کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2050566 | 1074174 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome](/preview/png/2050566.png)
Non-alcoholic fatty liver disease (NAFLD) is associated with the metabolic syndrome characterized by dislipidemia and insulin resistance. We hypothesized that ezetimibe, an inhibitor of NPC1L1, improves these metabolic disorders in Zucker obese fatty rats (ZOF). Ezetimibe significantly lowered total cholesterol and triglycerides in ZOF with prominent reduction in the remnant lipoprotein fraction and small dense low density lipoprotein fraction. Moreover, lipid deposition and fibrosis of liver were decreased by ezetimibe. Interestingly, ezetimibe improved insulin and plasma glucose response after intraperitoneal glucose injection. Further, ezetimibe enhanced insulin signaling in cultured hepatocytes. Our results indicate the potential of ezetimibe in treating the metabolic syndrome and NAFLD.
Journal: FEBS Letters - Volume 581, Issue 29, 11 December 2007, Pages 5664–5670