease; DNA rep
Expression differences of miRNAs and genes on NF-κB pathway between the healthy and the mastitis Chinese Holstein cows
Keywords: NLS، سیگنال محلی سازی هسته ای; NF-κB, nuclear factor kappa B; IκB, inhibitor of NF-κB; IKK, inhibitor of NF-κB kinase; RHD, rel homology domain; NLS, nuclear localization signal; qRT-PCR, quantitative real-time PCR; TRAF6, TNF receptor-associated factor 6; IRAK1, interleukin receptor a
Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury
Keywords: NLS، سیگنال محلی سازی هسته ای; ALI, acute lung injury; BALF, bronchoalveolar lavage fluids; EP, ethyl pyruvate; GST, gluthatione-s-transferase; HMGB1, high mobility group box protein 1; MV, mechanical ventilation; NLS, nuclear localization signal; PMNs, polymorphonuclear neutrophils; R
Overexpression of OsMYB4P, an R2R3-type MYB transcriptional activator, increases phosphate acquisition in rice
Keywords: NLS، سیگنال محلی سازی هسته ای; R2R3 MYB transcription factor; Phosphate acquisition; Pi accumulation; Root system architecture; Phosphate transporter; Pi responsePi, Inorganic phosphate; PSI, phosphate starvation-induced; CaMV, Cauliflower mosaic virus; NLS, Nuclear localization signal
Cap-dependent translation initiation factor, eIF4E, is the target for Ouabain-mediated inhibition of HIF-1α
Keywords: NLS، سیگنال محلی سازی هسته ای; eIF4E, eukaryotic initiation factor 4E; eIF4G, eukaryotic initiation factor 4G; eIF2α, eukaryotic initiation factor 2α; HIF-1, hypoxia-inducible factor 1; mTORC1, mTOR complex 1; NLS, nuclear localization signal; GFP, green fluorescent protein; Rluc, reni
Transportin-1 and Transportin-2: Protein nuclear import and beyond
Keywords: NLS، سیگنال محلی سازی هسته ای; hnRNP, heterogeneous ribonucleoprotein; NES, nuclear export signal; NLS, nuclear localization signal; NPC, nuclear pore complex; TRN-1, Transportin-1; TRN-2, Transportin-2Transportin; Importins; Karyopherins; Nuclear import; Nucleo-cytoplasmic transport;
Spectrum of MECP2 gene mutations in a cohort of Indian patients with Rett syndrome: Report of two novel mutations
Keywords: NLS، سیگنال محلی سازی هسته ای; RTT, Rett syndrome; MECP2, methyl CpG-binding protein 2; MBD, methyl-CpG binding domain; TRD, transcriptional repression domain; NLS, nuclear localization signal; HDAC, histone deacetylase; PCR, polymerase chain reaction; XCI, X chromosome inactivation; C
Imaging of heme/hemeproteins in nucleus of the living cells expressing heme-binding nuclear receptors
Keywords: NLS، سیگنال محلی سازی هسته ای; NPAS2, neuronal PAS2; DCFH-DA, 2′,7′-dichlorodihydrofluorescin diacetate; DCFH, dichlorodihydrofluorescin; DCF, dichlorodihydrofluorescein; ROS, reactive oxygen species; NLS, nuclear localization signal; FCS, fetal calf serum; DMEM, Dulbecco’s modified Ea
The C-terminal region of Rad52 is essential for Rad52 nuclear and nucleolar localization, and accumulation at DNA damage sites immediately after irradiation
Keywords: NLS، سیگنال محلی سازی هسته ای; CTR, C-terminal region; DIC, differential interference contrast; DNA-PKcs, DNA-dependent protein kinase catalytic subunit; DSB, DNA double-strand break; HR, homologous recombination; NLS, nuclear localization signal; NHEJ, nonhomologous DNA-end-joining; S
