Keywords: NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; FC; free cholesterol; VLDL; very low density lipoprotein; LDL; low density lipoprotein; mTOR; mechanistic target of rapamycin signaling; AMPK; AMP-activated protein kinase; TG; t
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Keywords: Anthocyanins; Cholesterol; Sterol; Hypercholesterolemia; ABCG5 and 8; ATP binding cassette transporter 5 and 8; ACAT2; acyl CoA:cholesterol acyltransferase2; CYP7A1; cholesterol-7α-hydroxylase; CrA; cranberry anthocyanins; HMG-CoA-R; 3-Hydroxy-3-methylgl
Keywords: ABCA1; ATP-binding cassette transporter ABCA1 (member 1 of human transporter sub-family ABCA; BA; bioaccessibility; BCO1; β-carotene 15, 15â²-dioxygenase; BCO2; β-carotene-9,10â²-dioxygenase; CCE; carotenoid cleavage enzyme; CD-36; cluster determinant
Keywords: ACAT; acyl coenzyme A:cholesterol acyltransferase; ATP; binding cassette; CC; curcumin group; CHD; coronary heart disease; CVD; cardiovascular disease; CYP7A; cholesterol 7alpha-hydroxlyase; HDL-C; HDL-cholesterol; HMG-CoA reductase; 3-hydroxy-3-methyl-gl
Effect of luteolin on the expression of intestinal cholesterol transporters
Keywords: DMEM; Dulbecco's Modified Eagle Medium; EDTA; ethylenediaminetetraacetic acid; HC; high cholesterol group; HL; HC with 20 mM luteolin at 5 mL/kg body weight group; HMGCR; HMG CoA reductase; HNF4α; hepatocyte nuclear factor 4α; HQ; HC with 20 mM querceti
Keywords: Lutein; Beta-carotene; Lycopene; Food matrix; Single nucleotide polymorphism; Absorption; ABCA1; ATP binding cassette AI; BCO1; beta-carotene oxygenase 1; BCO2; beta-carotene oxygenase 2; CD36; CD36 molecule; NPC1L1; NPC1 like intracellular cholesterol tr
Keywords: ACC/AHA; American College of Cardiology/American Heart Association; ApoB; apolipoprotein B; ASCVD; atherosclerotic cardiovascular disease; CHD; coronary heart disease; DLCN; Dutch Lipid Clinic Network; FAMCAT; an FH prediction model; FDA; Food and Drug Ad
Keywords: Plant sterols; Cholesterol; Cholestanol; NPC1L1; Cardiovascular risk;
Keywords: ABCA1; ATP-binding cassette sub-family A member 1; AD; Alzheimer's disease; apoB48; apolipoprotein B-48; APP; amyloid precursor protein; BCMO1; β-carotene 15,15â²-monooxygenase; BLAOA; bovine α-lactalbumin complexed with oleic acid; CD36; cluster of di
Keywords: Plant sterols; Non-cholesterol sterols; Cholesterol; HMG CoA reductase; ABCG5/8; NPC1L1; SOAT2; Atherosclerosis; Xanthoma;
Overexpression of transforming growth factor β induced factor homeobox 1 represses NPC1L1 and lowers markers of intestinal cholesterol absorption
Keywords: Cholesterol metabolism; Lipoproteins; Liver; Transcription; Dyslipidemia; ABCA1; ATP-binding cassette transporter A1; ACAT2; acyl-Coenzyme A:cholesterol acyltransferase 2; apo; apolipoprotein; CYP7A1; cholesterol 7α-hydroxylase; HMGCR; 3-hydroxy-3-methyl
Part A: Temporal and dose-dependent transcriptional responses in the liver of fathead minnows following short term exposure to the polycyclic aromatic hydrocarbon phenanthrene
Keywords: SREBF1; sterol regulatory element binding transcription factor 1; FASN; fatty acid synthase; HSD17B12; hydroxysteroid (17-beta) dehydrogenase 12; ACACA; acetyl-CoA carboxylase alpha; CYB5A; cytochrome b5 type A (microsomal); SLC27A4; solute carrier family
Supplementation with curcumin inhibits intestinal cholesterol absorption and prevents atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice
Keywords: Atherosclerosis; ApoEâ/â mice; Curcumin; Cholesterol absorption; Niemann-Pick C1-like 1; ABCG5; ATP-binding cassette transporter G5; ACAT2; acyl-CoA/cholesterol acyltransferase 2; ApoE; apolipoprotein E; ApoEâ/â; ApoE knockout; CYP7A1; cholesterol
Developmental and extrahepatic physiological functions of SREBP pathway genes in mice
