Keywords: مدل سازی PBPK; Risk assessment; Exposure; Prediction; Reverse dosimetry; PBPK modeling; Plethem;
مقالات ISI مدل سازی PBPK (ترجمه نشده)
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Keywords: مدل سازی PBPK; Hg-Se interaction; MeHg demethylation; Marine fish; PBPK modeling;
Keywords: مدل سازی PBPK; Prediction of tissue distribution; Lysosomal sequestration; Basic drugs; PBPK modeling;
Keywords: مدل سازی PBPK; Biorelevant dissolution testing; USP apparatus III (BioDis); USP apparatus IV (flow-through cell); Food effects; Zolpidem; PBPK modeling; Qgut; Deconvolution;
Keywords: مدل سازی PBPK; PBPK modeling; Personalized medicine; Individualized treatment; Therapeutic drug monitoring; Pharmacokinetics;
Keywords: مدل سازی PBPK; PBPK modeling; Allometric scaling; Species difference; Urine; Phthalate
Keywords: مدل سازی PBPK; Perchlorate; Iodide; PBPK modeling; Thyroid hormones; DWEL; Drinking Water Equivalent Level; EPA; US Environmental Protection Agency; FDA; US Food and Drug Administration; fT4; free thyroxine levels; HPT; hypothalamic pituitary thyroid; NHANES; National H
Keywords: مدل سازی PBPK; ABC; ATP-binding cassette; ATR; atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-s-triazine; AUC; area under the curve; BW; body weight; 14C-ATR; 14C-atrazine; DACT; didealkylatrazine, 2-chloro-4,6-diamino-1,3,5-triazine; DE; desethylatrazine, 2-chlor
Comparing dietary and non-dietary source contribution of BPA and DEHP to prenatal exposure: A Catalonia (Spain) case study
Keywords: مدل سازی PBPK; Bisphenol-A; Di-(2-ethylhexyl) phthalate (DEHP); PBPK modeling; Exposure assessment;
Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mech
Keywords: مدل سازی PBPK; DMPK; hepatocytes; IVIVC; PBPK modeling; pharmacokinetics; unbound fraction;
Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption
Keywords: مدل سازی PBPK; Biorelevant dissolution; Weak base; PBPK modeling; BCS class II; pH dependent solubility; ACAT; advanced compartmental absorption and transit model; ADAM; advanced dissolution, absorption and metabolism model; API; active pharmaceutical ingredient; ASD;
Integration of a plasma protein binding factor to the Chemical-Specific Adjustment Factor (CSAF) for facilitating the estimation of uncertainties in interspecies extrapolations when deriving health-based exposure limits for active pharmaceutical ingredien
Keywords: مدل سازی PBPK; API; ADE; OEL; Occupational exposure limits; Pharmacokinetics; PBPK modeling; PDE; Protein binding; RFD; Toxicological risk assessment;
Using physiologically based pharmacokinetic modeling and benchmark dose methods to derive an occupational exposure limit for N-methylpyrrolidone
Keywords: مدل سازی PBPK; Occupational exposure limit; Benchmark dose; PBPK modeling; Developmental toxicity; Window of susceptibility;
Route-to-route extrapolation of 1,2-dichloroethane studies from the oral route to inhalation using physiologically based pharmacokinetic models
Keywords: مدل سازی PBPK; Ethylene dichloride; 1,2-dichloroethane; Extended one-generation study; PBPK modeling; Route-to-route extrapolation;
PBPK model of methotrexate in cerebrospinal fluid ventricles using a combined microdialysis and MRI acquisition
Keywords: مدل سازی PBPK; CSF; cerebrospinal fluid; MTX; methotrexate; PET; positron emission tomography; PBPK; Physiologically Based Pharmacokinetics; MRI; magnetic resonance imaging; IM; intramuscular administration; IV; intravenous administration; Gd-DOTA; gadolinium chelate; A
Derivation of exposure factors for infant lactational exposure to persistent organic pollutants (POPs)
Keywords: مدل سازی PBPK; Infant; Breast milk; Exposure; Risk assessment; Infant:mother ratio; Exposure factor; Persistent organic pollutants; PBPK modeling; Pharmacokinetic; Variability;
Drug Distribution to Human Tissues: Prediction and Examination of the Basic Assumption in In Vivo Pharmacokinetics-Pharmacodynamics (PK/PD) Research
Keywords: مدل سازی PBPK; ADME; clinical pharmacokinetics; disposition; distribution; partition coefficients; pharmacokinetics; PKPD; PBPK modeling;
The probabilistic aggregate consumer exposure model (PACEM): Validation and comparison to a lower-tier assessment for the cyclic siloxane D5