BBX proteins in green plants: Insights into their evolution, structure, feature and functional diversification
Keywords: NLS، سیگنال محلی سازی هسته ای; BBX, B-box proteins; VP, valine–proline; NLS, nuclear localization signal; CO, CONSTANS; COL, CO-likeBBX proteins; B-box domains; CCT domain; Nuclear localization signals (NLSs); Plant evolution
Chronic cerebral ischemia induces redistribution and abnormal phosphorylation of transactivation-responsive DNA-binding protein-43 in mice
Keywords: NLS، سیگنال محلی سازی هسته ای; TDP-43, transactivation-responsive DNA-binding protein-43; p-TDP-43, phosphorylated transactivation-responsive DNA-binding protein-43; FTLD, frontotemporal lobar degeneration; ALS, amyotrophic lateral sclerosis; NLS, nuclear localization signal; PBS, phos
Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities
Keywords: NLS، سیگنال محلی سازی هسته ای; MMR, DNA mismatch repair; HMGB1, high mobility group DNA binding protein; IRC, initial recognition complex; URC, ultimate recognition complex; CAF-1, chromatin assembly factor-1; PIP, PCNA interacting protein; NLS, nuclear localization signal; MNNG, N-met
β-Hairpin-Mediated Nucleation of Polyglutamine Amyloid Formation
Keywords: NLS، سیگنال محلی سازی هسته ای; FTIR, Fourier transform infrared; ssNMR, solid-state NMR; trpzip, tryptophan zipper; EM, electron microscopy; MAS, magic angle spinning; BMRB, Biological Magnetic Resonance Data Bank; NLS, nuclear localization signal; GFP, green fluorescent protein; EGFP,
Scythe cleavage during Fas (APO-1)-and staurosporine-mediated apoptosis
Keywords: NLS، سیگنال محلی سازی هسته ای; AIF, apoptosis-inducing factor; HSP, heat shock protein; PS, phosphatidylserine; NLS, nuclear localization signal; Z-VAD-FMK, N-benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketoneApoptosis; Fas (APO-1); Scythe; Caspases; Phosphatidylserine
Identification of a putative nuclear export signal motif in human NANOG homeobox domain
Keywords: NLS، سیگنال محلی سازی هسته ای; NES, nuclear export signal; LMB, leptomycin B; CRM1, chromosomal region maintenance 1; NLS, nuclear localization signal; HD, homeobox domainNANOG; Homeobox domain; Nuclear export signal; Leucine-rich motif
The nucleotide-binding domain of NLRC5 is critical for nuclear import and transactivation activity
Keywords: NLS، سیگنال محلی سازی هسته ای; NLR proteins, nucleotide-binding domain (NBD) leucine-rich repeat (LRR) containing proteins; CIITA, MHC class II transactivator; β2M, β2-microglobulin; NLS, nuclear localization signal; RFX, regulatory factor X; ATF1, activating transcription factor 1; NF
Identification of a novel isoform of DHRS4 protein with a nuclear localization signal
Keywords: NLS، سیگنال محلی سازی هسته ای; DHRS4, dehydrogenase/reductase member 4; NRDR, NADP(H)-dependent retinol dehydrogenase/reductase; SDR, short-chain dehydrogenase/reductase; EGFP, enhanced green fluorescent protein; NLS, nuclear localization signal; MTS, mitochondrial targeting signal; PT
Acetylation of Prrp K150 regulates the subcellular localization
Keywords: NLS، سیگنال محلی سازی هسته ای; anti-panAcK, Anti-pan-specific acetylated-lysine; K150, Lysine 150; MoAb, monoclonal antibody; NLS, nuclear localization signal; PEI, polyethylenimine; Prrp, proline-rich RNA binding protein; PTM, posttranslational modification; RRM, RNA recognition motif
