Keywords: ABC; ATP-binding cassette; ASBT; apical sodium-dependent bile acid transporter; Bamet-UD2; cisplatin-ursodeoxycholic acid derivative; CCA; cholangiocarcinoma; DHMEQ; dehydroxymethyl epoxyquinomicin; EGFR; epidermal growth factor receptor; 5-FU; 5-fluorour
مقالات ISI (ترجمه نشده)
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Keywords: 11βHSD; 11β-Hydroxysteroid dehydrogenase; ABC; ATP-binding cassette; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; BCRP; breast cancer resistance protein; CAR; constitutive androstane receptor; CYP; cytochrome P45
Keywords: ABC; transporter; ATP; binding cassette transporter; AR; androgen receptor; ASBT; apical sodium-dependent bile acid transporter; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BT; Bblood-testis barrier; CS; cholesterol sulfate; DHEA; de
Keywords: ABC; ATP-binding cassette; AHUI; aqueous humor uptake index; AUC; area under the curve; BAB; blood-aqueous barrier; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BRB; blood-retinal barrier; BUI; brain uptake index; MATE1; multidrug and
Keywords: BCRP; breast cancer resistant protein; BSEP; bile salt efflux pump; GA; gestational age; GLUT1; glucose transporter 1; MCT1; monocarboxylate transporter 1; MDR; multidrug-resistance protein; MRP; multidrug-resistance like protein; NTCP; Na+-taurocholate c
Keywords: ABC; ATP-Binding cassette; ARPE-19; human retinal pigment epithelial cells; BBB; blood-brain barrier; BCRP; breast cancer resistant protein; CNS; central nervous system; 3D-QSAR; 3-Dimensional Quantitative Structure Activity; ELC; elacridar; LAT1; l-Type
Keywords: ARV; antiretroviral; CHO; Chinese Hamster Ovary; CID; collision-induced dissociation; DMEM/F12; Dulbecco's Modified Eagle's Medium: Ham's F12 Medium; DMF; dimethylformamide; DMSO; dimethylsulfoxide; GGT; γ-glutamyltransferase; HIV; human immunodefi
Keywords: Androgens; Intracrinology; Steroid biosynthesis; Hormone-dependent cancer; Testosterone; 11-oxygenated androgens; 11KA4; 11-keto-androstenedione; 11KDHT; 11-keto-5α-dihydrotestosterone; 11KT; 11-keto-testosterone; 11OHA4; 11β-hydroxy-androstenedione; 11
Pharmacokinetics, tissue distribution and excretion of luteolin and its major metabolites in rats: Metabolites predominate in blood, tissues and are mainly excreted via bile
Keywords: Luteolin; Metabolite; Pharmacokinetics; Bioavailability; Distribution; Excretion; ADME; absorption, distribution, metabolism and excretion; AUC; area under the curve; BCRP; breast cancer resistance protein; CE; collision energy; Cmax; peak concentration;
Keywords: Acyl glucuronide; Drug development; Drug toxicity; In vitro screening; In vivo model; Immune activation; Protein adduct; Reactive metabolite; UDP-glucuronosyltransferase; ADR; adverse drug reaction; AG; acyl glucuronide; AGE; advanced glycation end prod
Keywords: HIV; Human Immunodeficiency Virus; CYP; Cytochrome P450; TKI; tyrosine kinase inhibitor; P-gp; P-glycoprotein; OATP; Organic Anion Transporting Polypeptide; INR; International Normalized Ratio; Drug-food interactions; Clinical practice; Cytochrome P450 3A
Keywords: Brain; Neuron; Thyroid hormone transport; Mct8; Deiodinase; T4; thyroxine; T3; 3,5,3â²-triiodothyronine; TH; thyroid hormones; 3,5-T2; 3,5-diiodothyronine; 3,3â²-T2; 3,3â²-diiodothyronine; 3-T1AM; 3-iodothyronamine; Tbg; thyroxin-binding globuline; Ttr
Keywords: Drug interactions; Hepatic transport; Transporters; ABC transporters; Bile acid transporters; BSEP; bile salt export pump; DILI; drug-induced liver injury; FXR; farnesoid X receptor; MDR; multidrug resistance protein; MRP; multidrug resistance-associated
