Keywords: hPSC; human pluripotent stem cell; hiPSC; human induced pluripotent stem cell; NPC; neuronal progenitor cell; hPSC-NPC; human pluripotent stem cell derived neuronal progenitor cell; EB; embryoid body; CNS; central nervous system; DG; dentate gyrus; GECI;
مقالات ISI (ترجمه نشده)
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Keywords: Adora2a; adenosine A2a receptor; ACTH; adrenocorticotropic hormone; AVP; arginine vasopressin; α-CaMKII; Ca2+/calmodulin-dependent protein kinase II-α; β-actin; Rattus norvegicus actin, beta; cAMP; cyclic adenosine monophosphate; CORT; corticosterone;
Keywords: 5-HT; serotonin (5-hydroxytryptamine); A83-01; TGF-β kinase/activin receptor-like kinase inhibitor; ACTB; actin beta/beta-actin; ASCL1; achaete-scute homolog 1 (MASH1); ASOs; anti-sense oligonucleotides; Bcl-xL; b-cell lymphoma-extra large; BDNF; brain d
Keywords: Pax6; string; atonal; Evolution of development; Genetic redundancy; Arthropod; Ocular segment; Ocelli; Compound eye; Subfunctionalization; Neofunctionalization;
Keywords: Direct reprogramming; Induced neuronal cell; Retina; Fibroblast; Ascl1; Pax6;
Keywords: Pax6; Pitx3; Beta-crystallins; Eye disease; Neurogenesis; Parkinson's disease; Neourogenesis; Schizophrenia;
Keywords: Ovarian cancer; Chemotherapy resistance; Natural compounds; Autophagy; Apoptosis; Ovarian cancer stem-like cells; ABCG2; ATP-binding cassette G2; AE; Amla extracts; Akt; protein kinase B; ALDH1; aldehyde dehydrogenase 1; ARE; antioxidant-response element;
Keywords: 2210010C04Rik; RIKEN cDNA 2210010C04 gene; 5330417C22Rik; RIKEN cDNA 5330417C22 gene; A1AT; alpha1-antitrypsin; Ago1; argonaute RISC catalytic component 1; Amy2a5; amylase 2a5; Amy2b; amylase, alpha 2B; AP1/JUN; jun proto-oncogene; Bmp; bone morphogenetic
Keywords: ARC; activity-regulated cytoskeleton-associated protein; CA; cornu ammonis; CALB2; calbindin-D-29K; COX2; cyclooxygenase-2; DAB; 3,3â²-diaminobenzidine; DCX; doublecortin; DNT; developmental neurotoxicity; DPYSL3; dihydropyrimidinase-like 3; EOMES; eomes
Keywords: Crystalline lens; Ionizing radiation; DNA repair factors; Nontargeted effects; Inflammation; Tumor suppressors; A-bomb; atomic-bomb; Acvr1; activin A type 1 receptor; AP; apurinic/apyrimidinic; APE1; apurinic/apyrimidinic endonuclease 1; AQP; aquaporin; A
Keywords: Calb1; Calbindin-D-28K; Calb2; Calretinin; CT; Threshold cycle; DAB; 3,3â²-diaminobenzidine; DCX; Doublecortin; Dpysl3; Dihydropyrimidinase-like 3; GABA; Gamma-aminobutyric acid; Gapdh; Glyceraldehyde 3-phosphate dehydrogenase; GFAP; Glial fibrillary aci
Keywords: DAPI; 4â²,6-diamidino-2-phenylindole; DCX; doublecortin; DG; dentate gyrus; DGM; deep gray matter; FAM; 6-carboxy-fluorescein; GCL; granule cell layer; HPRT; hypoxanthine-guanine phosphoribosyltransferase; NSC; neuronal stem cell; NeuN; neuronal nuclei
Knockdown of the thyroid hormone transporter MCT8 in chicken retinal precursor cells hampers early retinal development and results in a shift towards more UV/blue cones at the expense of green/red cones
Keywords: Thyroid hormone; Monocarboxylate transporter 8; Retina; Development; Chicken embryo; RNA interference; AP; alkaline phosphatase; BRN3a; brain-specific homeobox/POU domain protein 3a; CNS; central nervous system; CRX; Cone-Rod homeobox; DAC; displaced amac
In silico analysis of Pax6 protein glycosylation in vertebrates
Keywords: PD; paired domain; HD; homeodomain; PST; Proline/Serine/Threonine; Pro; proline; Ser; serine; Thr; threonine; Asn; asparagine; GlcNAc; N-acetylglucosamine; GalNAc; N-acetylgalactosamine; 3D; three dimensional; 2D; secondary structure; EVP; enhancement val
Generation of Pax6-IRES-EGFP knock-in mouse via the cloning-free CRISPR/Cas9 system to reliably visualize neurodevelopmental dynamics
Keywords: Pax6; IRES; EGFP; CRISPR/Cas9; knock-in mouse;
Coordinate regulation by transcription factors and DNA methylation in the core promoter region of SIRT6 in bovine adipocytes
Keywords: SIRT6; Promoter; Transcriptional regulation; DNA methylation; Bovine; Adipocyte; qPCR; real-time quantitative; CEBPβ; CCAAT enhancer binding protein beta; PAX6; paired box 6; KLF2; Kruppel-like factor 2; CMYB; myb proto-oncogene protein; NRF1; nuclear re
Age-dependent alterations in expression and co-localization of Pax6 and Ras-GAP in brain of aging mice
