دانلود مقالات ISI درباره NR، گیرنده هسته ای + ترجمه فارسی

ارزیابی فارماکولوژیک مکانیسم های درگیر در افزایش چربی دریایی در ماهی قزل آلا ناشی از آلودگی محیط زیست تبتالیتین

Pharmacological evaluation of the mechanisms involved in increased adiposity in zebrafish triggered by the environmental contaminant tributyltin

Keywords: NR، گیرنده هسته ای; DBD, DNA-binding domain; DMSO, dimethylsulfoxide; DHA, docosahexaenoic acid; ER, estrogen receptor; HFD, high fat diet; LBD, ligand-binding domain; LXR, liver X receptor; MSC, multipotent stromal stem cell; NR, nuclear receptor; PPAR, peroxisome prolifera

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity

Keywords: NR، گیرنده هسته ای; LC–MS/MS, liquid chromatography coupled to mass spectrometry; PTM, post-translational modification; DR, direct repeats; ER, everted repeats; NR, nuclear receptor; IP, immunoprecipitation; FLAG, FLAG octapeptide; Ac-CoA, acetyl coenzyme A; AcK, acetyllysin

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor

Keywords: NR، گیرنده هسته ای; Constitutive androstane receptor; CINPA1; Inverse agonist; TR-FRETCAR, constitutive androstane receptor; PXR, pregnane X receptor; NR, nuclear receptor; CYP2Bs, cytochrome P450, family 2, subfamily B proteins; CYP2Cs, cytochrome P450, family 2, subfamily

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2016 سفارش ترجمه

The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis

Keywords: NR، گیرنده هسته ای; NASH; Fibrosis; Lipogenesis; LXR; InflammationNASH, non-alcoholic steatohepatitis; LXR, Liver-X-Receptor; HTF, high trans-fat diet; NR, nuclear receptor

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

The HR96 activator, atrazine, reduces sensitivity of D. magna to triclosan and DHA

Keywords: NR، گیرنده هسته ای; NR, nuclear receptor; PXR, pregnane-X-receptor; CAR, constitutive androstane receptor; TAG, triacylglycerol; GST, glutathione S-transferase; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; LA, linoleic acid; qPCR, quantitative real-time polymerase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Structural development studies of PPARs ligands based on tyrosine scaffold

Keywords: NR، گیرنده هسته ای; PPARs; Stilbene; Phenyldiazene; PPARγ agonist; TyrosinePPARs, peroxisome proliferator-activated receptors; NR, nuclear receptor; PPARα, peroxisome proliferator-activated receptor α; PPARβ/δ, peroxisome proliferator-activated receptor β/δ; PPARγ, peroxisom

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of a naturally occurring retinoid X receptor agonist from Brazilian green propolis

Keywords: NR، گیرنده هسته ای; BGP, Brazilian green propolis; FBS, fetal bovine serum; HEK, human embryonic kidney; LBD, ligand binding domain; LXR, liver X receptor; NR, nuclear receptor; PPAR, peroxisome proliferator-activated receptor; RAR, retinoic acid receptor; RXR, retinoid X re

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Annotation of the Daphnia magna nuclear receptors: Comparison to Daphnia pulex

Keywords: NR، گیرنده هسته ای; NR, nuclear receptor; CDD, conserved domain database; DBD, DNA binding Domain; LBD, Ligand binding Domain; Pfam, Protein family; ML, Maximum Likelihood; EcR, Ecdysone Receptor; KNR, Knirp; THRL, Thyroid hormone receptor-like; RARL, Retinoid Acid Receptor-

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Expression of the murine Nr4a1 gene is controlled by three distinct genomic loci

Keywords: NR، گیرنده هسته ای; cAMP, Cyclic adenosine 3′,5′-monophosphate; CREB, cAMP response element binding protein; NR, Nuclear receptor; i.p., Intraperitoneal; Hprt, Hypoxanthine-guanine phosphoribosyl transferase; RACE, Rapid amplification of cDNA ends; UTR, Untranslated regionNu

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

PXR-mediated P-glycoprotein induction by small molecule tyrosine kinase inhibitors

Keywords: NR، گیرنده هسته ای; ABC, ATP-binding cassette; ATP, adenosine triphosphate; DMSO, dimethylsulfoxide; MDCKII, Madin Darby canine kidney II – MDCKII; MDR1, multidrug resistance protein 1; NR, nuclear receptor; PGP, P-glycoprotein; PXR, pregnane X receptor; siRNA, short inhibit

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Human TNFα-induced protein 3-interacting protein 1 (TNIP1) promoter activation is regulated by retinoic acid receptors

