Functional interaction between purinergic receptors: effect of ligands for A2A and P2Y12 receptors on P2Y1 receptor function

► A2AR, P2Y1R and P2Y12R are predominantly expressed on human platelets. ► Hetero-oligomerization between these three receptors has been shown to occur. ► Ca2+ signaling of P2Y1R agonist was inhibited by the A2AR and the P2Y12R antagonists. ► It was confirmed that this inhibition was mediated through these receptors.