Keywords: HP; hippocampus; OL; olfactory lobe; C; cerebellum; CC; cerebral cortex; Amyg; amygdala; CN; caudate nucleus; DG; dentate gyrus; SGZ; sub granular zone; GlLa; glomerular layer; GrCl; granular cell layer; MiCe; mitral cell layer; InPl; internal plexiform l
A long range distal enhancer controls temporal fine-tuning of PAX6 expression in neuronal precursors
Keywords: PAX6; NEUROG2; Retinoic acid; Neural tube; Transcriptional regulation;
Anolis carolinensis as a model to understand the molecular and cellular basis of foveal development
Keywords: Fovea; Development; Anolis carolinensis; Green anole; Pax6; Animal model;
Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation
Keywords: TSC; Tuberous Sclerosis Complex; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; LOH; loss of heterozygosity; iPSCs; induced pluripotent stem cells; NPCs; neural progenitor cells; PI3K; phosphoinositide 3-kinase; SENs; subependymal nodules; S
An overview of type 2 diabetes and importance of vitamin D3-vitamin D receptor interaction in pancreatic β-cells
Keywords: Vdr; vitamin D receptor; 1,25(OH)2D3; 1α 25 dihydroxyvitamin D3; VDRE; vitamin D response element; CYP24A1; 1 α, 25dihydroxyvitaminD3 24-hydroxylase; DRIP; vitamin D receptor interacting protein complex; Ins1; insulin 1; Ins2; insulin 2; Glut2; glucose
Short communicationA CGH array procedure to detect PAX6 gene structural defects
Keywords: Aniridia; PAX6; CGH array;
Pax6 interacts with Iba1 and shows age-associated alterations in brain of aging mice
Keywords: Pax6; Brain; Aging; Microglia; Inflammation;
Multiple sevoflurane anesthesia in pregnant mice inhibits neurogenesis of fetal hippocampus via repressing transcription factor Pax6
Keywords: Sevoflurane; Cognitive function; Neurogenesis; Pax6; Ccnd1; Lithium;
Comparative analysis of the neurula transcriptomes of two species of flatfishes: Platichthys stellatus and Paralichthys olivaceus
Keywords: BMP; Bone Morphogenetic Protein; BMPR; Bone Morphogenetic Protein Receptor; BLAST; Basic Local Alignment Search Tool; ERBB; Erb-b2 Receptor Tyrosine Kinase; FGF; Fibroblast Growth Factor; FGFR; Fibroblast Growth Factor Receptor; FZ; Frizzled; HOXB1B; Home
A mouse model of aniridia reveals the in vivo downstream targets of Pax6 driving iris and ciliary body development in the eye
Keywords: CNS; central nervous system; E14.5; embryonic day 14.5; PCR; polymerase chain reaction; TBE; Tris-boric acid-EDTA; OCT; optical cutting temperature; PBS; phosphate buffered saline; ORF; open reading frame; DMEM; Dulbecco's modified eagle's medium; BSA; bo
Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance
Keywords: FFAR1/GPR40; Free fatty acids; Insulin secretion; ENU-mutated Ffar1; FFAR1 deficient mice; High fat diet; CD; regular chow diet; ENU; N-ethyl-N-nitrosourea; FFAR1; free fatty acid receptor 1; GIIS; glucose-induced insulin secretion; GLP-1; glucagon like p
PAX6 regulates human corneal epithelium cell identity
Keywords: PAX6; CRISPR/Cas9; Corneal epithelial cell; Cornea; Keratinization; Corneal epithelium; Keratin 12; Transcription factor;
Experimental assessment of novel PAX6 splicing mutations in two Chinese families with aniridia
Keywords: PAX6; paired box gene 6; bp; base pair(s); del; delete; ins; insert; WAGR; Wilms tumor, aniridia, genitourinary anomalies and mental retardation; PD; paired domain; HD; homeodomain; PST; proline/serine/threonine-rich; PCR; polymerase chain reaction; NCBI;
MiR-433 inhibits retinoblastoma malignancy by suppressing Notch1 and PAX6 expression
Keywords: MiR-433; Retinoblastoma; Notch1; PAX6
Regulation of twin of eyeless during Drosophila development
Keywords: Drosophila melanogaster; Eye development; Pax6; twin of eyeless
Brg1 directly regulates Olig2 transcription and is required for oligodendrocyte progenitor cell specification
Keywords: Brg1; Oligodendrocyte progenitors; Radial glia; Olig2; Pax6;
Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development
Keywords: bMN; branchiomotor neurons; Leca; lens corneal adhesion; LMC; lateral motor column; MMC; medial motor column; Nkx2.2; Nk2 homeobox 2; Pax6; paired box 6; sMN; somatic motor neurons; Sp8; trans-acting transcription factor 8; vMN; visceromotor neurons; Pax6
A novel PAX6 deletion in a Chinese family with congenital aniridia