Keywords: NR، گیرنده هسته ای; HIV, human immunodeficiency virus; NR, nuclear receptor; TNFα, tumor necrosis factor α; TNIP1, TNFα-induced protein 3-interacting-protein 1; ATRA, all trans retinoic acid; RIP140, receptor interacting protein 140; NF-κB, nuclear factor κB; Sp1, specificit

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Epigenomic regulation of bile acid metabolism: Emerging role of transcriptional cofactors

Keywords: NR، گیرنده هسته ای; FXR, farnesoid X Receptor; PTM, post-translational modification; NR, nuclear receptor; DBD, DNA binding domain; LBD, ligand binding domain; GPCR, G-protein coupled receptor; GLP-1, glucagon-like peptide 1; ChIP, chromatin immunoprecipitation; Cyp7a1, chol

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Design and synthesis of a series of α-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility

Keywords: NR، گیرنده هسته ای; NR, nuclear receptor; hPPAR, human peroxisome proliferator-activated receptor; LBD, ligand-binding domain; PDB, protein data bank3VSO; hPPARγ LBD-(R)-7JHuman peroxisome proliferator-activated receptor; PPAR gamma; Partial agonist; Structural biology

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation

Keywords: NR، گیرنده هسته ای; RXRα; tRXRα modulator; AKT activation; Sulindac analogsRXRα, retinoid X receptor alpha; tRXRα, N-terminally-truncated retinoid X receptor alpha; PI3K, phosphatidylinositol-3-OH kinase; NR, nuclear receptor; LBD, ligand-binding domain; LBP, ligand-binding

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2013 سفارش ترجمه

FXR and PXR: Potential therapeutic targets in cholestasis

Keywords: NR، گیرنده هسته ای; BDL, bile duct ligation; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; FXR, Farnesoid X Receptor; LCA, lithocholic acid; LXR, liver X receptor; NR, nuclear receptor; PBC, primary biliary cirrhosis; PCN, pregnenolone 16α-carbonitrile

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

PPARγ and NF-κB regulate the gene promoter activity of their shared repressor, TNIP1

Keywords: NR، گیرنده هسته ای; Nef, negative factor of HIV; NR, nuclear receptor; PP, peroxisome proliferator; PPRE, PP response element; RIP, receptor interacting protein; RQ, relative quantitation; scZ, scrambled sequence of Z element; TNIP1, TNFAIP3-interacting protein 1; TNFAIP3, T

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Proteomics for the discovery of nuclear bile acid receptor FXR targets

Keywords: NR، گیرنده هسته ای; NR, nuclear receptor; FXR, farnesoid X receptor; BA, bile acid; FXR−/−, FXR loss-of-functionNuclear receptor; FXR; Proteomic analysis; Expression profiling; Post-transcriptional modification; Mitochondrial

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

BTG2 is an LXXLL-dependent co-repressor for androgen receptor transcriptional activity

Keywords: NR، گیرنده هسته ای; AR, androgen receptor; NR, nuclear receptor; DHT, 5α-dihydrotestosterone; GST, glutathione-S-transferase; IP, immunoprecipitation; ARE, androgen responsive element; HDAC1, histone deacetylase 1; HDAC4, histone deacetylase 4BTG2; Androgen receptor; Prostat

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Nuclear receptor PXR, transcriptional circuits and metabolic relevance

Keywords: NR، گیرنده هسته ای; CYP, cytochrome P450; DDI, drug–drug interaction; G6Pase, glucose-6-phosphatase; GST, glutathione S-transferase; NR, nuclear receptor; PCN, prenenolone-16α-carbonitrile; PEPCK, phosphoenolpyruvate carboxykinase; PXR, pregnane X receptor; RIF, rifampicin;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

PNRC accumulates in the nucleolus by interaction with B23/nucleophosmin via its nucleolar localization sequence

Keywords: NR، گیرنده هسته ای; aa, amino acid; DAPI, 4′,6-diamidino-2-phenylindole; GFP, green fluorescence protein; NLS, nuclear localization sequence; NoLS, nucleolar localization sequence; NR, nuclear receptor; PNRC, proline-rich nuclear receptor coregulatory protein; siRNA, small i

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

High content imaging-based assay to classify estrogen receptor-α ligands based on defined mechanistic outcomes

Keywords: NR، گیرنده هسته ای; ER, estrogen receptor α; EDC, endocrine disrupting chemical; NR, nuclear receptor; ERE, estrogen response element; DES, diethylstilbestrol; SERM, selective estrogen receptor modulator; 4HT, 4-hydroxy-tamoxifen; RAL, raloxifene; E2, 17β estradiol; LBD, lig