Keywords: cilostazol; hepatic transport; OATP 1B1/1B3; biliary excretion; efflux transporter; AP; apical; BL; basolateral; DMEM; Dulbecco's modified Eagle's medium; EGCG; (-)-epigallocatechin gallate; HEK293 cells; human embryonic kidney cells; MDCKII cells; Madi
Keywords: transporters; metabolism; drug-metabolizing enzymes; pharmacokinetics; hepatic transport; hepatic metabolism; organic anion-transporting polypeptide transporters; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ATP; adenosine triphosphate;
Keywords: physiologically based pharmacokinetic modeling; transporters; hepatobiliary disposition; hepatic metabolism; mathematical model; AUC; area under the concentration-time curve; Cmax; maximum plasma concentration; CYP; cytochrome P450 enzyme; CL; clearance;
Keywords: physiologically based pharmacokinetic modeling; drug interactions; Monte Carlo; in vitro-in vivo correlations (IVIVC); nonlinear regression; biliary excretion; biliary recycling; hepatic metabolism; hepatic transport; AUC; area under the curve of concen
Keywords: absorption; computational ADME; efflux pumps; in vitro models; organic cation transporters; P-glycoprotein; peptide transporters; pulmonary delivery/absorption; ABC transporters; organic anion-transporting polypeptide transporters; BAL; bronchoalveolar l
Keywords: structure property relationships; molecular modeling; organic anion-transporting polypeptide transporters; drug interactions; 2D; two dimensional; 3D; three dimensional; DDI; drug-drug interaction; HEK cells; human embryonic kidney cells; IC50; inhibition
Keywords: in silico modeling; QSAR; transporters; computational ADME; high-throughput technologies; AUC; area under the curve; BCRP; breast cancer resistance protein; DDI; drug-drug interaction; fup; protein unbound fraction in plasma; ITC; International Transpor
Keywords: Intracellular drug concentration; Pharmacodynamics; OCT; MATE; PMAT; Drug transporter; ABC; ATP-binding cassette; ACC; acetyl-CoA carboxylase; AMP; adenosine monophosphate; AMPK; AMP-activated protein kinase; AUC; area under the concentration time curve;
Keywords: AAV; Adeno-associated virus; ABC; ATP-binding cassette; AD; Alzheimer's disease; BAC; Bacterial artificial chromosome; BBB; Blood-brain barrier; CNS; Central nervous system; EAE; Experimental autoimmune encephalomyelitis; IHC; Immunohistochemistry; MS;
Keywords: DW; diffusion-weighted; MRI; magnetic resonance imaging; CE; contrast-enhanced; US; ultrasound; CT; computed tomography; PET; positron emission tomography; HCC; hepatocellular carcinoma; MFC; mass-forming cholangiocarcinoma; OATP; organic anionic transpor
Keywords: ABCB; ATP-binding cassette sub-family B; Apo; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BDL; bile duct ligation; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; C/EBP; CCAAT-enhancer-binding protein; C
Keywords: ROS; reactive oxygen species; GSH; reduced glutathione; GSSG; oxidised glutathione; ER; endoplasmic reticulum; ɣ-GCS; gamma glutamylcysteine synthetase; GGT; ɣ-L-glutamyl transpeptidase; DP; dipeptidase; GR; glutathione reductase; GST; glutathione S-tra
Keywords: Tissue targeting; Transporter; Kidney; Liver; SGLT2; OATP;
Keywords: ATX; autotaxin; LPA; lysophosphatidic acid; TDI; toluene diisocyanate; oATP; oxidized ATP; TDA; toluene diamine; MCP-1; monocyte chemoattractant protein-1; Toluene diisocyanate toxicity; Autotaxin-lysophosphatidic acid axis; Purinergic receptors; Microves
Keywords: Tyrosine kinase inhibitors; Drug transporter; Drug interaction; Therapeutic drug monitoring; Skin disorders; ADR; Adverse drug reaction; AUC; Area under the curve; BBB; Blood-brain barrier; BCRP/ABCG2; Breast cancer resistance protein; CNS; Central nerv