Keywords: AAV; adeno-associated virus; ACC; acetyl-CoA carboxylase; AD; Alzheimer's disease; ADD1; adipocyte determination- and differentiation-dependent factor 1; APP; amyloid precursor protein; Api6; apoptosis inhibitor 6; ApoE; apolipoprotein E; ATF6; activati
Promotive effect of Bofutsushosan (Fangfengtongshengsan) on lipid and cholesterol excretion in feces in mice treated with a high-fat diet
Keywords: ABC; ATP-binding cassette transporters; ALT; aspartate aminotransferase; ANOVA; analysis of variance; AST; alanine aminotransferase; BTS; bofutsushosan (fanggentongshengsan); CT; computed tomography; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bo
Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion
Keywords: Biliary excretion; PPARα; Bile acids; Gender difference; 1oBAs; Primary bile acids; 2oBAs; secondary bile acids; 12-OH; 12-hydroxylated bile acid; Asbt; apical sodium-dependent bile acid transporter; BA; bile acid; Baat; bile acid CoA:amino acid N-acyltr
Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice
Keywords: Aryl hydrocarbon receptor; TCDD; Bile acids; Biliary excretion; Taurodeoxycholic acid; Cyp8b1; 1°BAs; Primary bile acids; 2°BAs; Secondary bile acids; 6-OH; 6-hydroxylated (6-OH); 12-OH; 12α-hydroxylated; Abc; ATP-binding cassette; AhR; Aryl hydrocarbo
Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR
Keywords: Natural products; Nuclear receptors; Liver X receptor; Farnesoid X receptor; Retinoid X receptor; Metabolic syndrome; Precision medicine; 6-ECDCA; 6α-ethyl-chenodeoxycholic acid (obeticholic acid); AA; arachidonic acid; ABC; ATP-binding cassette transpor
ReviewPlant sterols, cholesterol precursors and oxysterols: Minute concentrations-Major physiological effects
Keywords: ABC; ATP-binding cassette (transporter); HDL; high-density lipoproteins; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; LDL; low-density lipoproteins; LXR; liver X receptor; NPC1L1; Niemann-Pick C1-like 1; VLDL; very-low-density lipoproteins; Cholesterol
Permissiveness of human hepatocellular carcinoma cell lines for hepatitis C virus entry and replication
Keywords: HCV; hepatitis C virus; pegIFN-α; pegylated interferon alpha; DAAs; direct acting antivirals; BCLC; Barcelona ClÃnic Liver Cancer; IF; immunofluorescence; HCVpp; HCV pseudoparticles; HCVcc; HCV cell culture; JFH1; Japanese fulminant hepatitis 1; Apo; ap
The interrelationship between bile acid and vitamin A homeostasis
Keywords: ATGL; Adipose triglyceride lipase; ADH; Alcohol dehydrogenase; ALD; Alcoholic liver disease; atRA; All-trans retinoic acid; ASBT/SLC10A2; Apical sodium-dependent bile salt transporter; ABCA1; ATP-binding cassette transporter member 1; BCMO1; Beta-carotene
Statins can exert dual, concentration dependent effects on HCV entry in vitro
Keywords: HCV; Statins; CLDN-1; LDLR; NPC1L1; CD81; PCSK9; Lipids; CholesterolHMG-CoAR, 3-hydroxy-3-methylglutharyl-coenzyme A reductase; PEG-IFN, pegylated interferon; SVR, sustained viral response; LDLR, low density lipoprotein receptor; NPC1L1, Niemann–Pick C1-l
Identification and characterization of NPC1L1 variants in Uygur and Kazakh with extreme low-density lipoprotein cholesterol
Keywords: Low-density lipoprotein cholesterol; NPC1L1; Cholesterol absorption; Variants;
Comparison of the inhibition on cellular 22-NBD-cholesterol accumulation and transportation of monomeric catechins and their corresponding A-type dimers in Caco-2 cell monolayers
Keywords: A-type ECG dimer; A-type EGCG dimer; Caco-2 cell monolayers; Cholesterol uptake; NPC1L1; EC; (-)-epicatechin; ECG; (-)-epicatechin gallate; EGCG; (-)-epigallocatechin gallate; A-type EC dimer; epicatechin-(4βâ8, 2βâOâ7)-epicatechin; A-type ECG dim
Pleiotropic effects of antitumour alkylphospholipids on cholesterol transport and metabolism
