Keywords: گیرنده NOP; Radioligand binding; Mouse vas deferens; Opioid receptors; NOP receptor; Nociception; Bivalent ligands;
مقالات ISI گیرنده NOP (ترجمه نشده)
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Keywords: گیرنده NOP; Nociceptin/orphanin FQ; NOP receptor; Contextual fear memory; Reconsolidation; Hippocampus;
Nociceptin/orphanin FQ receptor agonists increase aggressiveness in the mouse resident-intruder test
Keywords: گیرنده NOP; Aggressiveness; Mouse; Resident-intruder test; NOP receptor; NOP ligands; NOP knockout mice;
Involvement of the N/OFQ-NOP system in rat morphine antinociceptive tolerance: Are astrocytes the crossroad?
Keywords: گیرنده NOP; Morphine tolerance; N/OFQ; NOP receptor; NOP(-/-) rats; Glial cells;
Mu-opioid peptide (MOP) and nociceptin/orphanin FQ peptide (NOP) receptor activation both contribute to the discriminative stimulus properties of cebranopadol in the rat
Keywords: گیرنده NOP; DOP receptor; Drug discrimination; KOP receptor; MOP receptor; NOP receptor; Stimulus property;
Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease
Keywords: گیرنده NOP; AAV2/9; adeno-associated viral vector pseudotype2/9; DA; dopamine; hα-syn; p.A53T human α-synuclein; MPTP; 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine; N/OFQ; nociceptin/orphanin FQ; NOP; N/OFQ peptide receptor; 6-OHDA; 6-hydroxydopamine; p-α-syn; pho
A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety
Keywords: گیرنده NOP; Nociceptin; NOP receptor; Orphanin FQ; Opioid receptor-like receptor-1; Drug discovery
Blockade of nociceptin/orphanin FQ receptor signaling reverses LPS-induced depressive-like behavior in mice
Keywords: گیرنده NOP; Nociceptin/orphanin FQ; NOP receptor; Lipopolysaccharide-induced depressive; Inflammation; Depression; Tail suspension test;
Structure activity studies of nociceptin/orphanin FQ(1-13)-NH2 derivatives modified in position 5
Keywords: گیرنده NOP; Nociceptin/orphanin FQ; Peptide synthesis; NOP receptor; [35S]GTPγS binding assay; Calcium mobilization assay;
Design, synthesis and evaluation of [3H]PF-7191, a highly specific nociceptin opioid peptide (NOP) receptor radiotracer for in vivo receptor occupancy (RO) studies
Keywords: گیرنده NOP; NOP receptor; ORL1; Radiotracer; Receptor occupancy; PET
Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats
Keywords: گیرنده NOP; Drug self-administration; Nociceptin/orphanin FQ; NOP receptor; SCH221510; Remifentanil; Opioids;
Retrodialysis of N/OFQ into the nucleus accumbens shell blocks cocaine-induced increases in extracellular dopamine and locomotor activity
Keywords: گیرنده NOP; Microdialysis; Nociceptin; N/OFQ; Nucleus accumbens; NOP receptor; Cocaine; Rat; Locomotion;
Research ReportAcute and subchronic treatments with selective serotonin reuptake inhibitors increase Nociceptin/Orphanin FQ (NOP) receptor density in the rat dorsal raphe nucleus; interactions between nociceptin/NOP system and serotonin
Keywords: گیرنده NOP; AUC; area under the curve; DOPAC; dihydroxyphenylacetic acid; DRN; dorsal raphe nucleus; HVA; homovanillic acid; NOP receptor; nociceptin-orphanin FQ receptor; ORL1 receptor; opioid receptor-like 1 receptor; pCPA; para-chlorophenylalanine; SSRI; selective
The role of NOP receptors in psychomotor stimulation and locomotor sensitization induced by cocaine and amphetamine in mice
Keywords: گیرنده NOP; Cocaine; Amphetamine; Locomotor sensitization; OFQ/N (Orphanin FQ/Nociceptin); NOP receptor; ORL1 (Opioid receptor-like) receptor; Knockout mouse;
Nociceptin receptor signaling in sympathetic neurons from septic rats
Keywords: گیرنده NOP; NOP receptor; Nociceptin; Sepsis; Ca2+ channels; Stellate ganglion; Prepronociceptin
Protective and worsening peripheral nociceptin/orphanin FQ receptor-mediated effect in a rat model of experimental colitis
Keywords: گیرنده NOP; N/OFQ; NOP receptor; Rat experimental colitisTNBS, 2,4,6 trinitrobenzenesulphonic acid; MPO, myeloperoxidase; IL-, interleukin-; IBD, inflammatory bowel disease
Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs
