Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; BBB; blood-brain barrier; BCAO; bilateral carotid artery occlusion; Cbx; carbenoxolone; CM; conditioned media; Cx43; connexin43; Cxs; connexins; ECM; extracellular matrix; FGF1; fibroblast growth factor; GFAP;