Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; DHA, docosahexaenoic acid; ICAM-1, intercellular adhesion molecule-1; LOX1, lectin-like oxidized low-density lipoprotein receptor-1; TXA2R, thromboxane A2 receptor; TNF-α, tumor necrosis factor-alpha; PAI-1, plasminogen activator inhibitor-1; eNOS, endoth
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Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; DM, diabetes mellitus; CV, cardiovascular; IL, interleukin; IGF-1, insulin-like growth factor-1; miRNA, micro RNA; NF-κB, nuclear factor κB; PPARγ, peroxisome proliferator-activated receptor γ; PAI-1, plasminogen activator inhibitor-1; ROS, reactive oxyge
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; PAI-1, plasminogen activator inhibitor-1; TGF-β, transforming growth factor beta; GC, glucocorticoid; DEX, dexamethasone; GR, glucocorticoid receptor; GRE, glucocorticoid response element; ECM, extracellular matrix; pGR-S211, phosphorylation of GR at Ser2
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; 20; 37CLT, clot lysis time; ELISA, enzyme-linked immunosorbent assay; F, factor; PAI-1, plasminogen activator inhibitor-1; Sao2, oxygen saturation; TAFI, thrombin activatable fibrinolysis inhibitor; TFPI, tissue factor pathway inhibitor; vWF, von Willebra
Propofol alleviates electroconvulsive shock-induced memory impairment by modulating proBDNF/mBDNF ratio in depressive rats
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; ECT, electroconvulsive therapy; ECS, electroconvulsive seizure; mBDNF, mature brain-derived neurotrophic factor; proBDNF, precursor of mBDNF; TPA, tissue plasminogen activator; PAI-1, plasminogen activator inhibitor-1; CUMS, chronic unpredictable mild str
Tongqiaohuoxue decoction ameliorates obesity-induced inflammation and the prothrombotic state by regulating adiponectin and plasminogen activator inhibitor-1
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; THD, Tongqiaohuoxue decoction; HFD, high-fat diet; HFD+THD, THD-treated mice on a HFD; PAI-1, plasminogen activator inhibitor-1; TNF, tumor necrosis factor; MCP-1, monocyte chemoattractant protein-1; IL, interleukin; TG, triglyceride; tPA, tissue-type pla
Modification of a traditional breakfast leads to increased satiety along with attenuated plasma increments of glucose, C-peptide, insulin, and glucose-dependent insulinotropic polypeptide in humans
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; Adipokines; Blood glucose; Diet; Gastrointestinal hormones; Humans; SatietyAUC, area under the curve; BMI, body mass index; GIP, glucose-dependent insulinotropic polypeptide; GLP-1, glucagon-like peptide-1; PAI-1, plasminogen activator inhibitor-1; VAS, v
Gemigliptin, a dipeptidyl peptidase-4 inhibitor, inhibits retinal pericyte injury in db/db mice and retinal neovascularization in mice with ischemic retinopathy
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; ROS, reactive oxygen species; DPP-4, dipeptidyl peptidase-4; GLP-1, glucagon-like peptide-1; VEGF, vascular endothelial growth factor; ICAM-1, intercellular adhesion molecule-1; PAI-1, plasminogen activator inhibitor-1; PEDF, pigment epithelium-derived fa
Positive association of adiponectin with soluble thrombomodulin, von Willebrand factor and soluble VCAM-1 in dyslipidemic subjects
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; vWF, von Willebrand factor; PAI-1, plasminogen activator inhibitor-1; t-PA, tissue-plasminogen activator; sTM, soluble thrombomodulin; sICAM-1, soluble intercellular adhesion molecule; sVCAM-1, soluble vascular cell adhesion molecule; hs-CRP, high sensiti
Self-reported sleep disturbance is associated with elevated levels of PAI-1 in individuals with a recorded history of depressive symptoms
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; PAI-1, plasminogen activator inhibitor-1; MetS, metabolic syndrome; MDD, major depressive disorder; BDI, Beck Depression Inventory; BMI, body mass index; 15D, 15-dimensional questionnaire; OSA, obstructive sleep apneaDepression; Inflammation; PAI-1; Sleep
Blockade by phosphorothioate aptamers of advanced glycation end products-induced damage in cultured pericytes and endothelial cells