Monoubiquitination-dependent chromatin loading of FancD2 in silkworms, a species lacking the FA core complex
Keywords: NLS، سیگنال محلی سازی هسته ای; FA, Fanconi anemia; MMC, mitomycin C; ICL, DNA interstrand cross-link; NLS, nuclear localization signal; RACE, rapid amplification of cDNA ends; dsRNA, double-stranded RNA; DBD, DNA binding domain; AD, transcriptional activation domain; UAS, GAL4 upstream
Nuclear transport of baculovirus: Revealing the nuclear pore complex passage
Keywords: NLS، سیگنال محلی سازی هسته ای; AcMNPV, Autographa californica multiple nucleopolyhedrovirus; EM, electron microscopy; FG, phenylalanine–glycine; GV, granulovirus; LSB, low-salt buffer; MBS, modified Barth’s saline; NE, nuclear envelope; NLS, nuclear localization signal; NPCs, nuclear p
Human mitochondrial transcription factor A functions in both nuclei and mitochondria and regulates cancer cell growth
Keywords: NLS، سیگنال محلی سازی هسته ای; BIRC5, baculoviral IAP repeat containing 5; ChIP, chromatin immunoprecipitation; HMG, high mobility group; mtDNA, mitochondrial DNA; MTP, mitochondrial targeting peptide; mtTFA/TFAM, mitochondrial transcription factor A; NLS, nuclear localization signal;
Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37
Keywords: NLS، سیگنال محلی سازی هسته ای; Ankrd37, ankyrin repeat domain-containing protein 37; Ankrd37Δ, Ankrd37 with its NLS motif deleted; NLS, nuclear localization signal; HEK293T cell, human embryonic kidney 293T cell; CHO cell, Chinese hamster ovary cell; RT-PCR, reverse transcription-polym
Establishment of a stable transgenic strain in a pelagic egg spawning marine teleost, Nibe croaker Nibea mitsukurii
Keywords: NLS، سیگنال محلی سازی هسته ای; eGfp, enhanced green fluorescent protein; GFP, green fluorescent protein; hsc71, heat-shock-cognate 71; PCR, polymerase chain reaction; NLS, nuclear localization signal; HUFA, highly unsaturated fatty acid; EPA, Eicosapentaenoic acid; DHA, Docosahexaenoic
What's Nu(SAP) in mitosis and cancer?
Keywords: NLS، سیگنال محلی سازی هسته ای; NuSAP/NUSAP1/Nusap1, Nucleolar-spindle associated protein; SAP, SAF-A/B, Acinus and PIAS; NLS, Nuclear localization signal; MT/MTs, Microtubule/Microtubules; KEN-box, amino acids lysine (K), glutamic acid (E) and asparagine (N); APC/C, Anaphase-promoting
Ceramide kinase: The first decade
Keywords: NLS، سیگنال محلی سازی هسته ای; Cer, ceramide; CERK, ceramide kinase; C1P, ceramide 1-phosphate; GC, glucosylceramide; GCS, GC synthase; NF-κB, Nuclear factor-κB; PPIn, polyphosphoinositide; PtdIns, phosphatidylinositol; NES, nuclear export signal; NLS, nuclear localization signal; SM,
Role of Interaction of XPF with RPA in Nucleotide Excision Repair
Keywords: NLS، سیگنال محلی سازی هسته ای; NER, nucleotide excision repair; dsDNA, double-stranded DNA; NLS, nuclear localization signal; EDTA, ethylenediaminetetraacetic acid; CPV, cell pellet volume; 6-4 PP, 6-4 photoproductXPF–ERCC1; RPA; nucleotide excision repair; subcellular localization; pr
MYC genes with differential responses to tapping, mechanical wounding, ethrel and methyl jasmonate in laticifers of rubber tree (Hevea brasiliensis Muell. Arg.)