Keywords: گیرنده NOP; Nociceptin/orphanin FQ; NOP receptor; NOP antagonists; Mood disorders; Stress; 5-HT neurotransmission5-HT, serotonin; ACTH, adrenocorticotropic hormone; Amy, amygdala; BDNF, brain derived neurotrophic factor; CRF, corticotropin release factor; DRN, dorsal
Sex differences in the Nociceptin/Orphanin FQ system in rat spinal cord following chronic morphine treatment
Keywords: گیرنده NOP; N/OFQ; Morphine; Sex difference; Tolerance; Spinal cord; NOP receptor;
The nociceptin orphanin FQ peptide receptor agonist, Ro64-6198, impairs recognition memory formation through interaction with glutamatergic but not cholinergic receptor antagonists
Keywords: گیرنده NOP; NOP receptor; Glutamate; Acetylcholine; Learning and memory; Mice
The NOP receptor involvement in both withdrawal- and CCk-8-induced contracture responses of guinea pig isolated ileum after acute activation of κ-opioid receptor
Keywords: گیرنده NOP; OFQ/N; UFP-101; NOP receptor; κ-Opioid receptor; CCk-8; GPI; Opioid withdrawal;
Nociceptin/orphanin FQ receptor knockout rats: In vitro and in vivo studies
Keywords: گیرنده NOP; NOP receptor; Anxiety; Depression; Locomotor activity; NociceptionN/OFQ, Nociceptin/orphanin FQ; NOP, N/OFQ peptide receptor; NOP(−/−), rats knockout for the NOP receptor gene; NOP(+/+), rats wild type for the NOP receptor gene
The role of nociceptin and dynorphin in chronic pain: Implications of neuro–glial interaction
Keywords: گیرنده NOP; Chronic pain; Neuropathy; Dynorphin; Nociceptin; KOP receptor; NOP receptor; Microglia; Non-neuronal cells
Comparative biochemical and pharmacological characterization of a novel, NOP receptor selective hexapeptide, Ac-RYYRIR-ol
Keywords: گیرنده NOP; N/OFQ; nociceptin/orphanin FQ; NOP receptor; N/OFQ peptide receptor; Ac-RYYRIK-ol; Acetyl-Arg-Tyr-Tyr-Arg-Ile-Lys-ol; Nociceptin/orphanin FQ (NOP) receptor; Hexapeptide ligands; Receptor binding; G-protein activation; In vitro pharmacology; Part
Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models
Keywords: گیرنده NOP; Cough; NOP receptor; Nociceptin/orphanin FQ; SCH 486757; Antitussive
Nociceptin and its metabolite attenuate U0126-induced memory impairment through a nociceptin opioid peptide (NOP) receptor-independent mechanism
Keywords: گیرنده NOP; Nociceptin/orphanin FQ; NOP receptor; Nociceptin metabolite; ERK; Memory U0126; MEK inhibitor; Protein kinase A; Rp-cAMPS; Hippocampus
The role of the NOP receptor in regulating food intake, meal pattern, and the excitability of proopiomelanocortin neurons
Keywords: گیرنده NOP; NOP receptor; OFQ; Nociceptin; Appetite; Glutamate; K+ channels;
Buprenorphine inhibits bradykinin-induced release of calcitonin gene-related peptide from rat trigeminal neurons via both μ-opioid and nociceptin/orphanin peptide receptors
Keywords: گیرنده NOP; Rat trigeminal neuron; Calcitonin gene-related peptide; Buprenorphine; NOP receptor; Bradykinin
Distinct effects of nociceptin analogs on scopolamine-induced memory impairment in mice
Keywords: گیرنده NOP; Nociceptin/orphanin FQ; NOP receptor; [Arg14, Lys15]nociceptin; [(pF)Phe4]nociceptin(1-13)NH2; Memory;
Peripheral anti-nociceptive effect of nociceptin/orphanin FQ in inflammation and stress-induced colonic hyperalgesia in rats
Keywords: گیرنده NOP; IBS; intestinal bowel syndrome; CRF; corticotropin-releasing factor; N/OFQ; nociceptin/orphanin/FQ; NOP receptor; nociceptin/orphanin peptide receptor; MPO; myeloperoxidase; ICV; intracerebroventricular; IP; intraperitoneal; IT; intrathecal; IC; intracolo
Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24
Keywords: گیرنده NOP; N/OFQ; Nociceptin/orphanin FQ; NOP; N/OFQ peptide receptor; Compound 24; 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4â²-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide; CHO; Chinese hamster ovary; DPN; diprenorphine; DPDPE; [d-Pen2,d-Pen5]enkephalin; BSA;
Further studies on the pharmacological features of the nociceptin/orphanin FQ receptor ligand ZP120
Keywords: گیرنده NOP; Nociceptin/orphanin FQ; NOP receptor; ZP120; Mouse and rat vas deferens; Tail-withdrawal assay
Activation of nociceptin opioid peptide (NOP) receptor impairs contextual fear learning in mice through glutamatergic mechanisms
Keywords: گیرنده NOP; NOP receptor; Glutamate; Learning; Memory; Mice