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; AGEs, advanced glycation end products; EC, endothelial cells; VEGF, vascular endothelial growth factor; PAI-1, plasminogen activator inhibitor-1; RAGE, receptor for AGEs; SELEX, systematic evolution of ligands by exponential enrichment; AGEs–thioaptamers,
Paeoniflorin of Paeonia lactiflora prevents renal interstitial fibrosis induced by unilateral ureteral obstruction in mice
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; PF, paeoniflorin; UUO, unilateral ureteral obstruction; PAI-1, plasminogen activator inhibitor-1; TGF-β1, transforming growth factor β1; BMP-7, bone morphogenetic protein-7; ECM, extracellular matrix; EMT, epithelial–mesenchymal transition; FSP-1, fibrobl
The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; α-GI, Alpha-glucosidase inhibitors; D2, type 2 iodothyronine deiodinase; FXR, farnesoid X receptor; G-6-Pase, glucose 6-phosphatase; GLP-1, glucagon-like peptide-1; MCP-1, monocyte chemotactic protein-1; PAI-1, plasminogen activator inhibitor-1; TNF-α, tu
Bison meat has a lower atherogenic risk than beef in healthy men
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; FMD, Flow Mediated Dilation; IL-6, interleukin-6; PAI-1, plasminogen activator inhibitor-1; CRP, c-reactive protein; Ox-LDL, oxidized low-density lipoprotein; TG, triglycerides; PUFA, polyunsaturated fatty acids; SFA, saturated fatty acids; MUFA, monounsa
The relationship between aortic aneurysm sac thrombus volume on coagulation, fibrinolysis and platelet activity
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; AAA, Abdominal Aortic Aneurysm; ADP, Adenosine diphosphate; APC-PCI, activated protein C-protein C inhibitor complex; cm3, cubic centimetres; CTA, computed tomographic aortograms; IQR, Inter-quartile range; PAI-1, Plasminogen activator inhibitor-1; sP-Sel
Altered fibrin clot properties are associated with residual vein obstruction: Effects of lipoprotein(a) and apolipoprotein(a) isoform
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; DVT, deep vein thrombosis; Lp(a), lipoprotein (a); PAI-1, plasminogen activator inhibitor-1; RVO, residual vein obstruction; tPA, tissue-type plasminogen activator; VTE, venous thromboembolismCoagulation; Fibrin clot; Fibrinolysis; Lipoprotein(a); Venous
Thrombosis and obesity: Cellular bases
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; VCAM-1, vascular cell adhesion molecule-1; ICAM-1, inter-cellular adhesion molecule; MCP-1, monocyte chemotactic protein-1; NO, nitric oxide; TF, tissue factor; PAI-1, plasminogen activator inhibitor-1; TGF-β, transforming growth factor-β; CRP, C reactive
Coagulation and fibrinolytic system protein profiles in women with normal pregnancies and pregnancies complicated by hypertension
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; CTL, control; CH, complicated hypertension; PAI-1, plasminogen activator inhibitor-1; T-Pa, tissue type plasminogen activatorPregnancy; Preeclampsia; Coagulation; Fibrinolysis; T-Pa; Fibrinogen
Biochemical dynamics relevant to the safety of low-dose, intraclot alteplase for deep vein thrombosis
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; DVT, deep vein thrombosis; EACA, epsilon amino caproic acid; IU, international units; PAI-1, plasminogen activator inhibitor-1; tPA, tissue-type plasminogen activator inhibitor
Effect of premature aging on murine adipose tissue
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; SC, subcutaneous; GON, gonadal; PAI-1, plasminogen activator inhibitor-1; Bmal1, brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein 1; UCP-1, uncoupling protein-1; TNF-α, tumor necrosis factor-α; PPARα, peroxisome proliferator-ac
Effects of the insulin sensitizing drug, pioglitazone, and lipopolysaccharide administration on markers of systemic inflammation and clinical parameters in horses
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; EMS, equine metabolic syndrome; NIDDM, non-insulin dependent (type 2) diabetes mellitus; APP, acute phase proteins; SAA, serum amyloid A; PAI-1, plasminogen activator inhibitor-1; TZD, thiazolidinedione; PPARγ, peroxisome proliferator-activated receptor-γ
Vascular endothelial growth factor and uPA/suPAR system in early and advanced chronic kidney disease patients: a new link between angiogenesis and hyperfibrinolysis?
