Interaction of the antiviral drug telaprevir with renal and hepatic drug transporters
Keywords: OCT; MATE1; Telaprevir; OATP; Drug-drug interaction; Drug transporter;
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Differential inhibitory effect of cyclosporin A and bosentan on taurocholate uptake in human and rat hepatocytes as a function of culturing time
Keywords: NTCP; Na(+)-taurocholate co-transporting polypeptide; BSEP; bile salt export pump; OATP; organic anion transporting polypeptide; TC; taurocholate; BSP; sulfobromophthaleine; HBSS; Hanks' Balanced Salt Solution; Hepatocyte; NTCP; Taurocholate; Drug inter
Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions
Keywords: AR; androgen receptor; STX64; 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate; CRPC; castration-resistant prostate cancer; STS; steroid sulfatase; OATP; organic anion transporting polypeptide; DHEA; dehydroepiandrosterone; DHEAS; dehydroe
Impact of testosterone on the expression of organic anion transporting polypeptides (OATP-1A2, OATP-2B1, OATP-3A1) in malignant and non-malignant human breast cells in vitro
Keywords: OATP; Mammary gland; Breast cancer; Testosterone; Anastrozole; AndrogenA, anastrozole; AR, androgen receptor; BC, breast cancer; CK, cytokeratin; DHEAS, dehydroepiandrosterone sulfate; EGFR, epidermal growth factor receptor; EPT, estrogen plus progestin t
Original Full Length ArticleGender- and dose-related effects of cyclosporin A on hepatic and bone metabolism
Keywords: ANOVA; analysis of variance; BMD; bone mineral density; BW; body weight; CsA; cyclosporin A; E2; 17β-estradiol; GX; gonadectomized; HRT; hormone replacement therapy; MCT; medium chain triglycerides; OATP; organic anion transporter; OVX; ovariectomized; O
Polymyxin B increases the depletion of T regulatory cell induced by purinergic agonist
Keywords: PMB; polymyxin B; Treg; regulatory T cells; IL-2; interleukin 2; CD25; interleukin 2 receptor α chain; BBG; brilliant blue G; oATP; oxidized ATP; PPADS; pyridoxal-phosphate-6-azophenyl-2â²,4â²-disulfonate; NAD; nicotinamide adenine dinucleotide; BzATP;
Long-Lasting Inhibition of the Intestinal Absorption of Fexofenadine by Cyclosporin a in Rats
Keywords: intestinal absorption; drug interactions; OATP; transporters; membrane transport; bioavailability; cyclosporin A; fexofenadine;
Glutathione and modulation of cell apoptosis
Keywords: âΨ; mitochondrial membrane potential; ANT; adenine nucleotide translocase; Apaf-1; apoptotic protease-activating factor-1; ASK-1; apoptosis signal-regulating kinase-1; ATO; arsenic trioxide; AVD; apoptotic volume decrease; BSO; l-buthionine (S,R)-sulfo
New fluorescent bile acids: Synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid
Keywords: NBD label; Ursodeoxycholic acid; Deoxycholic acid; Bile acid transporter; OATP; Stereoselective;
Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy
Keywords: Stearoyl coenzyme A; SCD; Liver-targeted; OATP; Nicotinic acid
Neonatal hypothyroidism caused by maternal nicotine exposure is reversed by higher T3 transfer by milk after nicotine withdraw
Keywords: TH; thyroid hormones; NIS; sodium-iodide symporter; TSH; thyrotropin; T3; triiodothyronine; T4; thyroxine; NIC; nicotine; C; control; RAIU; radioiodine uptake; type 1 D1; deiodinase; D2; type 1 deiodinase; OATP; Organic anion transporter polypeptides; NTC
Similar uptake profiles of microcystin-LR and -RR in an in vitro human intestinal model
Keywords: Microcystins congeners; OATP; Caco-2; Cyanotoxin uptake; Immunofluorescence
OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture
Keywords: OATP; organic anion-transporting polypeptide; SNP; single nucleotide polymorphism; E17βG; estradiol-17β-d-glucuronide; FBS; fetal bovine serum; HBSS; Hanks' balanced salt solution; PBS; phosphate-buffered saline; PCR; polymerase chain reaction; Ct; cy
Spatial expression and functionality of drug transporters in the intact lung: Objectives for further research
Keywords: Transporter; Lung; Pulmonary; Delivery; ATP; P-glycoprotein; MRP; BCRP; OAT; OATP; OCT; OCTN; Pharmacokinetics
Central sensitization of nociceptive neurons in rat medullary dorsal horn involves purinergic P2X7 receptors
Keywords: ATP; benzoylbenzoyl ATP; brilliant blue G; minocycline; mustard oil; periodated oxidized ATP; ANOVA; analysis of variances; BBG; brilliant blue G; BzATP; 2â²3â²-o-(4-benzoylbenzoyl) adenosine 5â²-triphosphate (ATP); DPCPX; 8-cyclopentyl-1,3-dipropylxan
Differential Effect of Grapefruit Juice on Intestinal Absorption of Statins Due to Inhibition of Organic Anion Transporting Polypeptide and/or P-glycoprotein
Keywords: intestinal absorption; interaction; grapefruit juice; pitavastatin; pravastatin; naringin; OATP; P-glycoprotein
Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer
Keywords: Breast cancer; Estrogen; Transporter; MCF-7 cells; DNA microarray; OATP
Screening of OATP1B1/3 and OCT1 inhibitors in cryopreserved hepatocytes in suspension
Keywords: Hepatocytes; Transporters; Inhibition; OATP; OCT1; Screening
The genetics of statin-induced myopathy
Keywords: HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; LDL; low density lipoprotein; OATP; organic anion transporter protein; SNP; single nucleotide polymorphism; CK; creatine kinase; Genetics; Organic anion transporter; Inherited;
The HMG-CoA Reductase Inhibitor Pravastatin Stimulates Insulin Secretion through Organic Anion Transporter Polypeptides
Keywords: SLCO (SLC21); SLC transporters; HMG-CoA reductase inhibitors; xenobiotics; diabetes; disease; insulin; endobiotics; adipose; organ; islet; OATP; SLC transporters
Organic anion transporting polypeptides (OATP) in zebrafish (Danio rerio): Phylogenetic analysis and tissue distribution
Keywords: OATP; Zebrafish; Phylogenetic analysis; Membrane topology; Tissue distribution
Telmisartan pharmacokinetics in Japanese renal transplant recipients
Keywords: Telmisartan; UGT; OATP; MRP2; Pharmacokinetics
Identification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport
Keywords: OATP; CoMFA; Drug-drug interaction; Nuclear receptor;
Nanoscale particles for polymer degradation and stabilization-Trends and future perspectives
Keywords: μm; micrometer; AAGR; average annual growth rate; AGU; anhydroglucose unit; ATH; aluminium trihydroxides; BZD; benzidine; CMC; critical micelle concentration; CNT; carbon nanotubes; CVD; chemical vapour deposition; DMA; dynamo-mechanical analysis; DNA; d
Sex-specific extraction of organic anions by the rat liver
Keywords: Oatp; Mrp3; BSP; Organic anion transport; Bile; Sinusoidal; Canalicular
Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation
Keywords: cerebral microvessels; choroid plexus; luminal; abluminal; ABC transporter; Abc; ATP-binding cassette; BBB; blood-brain barrier; BMEC; brain microvessel endothelial cell; CSF; cerebrospinal fluid; CT; cycle threshold; DTT; dithiothreitol; EM; electron m
P-glycoprotein and cytochrome P450 3A4 involvement in risperidone transport using an in vitro Caco-2/TC7 model and an in vivo model
Keywords: ab; apical to basolateral; AQ; absorptive quotient; AUCT; area under the curve; ba; basolateral to apical; ClR; renal clearance; Cmax; maximum plasma concentration; CYP; cytochrome P450; ER; efflux ratio; F; fraction not metabolised; FA; fraction absorbed
Evidence of Oatp and Mdr1 in cryopreserved rat hepatocytes
Keywords: Hepatocytes; Cryopreservation; Transport proteins; Oatp; Mdr1; Sandwich culture; Conventional culture
Expression in Human Trophoblast and Choriocarcinoma Cell Lines, BeWo, Jeg-3 and JAr of Genes Involved in the Hepatobiliary-like Excretory Function of the Placenta
Keywords: ABC proteins; Bile acid; Carrier; Liver; Nuclear receptors; OATP; PregnancyBCRP, breast cancer resistance protein; BSEP, bile salt export pump; E217βG, estradiol 17β-d-glucuronide; hCC, human choriocarcinoma cells; hTr, human primary trophoblasts; MDR, mu
Genetic variation in thyroid hormone transporters
Keywords: MCT; OATP; polymorphism; thyroid hormone transporter;
Development of a fluorescence-based assay for screening of modulators of human Organic Anion Transporter 1B3 (OATP1B3)
Keywords: active transport; bioavailability; hepatic uptake; OATP; human; substrate specifity
Effect of maternal cholestasis and treatment with ursodeoxycholic acid on the expression of genes involved in the secretion of biliary lipids by the neonatal rat liver
Keywords: ABC proteins; Bile acid; Carrier; Nuclear receptors; OATP; Pregnancy
The effect of pancreatic and biliary depletion on the in vivo pharmacokinetics of digoxin in pigs
Keywords: Digoxin; Cholestasis; P-glycoprotein; OATP; Pigs; Bioavailability; Pharmacokinetics;
Retention of structural and functional polarity in cultured skate hepatocytes undergoing in vitro morphogenesis
Keywords: Polarized hepatocyte culture model; Bile secretion; Membrane transport; Bsep; Mrp2; Oatp; ATP; Glutathione
Human renal organic anion transporters: Characteristics and contributions to drug and drug metabolite excretion
Keywords: Kidney; Organic anions; Transport; Human; Excretion; α-KG; α-ketoglutarate; aa; amino acid; ABCC; Family C of the ATP-binding cassette superfamily; AG; acetaminophen glucuronide; BBM; brush border membrane; BLM; basolateral membrane; DHEAS; dehydroepian
Implications of genetic polymorphisms in drug transporters for pharmacotherapy
Keywords: ABC transporter; SLC transporter; Uptake; Efflux; ABCB1; MDR1; P-glycoprotein; Pgp; OATP; OCT; OAT; MRP; Single nucleotide polymorphism (SNP); Haplotype analysis; Expression; Function; Pharmacokinetics; Pharmacodynamics
Nuclear Receptor Ligands: Rational and Effective Therapy for Chronic Cholestatic Liver Disease?
Keywords: ABCG5/8; cholesterol export pump; BSEP; bile salt export pump; CAR; constitutive androstane receptor; CYP; cytochrome P-450; FTF; fetal transcription factor; FXR; farnesoid X receptor; GST; glutathione-S-transferase; LXR; liver X receptor; MDR; multidrug
Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin
Keywords: OATP; human organic anion transporting polypeptide; Oatp; rodent organic anion transporting polypeptide; BSP; bromosulfophthalein; TC; taurocholate; Microcystin-LR; CAS-RN: 101043-37-2; Molecular formula: C49H74N10O12; Hepatotoxicity; Neurotoxicity; Trans
Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2
Keywords: BSA; bovine serum albumin; DHEAS; Dehydroepiandrosterone-sulfate; E217βG; 17β-estradiol-17β-glucuronide; E1S; estrone 3-sulfate; FBS; fetal bovine serum; HA; hemagglutinin; HBSS; Hanks balanced salt solution; MDCK; Mardin Darby canine kidney cells; M
Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat
Keywords: Glutathione; Bile acids; Glutathione conjugates; Organic anion transport; Isolated rat liver perfusion; Steatosis; BCRP; breast cancer resistance protein; BDBF; bile salt-dependent bile flow; BIBF; bile salt-independent bile flow; Bsep; bile salt export p
Complementary Stimulation of Hepatobiliary Transport and Detoxification Systems by Rifampicin and Ursodeoxycholic Acid in Humans
Keywords: 4β-OH-C; 4β-hydroxy cholesterol; BAAT; bile acid amino transferase; BSEP; bile salt export pump; C4; 7α-hydroxy-4-cholesten-3-one; CA; cholic acid; CYP; cytochrome P450; DCA; deoxycholic acid; HCA; hyocholic acid; LCA; lithocholic acid; CDCA; chenodeox
Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes
Keywords: AS; antisense oligonucleotides; CELL; non-treated control-cells; CLO; clotrimazole; CYP; cytochrome P450; DEX; dexamethasone; FBS; foetal bovine serum; GST; glutathione S-transferase; MDR1; multidrug resistance-1; MP; metyrapone; MRP; multidrug resistance
Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR)
Keywords: AR; androgen receptor; β-Gal; β-galactosidase; CYP3A; cytochrome P4503A; DMEM; Dulbecco's modified Eagle medium; DMSO; dimethyl sulfoxide; DR3; direct repeat with 3 nucleotide spacer; EC50; effective concentration for half-maximal response; ER; estrogen
Efflux transport systems at the blood-brain barrier and blood CSF barrier
Keywords: Efflux transport; Organic anion; OATP; OAT; MRP; BCRP;
Active Efflux across the Blood-Brain Barrier: Role of the Solute Carrier Family
Keywords: Efflux; blood-brain barrier; organic anion transporter; OAT; OATP; ABC transporter;
Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins
Keywords: ABC; ATP-binding cassette; Bpt1p; bile pigment transporter-1; BSO; l-buthionine (S,R)-sulfoximine; CFTR; cystic fibrosis transmembrane conductance regulator; DTY167; yeast strain lacking functional Ycf1p; EHBR; Sprague-Dawley Eisai hyperbilirubinuric ra
Polymorphisms affecting gene regulation and mRNA processing: Broad implications for pharmacogenetics
Keywords: 5-FU; 5-fluorouracil; 5-HTT; serotonin transporter; 5-HTTLPR; serotonin gene-linked polymorphic region; 6-MP; 6-mercaptopurine; 6-TG; 6-thioguanine; ABCB; ATP-binding cassette (ABC), subfamily B; ACE; angiotensin I converting enzyme (peptidyl-dipeptidase
Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
Keywords: ABC; ATP-binding cassette; AIDS; immunodeficiency syndrome; BBB; blood-brain barrier; BCRP; breast cancer related protein; CNS; central nervous system; CSF; cerebrospinal fluid; HIV; human immunodeficiency virus; HPA axis; hypothalamic-pituitary-adr