Keywords: NLS، سیگنال محلی سازی هسته ای; bHLH, basic helix-loop-helix; BLAST, basic local alignment search tool; CTAB, cetyl-trimethylammonium bromide; MYC, myelocytomatosis protein; NCBI, national centre for biotechnology information; NLS, nuclear localization signal; ORF, open reading frame; R
The candidate tumor suppressor SASH1 interacts with the actin cytoskeleton and stimulates cell–matrix adhesion
Keywords: NLS، سیگنال محلی سازی هسته ای; F-actin, Filamentous actin; G-actin, Monomeric actin; GFP, Green fluorescent protein; NLS, Nuclear localization signal; SAM, Sterile alpha-motif; SASH1, SAM and SH3 domain containing 1; SH3, Src-homology 3 domain; SLY, SH3-domain containing protein expres
The Structure of BRMS1 Nuclear Export Signal and SNX6 Interacting Region Reveals a Hexamer Formed by Antiparallel Coiled Coils
Keywords: NLS، سیگنال محلی سازی هسته ای; BRMS1; metastasis suppressors; coiled-coil domain; X-ray diffraction; structureBRMS1, breast cancer metastasis suppressor 1; SNX6, sorting nexin 6; NES, nuclear export signal; NLS, nuclear localization signal; DOSY-NMR, diffusion-ordered spectroscopy nucl
Identification of Critical Motifs within HIV-1 Integrase Required for Importin α3 Interaction and Viral cDNA Nuclear Import
Keywords: NLS، سیگنال محلی سازی هسته ای; HIV-1, human immunodeficiency virus type 1; PIC, pre-integration complex; Vpr, viral protein R; MA, matrix; IN, integrase; CCD, catalytic core domain; CTD, C-terminal domain; NLS, nuclear localization signal; LTR, long terminal repeat; Co-IP, co-immunopre
Facioscapulohumeral Muscular Dystrophy Region Gene 1 Is a Dynamic RNA-Associated and Actin-Bundling Protein
Keywords: NLS، سیگنال محلی سازی هسته ای; TAP; karyopherin α2; actin binding; nucleolus; mRNA transportFRG1, FSHD region gene 1; NLS, nuclear localization signal; FSHD, facioscapulohumeral muscular dystrophy; ICC, immunocytochemistry; HA, hemagglutinin; DAPI, 4′,6-diamidino-2-phenylindole; DFC, d
In Vitro DNA Tethering of HIV-1 Integrase by the Transcriptional Coactivator LEDGF/p75
Keywords: NLS، سیگنال محلی سازی هسته ای; IN, integrase; NLS, nuclear localization signal; LTR, long terminal repeat; PIC, preintegration complex; IBD, integrase binding domain; HIV-1, human immunodeficiency virus type 1; 1O2, singlet oxygen; CR1, charged region 1; MBP, maltose binding protein; F
A novel bipartite nuclear localization signal with an atypically long linker in DOF transcription factors
Keywords: NLS، سیگنال محلی سازی هسته ای; Arabidopsis; Bipartite NLS; Nucleus; Transcription regulationaa, amino acid(s); CT, C-terminus; DAPI, 4′,6-diamidino-2-phenylindole; GFP, green fluorescent protein; NLS, nuclear localization signal; NT, N-terminus
A novel mutation in GATA4 gene associated with dominant inherited familial atrial septal defect
Keywords: NLS، سیگنال محلی سازی هسته ای; 20; 29ASD, atrial septal defect; CHD, congenital heart disease; CZf, C-terminal zinc finger; NLS, nuclear localization signal; NZf, N-terminal zinc finger
Repression of estrogen receptor β function by putative tumor suppressor DBC1
Keywords: NLS، سیگنال محلی سازی هسته ای; E2, 17β-estradiol; ER, estrogen receptor; FBS, fetal bovine serum; NLS, nuclear localization signal; NR, nuclear receptor; AF, activation function; GST, glutathione-S-transferaseDBC1; ERβ; Breast cancer; Transcription; Repression
Shuttling of SOX proteins
Keywords: NLS، سیگنال محلی سازی هسته ای; HMG, high mobility group; NLS, nuclear localization signal; NES, nuclear export signalSOX protein; Nuclear localization signal; Nuclear export signal; Importin-β; Calmodulin