Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; Alternatives to animal testing; QIVIVE; Regulatory acceptance; Food toxicology; Drivers and barriers; Multilevel perspective on technology transitions; 3R; replace, reduce, or refine; EFSA; European Food Safety Authority; EU; European Union; PBPK; physiol
مقالات ISI فارماکوکینتیک مبتنی بر فیزیولوژی (ترجمه نشده)
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Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; CLint; Intrinsic hepatic clearance; HLM; Human liver microsomes; LC/MS/MS; Liquid chromatography tandem mass spectrometry; LC/UV/RAD; Liquid chromatography/ultraviolet/radioactive detection; MRM; Multiple reaction monitoring; NADPH; Nicotinamide adenine d
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; ADAM; advanced dissolution, absorption, and metabolism; AED; antiepileptic drug; AUC; area-under-the-curve; B/P; blood to plasma ratio; BID; twice daily; BMI; body mass index; CBZ; carbamazepine; CLint; intrinsic clearance; CLR; renal clearance; CL; clear
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; albumin; mathematical model; pharmacokinetics; protein binding; organic anion-transporting polypeptide transporters; food effects; hepatic transport; nonlinear pharmacokinetics; clinical pharmacokinetics; ADME; BA; bioavailability; BCS; biopharmaceutica
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; preclinical pharmacokinetics; physiological model; simulations; clearance; absorption; distribution; ADAM; advanced dissolution absorption and metabolism; B:P; blood-to-plasma ratio; CLint; intrinsic clearance; CLiv; intravenous clearance; CLu,intH; unbou
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; AD; Alzheimer disease; ADME; absorption, distribution, metabolism and excretion; AO; adverse outcome; AOP; adverse outcome pathway; AOP-KB; adverse outcome pathway knowledge base; BDNF; brain derived neurotrophic factor; B/H; Bradford-Hill; CI; complex I
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; pulmonary; tissue partition; pharmacokinetics; pulmonary drug delivery; distribution; Cu,cell; intracellular unbound drug concentration; Cu,lungISF; unbound drug concentration in the lung interstitial fluid; fu,lung; fraction of unbound drug in diluted lu
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; Perchlorate; Iodide; PBPK modeling; Thyroid hormones; DWEL; Drinking Water Equivalent Level; EPA; US Environmental Protection Agency; FDA; US Food and Drug Administration; fT4; free thyroxine levels; HPT; hypothalamic pituitary thyroid; NHANES; National H
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; Physiologically based pharmacokinetics model; Pharmacokinetics; Bayesian inference; Robust parameter estimation; Tegafur; 5-fluorouracil; PBPK; physiologically based pharmacokinetic; DDM; drug dissolution model; MLE; maximum likelihood estimation; MAP; ma
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; Methyl methacrylate; Olfactory effects; Human relevance; Occupational levels; Physiologically based pharmacokinetic (PBPK) model; Dosimetric adjustment factors; 2-EH; 2-ethyl Hexanol; AA; acrylic acid; ACGIH; American Conference of Governmental Industrial
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; AUC; area under the curve; BW; body weight; Cant50; tolerance “concentration”; CLKC; nicotine renal clearance; CLMC; nicotine metabolic clearance; COTCL; total cotinine clearance (unscaled); COTCLC; total cotinine clearance (scaled); CVVB; blood nicot
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; ABC; ATP-binding cassette; ATR; atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-s-triazine; AUC; area under the curve; BW; body weight; 14C-ATR; 14C-atrazine; DACT; didealkylatrazine, 2-chloro-4,6-diamino-1,3,5-triazine; DE; desethylatrazine, 2-chlor
Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; 3Rs; Reduction, Replacement, Refinement; PBPK; physiologically based pharmacokinetic; 2D; two-dimensional; 3D; three-dimensional; HTS; high-throughput screening; IVIVE; in vitro-in vivo extrapolation; ADME; absorption, distribution, metabolism and excreti
Minimal physiologically-based pharmacokinetic model to investigate the effect of pH dependent FcRn affinity and the endothelial endocytosis on the pharmacokinetics of anti-VEGF humanized IgG1 antibody in cynomolgus monkey
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; AIC; Akaike Information Criterion; ATA; anti-therapeutic antibody; AUC; area under the curve; CLe; antibody clearance in endothelial space; CDP; Complex Dedrick Plot; CV; coefficient of variations; FR; recycling fraction of IgG; F1; modulation factor of m
Imaging techniques to study drug transporter function in vivo
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; ABC; ATP-binding cassette; AD; Alzheimer's disease; ADME; absorption, distribution, metabolism and elimination; ATP; adenosine triphosphate; AUC; area under the curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BPND; non-displaceabl
Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; clinical trial simulations; drug interactions; pharmacokinetics; physiologically based pharmacokinetic modeling; organic anion-transporting polypeptide transporters; CYP enzymes; AUC; area under the blood concentration-time curve; AUCR; area under the b
Simulations of Cytochrome P450 3A4-Mediated Drug-Drug Interactions by Simple Two-Compartment Model-Assisted Static Method
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; bioavailability; cytochrome P450; drug interaction; dynamic simulation; first pass metabolism; hepatic clearance; intestinal metabolism; pharmacokinetics; simulations; parallel tube model; Ae (Ae,oral); dose fractions of urinary excreted unchanged drug af