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; CKD, chronic kidney disease; CVD, cardiovascular disease; ECM, extracellular matrix; eGFR, estimated glomerular filtration rate; NKF-KDOQI, National Kidney Foundation-kidney disease outcomes quality initiative; PAI-1, plasminogen activator inhibitor-1; PA
Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; SFN, DL-sulforaphane; Nrf2, NF-E2-related factor 2; TGF-β, transforming growth factor-β; BDL, bile duct ligation; TIMP-1, tissue inhibitor of matrix metalloproteinase-1; PAI-1, plasminogen activator inhibitor-1; ECM, extracellular matrix; HSC, hepatic ste
Activated inflammatory cells participate in thrombus size through tissue factor and plasminogen activator inhibitor-1 in acute coronary syndrome: Immunohistochemical analysis
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; ACS, acute coronary syndrome; MPO, myeloperoxidase; TF, tissue factor; PAI-1, plasminogen activator inhibitor-1; HE, hematoxylin and eosin; Azan, Azan-Mallory; PTAH, phosphotungstic acid hematoxylinAcute coronary syndrome; Pathology; Thrombus; Leukocytes;
Neutrophil–cytokine interactions in a rat model of sulindac-induced idiosyncratic liver injury
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; ALT, alanine aminotransferase; CINC-1, cytokine-induced neutrophil chemoattractant-1; HOCl, hypochlorous acid; LPS, lipopolysaccharide; MIP-1α, macrophage inflammatory protein-1α; PAI-1, plasminogen activator inhibitor-1; PMN, polymorphonuclear neutrophil
Plasminogen activator inhibitor-1 is an aggregate response factor with pleiotropic effects on cell signaling in vascular disease and the tumor microenvironment
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; PAI-1, plasminogen activator inhibitor-1; uPA, urokinase plasminogen activator; tPA, tissue plasminogen activator; MMP, matrix metalloprotease; uPAR, urokinase plasminogen activator receptor; VN, vitronectin; LRP-1, low density lipoprotein-like receptor-1
Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; PAI-1, plasminogen activator inhibitor-1; tPA, tissue-type plasminogen activator; HCAEC, human coronary artery endothelial cells; MAPK, mitogen activated protein kinasesLeptin; Plasminogen activator inhibitor; Atherosclerosis; Obesity; Fibrinolysis
CHFR functions as a ubiquitin ligase for HLTF to regulate its stability and functions
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; CHFR, checkpoint protein with FHA and RING finger domains; HLTF, helicase-like transcription factor; PAI-1, plasminogen activator inhibitor-1; FHA, forkhead-associated; CR, cysteine-rich; GST, glutathione S-transferaseCHFR; HLTF; Ubiquitination; PAI-1; Ce
Circulating levels and hepatic expression of molecular mediators of atherosclerosis in nonalcoholic fatty liver disease
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; PAI-1, plasminogen activator inhibitor-1; sICAM-1, soluble intercellular adhesion molecule-1; sCD40L, soluble CD40 ligand; ELISA, enzyme-linked immuno-sorbent assayICAM-1; PAI-1;
The impact of the PAI-1 4G/5G polymorphism on the outcome of patients with ALI/ARDS
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; ALI, acute lung injury; ARDS, acute respiratory distress syndrome; PAI-1, plasminogen activator inhibitor-1; BALF, bronchoalveolar lavage fluid; PCR, polymerase chain reaction; ICU, intensive care unit; PEEP, positive end-expiratory pressure; FiO2, fracti
Synthetic retinoid Am80 inhibits interaction of KLF5 with RARα through inducing KLF5 dephosphorylation mediated by the PI3K/Akt signaling in vascular smooth muscle cells
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; ATRA, all-trans retinoic acid; DMSO, dimethyl sulfoxide; FBS, fetal bovine serum; iNOS, inducible NO synthase; KLF5, Krüppel-like factor 5; MAPK, mitogen-activated protein kinase; PAI-1, plasminogen activator inhibitor-1; PI3K, phosphoinositide 3-kinase;