Keywords: Toxic trace elements; Food; Transformations; Bioavailability; Intestinal absorption; Gastrointestinal toxicity; AECOSAN; Agencia Española de Consumo, Seguridad Alimentaria y Nutrición; AQP; Aquaglyceroporins; As(III); Arsenite; As(V); Arsenate; ATSDR; A
Keywords: Steviol glucuronide; OAT3; Uptake transport; Food-drug interaction; BCRP; breast cancer resistant protein; MATE; multidrug and toxin extrusion protein; MRP; multidrug resistant protein; OAT; organic anion transporter; OATP; organic anion transport protein
Keywords: Oatp; organic anion-transporting polypeptide; PCR; polymerase chain reaction; RIPA; Radioimmunoprecipitation assay; PMSF; phenylmethanesulfonyl fluoride; BCA; bicinchoninic acid; PVDF; polyvinylidene fluoride; ECL-Plus; enhanced chemiluminescent reagent;
Keywords: ADR; adverse drug reaction; Oatp; organic anion transporting polypeptide; SNP; single nucleotide polymorphism; NASH; Non-alcoholic steatohepatitis; NAFLD; Non-alcoholic fatty liver disease; MCD; methionine and choline deficient; AUC; area under the curve;
Keywords: HMG-CoA reductase inhibitors; Statins; Mycetes; LDL receptors; Hypercholesterolemia; CYP450; OATP
Keywords: Crigler-Najjar Syndrome; Hepatic Storage Disease; Glucuronosyl Transferase; Bile Secretion; Kernicterus; ATP; adenosine triphosphate; BSP; bromosulphophthalein; CN; Crigler-Najjar; DJS; Dubin-Johnson syndrome; GS; Gilbert syndrome; ICG; indocyanine
Keywords: ABC; ATP-binding cassette; AE2 (SLC4A2); anion exchanger 2; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ALP; alkaline phosphatase; ASBT (SLC10A2); apical sodium-dependent bile acid transporter; ASCOM; activating signal cointegrator-
T1 mapping on gadoxetic acid-enhanced MR imaging predicts recurrence of hepatocellular carcinoma after hepatectomy
Keywords: ADC; apparent diffusion coefficient; AFP; alpha-fetoprotein; BCLC stage; Barcelona Clinic Liver Cancer stage; CT; computed tomography; DW; diffusion-weighted; EM; extrahepatic recurrence; HBPI; hepatobiliary phase imaging; HCC; hepatocellular carcinoma; I
Quantification of membrane transporter proteins in human lung and immortalized cell lines using targeted quantitative proteomic analysis by isotope dilution nanoLC-MS/MS
Keywords: BCRP; breast cancer resistant protein; BEAS; bronchial epithelium and adenovirus; MDCK; madin darby canine kidney; MDR1; multidrug resistance protein 1 (also known as P-gp); MRM; multiple reaction monitoring; MRP; multidrug resistance-associated protein;
Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
Keywords: AhR; aryl hydrocarbon receptor; AP1; activating protein 1; ARE; antioxidant-response element; CAR; constitutive androstane receptor; CYP; cytochrome P450; DREs; dioxin-responsive elements; EMSA; electromobility gel shift assay; FBS; fetal bovine serum; GS
Significance of A-to-I RNA editing of transcripts modulating pharmacokinetics and pharmacodynamics
Keywords: ABC; ATP-binding cassette transporter; ADAR; adenosine deaminase acting on RNA; ADH; alcohol dehydrogenase; AhR; aryl hydrocarbon receptor; AKR; aldo-keto reductase; ALS; amyotrophic lateral sclerosis; AZIN1; antizyme inhibitor 1; AMPA; α-amino-3-hydroxy
PDZ domain containing protein 1 (PDZK1), a modulator of membrane proteins, is regulated by the nuclear receptor THRβ
Keywords: Thyroid hormones; Scaffold protein; PDZ-domain; Gene regulation; Thyroid hormone receptors; 5-HT2A; Serotonin 2A receptor; ABC; ATP-binding cassette transporter; AhR; Transcription factor aryl hydrocarbon receptor; BCRP; Breast cancer resistance protein;
