Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E2P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump
Keywords: EDTA; Ethylenediaminetetraacetic acid; EP; phosphoenzyme; DMSO; Dimethyl sulfoxide; pNPP; para-nitrophenyl phosphate; TCA; trichloroacetic acid; Na,K-ATPase; Nigella Sativa; Oleic acid; Linoleic acid; Ouabain affinity; Anthroyl ouabain;