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

HOXC6 Is Transcriptionally Regulated via Coordination of MLL Histone Methylase and Estrogen Receptor in an Estrogen Environment

Keywords: NR، گیرنده هسته ای; gene regulation; estrogen receptors; MLL histone methylase; HOXC6; steroid signalingHOX, homeobox; E2, estrogen; ERE, estrogen response element; ER, estrogen receptor; MLL, mixed lineage leukemia; H3K4, H3 lysine-4; NR, nuclear receptor; RT, reverse trans

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

Crystal structure of hereditary vitamin D-resistant rickets—Associated mutant H305Q of vitamin D nuclear receptor bound to its natural ligand

Keywords: NR، گیرنده هسته ای; NR, nuclear receptor; VDR, vitamin D NR; LBD, ligand binding domain; LBP, ligand binding pocketVDR mutant rickets; Calcitriol; Crystal structure

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Molecular determinants of the interactions between SRC-1 and LXR/RXR heterodimers

Keywords: NR، گیرنده هسته ای; 9cisRA, 9-cis retinoic acid; 22ROHC, 22(R)-hydroxycholesterol; AF2, activation function 2; MBP, maltose-binding protein; LBD, ligand-binding domain; LXR, liver X receptor; NR, nuclear receptor; NR box-1/-2/-3, the first/second/third NR box of SRC-1, respe

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Repression of estrogen receptor β function by putative tumor suppressor DBC1

Keywords: NR، گیرنده هسته ای; E2, 17β-estradiol; ER, estrogen receptor; FBS, fetal bovine serum; NLS, nuclear localization signal; NR, nuclear receptor; AF, activation function; GST, glutathione-S-transferaseDBC1; ERβ; Breast cancer; Transcription; Repression

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

ERRα regulates osteoblastic and adipogenic differentiation of mouse bone marrow mesenchymal stem cells

Keywords: NR، گیرنده هسته ای; NR, nuclear receptor; ERRα, estrogen-related receptor-α; MSC, mesenchymal stem cell; BSP, bone sialoproteinEstrogen-related receptor; Nuclear receptor; Osteoblast; Bone

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

cAMP-mediated regulation of HNF-4α depends on the level of coactivator PGC-1α

Keywords: NR، گیرنده هسته ای; 8-CPT, 8-parachlorophenylthio; cAMP, cyclic adenosine monophosphate; CREB, cAMP-response element binding protein; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; G6Pase, glucose-6-phosphatase; HNF-4α, hepatocyte nuclear factor 4α; NR, nuclear receptor; P

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Crosstalk and DC-SCRIPT: Expanding nuclear receptor modulation

Keywords: NR، گیرنده هسته ای; ECM, extracellular matrix; NR, nuclear receptor; DBD, DNA binding domain; ER, Estrogen Receptor; PR, Progesterone Receptor; AR, Androgen Receptor; GR, Glucocorticoid Receptor; RXR, Retinoid X Receptor; RAR, Retinoic Acid Receptor; PPAR, peroxisome prolife

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

An interpretation of positional displacement of the helix12 in nuclear receptors: Preexistent swing-up motion triggered by ligand binding

Keywords: NR، گیرنده هسته ای; NR, nuclear receptor; H12, helix 12; FMO, fragment molecular orbital; ERα, estrogen receptor α; MD, molecular dynamics; RA, retinoic acid; RAR, retinoic acid receptor; RMSD, root mean square deviation; PC1, first principal component; PC2, second principal

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Rational quantitative structure–activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands

Keywords: NR، گیرنده هسته ای; BPA, bisphenol A; CAR, constitutive androstane receptor; CITCO, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime; DMSO, dimethylsulfoxide; LBD, ligand binding domain; NR, nuclear receptor; PK11195, 1-(2-chlorophenyl

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Global gene expression profiling of progesterone receptor modulators in T47D cells provides a new classification system

Keywords: NR، گیرنده هسته ای; FBS, fetal bovine serum; FC, fold change; GO, gene ontology; HRT, hormone replacement therapy; NR, nuclear receptor; PA, progesterone receptor antagonist; PCA, principle component analysis; PR, progesterone receptor; PRM, progesterone receptor modulator;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta

Keywords: NR، گیرنده هسته ای; Estrogen receptor; Estrogen receptor beta; Stilbestrol; Hexestrol; Selective ligandDPN, diarylpropionitrile; ER, estrogen receptor; LBD, ligand binding; NR, nuclear receptor; RBA, relative binding affinity; RTP, relative transcriptional potency; SERM, sel

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه

Orthologues of the Drosophila melanogaster E75 molting control gene in the filarial parasites Brugia malayi and Dirofilaria immitis

