کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5857203 | 1131996 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The sub-chronic oral toxicity of 1,3,5-trimethylbenzene in Sprague-Dawley rats
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کلمات کلیدی
NOAELUFSDMHABWABWHHydrocarbon solventACGIHECETOCUFAGGTLOAELUFHDNELRfDTBANTPALTDMBAPODTLVThreshold Limit Values1,2,4-Trimethylbenzene - 1،2،4-ترملتی بنزن1,3,5-Trimethylbenzene - 1،3،5-ترملتی بنزن5′-NT - 5'-NT5′-Nucleotidase - 5'-Nucleotidaseγ-glutamyltransferase - γ-گلوتامیل ترانسفرازAlanine aminotransferase - آلانین آمینوترانسفرازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییNational Toxicology Program - برنامه سم شناسی ملیTrimethylbenzene - تری متیل بنزنReference dose - دوز مرجعDerived No Effect Level - سطح متوالی بدون اثرOral toxicity - سمیت دهانیOccupational exposure limit - محدودیت قرار گرفتن در معرض شغلیPBPK modeling - مدل سازی PBPKPhysiologically based pharmacokinetic modeling - مدلسازی فارماکوکینتیک مبتنی بر فیزیولوژیMesitylene - مسیتیلنPoint of departure - نقطه عزیمتtotal bile acid - کل اسید صفراویAmerican Conference of Governmental Industrial Hygienists - کنفرانس آمریکایی بهداشت صنعتی دولتی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The systemic toxicity of a trimethylbenzene isomer and constituent of C9 aromatic solvents (1,3,5-trimethylbenzene, 135-TMB) was studied in Sprague-Dawley rats following a 90-day oral gavage exposure to 0, 50, 200 and 600Â mg/kg/day. No statistically significant effects on body weight, body weight gain or food consumption were observed at study termination. Treatment-related changes in clinical chemistry parameters at the end of the 90-day dosing period were limited to small, but statistically significant, increases in phosphorus levels in high dose males and females. Liver enlargement in high dose male/female rats was considered an adaptive response as this was reversible and was not associated with histopathological lesions or increased liver enzyme markers indicative of liver damage. Kidney weight changes were limited to a small, but statistically significant, increase in relative weights in high dose males. This was not associated with histopathological lesions and thus not considered toxicologically relevant. Overall, the No-Observed-Adverse-Effect-Level (NOAEL) was the highest concentration tested (600Â mg/kg/day). The results of the present study are relevant for assessing the risk of trimethylbenzenes through the oral route of exposure and provide a basis for the development of provisional screening values for trimethylbenzene isomers while avoiding the uncertainty associated with route-to-route extrapolation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 69, Issue 2, July 2014, Pages 143-153
Journal: Regulatory Toxicology and Pharmacology - Volume 69, Issue 2, July 2014, Pages 143-153
نویسندگان
David Adenuga, Juan-Carlos Carrillo, Richard H. Mckee,