Keywords: ABCA1; ATP-binding cassette transporter isoform A1; APL; alkylphospholipid; apoA1; apolipoprotein A1; CETP; cholesteryl ester transfer protein; CYP7A1; cholesterol 7α-hydroxylase; CYP27; sterol 27-hydroxylase; DHCR7; 7-dehydrocholesterol reductase; ER; e
Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression
Keywords: CREBH; Npc1l1; Cholesterol; Intestine; Abca1; ATP-binding cassette, sub-family A1; ABCG5/8; adenosine triphosphate-binding cassette transporter G5/G8; ALT; alanine aminotransferase; Apoa4; apolipoprotein A-IV; AST; aspartate aminotransferase; CREBH; cycli
The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction
Keywords: p53; obesity; diabetes; islet hypertrophy; NAFLD; lipid metabolism; inflammation; Pck1; Ccl2; Tnf; Npc1l1
Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes
Keywords: ABC; ATP-binding cassette transporter; AGPAT2; 1-acylglycerol-3-phosphate O-acyltransferase; AhR; arylhydrocarbon receptor; AKR1C1; aldo-keto reductase 1C1; APO; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BAs; bile acids; BSEP; b
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis
Keywords: NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; Kelch-like ECH associated protein 1; TUNEL; terminal deoxynucleotidyl transferase dUTP nick end labeling; MTT; 3-(4,5-di
Chylomicrons: Advances in biology, pathology, laboratory testing, and therapeutics
Keywords: ACAT; acyl CoA acyl transferase; Angptl3; angiopoietin-like protein 3; Angptl4; angiopoietin-like protein 4; Angptl8; angiopoietin-like protein 8; apo; apolipoprotein; apobec 1; apoB mRNA editing enzyme 1; CM; chylomicron; CMs; chylomicrons; COPII; coat p
CD81 and CLDN1 polymorphisms and hepatitis C virus infection susceptibility: A case-control study
Keywords: HCV; hepatitis C virus; CD81; Cluster of Differentiation 81; CLDN1; claudins; LDLR; low-density-lipoprotein receptor; SRB1; scavenger receptor class B member 1; NPC1L1; Niemann-Pick C1-like 1; CD81-LEL; the large extracellular loop of CD81; SNP; single
Common single nucleotide polymorphisms at the NPC1L1 gene locus significantly predict cardiovascular risk in coronary patients
Keywords: Coronary artery disease; Cardiovascular risk; Cholesterol; Single nucleotide polymorphisms; NPC1L1;
Plasma cholesterol-raising potency of dietary free cholesterol versus cholesteryl ester and effect of β-sitosterol
Keywords: Cholesterol; Cholesteryl ester; Lipoprotein profile; NPC1L1; β-Sitosterol;
Pulmonary, gastrointestinal and urogenital pharmacologyOrlistat limits cholesterol intestinal absorption by Niemann-pick C1-like 1 (NPC1L1) inhibition
Keywords: Orlistat; Cholesterol; NPC1L1;
SKI-1/S1P inhibitor PF-429242 impairs the onset of HCV infection
Keywords: HCV; hepatitis C virus; HCVpp; HCV pseudotyped particles; HCVcc; cell culture produced HCV virions; VSVpp; vesicular stomatitis virus pseudotyped particles; HDV; hepatitis delta virus; SKI-1/S1P; subtilisin/hexin-isoenzyme-1/site-1 protease; SRE; sterol r
Deficiency in Lysophosphatidylcholine Acyltransferase 3 Reduces Plasma Levels of Lipids by Reducing Lipid Absorption in Mice
Keywords: Mouse Model; Lipid Regulation; PUFA; Phosphatidylcholine Remodeling; BLp; apoB-containing lipoprotein; ER; endoplasmic reticulum; FATP4; fatty acid transport protein 4; HDL; high-density lipoprotein; KO; knockout; LC/MS/MS; liquid chromatography with tand
Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; EC; esterified cholesterol; ERT; enzyme replacement therapy; LAL; lysosomal acid lipase; LIPA; gene that encodes LAL; NPC1L1; Niemann-Pick C1-Like1; SI; small intestine; SOAT2; sterol O-acylt
Hypocholesterolemic activity of buckwheat flour is mediated by increasing sterol excretion and down-regulation of intestinal NPC1L1 and ACAT2
Keywords: ACAT2; Hypocholesterolemia; NPC1L1; Rice flour; Tartary buckwheat flour; Wheat flour;
