کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
914711 | 918413 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Peripheral anti-nociceptive effect of nociceptin/orphanin FQ in inflammation and stress-induced colonic hyperalgesia in rats
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کلمات کلیدی
PRSintracolonicTNBSIBSCRDCRFnociceptinICVintracerebroventricularDRGMPO - DFON/OFQ - N / OFQcolorectal distension - اختلال کولورکتالStress - استرس یا فشار روانیColonic inflammation - التهاب کولونintrathecal - اینتراکتالVisceral hypersensitivity - حساسیت اسکلرودرمیintraperitoneal - داخل صفاقیPain - دردcorticotropin-releasing factor - عامل تخریب کورتیکوتروپینmyeloperoxidase - میلوپراکسیداز dorsal root ganglia - گانگلیس ریشه پشتیNOP receptor - گیرنده NOP
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Nociceptin/orphanin FQ (N/OFQ) and its NOP receptors are present in the central nervous system and in the periphery playing important roles in the modulation of gastrointestinal functions and pain. The aim of this study was to investigate the role of central and peripheral N/OFQ-NOP receptor system in the nociceptive response to colorectal distension (CRD) in basal condition and in two models of gut hypersensitivity triggered by both inflammation and stress. Male Wistar rats were tested in basal and in post-inflammatory conditions, i.e., 5 days after IC TNBS instillation (80Â mg/Kg) and received N/OFQ (2Â nmol/Kg IP), UFP-101 (a selective NOP receptor antagonist, 10Â nmol/Kg IP), N/OFQ+UFP-101, N/OFQ (0.5Â nmol/rat ICV) or vehicle. Female rats were tested in basal and after partial restraint stress receiving the same pharmacological treatment. CRD was performed using barostat and abdominal contractions were recorded by electromyography. In basal condition, N/OFQ, ICV and IP injected, did not modify basal visceral sensitivity. Both in TNBS and stress-induced hyperalgesia, IP but not ICV injection of N/OFQ significantly decreased the number of abdominal contractions. Peripheral injection of UFP-101 antagonized N/OFQ effect. Moreover, in post-inflammatory colitis, UFP-101, injected alone, exacerbated visceral hyperalgesia to CRD compared with vehicle. These findings indicate that in rats, N/OFQ, only peripherally injected, reduces visceral hypersensitivity triggered by inflammation or stress without affecting basal sensitivity. N/OFQ visceral anti-hyperalgesic effect involves peripheral NOP receptors. In a post-inflammatory, but not in an acute stress colitis model, N/OFQergic system is endogenously activated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PAIN - Volume 141, Issue 3, February 2009, Pages 292-299
Journal: PAIN - Volume 141, Issue 3, February 2009, Pages 292-299
نویسندگان
Simona Agostini, Helene Eutamene, Maria Broccardo, Giovanna Improta, Carla Petrella, Vassillia Theodorou, Lionel Bueno,