Keywords: گیرنده P2Y12; Platelets; TCIPA; Breast cancer cells; P2Y12 receptor; Phospholipase C; Calcium signaling; Rap1;
مقالات ISI گیرنده P2Y12 (ترجمه نشده)
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Keywords: گیرنده P2Y12; Prasugrel; P2Y12 receptor; Contractile function; Membrane potential; Nitric oxide;
Keywords: گیرنده P2Y12; aortic stenosis; surgical aortic valve replacement; transcatheter aortic valve replacement; balloon-inflatable prosthesis; self-inflating prosthesis; surgical risk; Society of Thoracic Surgeons; Cardiothoracic Surgical Trials Network; PARTNER trials; NOTI
Keywords: گیرنده P2Y12; Thrombosis; Platelet aggregation; Neointimal hyperplasia; Prasugrel; Thienopyridine; P2Y12 receptor;
Cangrelor
Keywords: گیرنده P2Y12; Cangrelor; P2Y12 receptor; Stent thrombosis; Myocardial infarction; Percutaneous coronary intervention; Thienopyridine;
P2Y12 shRNA treatment relieved HIV gp120-induced neuropathic pain in rats
Keywords: گیرنده P2Y12; HIV gp120-associated neuropathic pain; P2Y12 receptor; Dorsal root ganglia; Satellite glia cells;
Clopidogrel Partially Counteracts Adenosine-5â²-Diphosphate Effects on Blood Pressure and Renal Hemodynamics and Excretion in Rats
Keywords: گیرنده P2Y12; Adenosine-5â²-diphosphate; Clopidogrel; P2Y12 receptor; Renal blood flow; Urine concentration ability;
Eisenia bicyclis (brown alga) modulates platelet function and inhibits thrombus formation via impaired P2Y12 receptor signaling pathway
Keywords: گیرنده P2Y12; Eisenia bicyclis; Platelet; P2Y12 receptor; MAPK; Natural anti-thrombotic agent; EBE; Eisenia bicyclis extract; ADP; Adenosine diphosphate; SFK; Src family kinases; MAPK; Mitogen activated protein kinases; ERK; Extracellular signal-regulated kinase; JNK;
Additive antithrombotic effect of ASP6537, a selective cyclooxygenase (COX)-1 inhibitor, in combination with clopidogrel in guinea pigs
Keywords: گیرنده P2Y12; ASP6537 (PubChem CID: 9922739), Aspirin (PubChem CID: 2244); Clopidogrel (PubChem CID: 60606); Platelet; Cyclooxygenase-1; P2Y12 receptor; Aspirin; Clopidogrel; Thrombosis;
P2Y12 antibody inhibits platelet activity and protects against thrombogenesis
Keywords: گیرنده P2Y12; Platelets; P2Y12 receptor; P2Y12 inhibitor; Antibody; Thrombosis;
1, 6-di-O-caffeoyl-β-D-glucopyranoside, a natural compound from Callicarpa nudiflora Hook impairs P2Y12 and thromboxane A2 receptor-mediated amplification of platelet activation and aggregation
Keywords: گیرنده P2Y12; Platelet activation; P2Y12 receptor; TP receptor; Callicarpa nudiflora; 1, 6-di-O-caffeoyl-β-D-glucopyranoside; 5-HT; 5-serotonin; AA; Arachidonic acid; ADP; Adenosine diphosphate; AP; Alkaline phosphatase; CGP; 1, 6-di-O-caffeoyl-β-D-glucopyranoside; C
Safety and effectiveness of the new P2Y12r inhibitor agents vs clopidogrel in ACS patients according to the geographic area: East Asia vs Europe
Keywords: گیرنده P2Y12; Acute coronary syndrome; Clopidogrel; Ethnicity; Platelet inhibitor; Prasugrel; P2Y12 receptor; Ticagrelor;
Platelet Inhibition With Ticagrelor 60 mg Versus 90 mg Twice Daily in the PEGASUS-TIMI 54 Trial
