Keywords: Pyrimidine biosynthesis; Orotidine monophosphate decarboxylase; Ligand-enzyme interactions; Antimalarial agents; BMP; barbituric acid ribosyl 5â²-monophosphate (6-hydroxy UMP); CTP; cytidine 5â²-triphosphate; dCTP; deoxycytidine 5â²-triphosphate; HMOA;