Transgenic overexpression of a stable Plasminogen Activator Inhibitor-1 variant
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; PAI-1, Plasminogen Activator Inhibitor-1; SERPIN, Serine Protease Inhibitor; tPA, tissue Plasminogen Activator; uPA, urokinase Plasminogen Activatorfibrinolysis; serine protease inhibitor; latency; transgene
Differential requirement for MEK/ERK and SMAD signaling in PAI-1 and CTGF expression in response to microtubule disruption
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; PAI-1, plasminogen activator inhibitor-1; CTGF, connective tissue growth factor; EGFR, epidermal growth factor receptor; ROS, reactive oxygen species; ERK, extracellular signal-regulated kinases; ROCK, Rho-associated, coiled-coil containing protein kinase
Human Neuroserpin: Structure and Time-Dependent Inhibition
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; hNS, human neuroserpin; tPA, tissue plasminogen activator; RCL, reactive centre loop; FENIB, familial encephalopathy with neuroserpin inclusion bodies; IPR-pNA, H-D-Ile-Pro-Arg-p-nitroanilide; PAI-1, plasminogen activator inhibitor-1; VR-1, tPA variable r
Characteristic response of astrocytes to plasminogen/plasmin to upregulate transforming growth factor beta 3 (TGFβ3) production/secretion through proteinase-activated receptor-1 (PAR-1) and the downstream phosphatidylinositol 3-kinase (PI3K)-Akt/PKB signa
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; CNS, central nervous system; PLGn, plasminogen; PAI-1, plasminogen activator inhibitor-1; PLn, plasmin; TGFβ, transforming growth factor beta; PAR, proteinase-activated receptor; PI3K, phosphatidylinositol 3 kinase; PKB, protein kinase B; CM, conditioned
S35225 is a direct inhibitor of Plasminogen Activator Inhibitor type-1 activity in the blood
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; PAI-1, Plasminogen Activator Inhibitor-1; rhPAI-1, active recombinant human PAI-1; rrPAI-1, active recombinant rat: PAI-1; uPA, urokinase; tPA, tissue-type plasminogen activato; DMSO, dimethylsulfoxyde.PAI-1; PAI-1, inhibitor; Thrombolysis; Fibrinolysis;
Impaired capacity for acute endogenous fibrinolysis in smokers is restored by ascorbic acid
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; CRP, C-reactive protein; FBF, forearm blood flow; PAI-1, plasminogen activator inhibitor-1; SNP, sodium nitroprusside; t-PA, tissue plasminogen activatorVitamin C; Endothelial dysfunction; Endogenous fibrinolysis
C-reactive protein increases plasminogen activator inhibitor-1 expression in human endothelial cells
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; CRP, C-reactive protein; PAI-1, plasminogen activator inhibitor-1; HCAEC, human coronary artery endothelial cell; MAPK, mitogen-activated protein kinase; HMVEC-L, human lung microvascular endothelial cell; HUVEC, human umbilical vein endothelial cell; HME
Effects of IL-1β and IL-6 on tissue-type plasminogen activator expression in vascular endothelial cells
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; t-PA, Tissue-type plasminogen activator; IL, Interleukin; HUVEC, Human umbilical vein endothelial cells; NF-κB, Nuclear factor κB; MAPK, Mitogen activated protein kinase; PAI-1, Plasminogen activator inhibitor-1; TNF-α, Tumor necrosis factor-α; EMSA, Elec
NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; DCFH-DA, dichlorofluorescein diacetate; DHE, dihydroethidium; DPI, diphenyleneiodonium; EtBr, ethidium bromide; ICAM-1, intercellular adhesion molecule-1; NAC, N-acetylcysteine; NFκB, nuclear factor kappaB; PAI-1, plasminogen activator inhibitor-1; QOL, q