Keywords: aa; amino acid(s); bp; base pair(s); del; delete; fs; frameshift; cDNA; DNA complementary to RNA; dNTP; deoxyribonucleoside triphosphate; oligo; oligodeoxyribonucleotide; PAX6; paired box gene 6; PD; paired domain; HD; homeodomain; PCR; polymerase chain r
SOX2, OTX2 and PAX6 analysis in subjects with anophthalmia and microphthalmia
Keywords: Anophthalmia; Microphthalmia; SOX2; OTX2; PAX6
Hypermethylation in gastric cancer
Keywords: 5-hmC; 5-hydroxymethylcytosine; 5-mC; 5-methylcytosine; ADAM23; ADAM metallopeptidase domain 23; APC; adenomatosis polyposis coli; ATP; adenosine-triphosphate; BCL6B; B-Cell CLL/Lymphoma 6, Member B; BGS; bisulfite genomic sequencing; BMP-2; bone morphoge
MicroRNA-7: A miRNA with expanding roles in development and disease
Keywords: ACK1; activated CDC42 kinase 1; BASP1; brain abundant, membrane attached signal protein 1; c-Myc; v-Myc avian myelocytomatosis viral oncogene homolog; CD57; cluster of differentiation 57; CD44; cluster of differentiation 44; ciRS-7; circular RNA sponge fo
Xenopus laevis FGF receptor substrate 3 (XFrs3) is important for eye development and mediates Pax6 expression in lens placode through its Shp2-binding sites
Keywords: FGF; Frs3; Xenopus; Shp2; Eye development; Pax6; Lens placode;
Onecut1 and Onecut2 transcription factors operate downstream of Pax6 to regulate horizontal cell development
Keywords: Pax6; Onecut; Retina; Horizontal cell
Concomitant PIK3CA amplification and RASSF1A or PAX6 hypermethylation predict worse survival in gastric cancer
Keywords: Q-MSP; quantitative methylation-specific PCR; PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; RASSF1A; Ras association domain family 1 isoform A; PAX6; paired box 6; SDS; sodium dodecyl sulfate; H&E; hematoxylin and eosin;
Glucose modulates Pax6 expression through the JNK/p38 MAP kinase pathway in pancreatic beta-cells
Keywords: Pax6; Glucose; JNK; p38 MAP kinase; PTEN; Beta-cells
Extra-nuclear activity of INSM1 transcription factor enhances insulin receptor signaling pathway and Nkx6.1 expression through RACK1 interaction
Keywords: INSM1; insulinoma-associated antigen-1; Ngn3; neurogenin 3; Pdx-1; pancreatic duodenal homeobox-1; MafA; musculoaponeurotic fibrosarcoma oncogene homolog A; ITF; islet transcription factor; NeuroD/β2; neurogenic differentiation factor D/beta 2; Pax6; pai
Lens specific RLIP76 transgenic mice show a phenotype similar to microphthalmia
Keywords: RLIP76; lens development; microphthalmia; Hsf1; Hsf4b; Pax6; Cdc42; cytoskeleton organization
Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation
Keywords: Atonal; Eyeless; Pax6; Daughterless; bHLH proteins; Drosophila eye development;
The Pax6 genes eyeless and twin of eyeless are required for global patterning of the ocular segment in the Tribolium embryo
Keywords: Pax6; Eyeless; Dachshund; Tribolium; Drosophila; Evolution of development; Eye; Visual system; Mushroom body; Bilaterian brain;
A survey of ancient conserved non-coding elements in the PAX6 locus reveals a landscape of interdigitated cis-regulatory archipelagos
Keywords: Ancient conserved gnathostome enhancers; Reporter transgenics; PAX6; Elephant shark; Long-range enhancers; cis-Regulatory landscape; Regulatory archipelagos;
Pax6 is expressed in subsets of V0 and V2 interneurons in the ventral spinal cord in mice
Keywords: Pax6; Ventral spinal cord; V2 interneurons; V0 interneurons;
MiR-365b-3p, down-regulated in retinoblastoma, regulates cell cycle progression and apoptosis of human retinoblastoma cells by targeting PAX6
Keywords: miRNA, microRNA; miR-365b-3p, microRNA-365b-3p; RB, retinoblastoma; UTR, untranslated region; EGFP, enhanced green fluorescence protein; GAPDH, glyceraldehyde phosphate dehydrogenaseRetinoblastoma; PAX6; MicroRNA-365b-3p; Cell cycle; Cell apoptosis
Guía para el estudio genético de la aniridia
Keywords: Guía; Estudio genético; Aniridia; PAX6; Consejo genéticoGuideline; Genetic testing; Aniridia; PAX6; Genetic counseling
Prenatal exposure to bisphenol A interferes with the development of cerebellar granule neurons in mice and chicken
Keywords: BPA, bisphenol A; DIV, days in vitro; ED, embryonic day; EGL, external granule layer; H&E, hematoxylin and eosin; IGL, internal granule layerBisphenol A; Cerebellar granule neuron; Pax6