Keywords: گیرنده P2Y12; aspirin; coronary artery disease; P2Y12 receptor; ACS; acute coronary syndrome; ADP; adenosine diphosphate; bid; twice a day; LTA; light transmittance aggregometry; MI; myocardial infarction; PD; pharmacodynamic; PK; pharmacokinetic; PRI; platelet reactiv
Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain
Keywords: گیرنده P2Y12; Microglia; P2Y12 receptor; Neuropathic pain; Electrophysiology; Surveillance; 2-Photon imaging;
Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury
Keywords: گیرنده P2Y12; 4-AP, 4-aminopyridine; ACSF, artificial cerebrospinal fluid; CNS, central nervous system; P2Y12 KO, P2Y12R knockout; P2Y12R, P2Y12 receptors; PI3K, phosphoinositide 3-kinase; PTX, pertussis toxin; TEA, tetraethylammoniummicroglia; P2Y12 receptor; ATP; K+
State of affairs: Design and structure-activity relationships of reversible P2Y12 receptor antagonists
Keywords: گیرنده P2Y12; P2Y12 receptor; G protein-coupled receptors; Acute coronary syndrome (ACS); Platelet aggregation; Thromboembolism; Antithrombotics;
Diabetes Mellitus and Clopidogrel Response Variabilityâ
Keywords: گیرنده P2Y12; acute coronary syndrome(s); diabetes; pharmacokinetics; platelet function testing; P2Y12 receptor; thienopyridine; ticagrelor;
Optimization of ketone-based P2Y12 receptor antagonists as antithrombotic agents: Pharmacodynamics and receptor kinetics considerations
Keywords: گیرنده P2Y12; Acute coronary syndrome (ACS); Acyl sulfonamides; Ketones; Esters; P2Y12 receptor; Piperidinyl-pyridines; Platelet aggregation; Receptor kinetics; Thromboembolism;
Naturally occurring N6-substituted adenosines (cytokinin ribosides) are in vitro inhibitors of platelet aggregation: An in silico evaluation of their interaction with the P2Y12 receptor
Keywords: گیرنده P2Y12; Cytokinin ribosides; Platelets; Anti-aggregation activity; P2Y12 receptor; Homology modeling; Molecular docking;
Optimization of 2-phenyl-pyrimidine-4-carboxamides towards potent, orally bioavailable and selective P2Y12 antagonists for inhibition of platelet aggregation
Keywords: گیرنده P2Y12; P2Y12 receptor; P2Y12 antagonist; GPCR antagonist; Antiplatelet; Antithrombotic;
Off-target effect of the Epac agonist 8-pCPT-2â²-O-Me-cAMP on P2Y12 receptors in blood platelets
Keywords: گیرنده P2Y12; 8-Br-PET-cGMP; (β-phenyl-1), N2-etheno-8-bromoguanosine-3â²,5â²-cyclic monophosphate; 8-pCPT-2â²-O-Me-cAMP; 8-(4-chlorophenylthio)-2â²-O-methyladenosine-3â²,5â²-cyclic monophosphate; 2MeSADP; 2-methylthio-adenosine diphosphate; 2MeSAMP; 2-methylthi
Progress in Platelet Blockers: The Target is the P2Y12 Receptor
Keywords: گیرنده P2Y12; platelets; P2Y12 receptor; adenosine diphosphate; ticlopidine; clopidogrel; thienopyridines; prasugrel; ticagrelor; cangrelor; elinogrel; guidelines; perioperative period; thrombosis; bleeding; percutaneous coronary intervention; cardiac surgery; noncardi
The Role of Platelet Function Testing in Risk Stratification and Clinical Decision-Making
Keywords: گیرنده P2Y12; P2Y12 receptor; Platelet function testing; Clopidogrel; High on-treatment platelet reactivity; Bleeding; Percutaneous coronary intervention;
Synthesis, structure–property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y12 receptor
