Double stranded promoter region of BRAF undergoes to structural rearrangement in nearly physiological conditions
Keywords: انکوژن; BRAF; G-quadruplex; i-motif; Oncogene
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HCV core protein promotes hepatocyte proliferation and chemoresistance by inhibiting NR4A1
Keywords: انکوژن; Hepatocellular carcinoma; NR4A1; RUNX3; HCV core protein; Chemoresistance; Oncogene;
MicroRNA-575 targets BLID to promote growth and invasion of non-small cell lung cancer cells
Keywords: انکوژن; Non-small cell lung cancer; MicroRNA-575; BLID; Oncogene;
Attempts on producing lymphoid cell line from Penaeus monodon by induction with SV40-T and 12S EIA oncogenes
Keywords: انکوژن; Oncogene; SV40-T; 12S E1A; Penaeus monodon; Lymphoid cell culture; In vitro transformation
The sulfiredoxin-peroxiredoxin (Srx-Prx) axis in cell signal transduction and cancer development
Keywords: انکوژن; Sulfiredoxin; Peroxiredoxin; Redox signaling; Tumorigenesis; Oncogene;
MicroRNAs as regulators and mediators of c-MYC function
Keywords: انکوژن; MYC; Oncogene; miRNA; Cancer;
The interplay of NR4A receptors and the oncogene-tumor suppressor networks in cancer
Keywords: انکوژن; Nuclear receptor; NR4A; Nur77; Nurr1; Oncogene; Tumour suppressor;
Regulation of the tumor marker Fascin by the viral oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) depends on promoter activation and on a promoter-independent mechanism
Keywords: انکوژن; Tumor virus; HTLV-1; Oncogene; Tax; ATL; Fascin; Transcription regulation; Promoter; NFâkappa B (NFâKB); PP2;
EMT in cervical cancer: Its role in tumour progression and response to therapy
Keywords: انکوژن; Epithelial Mesenchymal Transition; Mesenchymal transition (EMT); Therapeutics; Oncogene; Tumour-suppressor; Cervical cancer;
A Hot-spot of In-frame Duplications Activates the Oncoprotein AKT1 in Juvenile Granulosa Cell Tumors
Keywords: انکوژن; AKT1; Ovary; Juvenile granulosa cell tumor; Activating mutation; Oncogene; Oncoprotein
Original ResearchFull Report: Clinical-Alimentary TractMolecular Markers Identify Subtypes of Stage III Colon Cancer Associated With Patient Outcomes
Keywords: انکوژن; Colorectal Cancer; Oncogene; Prognostic Factor; Genetics; CI; confidence interval; CIMP; CpG island methylator phenotype; CIN; chromosomal instability; CRC; colorectal cancer; DFS; disease-free survival; dMMR; deficient DNA mismatch repair; FOLFOX; 5-fluo
MicroRNAs in colorectal cancer: Small molecules with big functions
Keywords: انکوژن; Colorectal cancer; MicroRNA; Tumor suppressor; Oncogene;
MicroRNA-based therapy and breast cancer: A comprehensive review of novel therapeutic strategies from diagnosis to treatment
Keywords: انکوژن; miRNA; Apoptosis; Oncogene; Tumor suppressor; Drug resistance; Breast cancer; Therapy;
Genomic Instability Causes HGF Gene Activation in Colon Cancer Cells, Promoting Their Resistance to Necroptosis
Keywords: انکوژن; Signal Transduction; Receptor Tyrosine Kinase; Oncogene; Gene Regulation; CRC; colorectal carcinoma; DATE; deoxyadenosine tract element; HGF; hepatocyte growth factor; MMR; mismatch repair; MSI; microsatellite instability; MSS; microsatellite stable;
Loss of Somatostatin Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16
Keywords: انکوژن; Tumor Suppressor; Signal Transduction; Oncogene; Mouse Model; 3D; 3-dimensional; ADM; acinar-to-ductal metaplasia; AFL; atypical flat lesion; AKT or PKB; protein kinase B; CK-19; cytokeratin-19; CXCL16; chemokine (C-X-C motif) ligand 16; CXCR6; chemokine
The human oncogene SCL/TAL1 interrupting locus is required for mammalian dopaminergic cell proliferation through the Sonic hedgehog pathway
Keywords: انکوژن; Stil; Oncogene; Dopaminergic cells; Proliferation; Differentiation; Shh signaling;
Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells
Keywords: انکوژن; Extracellular vesicle; DNA; Oncogene; Ras; Chromatin; Sphingomyelinase;
RET Mutation and Expression in Small-Cell Lung Cancer
Keywords: انکوژن; RET; Small-cell lung cancer; Oncogene; SNP; Tyrosine kinase inhibitors;
Regulation of the localisation and function of the oncogene LYRIC/AEG-1 by ubiquitination at K486 and K491
