کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8299821 | 1537137 | 2018 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interactions of Pannexin1 channels with purinergic and NMDA receptor channels
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کلمات کلیدی
AMPPannexinspannexin1NMDARN-methyl-d-aspartateNMDAADPARSNMDA receptor - NMDA گیرندهadenosine 5′-triphosphate - آدنوزین 5'-تری فسفاتadenosine 5′-diphosphate - آدنوزین 5'-دی فسفاتATP - آدنوزین تری فسفات یا ATPadenosine monophosphate - آدنوزین مونوفسفرهCxs - تحت محاصرهCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیNMDA receptors - گیرنده NMDAP2X receptors - گیرنده های P2XPurinergic receptors - گیرنده های PurinergicAdenosine receptors - گیرنده های آدنوزین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Pannexins are a three-member family of vertebrate plasma membrane spanning molecules that have homology to the invertebrate gap junction forming proteins, the innexins. However, pannexins do not form gap junctions but operate as plasma membrane channels. The best-characterized member of these proteins, Pannexin1 (Panx1) was suggested to be functionally associated with purinergic P2X and N-methyl-D-aspartate (NMDA) receptor channels. Activation of these receptor channels by their endogenous ligands leads to cross-activation of Panx1 channels. This in turn potentiates P2X and NMDA receptor channel signaling. Two potentiation concepts have been suggested: enhancement of the current responses and/or sustained receptor channel activation by ATP released through Panx1 pore and adenosine generated by ectonucleotidase-dependent dephosphorylation of ATP. Here we summarize the current knowledge and hypotheses about interactions of Panx1 channels with P2X and NMDA receptor channels. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1860, Issue 1, January 2018, Pages 166-173
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1860, Issue 1, January 2018, Pages 166-173
نویسندگان
Shuo Li, Ivana Bjelobaba, Stanko S. Stojilkovic,