Quantitative Analyses of the Influence of Parameters Governing Rate-Determining Process of Hepatic Elimination of Drugs on the Magnitudes of Drug-Drug Interactions via Hepatic OATPs and CYP3A Using Physiologically Based Pharmacokinetic Models
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; cytochrome P450; drug interaction; hepatic clearance; mathematical model; organic anion-transporting polypeptide transporters; pharmacokinetics; AUC; area under the plasma concentration-time curve; CL; clearance; CLint,all; overall hepatic intrinsic cle
Breast Cancer Resistance Protein Abundance, but Not mRNA Expression, Correlates With Estrone-3-Sulfate Transport in Caco-2
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; Caco-2 cells; proteomics; liquid chromatography; mass spectrometry; intestinal absorption; efflux pumps; ABC transporters; ABC; ATP-dependent binding cassette; BCRP; breast cancer resistance protein; BSA; bovine serum albumin; E-3-S; estrone-3-sulfate; HB
Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; clinical pharmacokinetics; CYP enzymes; drug interaction; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasm
Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; pharmacokinetics; pulmonary drug delivery; tissue partition; distribution; pulmonary; IT; intratracheal; PBPK; physiologically based pharmacokinetic; PK; pharmacokinetic; t1/2; half-life; V0; volume of the airspaces in the lung slices; Vu,lung; unbound dr
Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; 4-VCH; 4-vinylcyclohexene; ARA; Alliance for Risk Assessment; ATSDR; Agency for Toxic Substances and Disease Registry; BEs; biomonitoring equivalents; BMD; benchmark dose; BMDL; benchmark dose lower confidence limit; CCl4; carbon tetrachloride; CDC; Cente
Aligning the 3Rs with new paradigms in the safety assessment of chemicals
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; 3Rs; replacement, refinement and reduction of animals in research; AOP; adverse outcome pathway; EURL-ECVAM; European Union Reference Laboratory for Alternatives to Animal Testing; ICCVAM; Interagency Coordinating Committee on the Validation of Alternativ
Improving in vitro to in vivo extrapolation by incorporating toxicokinetic measurements: A case study of lindane-induced neurotoxicity
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; MEA; microelectrode array; PBPK; physiologically based pharmacokinetic; IVIVE; in vitro to in vivo extrapolation; GC-μECD; gas chromatograph micro electron capture detector; GABA; γ-aminobutyric acid; EC50; effective concentration 50%; RSD; relative sta
Quantitative in vitro to in vivo extrapolation of tissues toxicity
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; ADME; absorption, distribution, metabolism, and excretion; ARE; antioxidant responses elements; BBB; blood brain barrier; CsA; cyclosporine A; CYP; cytochrome P450; EPA; Environmental Protection Agency; GCL; glutamate cysteine ligase; GCLC; glutamate cyst
Intramuscular Administration of Paliperidone Palmitate Extended-Release Injectable Microsuspension Induces a Subclinical Inflammatory Reaction Modulating the Pharmacokinetics in Rats
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; prodrugs; nanoparticles; muscle; disposition; biocompatibility; pharmacokinetics; paliperidone palmitate; sustained release; histopathology; inflammation; API; active pharmaceutical ingredient; AUC; area under the (plasma concentration vs. time) curve; CL
Application of in vitro biopharmaceutical methods in development of immediate release oral dosage forms intended for paediatric patients
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; BCS; Biopharmaceutics classification system; EMA; European Medicines Agency; FaSSIF; Fasted state simulated intestinal fluid; FDA; (United States) Food and Drug Administration; FeSSIF; Fed state simulated intestinal fluid; GI; Gastrointestinal; IVIVR; In
S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; ALS; amyotrophic lateral sclerosis; ARE; antioxidant response element; carboxy-H2DCFDA; 6-carboxy-2â²,7â²-dichlorodihydrofluorescein diacetate; CNS; central nervous system; DCF; dichlorofluorescein; MEFs; mouse embryonic fibroblasts; Nrf2; nuclear eryth
Contribution of Modeling Approaches and Virtual Populations in Transposing the Results of Clinical Trials into Real Life and in Enlightening Public Health Decisions
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; modeling; simulation; clinical trials; public decision; virtual populations; CEPS; Economic committee of the health products in France (Comité économique des produits de santé); CTV; Technical committe of vaccinations in France (Comité technique des v
Apport de la modélisation et des populations virtuelles pour transposer les résultats des essais cliniques à la vie réelle et éclairer la décision publique
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; modélisation; simulation; essais cliniques; décision publique; populations virtuelles; AMM; autorisation de mise sur le marché; ANAES; Agence nationale d'accréditation et d'évaluation en santé; ANR; Agence nationale de la recherche; CEPS; ComitÃ
A novel application of the Margin of Exposure approach: Segregation of tobacco smoke toxicants
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; AIC; Akaike's information criteria; ALARA; as low as reasonably achievable; B(a)P; benzo(a)pyrene; BMD; benchmark dose; BMDL and BMDL10; benchmark dose lower confidence limit; BMDS; Benchmark Dose Software; BMR; benchmark response; CalEPA; Californian E
Modeling VOC-odor exposure risk in livestock buildings
Keywords: فارماکوکینتیک مبتنی بر فیزیولوژی; Toulene; Xylene; Probabilistic; Risk assessment; Physiologically based pharmacokinetic; Pharmacodynamic; Livestock building; VOC