Keywords: فسفاتیدیلینوزیتید 3-کیناز; AD; Alzheimer's disease; TLRs; toll-like receptors; AβPP; amyloid-β protein precursor; NSAIDs; non-steroidal anti-inflammatory drugs; CNS; central nervous system; TNF-α; tumor necrosis factor-α; IL-1β; interleukin 1-β; IL-6; interleukin-6; NO; nit
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Keywords: فسفاتیدیلینوزیتید 3-کیناز; OS; overall survival; MAPK; mitogen-activated protein kinase; RTKs; receptor tyrosine kinases; PI3K; phosphatidylinositide 3-kinases; GEFs; guanine nucleotide exchange factors; GAPs; GTPase-activating proteins; FTIs; farnesyltransferase inhibitors; mTOR;
Keywords: فسفاتیدیلینوزیتید 3-کیناز; Dendritic spine; Synaptic plasticity; Neurodegenerative diseases; Psychiatric disorders; Glutamate receptor; Calcium signaling; ADHD; attention deficit hypersensitive disorders; FXS; Fragile X-syndrome; CNS; central nervous system; GABA; gamma amino butyr
Keywords: فسفاتیدیلینوزیتید 3-کیناز; AKT; a serine/threonine-specific protein kinase, also known as Protein Kinase B (PKB); CCS; charcoal-stripped fetal-calf serum; CSC; cancer stem cell; E2; 17β-estradiol; E2:ER; E2-bound estrogen receptor; EGFR; epidermal growth factor receptor; ER; estro
Apelin, a promising target for Alzheimer disease prevention and treatment
Keywords: فسفاتیدیلینوزیتید 3-کیناز; Alzheimer disease; Apelin; Amyloid beta; Central nervous system; Oxidative stress; AAA; Abdominal aortic aneurysm; ABCA1; ATP-binding cassette transporter A1; ACE; Angiotensin converting enzyme; ACh; Acetylcholine; AChE; Acetyl choline esterase; AD; Alzhe
Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies
Keywords: فسفاتیدیلینوزیتید 3-کیناز; NF-κB; nuclear factor kappa B; AP-1; activator protein; STAT3; signal transducer and activator of transcription 3; NK cells; natural killer cells; TNF-α; tumor necrosis factor-α; NO; nitric oxide; iNOS; inducible nitric oxygen synthase; ROS; reactive o
Ethanol-induced PGE2 up-regulates Aβ production through PKA/CREB signaling pathway
Keywords: فسفاتیدیلینوزیتید 3-کیناز; Aβ; amyloid beta; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; beta-site APP-cleaving enzyme 1; ROS; reactive oxygen species; ER; endoplasmic reticulum; eIF2α; eukaryotic initiation factor alpha; CHOP; C/EBP-homologous protein; PGE2;
Invited reviewPersonalizing cardiac regenerative therapy: At the heart of Pim1 kinase
Keywords: فسفاتیدیلینوزیتید 3-کیناز; MI; myocardial infarction; CPC; cardiac progenitor cell; NFκB; nuclear factor kappa-light-chain-enhancer of activated B cells; STAT; signal transducers and activators of transcription; PI3K; phosphatidylinositide 3-kinases; Klf5; kruppel-like factor 5; E
Dehydroepiandrosterone prevents linoleic acid-induced endothelial cell senescence by increasing autophagy
Keywords: فسفاتیدیلینوزیتید 3-کیناز; ANOVA; one-way analysis of variance; AMPK; AMP-activated protein kinase; ATG; autophagy related genes; CVD; cardiovascular disease; DHEA; dehydroepiandrosterone; DHEA-S; dehydroepiandrosterone sulfate; DMSO; dimethyl sulfoxide; eNOS; endothelial nitric ox
Boerhavia diffusa L. ethanol extract suppresses inflammatory responses via inhibition of Src/Syk/TRAF6
Keywords: فسفاتیدیلینوزیتید 3-کیناز; Bd-EE; Boerhavia diffusa L. ethanol extract; HPLC; high performance liquid chromatography; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TLR; Toll-like receptor (TLR); NF-κB; nuclear factor-κB; AP-1; Activat
Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies
Keywords: فسفاتیدیلینوزیتید 3-کیناز; Coumarins; Anticancer; Synthesis; Targets; SAR; IC50; ARI; aromatase inhibitor; CAM; choriallanotoic membrane; CDC; cell cycle division protein; CDK2; cyclin dependent kinase 2; CDKN1A; cyclin-dependent kinase inhibitor 1A; CYP; cytochromes P450; DDIT4; D
Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages
Keywords: فسفاتیدیلینوزیتید 3-کیناز; SAA; serum amyloid A; H3K27me3; trimethylation of histone H3 at lysine 27; HDACs; histone deacetylases; FPR2; formyl peptide receptor 2; G-CSF; granulocyte colony-stimulating factor; IL-23p19; interleukin-23 alpha subunit p19; IL-12p40; interleukin-12 p40
Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway
Keywords: فسفاتیدیلینوزیتید 3-کیناز; Bf; free bilirubin; UCB; unconjugated bilirubin; OS; oxidative stress; ROS; reactive oxygen species; NAC; N-acetylcystein; Nrf2; NF-E2 related factor 2; ARE; Antioxidant Response Element; GSH; glutathione; xCT; cystine/glutamate exchanger system; Gly1; gl
In vivo hyperoxia induces hypoxia-inducible factor-1α overexpression in LNCaP tumors without affecting the tumor growth rate
Keywords: فسفاتیدیلینوزیتید 3-کیناز; In vivo hypoxia; In vivo hyperoxia; LNCaP tumor; Angiogenesis; Hypoxia-inducible factor; Akt; phosphatidylinositol-3-phosphate/protein kinase B; Hb; hemoglobin; HIF-1α; hypoxia-inducible factor-1α; Ki67; Antigen anti-KI-67; LNCaP; androgen-sensitive hum
Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum
Keywords: فسفاتیدیلینوزیتید 3-کیناز; AMPK; AMP-activated protein kinase; STAT; activator of transcription; AGE; advanced glycation end products; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-β peptide; ACE; angiotensin converting enzyme; Ang I; angiotensin I; AR-II;