Keywords: NR، گیرنده هسته ای; NR, nuclear receptor; DBD, DNA binding domain; LBD, ligand binding domain; RT-PCR, reverse transcription-polymerase chain reaction; PCR, polymerase chain reaction; CTE, carboxy terminal extension; EMSA, electrophoretic mobility shift assay; AF-2 AD, activ

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

FGF-8 stimulates the expression of NR4A orphan nuclear receptors in osteoblasts

Keywords: NR، گیرنده هسته ای; NR, nuclear receptor; FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; MAPK, mitogen activated protein kinase; PI-3K, phophatidylinositol-3 kinase; PKA, protein kinase A; PKC, protein kinase C; RXR, retinoid X receptorNuclear recept

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Helix 3–helix 5 interactions in steroid hormone receptor function

Keywords: NR، گیرنده هسته ای; hPR, human progesterone receptor; hGR, human glucocorticoid receptor; hMR, human mineralocorticoid receptor; LBD, ligand-binding domain; NR, nuclear receptor; H3, helix 3; H5, helix 5; vdW, van der Waals

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Caveats of caveolin-1 in cancer progression

Keywords: NR، گیرنده هسته ای; Cav-1, caveolin-1; KO, knock-out; NOS, nitric oxide synthase; NR, nuclear receptor; MDR, multidrug resistance; GI, gastrointestinal tract; TJ, tight junction; ZA, adherens junction; ECM, extracellular matrix; VSMC, vascular smooth muscle cells; EC, endoth

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2008 سفارش ترجمه

Rosiglitazone attenuates suppression of RXRα-dependent gene expression in inflamed liver

Keywords: NR، گیرنده هسته ای; Liver; Inflammation; RXR; JNK; Rosiglitazone; PPARγ; Nuclear exportRXR, retinoid X receptor; PPAR, peroxisome proliferator-activated receptor; NR, nuclear receptor; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccharide; AP-1, activator protein-1; Ntcp, so

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: Implications for oral carcinogenesis

Keywords: NR، گیرنده هسته ای; NR, nuclear receptor; GR, glucocorticoid receptor; AR, androgen receptor; ER, oestrogen receptor; RAR, retinoic acid receptor; VDR, vitamin D receptor; NK, primary normal oral keratinocytes; 1α,25(OH)2D3, 1α,25-dihydroxyvitamin D3; VDRE, vitamin D respons

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2007 سفارش ترجمه

Retinoid Regulated Association of Transcriptional Co-regulators and the Polycomb Group Protein SUZ12 with the Retinoic Acid Response Elements of Hoxa1, RARβ2, and Cyp26A1 in F9 Embryonal Carcinoma Cells

Keywords: NR، گیرنده هسته ای; RA, retinoic acid; RAR, retinoic acid receptor; RXR, retinoid X receptor; NR, nuclear receptor; RARE, retinoic acid response element; HAT, histone acetyl transferase; pol II, RNA polymerase II; Hox, homeobox; EC, embryonal carcinoma; PcG, polycomb group p

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2007 سفارش ترجمه

Epigenetic regulation of nuclear steroid receptors

Keywords: NR، گیرنده هسته ای; NR, nuclear receptor; AR, androgen receptor; ERα, estrogen receptor; PPARγ, peroxisome proliferator-activated receptor γ; HAT, histone acetyltransferase; HDAC, histone deacetylase; SRC, steroid receptor coactivator; N-CoR, nuclear receptor corepresssor; S

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Intracellular localization of RORα is isoform and cell line-dependent

Keywords: NR، گیرنده هسته ای; CLSM, confocal laser scan microscopy; DBD, DNA binding domain; EGFP, enhanced green fluorescent protein; LBD, ligand binding domain; NES, nuclear export signal; NLS, nuclear localization signal; NR, nuclear receptor; ROR, retinoid-related orphan receptor;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Schistosoma mansoni (Platyhelminthes, Trematoda) nuclear receptors: Sixteen new members and a novel subfamily

Keywords: NR، گیرنده هسته ای; NR, nuclear receptor; DBD, DNA-binding domain; Sm2DBD, S. mansoni nuclear receptor with two DNA binding-domains; BAC, Bacterial artificial chromosome; WGS, whole genomic sequenceNuclear receptors; Schistosoma mansoni

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه

Classification and comparison of ligand-binding sites derived from grid-mapped knowledge-based potentials

Keywords: NR، گیرنده هسته ای; AR, androgen receptor; LBD, ligand-binding domain; NR, nuclear receptor; PCA, principal component analysis; PLS, partial least squares; PPAR, peroxisome proliferator-activated receptor; PR, progesterone receptor; RMSD, root mean square deviationMolecular

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه