کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2563879 | 1127572 | 2006 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human renal organic anion transporters: Characteristics and contributions to drug and drug metabolite excretion
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کلمات کلیدی
OATPPAHsat-1BBMα-KGURAT1ABCCE217βGBLMMRPDHEASp-Aminohippurate - p-aminohippurateα-ketoglutarate - α-کتوگلووتراتamino acid - آمینو اسیدOrganic anions - آنیون های ارگانیکacetaminophen glucuronide - استامینوفن گلوکورونایدEstrone sulfate - استرون سولفاتHuman - انسانBrush border membrane - برس غشای مرزExcretion - تخفیفOat - جو دو سرTransport - حمل و نقل یا ترابریorganic anion transporter - حمل کننده آنیون آلیUrate transporter 1 - حمل کننده اورات 1dehydroepiandrosterone sulfate - سولفات dehydroepiandrosteroneBasolateral membrane - غشای نازکOrganic anion transporting polypeptide - پلیپپتید حمل آنیون ارگانیکKidney - کلیه
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The kidney is a key organ for promoting the excretion of drugs and drug metabolites. One of the mechanisms by which the kidney promotes excretion is via active secretion. Secretion of drugs and their metabolites from blood to luminal fluid in the nephron is a protein-mediated process that normally involves either the direct or indirect expenditure of energy. Renal transporters for organic anions are located in the proximal tubule segment of the nephron. The primary transporters of organic anions on the basolateral membrane (BLM) of proximal tubule cells are members of the organic anion transporter (OAT) family (mainly OAT1 and OAT3). The sulfate-anion antiporter 1 (SAT-1; hsat-1) may also contribute to organic anion transport at the basolateral membrane. On the apical membrane, the multi-drug resistance-associated protein 2 (MRP2) is an important transport protein to complete the secretion process. However, there are several transport proteins on the basolateral and apical membranes of proximal tubule cells in human kidneys that have not been fully characterized and whose role in the secretion of organic anions remains to be determined. This review will primarily focus on the human renal basolateral and apical membrane transporters for organic anions that may play a role in the excretion of drugs and drug metabolites.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 109, Issue 3, March 2006, Pages 399-412
Journal: Pharmacology & Therapeutics - Volume 109, Issue 3, March 2006, Pages 399-412
نویسندگان
Eliza E. Robertson, Gary O. Rankin,