High hepatic exposure of furanocoumarins in Radix Angelica dahuricae is associated with transporter mediated active uptake
Keywords: ABT; 1-aminobenzotriazole; AUC0-â; area under the curve; BER; bergapten; Cmax; maximum plasma concentration; CsA; cyclosporine A; CYP; cytochrome P450; DMEM/F-12; Dulbecco's modified Eagle medium nutrient mixture F-12; DMSO; dimethyl sulfoxide; Æu; unb
Maternal betaine administration modulates hepatic type 1 iodothyronine deiodinase (Dio1) expression in chicken offspring through epigenetic modifications
Keywords: AHCYL1; adenosylhomocysteinase-like 1; BHMT; betaineâhomocysteineâSâmethyltransferase; DNMT1; DNA methyltransferase 1; Dio1; type 1 iodothyronine deiodinase; Dio2; type 2 iodothyronine deiodinase; Dio3; type 3 iodothyronine deiodinase; LAT1; L-type
Hypovascular hypointense nodules in hepatobiliary phase without T2 hyperintensity: long-term outcomes and added value of DWI in predicting hypervascular transformation
Keywords: OATP; organic anionic transporting polypeptides; HBP; hepatobiliary phase; DWI; diffusion weighted imaging; HHN; hypovascular HBP hypointense nodule; HCC; hepatocellular carcinoma; T1WI; T1 weighted images; Magnetic resonance imaging; Gadoxetic acid; Hepa
Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations
Keywords: NR; nuclear receptor; FXR; farnesoid X receptor; RXR; retinoid X receptor; PXR; pregnane X receptor; VDR; Vitamin D receptor; TGR5; G protein-coupled bile acid receptor; Lrh1; liver receptor homolog 1; Mdr; multidrug resistance protein; Abcb4; ATP Bindi
Human and rat precision-cut intestinal slices as ex vivo models to study bile acid uptake by the apical sodium-dependent bile acid transporter
Keywords: ASBT; apical sodium-dependent bile acid transporter; DMSO; dimethyl sulfoxide; NTCP; Na+-taurocholate cotransporting polypeptide; OATP; organic anion transporting polypeptide; PBS; phosphate buffered saline; PCIS; precision-cut intestinal slices; PPPD; pa
Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion
Keywords: Biliary excretion; PPARα; Bile acids; Gender difference; 1oBAs; Primary bile acids; 2oBAs; secondary bile acids; 12-OH; 12-hydroxylated bile acid; Asbt; apical sodium-dependent bile acid transporter; BA; bile acid; Baat; bile acid CoA:amino acid N-acyltr
Transhepatic bile acid kinetics in pigs and humans
Keywords: Bile acids; TGR5; Porcine; Postprandial; Portal concentrations; BAs; bile acids; ASBT; apical sodium-dependent bile acid transporter; OST; organic solute transporter; NTCP; taurocholate cotransporting polypeptide; OATP; organic anion transporting polypept
Tumor-promoting cyanotoxin microcystin-LR does not induce procarcinogenic events in adult human liver stem cells
Keywords: HL1-hT1; Microcystin-LR; Adult liver stem cells; Liver tumor-promotion; OATP; Multidrug resistance proteins; AB; Alamar Blue; AFP; α-fetoprotein; ALB; albumin; BCRP; breast cancer resistance protein; BSP; bromosulfophthalein; CFDA-AM; 5-carboxyfluorescei
Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment
Keywords: 3Rs; Reduction, Replacement, Refinement; PBPK; physiologically based pharmacokinetic; 2D; two-dimensional; 3D; three-dimensional; HTS; high-throughput screening; IVIVE; in vitro-in vivo extrapolation; ADME; absorption, distribution, metabolism and excreti
Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice
Keywords: Aryl hydrocarbon receptor; TCDD; Bile acids; Biliary excretion; Taurodeoxycholic acid; Cyp8b1; 1°BAs; Primary bile acids; 2°BAs; Secondary bile acids; 6-OH; 6-hydroxylated (6-OH); 12-OH; 12α-hydroxylated; Abc; ATP-binding cassette; AhR; Aryl hydrocarbo