The role of proteases in transforming growth factor-β activation
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; TGF-β, transforming growth factor-β; LAP, latency associated peptide; LTBP, latent TGFβ Binding Protein; PAR, protease activated receptor; TSP1, thrombospondin-1; PAI-1, plasminogen activator inhibitor-1; uPA, urokinase type plasminogen activator; tPA, ti
Thrombospondin-1 enhances human thyroid carcinoma cell invasion through urokinase activity
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; ECM, extracellular matrix; FTC, follicular thyroid carcinoma; MMP, matrix metalloproteinase; PAI-1, plasminogen activator inhibitor-1; TIMP2, tissue inhibitor of metalloproteinase-2; TSP-1, thrombospondin-1; uPA, urokinase plasminogen activator; uPAR, uPA
Hepatocyte Growth Factor Suppresses Profibrogenic Signal Transduction via Nuclear Export of Smad3 With Galectin-7
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; HGF, hepatocyte growth factor; HSC, hepatic stellate cell(s); MRP, migration inhibitory factor-related protein; PAI-1, plasminogen activator inhibitor-1; SBE, Smad binding element; SDS, sodium dodecyl sulfa
Inhibition of oxidative-stress-induced platelet aggregation by androgen at physiological levels via its receptor is associated with the reduction of thromboxane A2 release from platelets
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; DHT, dihydrotestosterone; ADP, adenosine 5′-diphosphate; TXA2, thromboxane A2; TXB2, thromboxane B2; H2O2, hydrogen peroxide; CVST, cerebral venous sinus thrombosis; PAI-1, plasminogen activator inhibitor-1; PRP, platelet-rich plasma; PPP, platelet-poor p
Changes in peritoneal mesothelial cells phenotype after chronic exposure to glucose or N-acetylglucosamine
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; EDTA, ethylenediamine tetraacetic acid; IL-6, interleukin-6; NAG, N-acetylglucosamine; PAI-1, plasminogen activator inhibitor-1; PDT, population doubling time; ROS, reactive oxygen species; TCA, trichloric acid; TGFβ, transforming growth factor beta; t-PA
Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; EMSA, electrophoretic mobility shift assay; hMCs, human mast cells; NRE, negative regulatory element; PA, plasminogen activator; PAI-1, plasminogen activator inhibitor-1; TFE3, transcription factor E3; USF, upstream stimulating factor; WT, wild-typePlasmi
Coagulation markers in healthy human subjects exposed to diesel exhaust
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; CRP, C-reactive protein; DE, diesel exhaust; DE100, 100 μg PM2.5/m3; DE200, 200 μg PM2.5/m3; FA, filtered air; PAI-1, plasminogen activator inhibitor-1; PM, particulate matter; PM2.5, particulate matter of 2.5 μm or less; TEOM, tapered element oscillating
Salvianolic acid B modulates hemostasis properties of human umbilical vein endothelial cells
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; SM, Salvia multiorrhiza; Sal B, salvianolic acid B; HUVECs, human umbilical vein endothelial cells; TM, thrombomodulin; t-PA, tissue-type plasminogen activator; PAI-1, plasminogen activator inhibitor-1
PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; BDL, Bile duct ligation; HGF, hepatocyte growth factor; MMP, matrix metalloproteinase; PAI-1, plasminogen activator inhibitor-1; qRT-PCR, quantitative real time reverse transcriptase polymerase chain reaction; TGF-β1, transforming growth factor-beta 1; tP
Integrin α6 cleavage: A novel modification to modulate cell migration
Keywords: PAI-1، مهارکننده فعال کننده پلاسمینوژن-1; uPA, urokinase-type plasminogen activator; PAI-1, plasminogen activator inhibitor-1; EGF, epidermal growth factor; SDS, sodium dodecyl sulphate; PAGE, polyacrylamide gel electrophoresis; DOX, doxycyclineIntegrin α6; Cleavage; Prostate cancer; ECM; Migrati