Keywords: مدل سازی PBPK; Aggregate exposure; Tiered approach; PBPK modeling; Human biomonitoring; Decamethylcyclopentasiloxane;
Prediction of Drug Distribution in Subcutaneous Xenografts of Human Tumor Cell Lines and Healthy Tissues in Mouse: Application of the Tissue Composition-Based Model to Antineoplastic Drugs
Keywords: مدل سازی PBPK; ADME; chemotherapy; oncology; disposition; distribution; partition coefficients; pharmacokinetics; PBPK modeling; tumor; xenograft;
Physiologically based pharmacokinetic modeling of POPs in Greenlanders
Keywords: مدل سازی PBPK; DDE; Greenland; HCB; Humans; Oxychlordane; PBPK modeling
The sub-chronic oral toxicity of 1,3,5-trimethylbenzene in Sprague-Dawley rats
Keywords: مدل سازی PBPK; 123-TMB; 1,2,3-trimethylbenzene; 124-TMB; 1,2,4-trimethylbenzene; 135-TMB; 1,3,5-trimethylbenzene; 5â²-NT; 5â²-nucleotidase; ACGIH; American Conference of Governmental Industrial Hygienists; ALT; alanine aminotransferase; AP; alkaline phosphatase; ASVCP
Hepatocyte Composition-Based Model as a Mechanistic Tool for Predicting the Cell Suspension: Aqueous Phase Partition Coefficient of Drugs in In Vitro Metabolic Studies
Keywords: مدل سازی PBPK; distribution; hepatocytes; liver; metabolism; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;
Prediction of Total Hepatic Clearance by Combining Metabolism, Transport, and Permeability Data in the In Vitro-In Vivo Extrapolation Methods: Emphasis on an Apparent Fraction Unbound in Liver for Drugs
Keywords: مدل سازی PBPK; hepatocytes; intrinsic clearance; unbound fraction; metabolism; transport; permeability; in vitro-in vivo extrapolation; in vitro-in vivo correlation; IVIVE; pharmacokinetics; physiologically based pharmacokinetics; PBPK modeling;
Development of a Hybrid Physiologically Based Pharmacokinetic Model with DrugâSpecific Scaling Factors in Rat to Improve Prediction of Human Pharmacokinetics
Keywords: مدل سازی PBPK; ADME; in vitroâin vivo extrapolation (IVIVE); metabolic clearance; modeling and simulation; PBPK modeling; pharmacokinetics; physiological model; prediction of human pharmacokinetics; simulations; translational research;
Toward a new paradigm for the efficient in vitro–in vivo extrapolation of metabolic clearance in humans from hepatocyte data
Keywords: مدل سازی PBPK; hepatocytes; intrinsic clearance; unbound fraction; computational ADME; in vitro–in vivo extrapolation; in vitro–in vivo correlation; IVIVE; pharmacokinetics; physiologically based pharmacokinetics; PBPK modeling
Prediction and evaluation of route dependent dosimetry of BPA in rats at different life stages using a physiologically based pharmacokinetic model
Keywords: مدل سازی PBPK; Bisphenol A; PBPK modeling; Rats; Kinetics; Rat pups; BPA
Correlation of Tissue-Plasma Partition Coefficients Between Normal Tissues and Subcutaneous Xenografts of Human Tumor Cell Lines in Mouse as a Prediction Tool of Drug Penetration in Tumors
Keywords: مدل سازی PBPK; ADME; chemotherapy; oncology; disposition; distribution; partition coefficients; pharmacokinetics; PBPK modeling; xenograft;
Tissue lipids and drug distribution: Dog versus rat
Keywords: مدل سازی PBPK; dog; tissue constituents; in silico modeling; pharmacokinetics; phospholipids; tissue partition; physiological model; physicochemical properties; partition coefficients; PBPK modeling;
Biologically-based modeling insights in inhaled vapor absorption and dosimetry
Keywords: مدل سازی PBPK; Pulmonary vapor absorption; Inhalation dosimetry; PBPK modeling
In Vitro-In Vivo Extrapolation of Clearance: Modeling Hepatic Metabolic Clearance of Highly Bound Drugs and Comparative Assessment with Existing Calculation Methods
Keywords: مدل سازی PBPK; disposition; microsomes; hepatic clearance; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;
Comparative Assessment of In Vitro-In Vivo Extrapolation Methods used for Predicting Hepatic Metabolic Clearance of Drugs
Keywords: مدل سازی PBPK; disposition; microsomes; clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; in vitro-in vivo correlation; IVIVE; pharmacokinetics; PBPK modeling;
Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents
Keywords: مدل سازی PBPK; PBPK modeling; Benzo[a]pyrene; Dibenzo[def,p]chrysene; Polycyclic aromatic hydrocarbons;
Pharmacokinetic modeling: Prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans
Keywords: مدل سازی PBPK; Bisphenol A; PBPK modeling; Kinetics; Monkey; Human
Extension of a PBPK model for ethylene glycol and glycolic acid to include the competitive formation and clearance of metabolites associated with kidney toxicity in rats and humans
Keywords: مدل سازی PBPK; Ethylene glycol; Glycolic acid; Glyoxylic acid; Oxalic acid; Calcium oxalate; Kidney toxicity; PBPK modeling;
Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes
Keywords: مدل سازی PBPK; distribution; microsomes; clearance; metabolism; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;
PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration-time profiles in human by using the physiologicallyâbased pharmacokinetic modeling approach
Keywords: مدل سازی PBPK; animal alternative; computational ADME; drug discovery; drug development; absorption; distribution; disposition; in vitro-in vivo correlation; pharmacokinetics; PBPK modeling;
Analysis of Nifedipine Absorption from Soft Gelatin Capsules Using PBPK Modeling and Biorelevant Dissolution Testing
Keywords: مدل سازی PBPK; absorption; biorelevant media; computational ADME; dissolution; nifedipine; PBPK modeling; pharmacokinetics; PK-Sim; precipitation; solubility;
Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model
Keywords: مدل سازی PBPK; Deltamethrin; Pyrethroids; Toxicokinetics; PBPK modeling; Maturation; Children's risk assessment
Extrapolating In vitro Metabolic Interactions to Isolated Perfused Liver: Predictions of Metabolic Interactions between R-Bufuralol, Bunitrolol, and Debrisoquine
Keywords: مدل سازی PBPK; metabolism in vitro; in vitro-in vivo extrapolation; IVIVE; drug interaction; DDI; microsomes; liver model; isolated perfused liver; metabolic clearance; PBPK modeling;
Prediction of food effects on the absorption of celecoxib based on biorelevant dissolution testing coupled with physiologically based pharmacokinetic modeling
Keywords: مدل سازی PBPK; Food effects; Dissolution; Prediction; PBPK modeling; Celecoxib
Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods
Keywords: مدل سازی PBPK; distribution; volume of distribution; in vitro models; pharmacokinetics; physiological modeling; PBPK modeling; tissue/plasma partition coefficients;
Are highly lipophilic volatile compounds expected to bioaccumulate with repeated exposures?
Keywords: مدل سازی PBPK; Decamethylcyclopentasiloxane (D5); Octamethylcyclotetrasiloxane (D4); Inhalation pharmacokinetics; PBPK modeling; Bioaccumulation; Volatile compounds
General approach for the calculation of tissue to plasma partition coefficients
Keywords: مدل سازی PBPK; Tissue:plasma partition coefficients; Tissue distribution; Tissue exposure; PBPK modeling
Application of PBPK modeling in support of the derivation of toxicity reference values for 1,1,1-trichloroethane
Keywords: مدل سازی PBPK; PBPK modeling; 1,1,1-Trichloroethane; Internal dose metric; Extrapolation; Health risk assessment; Reference dose (RfD); Reference concentration (RfC)
Quantitative Interpretation of Human Biomonitoring Data
Keywords: مدل سازی PBPK; Biomonitoring; Pharmacokinetics; PBPK modeling; Risk assessment
A physiologically based pharmacokinetic (PBPK) model to characterize and predict the disposition of monoclonal antibody CC49 and its single chain Fv constructs
Keywords: مدل سازی PBPK; Antibody pharmacokinetics; PBPK modeling; Tumor radioimmunotherapy; scFvs; IgG; FcRn
Initial analyses of the relationship between “Thresholds” of toxicity for individual chemicals and “Interaction Thresholds” for chemical mixtures
Keywords: مدل سازی PBPK; Chemical mixtures; Interaction thresholds; Dose-response relationship; NHEK cells; MCF cells; PBPK modeling; Metals; Endocrine disruptors; Gasoline; BMDS
Oral absorption and oxidative metabolism of atrazine in rats evaluated by physiological modeling approaches
Keywords: مدل سازی PBPK; PBPK modeling; Atrazine; DACT
Physiologically Based Pharmacokinetic (PBPK) Modeling of Disposition of Epiroprim in Humans
Keywords: مدل سازی PBPK; allometric scaling; biliary excretion; clearance; distribution; hepatocyte; PBPK modeling;
The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene
Keywords: مدل سازی PBPK; PBPK modeling; Risk assessment; Perchloroethylene; Markov chain Monte Carlo