Keywords: انکوژن; Ubiquitin; Oncogene; Localisation; Protein-protein interaction;
Y-box binding protein 1 – A prognostic marker and target in tumour therapy
Keywords: انکوژن; Oncogene; Transcription factor; Translational regulation; DNA repair; Proliferation; Survival; Migration/invasion; Chemoresistance; Angiogenesis; Genomic instability
Small molecule with big role: MicroRNAs in cancer metastatic microenvironments
Keywords: انکوژن; MicroRNA; Cancer metastasis; Microenvironment; Oncosuppressor gene; Oncogene
MicroRNAs in cancer biology and therapy: Current status and perspectives
Keywords: انکوژن; Cancer biology; Drug therapy; miRNAs; Nanoparticles; Oncogene; Tumor suppressor
The gep proto-oncogene Gα12 mediates LPA-stimulated activation of CREB in ovarian cancer cells
Keywords: انکوژن; LPA; Lysophosphatidic Acid; LPAR; LPA-receptor; CREB; Cyclic-AMP Response Element Binding Protein; ERK; Extracellular-signal Regulated Kinase; MSK1; Mitogen and Stress-activated protein Kinase-1; p38MAPK; p38-Mitogen-activated Protein Kinase; LPA; Gα12;
Mediator of RNA polymerase II transcription subunit 19 promotes osteosarcoma growth and metastasis and associates with prognosis
Keywords: انکوژن; Med19; Osteosarcoma; Oncogene; RNA interference; Lentivirus;
Original ResearchFull Report: Basic and Translational-Alimentary TractTRIM59 Is Up-regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of p53
Keywords: انکوژن; Oncogene; Stomach Cancer; Tumor Formation; Progression; MDM2; murine double minute 2; mRNA; messenger RNA; q-PCR; quantitative polymerase chain reaction; shRNA; short hairpin RNA; TRIM; tripartite motif;
The epigenetic factor BORIS/CTCFL regulates the NOTCH3 gene expression in cancer cells
Keywords: انکوژن; T cell acute lymphoblastic leukemia; Oncogene; Cancer testis antigen; Chromatin; DNA/histone methylation;
PI3K Regulation of RAC1 Is Required for KRAS-Induced Pancreatic Tumorigenesis in Mice
Keywords: انکوژن; Pancreatic Cancer; Signal Transduction; Cytoskeleton; Oncogene; ADM; acinar-to-ductal metaplasia; DAPI; 4â²,6-diamidino-2-phenylindole; EGFR; epidermal growth factor receptor; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GEF; guanine nucleotide excha
Ribonucleoprotein HNRNPA2B1 Interacts With and Regulates Oncogenic KRAS in Pancreatic Ductal Adenocarcinoma Cells
Keywords: انکوژن; Signal Transduction; Carcinogenesis; Oncogene; Mouse Model; AKT; c-akt murine thymoma oncogene homolog 1; FCS; fetal calf serum; GFP; green fluorescent protein; GTP; guanosine triphosphate; HA; hemagglutinin; hnRNP; heterogeneous nuclear ribonucleoprotein
Increased Expression of EIF5A2, Via Hypoxia or Gene Amplification, Contributes to Metastasis and Angiogenesis of Esophageal Squamous Cell Carcinoma
Keywords: انکوژن; Oxygen; Gene Regulation; EMT; Oncogene; ChIP; chromatin immunoprecipitation; eIF5A2; eukaryotic initiation factor 5A2; EMT; epithelial-to-mesenchymal transition; ESCC; esophageal squamous cell carcinoma; FISH; fluorescence in situ hybridization; HIF-1; hy
Critical lysine residues of Klf4 required for protein stabilization and degradation
Keywords: انکوژن; Oncogene; Proteasomal degradation; Tumor suppressor; Ubiquitin; Ubiquitination;
MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression
Keywords: انکوژن; Pancreatic Cancer; miRNAâmRNA Interaction; Tumorigenesis; Oncogene; anti-miR; antisense miRNA inhibitor; miRNA; microRNA; mRNA; messenger RNA; NC; negative control; OS; overall survival; PDAC; pancreatic ductal adenocarcinoma; pre-miR; precursor miRNA;
Activation of β-Catenin and Yap1 in Human Hepatoblastoma and Induction of Hepatocarcinogenesis in Mice
Keywords: انکوژن; Liver Cancer; Gene Regulation; Oncogene; Tumor Formation; Dlk1; delta-like protein/preadipocyte factor 1/fetal antigen 1 delta-like protein/preadipocyte factor 1/fetal antigen 1; EpCAM; epithelial cell adhesion molecule; HB; hepatoblastoma; HCC; hepatocel
Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is regulated by protein palmitoylation
