کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8302242 | 1537725 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis
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کلمات کلیدی
SREBP-2nuclear factor-YSLOS7DHCNF-Y7-dehydrocholesterol reductaseDHCR7NPC1L17-DehydrocholesterolDHCR24SRELDLR24-dehydrocholesterol reductase - 24-دی هیدروکلوسترول ردوکتازSp1 - SP1Smith–Lemli–Opitz syndrome - اسمیت-لملی-اپیتس سندرمCooperativity - تعاونیsterol regulatory element - عنصر نظارتی استرولSpecificity protein 1 - مشخصات پروتئین 1Transcription regulation - مقررات رونویسیLow-density lipoprotein receptor - گیرنده لیپوپروتئین با چگالی کم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis](/preview/png/8302242.png)
چکیده انگلیسی
In this study, we look specifically at how DHCR7 is regulated by the sterol regulatory element-binding protein-2 (SREBP-2) transcription factor. Sterol regulation has previously been studied in the rat DHCR7 promoter, but we have found that its regulatory elements are not all conserved in humans. Rather, the human promoter contains two binding sites for SREBP-2 (at â 155 and â 55) and a binding site for the nuclear factor-Y (NF-Y) cofactor (at â 136). The â 155 site is a particularly responsive sterol regulatory element (SRE) which is well conserved in mammals, and was possibly overlooked in the rat promoter study. The exact location of the weaker â 55 site (close to the known rat SRE) may have shifted during evolution. Furthermore, we established that the two SREs that bind SREBP-2 work in cooperation to synergistically activate DHCR7. We have previously characterized the SREs in DHCR24, the final enzyme in the alternate Bloch pathway of cholesterol synthesis. Here, comparison of the sterol regulation of these terminal enzymes demonstrates the unique cooperative system that helps to control cholesterol synthesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1841, Issue 10, October 2014, Pages 1431-1439
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1841, Issue 10, October 2014, Pages 1431-1439
نویسندگان
Anika V. Prabhu, Laura J. Sharpe, Andrew J. Brown,