Role and classification of cholesterol-lowering functional foods
Keywords: ACAT; CETP; Cholesterol; HDL; HMG-CoA reductase; LDL; Lipoproteins; Nutraceuticals; NPC1L1
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Hepatic Overexpression of Abcb11 Promotes Hypercholesterolemia and Obesity in Mice
Keywords: Mouse Model; Micelle; Energy Expenditure; Bile Salt Export Pump; CYP7A1; cholesterol 7α-hydroxlyase; FGF; fibroblast growth factor; HMG-CoAR; HMG-CoA reductase; NPC1L1; Niemann-Pick C1 like 1; TTR; transthyretin; WT; wild-type;
Involvement of angiotensin II in intestinal cholesterol absorption
Keywords: Cholesterol absorption; NPC1L1; Angiotensin II; Oxidative stress
Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters
Keywords: ABCG; ATP-binding cassette superfamily G; BBR; berberine chloride; BBRPS; combination of BBR and plant stanols; BW; body weight; CT; control; FSR; free cholesterol fractional synthesis rate; CYP7A1; cholesterol-7α-hydroxylase; CYP27A1; sterol 27-hydroxla
Polyunsaturated fatty acids down-regulate in vitro expression of the key intestinal cholesterol absorption protein NPC1L1: no effect of monounsaturated nor saturated fatty acids
Keywords: NPC1L1; Fatty acids; Intestinal cholesterol absorption; Enterocytes; Gene expression; Transcription factors
Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand
Keywords: Sulfur-35; NPC1L1; Radioligand; Synthesis
Impact of Ezetimibe on Atherosclerosis: Is the Jury Still Out?
Keywords: CAD; coronary artery disease; CIMT; carotid artery intima-media thickness; CVD; cardiovascular disease; ENHANCE; Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression; FMD; flow mediated dilatation; FBF; forearm blood flow;
Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol
Keywords: SPT; serine palmitoylCoA transferase; Sptlc1; serine palmitoylCoA transferase long chain base subunit 1; ABC; ATP binding cassette protein; NPC1L1; Niemann-Pick C1-like 1; KO; knockout; WT; wild type; Myriocin; SPT gene knockout; Cholesterol absorption; D
New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism
Keywords: ACAT; acyl-CoA:cholesterol acyltransferase; ABC; adenosine triphosphate-binding cassette transporter; ANXA2-CAV1; annexin 2/caveolin 1; apo; apolipoprotein; CVD; cardiovascular disease; CYP7A1; cytochrome P450 family 7 subfamily A polypeptide 1; FPPS; f
Cholesterol homeostasis by the intestine: Lessons from Niemann-Pick C1 Like 1 [NPC1L1)
Keywords: Ezetimibe; Cholesterol absorption inhibitor; NPC1L1; Cholesterol transporter
Los ácidos grasos poliinsaturados disminuyen la expresión in vitro de la proteÃna NPC1L1, clave en la absorción intestinal de colesterol
Keywords: NPC1L1; Ácidos grasos; Absorción intestinal de colesterol; Enterocitos; Expresión génica; Factores de transcripción; NPC1L1; Fatty acids; Intestinal cholesterol absorption; Enterocytes; Gene expression; Transcription factors;
Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption
Keywords: NPC1L1; Cholesterol absorption inhibitor; Hypercholesterolemia; Dyslipidemia
Plant sterols and stanols: Their role in health and disease
Keywords: ABCG5; ABCG8; Atherosclerosis; Ezetimibe; NPC1L1
Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: A randomized trial in healthy men
Keywords: Ezetimibe; Simvastatin; LDL receptor; HMG-CoA reductase; Gene expression; PCSK9; NPC1L1
Dramatically Increased Intestinal Absorption of Cholesterol Following Hypophysectomy Is Normalized by Thyroid Hormone
Keywords: C4; 7α-hydroxy-4-cholesten-3-one; Cyp7a1; cholesterol 7α-hydroxylase; EZE; ezetimibe; FPLC; fast-performance liquid chromatography; GH; growth hormone; Hx; hypophysectomized; LDL; low-density lipoprotein; LDLR; LDL receptor; NPC1L1; Niemann-Pick C1-like
Serum sterols in patients with primary biliary cirrhosis and acute liver failure before and after liver transplantation
Keywords: LTX; liver transplantation; ALF; acute liver failure; PBC; primary biliary cirrhosis; ABC; adenosine triphosphate-binding cassette; ATP; adenosine triphosphate; NPC1L1; Niemann-Pick C1-like 1 protein; LXR; liver X receptor; MARS; molecular adsorbent immun
Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome
Keywords: Metabolic syndrome; Lipid metabolism; Liver steatosis; Insulin resistance; NPC1L1; Ezetimibe
Human NPC1L1 and NPC1 can functionally substitute for the ncr genes to promote reproductive development in C. elegans
Keywords: NPC1L1; NPC1; NCR genes; Ezetimibe; Dauer
Niemann–Pick C1 like 1 gene expression is down-regulated by LXR activators in the intestine
Keywords: Intestinal cholesterol absorption; Nuclear receptors; Transcriptional regulation; NPC1L1; LXR; PPARα; Caco-2 cells; Atherosclerosis murine model
Sterol transporters: targets of natural sterols and new lipid lowering drugs
Keywords: ACTA2; acyl CoA: cholesterol acyltransferase 2; ABC A1/G5/G8; ATP-binding cassette transporter A1/G5/G8; ANX2; annexin 2; apo B-48; apo lipoprotein B-48; CAV1; caveolin 1; CE; cholesterylester; LXR; liver X receptor; MTP; microsomal triglyceride transfer
Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment
Keywords: Target of ezetimibe; NPC1L1; Drug response; Genetic association; Clinical trial; Cholesterol;
Molecular mechanisms of cholesterol absorption and transport in the intestine
Keywords: PTL; pancreatic triglyceride lipase; CEL; carboxyl ester lipase; PTLRP; pancreatic triglyceride lipase related protein; ASBT; apical sodium-dependent bile acid transporter; ABC; ATP binding cassette; SR-BI; scavenger receptor class B type I; NPC; Niemann-
Changes in intestinal and liver global gene expression in response to a phytosterol-enriched diet
Keywords: ABCA1; ATP-binding cassette transporter A1; ABCG5; ATP-binding cassette transporter G5; ABCG8; ATP-binding cassette transporter G8; ALT; alanine aminotransferase; apoE; apolipoprotein E; apoEâ/â; apoE-deficient mice; ETV6; ETS variant gene 6; FDPS; fa
Characterization of the putative native and recombinant rat sterol transporter Niemann-Pick C1 Like 1 (NPC1L1) protein
Keywords: NPC1L1; Niemann-Pick C1 Like 1; rNPC1L1; rat NPC1L1; CHD; coronary heart disease; HMG; 3-hydroxy-3-methyl-glutaryl; LDL; low density lipoprotein; ABC; ATP binding cassette; HKG; hepes KCl glucose; HKNG; hepes KCl NaCl glucose; HDAC1; histone deacetylase 1
New Insights Into the Genetic Regulation of Intestinal Cholesterol Absorption
Keywords: ABC; adenosine triphosphate-binding cassette transporter; ACAT; acyl-CoA:cholesterol acyltransferase; HMG; 3-hydroxy-3-methylglutaryl; LXR; liver X receptor; NPC1L1; Niemann-Pick C1-like 1 protein; QTL; quantitative trait locus; SR-BI; scavenger receptor