The nociceptin system and hippocampal cognition in mice A pharmacological and genetic analysis
Keywords: گیرنده NOP; N/OFQ, nociceptin/orphanin FQ; Nphe1, [Nphe1]N/OFQ(1-13)-NH2; NOP, N/OFQ receptor; Ro 64-6198, ((1S,3aS)-8-(2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one hydrochloride)Nociceptin; NOP receptor; Ro 64-6198; Learning a
Pharmacological properties of a novel nociceptin/orphanin FQ receptor agonist, 2-(3,5-dimethylpiperazin-1-yl)-1-[1-(1-methylcyclooctyl)piperidin-4-yl]-1H-benzimidazole, with anxiolytic potential
Keywords: گیرنده NOP; NOP receptor; PCPB; Nonpeptide agonist; Vogel conflict test; Anxiety
Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: Comparison to morphine
Keywords: گیرنده NOP; Nociceptin; NOP receptor; mu receptor; Analgesia; (Mice)
Nociceptin/orphanin FQ reverses mecamylamine-induced learning and memory impairment as well as decrease in hippocampal acetylcholine release in the rat
Keywords: گیرنده NOP; Nociceptin; Orphanin FQ; NOP receptor; Microdialysis; Acetylcholine; Passive avoidance
Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism
Keywords: گیرنده NOP; J-113397; L-DOPA; MPTP; Nociceptin/orphanin FQ; NOP−/− mice; NOP receptor; Parkinson's disease
GABAA signalling is involved in N/OFQ anxiolytic-like effects but not in nocistatin anxiogenic-like action as evaluated in the mouse elevated plus maze
Keywords: گیرنده NOP; N/OFQ, nociceptin/orphanin FQ; ppN/OFQ, prepronociceptin/orphanin FQ; i.p., intraperitoneal; i.c.v., intracerebroventricularAnxiety; Nociceptin/orphanin FQ; Nocistatin; NOP receptor; GABAA receptor ligands; Mouse
Synthesis and structure–activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands
Keywords: گیرنده NOP; Nociceptin; Orphanin FQ; NOP receptor; Agonist
Bradycardia elicited by microinjections of nociceptin/orphanin FQ into the intermediolateral cell column at T1–T2 in the rat
Keywords: گیرنده NOP; Atenolol; Bradycardia; Denopamine; IML; NOP receptor
Effects of social crowding on emotionality and expression of hippocampal nociceptin/orphanin FQ system transcripts in mice
Keywords: گیرنده NOP; Nociceptin peptide; NOP receptor; Social crowding stress; Anxiety; Mice
Anti-nociceptive and anti-allodynic effects of a high affinity NOP hexapeptide [Ac-RY(3-Cl)YRWR-NH2] (Syn 1020) in rodents
Keywords: گیرنده NOP; NOP receptor; Antinociception; Nociception; Analgesia; Allodynia; Nociceptin; Thermal pain; Mechanical pain
Changes in expression of nociceptin/orphanin FQ and its receptor in spinal dorsal horn during electroacupuncture treatment for peripheral inflammatory pain in rats
Keywords: گیرنده NOP; Peripheral inflammatory pain; Electroacupuncture; Spinal cord; N/OFQ; NOP receptor
Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Cα,α-dialkylated amino acids
Keywords: گیرنده NOP; Nociceptin/orphanin FQ; NOP receptor; Structure–activity study; Peptide synthesis
Altered anxiety-related behavior in nociceptin/orphanin FQ receptor gene knockout mice
Keywords: گیرنده NOP; Nociceptin/orphanin FQ; NOP receptor; Anxiety disorders; Behavioral tests; Knockout mice phenotype
Effect of novel nociceptin/orphanin FQ–NOP receptor ligands on ethanol drinking in alcohol-preferring msP rats
Keywords: گیرنده NOP; Nociceptin/orphanin FQ; NOP receptor; Alcohol intake
Anxiolytic-like effects of nociceptin/orphanin FQ in the elevated plus maze and in the conditioned defensive burying test in rats
Keywords: گیرنده NOP; Nociceptin/orphanin FQ (N/OFQ); UFP-101; NOP receptor; Anxiety tests; Corticosterone; Rat;
In vitro and in vivo pharmacological characterization of the nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-ol
Keywords: گیرنده NOP; Nociceptin/orphanin FQ; NOP receptor; Ac-RYYRIK-ol; Isolated tissue; Behavioral assay; (Mice)
Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist
Keywords: گیرنده NOP; Nociceptin/orphanin FQ; NOP receptor; Non peptide antagonists; J-113397; Mouse vas deferens assay; Structure–activity study
Nociceptin/orphanin FQ prevents ethanol-induced gastric lesions in the rat
Keywords: گیرنده NOP; NOP receptor; NOP receptor agonist; NOP receptor antagonist; UFP-101; Gastro-protection;