Keywords: گیرنده P2Y12; P2Y12 receptor; Anti-platelet; Sulfonylureas; Solubility; Stability3-aze, 3-amino-azetidinyl; CDI, N,N′-carbonyl diimidazole; CLint, intrinsic clearance; cy-Pr, cyclopropyl; Caco-2, adenocarcinoma cells from human colon; DIPEA, N,N-diisopropylethylamine;
Functional interaction between purinergic receptors: effect of ligands for A2A and P2Y12 receptors on P2Y1 receptor function
Keywords: گیرنده P2Y12; GPCR; G protein-coupled receptor; A2AR; A2A adenosine receptor; P2Y1R; P2Y1 receptor; P2Y12R; P2Y12 receptor; HEK; human embryonic kidney; 2MeSADP; 2-methylthiol-ADP; ZM241385; 4-(2-[7-amino-2-(2-furyl)[1,2,4]-triazolo[2,3-α][1,3,5]triazin-5-yl amino]eth
Molecular mechanism of action for reversible P2Y12 antagonists
Keywords: گیرنده P2Y12; P2Y12 receptor; ADP; Antagonists; Platelets aggregation;
La thrombose de stent, de plus en plus rare !
Keywords: گیرنده P2Y12; Thrombose de stent; Agrégation plaquettaire; P2Y12; Stent thrombosis; Platelet aggregation; P2Y12 receptor;
Two-pore potassium ion channels are inhibited by both Gq/11- and Gi-coupled P2Y receptors
Keywords: گیرنده P2Y12; ADP, adenosine 5′-diphosphate; ATP, adenosine 5′-triphosphate; GPCR, G protein-coupled receptors; K2P, two-pore potassium ion channels; PTX, pertussis toxinTwo-pore potassium channels; K2P2.1; P2Y1 receptor; P2Y12 receptor
Part II: Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation
Keywords: گیرنده P2Y12; P2Y12 receptor; GPCR antagonist; Antiplatelet; Antithrombotic; Cardiovascular disease
Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation
Keywords: گیرنده P2Y12; P2Y12 receptor; GPCR antagonist; Antiplatelet; Antithrombotic; Cardiovascular disease; Polymer-assisted solution-phase
Piperazinyl-glutamate-pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation
Keywords: گیرنده P2Y12; P2Y12 receptor; P2Y12 antagonist; GPCR antagonist; Antiplatelet; Antithrombotic; Cardiovascular disease
The P2Y1 and P2Y12 receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues
Keywords: گیرنده P2Y12; Noradrenaline release; P2Y1 receptor; P2Y12 receptor; Autoreceptors; Receptor cross-talk
Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): Pharmacodynamic and pharmacokinetic characterization
Keywords: گیرنده P2Y12; BX 667; P2Y12 receptor; Platelet inhibitor
The influence of P2Y12 receptor deficiency on the platelet inhibitory activities of prasugrel in a mouse model: Evidence for specific inhibition of P2Y12 receptors by prasugrel
Keywords: گیرنده P2Y12; Prasugrel; P2Y12 receptor; Platelet; ADP; Knockout mouse;
Assessment of clopidogrel responsiveness: Measurements of maximum platelet aggregation, final platelet aggregation and their correlation with vasodilator-stimulated phosphoprotein in resistant patients
Keywords: گیرنده P2Y12; Platelet; Clopidogrel; Non-responsiveness; P2Y12 receptor; Maximum aggregation; Late aggregation
Clopidogrel resistance?
Keywords: گیرنده P2Y12; Clopidogrel; Responsiveness; Resistance; Platelet aggregation; P2Y12 receptor
Clopidogrel Resistance
Keywords: گیرنده P2Y12; Platelet activation; Platelet aggregation; Platelet aggregation inhibitors; Receptors, Purinergic P2; P2Y12 receptor; Adenosine Diphosphate; Clopidogrel; Clopidogrel resistance; Cytochrome P-450 Enzyme System; Resistance to drugs