Keywords: انکوژن; GAP; GTPase activating protein; EGFR; epidermal growth factor receptor; IR; insulin receptor; EGF; epidermal growth factor; IGF-1; insulin-like growth factor1; FCS; fetal calf serum; PP2A; protein phosphatase 2A; IRS-1; insulin receptor substrate1; Fbw8;
Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1
Keywords: انکوژن; CAD; C-terminal transactivation domain; DEN; diethylnitrosamine; FIH-1; factor inhibiting hypoxia-inducible factor-1; firefly-luciferase; F-Luc; H&E; hematoxylin and eosin; HBX; hepatitis B virus X protein; HCC; hepatocellular carcinoma; HIF; hypoxia-indu
The CSB repair factor is overexpressed in cancer cells, increases apoptotic resistance, and promotes tumor growth
Keywords: انکوژن; Cockayne Syndrome group B protein; Oncogene; Apoptosis; Cancer cells;
Low frequency KRAS mutations in colorectal cancer patients and the presence of multiple mutations in oncogenic drivers in non-small cell lung cancer patients
Keywords: انکوژن; Ultradeep sequencing; non-small cell lung cancer; colorectal cancer; oncogene; low frequency mutations;
Research ReportThe miR-92b functions as a potential oncogene by targeting on Smad3 in glioblastomas
Keywords: انکوژن; Glioblastoma; Smad3; MicroRNA-92b; P21; Oncogene;
Original ResearchFull Report: Basic and Translational-PancreasA High-Fat Diet Activates Oncogenic Kras and COX2 to Induce Development of Pancreatic Ductal Adenocarcinoma in Mice
Keywords: انکوژن; Pancreatic Cancer; Signal Transduction; Oncogene; Prostaglandin; α-SMA; α-smooth muscle actin; BAC; bacterial-artificial-chromosome; BW; body weight; CD; control diet; COX; cyclooxygenase; Ela; elastase; ERK; extracellular signal-regulated kinase; GTP;
EZH2 Promotes E2F-Driven SCLC Tumorigenesis through Modulation of Apoptosis and Cell-Cycle Regulation
Keywords: انکوژن; Small-cell lung cancer; Enhancer of zeste homolog 2; Oncogene; Retinoblastoma protein; E2 promoter binding factor
BRAF splice variants in rheumatoid arthritis synovial fibroblasts activate MAPK through CRAF
Keywords: انکوژن; Rheumatoid arthritis; Oncogene; MAPK cascade
The prognostic significance of FOXQ1 oncogene overexpression in human hepatocellular carcinoma
Keywords: انکوژن; Forkhead box gene; Oncogene; FOXQ1; HCC
Analysis of the NCI-60 dataset for cancer-related microRNA and mRNA using expression profiles
Keywords: انکوژن; MicroRNA; Expression profile; Oncogene; Tumor suppressor gene; Pearson correlation; Spearman rank correlation; CpG island; MicroRNA cluster; Fragile sites
MiR-205 in cancer: An angel or a devil?
Keywords: انکوژن; miR-205; Cancer; Oncogene; Tumor suppressor; Epigenetics; Network
Characterization of Rare Mammary Tumours Appearing on the Neck of RIII/Sa Mice Infected with Mouse Mammary Tumour Virus
Keywords: انکوژن; ectopic breast cancer; mouse mammary tumour virus; neck tumour; oncogene
Cadmium modulates H-ras expression and caspase-3 apoptotic cell death in breast cancer epithelial MCF-7 cells
Keywords: انکوژن; Carcinogenesis; H-ras signaling; Cadmium; Breast cancer; Oncogene; MCF-7 cells
Studies on the interaction mechanism of aminopyrene derivatives with human tumor-related DNA
Keywords: انکوژن; Polycyclic aromatic hydrocarbons derivatives; Oncogene; Tumor suppressor gene; DNA interaction; PAGE
The Mutational Landscape of Prostate Cancer
Keywords: انکوژن; Sequencing; Genomics; Copy number aberrations; Oncogene; Tumor suppressor
Genetic deregulation of the PIK3CA oncogene in oral cancer
Keywords: انکوژن; HNSCC; PIK3CA mutation and amplification; Oncogene; Head and neck; PI3K/Akt signaling
Low-Level Amplification of Oncogenes Correlates Inversely with Age for Patients with Nontypical Meningiomas
Keywords: انکوژن; Atypical meningioma; Copy number; Copy number gains; Gene amplification; Meningioma; Multiplex ligation-dependent probe amplification; Oncogene; CE; Capillary electrophoresis; CGH; Comparative genomic hybridization; CN; Copy number; FFPE; Formalin-fixed p
ALK as a paradigm of oncogenic promiscuity: different mechanisms of activation and different fusion partners drive tumors of different lineages
Keywords: انکوژن; ALK; fusion proteins; oncogene; translocations; receptor tyrosine kinase