Liver-specific induction of Abcg5 and Abcg8 stimulates reverse cholesterol transport in response to ezetimibe treatment
Keywords: EZ; ezetimibe; RCT; reverse cholesterol transport; Abcg5/g8; Abcg5 and Abcg8; KO; knock-out; WT; wild-type; PHH; primary human hepatocytes; CDCA; chenodeoxycholic acid; BMM; bone marrow macrophages; TICE; trans-intestinal cholesterol excretion; Npc1l1; At
Ezetimibe enhances macrophage reverse cholesterol transport in hamsters: Contribution of hepato-biliary pathway
Keywords: RCT; reverse cholesterol transport; CETP; cholesterol ester transfer protein; BDL; bile duct ligation; TICE; transintestinal cholesterol efflux; LDLR; low-density lipoprotein receptor; ABCA1; ATP-binding cassette transporter A; NPC1L1; Niemann-Pick C1-l
The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis
Keywords: 7DHC; 7-dehydrocholesterol; DHCR7; 7-dehydrocholesterol reductase; DHCR24; 24-dehydrocholesterol reductase; LDLR; low-density lipoprotein receptor; NF-Y; nuclear factor-Y; NPC1L1; Niemann-pick C1 like-1; SLOS; Smith-Lemli-Opitz Syndrome; Sp1; specific
Identification of a novel partial agonist of liver X receptor α (LXRα) via screening
Keywords: ABC; ATP-binding cassette; ApoE; apolipoprotein E; DRIP205; vitamin D receptor-interacting protein 205; FAS; fatty acid synthase; GAPDH; glyceraldehyde-phosphate dehydrogenase; HDL; high-density lipoprotein; LBD; ligand-binding domain; LXR; liver X recept
Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors
Keywords: β-lactam; Cholesterol absorption inhibitor; Hyperlipidemia; Cardiovascular heart disease; TBDMSCl; tert-butyldimethylsilyl chloride; CBS; Corey-Bakshi-Shibata catalyst; CHD; cardiovascular heart disease; TEAA; tetraethylammonium acetate; FCS; fetal c
A silent mutation of Niemann-Pick C1-like 1 and apolipoprotein E4 modulate cholesterol absorption in primary hyperlipidemias
Keywords: Apolipoprotein (APO) E4; Campesterol; NPC1L1; Hyperlipidemias; Sitosterol;
EP 80317, a CD36 selective ligand, promotes reverse cholesterol transport in apolipoprotein E-deficient mice
Keywords: CD36; Reverse cholesterol transport; ABCG5; ABCG8; NPC1L1;
CommentaryVitamin E: A dark horse at the crossroad of cancer management
Keywords: ABCA1; ATP-binding cassette A1; ATBC; alpha-tocopherol, beta-carotene; HDL; high density lipoproteins; LDL; low density lipoproteins; NSCLC; non-small cell lung cancer; NPC1L1; Niemann-Pick C1-like 1; PKC; protein kinase C; PUFA; polyunsaturated fatty aci
rHDL administration increases reverse cholesterol transport in mice, but is not additive on top of ezetimibe or cholestyramine treatment
Keywords: HDL; Cholesterol; Reverse cholesterol transport; Sterol excretion; CVD; cardiovascular disease; HDL; high density lipoprotein; LDL; low density lipoprotein; RCT; reverse cholesterol transport; NPC1L1; Niemann-Pick C1-like protein 1; VLDL; very low density
Ezetimibe decreases serum oxidized cholesterol without impairing bile acid synthesis in Japanese hypercholesterolemic patients
Keywords: Plant sterols; Cholesterol precursors; Oxysterols; Ezetimibe; NPC1L1; Gas chromatography–mass spectrometry (GC–MS)
Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells
Keywords: ABC; ATP-binding cassette transporter; FAS; fatty acid synthase; HDL; high-density lipoprotein; LBD; ligand-binding domain; LDL; low-density lipoprotein; LXR; liver X receptor; NPC1L1; Niemann-Pick C1 Like 1; SCD-1; stearoyl-CoA desaturase 1; SPR; surface
Niemann-Pick C1-Like 1 and cholesterol uptake
Keywords: NPC1L1; Niemann-Pick C1-Like 1; LDL; low-density lipoprotein; PM; plasma membrane; ERC; endocytic recycling compartment; NTD; N-terminal domain; NFC; NPC1L1-Flotillin-Cholesterol; NPC1L1; Cholesterol absorption; Ezetimibe; NPC1; Flotillin; Lipid raf