Keywords: PKA، پروتئین کیناز A; PKA, protein kinase A; ATCC, American type culture collection; PAH, phenylalanine hydroxylase; RT-PCR, reverse transcriptase-polymerase chain reactionExchange factor; GTP-binding protein; Signal transduction; Galactose metabolism; Leloir pathway; Protein
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Keywords: PKA، پروتئین کیناز A; Beta-defensin; Epididymis; Sperm maturation; Flagellar motility pattern; Sperm-oocyte binding; iCre knock-inDefb, Beta-defensing; KI, Knock-in; AR, Androgen receptor; IVF, In vitro fertilization; PKA, Protein kinase A; SACY, Soluble adenylyl cyclase; ZP,
Keywords: PKA، پروتئین کیناز A; AMP-Activated kinase (AMPK); Estrogen receptor; Fibrosis; Angiotensin IIαSMA, alpha smooth muscle actin; ERβ, estrogen receptor beta; AngII, angiotensin II; AMPK, AMP kinase; ET-1, endothelin-1; PKA, protein kinase A; TGFβ, transforming growth factor beta
Keywords: PKA، پروتئین کیناز A; ASICs, acid-sensing ion channels; DRG, dorsal root ganglion; IpH, proton-gated current; TRPV1, transient receptor potential vanilloid type 1; PKA, protein kinase A; AC, adenylyl cyclase; 8-Br-cAMP, 8-bromo-cAMP; DAMGO, [d-Ala2,N-Me-Phe4,Gly5-ol]-enkephali
Keywords: PKA، پروتئین کیناز A; cAMP, cyclic AMP; PDE3, type III phosphodiesterase; eNOS, endothelial nitric oxide synthese; PKA, protein kinase A; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; LEC, lymphatic endothelial cells; kCYC+/−, k-
Keywords: PKA، پروتئین کیناز A; ADRB2, β-adrenergic receptor; IGF, insulin-like growth factor; IIS, insulin/IGF signaling; LMNA, lamin A/C; NIA, National Institute on Aging; PKA, protein kinase A; TOR, target of rapamycin; TORC1, target of rapamycin complex 1; TORC2, target of rapamycin
Prostaglandin D2 is a novel repressor of IFNγ induced indoleamine-2,3-dioxygenase via the DP1 receptor and cAMP pathway
Keywords: PKA، پروتئین کیناز A; IDO, Indoleamine 2,3-dioxygenase; Kyn, Kynurenine; IFNγ, Interferon-γ; PKA, Protein kinase A; DP1, Prostanoid DP receptor; CRTH2, Chemoattractant receptor homologous molecule expressed on Th2 cellsIndoleamine 2,3-Dioxygenase; Prostaglandin D2; DP1; Cyclic
Interaction between bradykinin B2 and Ang-(1–7) Mas receptors regulates erythrocyte invasion by Plasmodium falciparum
Keywords: PKA، پروتئین کیناز A; BK, bradykinin; ACE, angiotensin-converting enzyme; KKS, kallikrein-kinin system; RAS, renin-angiotensin system; PKA, protein kinase A; iPKA, PKA inhibitor; Epac, exchange protein activated by cAMPMalaria; Angiotensin-(1–7); Bradykinin; Host-parasite inte
Identification, origin and evidence for retained functionality of two IκBα paralogs in Megalobrama amblycephala
Keywords: PKA، پروتئین کیناز A; Fish; Innate immunity; NFκBiα; Gene expression; Genome duplication; Functional annotationaa, amino acids; hpi, hours post injection; LPS, lipopolysaccharides; NLS, nuclear localisation sequence; PKA, protein kinase A; t., tonnes
Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation
Keywords: PKA، پروتئین کیناز A; ECM, extracellular matrix; HMWH, high molecular weight hyaluronan; LMWH, low molecular weight hyaluronan; PKA, protein kinase A; PKC, protein kinase Cextracellular matrix; CD44; hyaluronan; nociceptor; hyperalgesia
Prostaglandin EP2 receptor signaling protects human trabecular meshwork cells from apoptosis induced by ER stress through down-regulation of p53
Keywords: PKA، پروتئین کیناز A; cAMP, cyclic adenosine monophosphate; EP2, E-prostanoid type 2 receptor; Epac, exchange proteins activated by cAMP; IOP, intraocular pressure; PKA, protein kinase A; PUMA, p53-upregulated mediator of apoptosis; TM, trabecular meshworkEP2 receptor; ER stre
The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca2 + signalling in steatotic hepatocytes
Keywords: PKA، پروتئین کیناز A; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; T2D, type 2 diabetes; [Ca2 +]cyt, cytoplasmic free Ca2 + concentration; PKC, protein kinase C; PKA, protein kinase A; ER, endoplasmic reticulum; SERCA, sarco/endoplasmic reticu
Tonic PKA Activity Regulates SK Channel Nanoclustering and Somatodendritic Distribution
Keywords: PKA، پروتئین کیناز A; Ca2 +, calcium; SK, small-conductance Ca2 +-activated potassium; SK2, SK channel subtype 2; EPSP, excitatory postsynaptic potential; PKA, protein kinase A; AFM, atomic-force microscopy; cAMP, cyclic adenosine monophosphate; CTF, corrected total fluoresce
PKA regulates calcineurin function through the phosphorylation of RCAN1: Identification of a novel phosphorylation site
Keywords: PKA، پروتئین کیناز A; Calcineurin; RCAN1; Phosphorylation; PKA; InflammationRCAN1, regulator of calcineurin 1; PKA, protein kinase A; NFAT, nuclear factors of activated T cells
PKA, PHO and stress response pathways regulate the expression of UDP-glucose pyrophosphorylase through Msn2/4 in budding yeast
Keywords: PKA، پروتئین کیناز A; PKA, protein kinase A; UDP-Glc, uridine diphosphate glucose; UGPase, UDP-glucose pyrophosphorylase; STRE, stress response element; GFP, green fluorescent protein; TAP, tandem affinity purificationUgp1; Msn2/4; Protein kinase A; Phosphate response; Stress
PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motility
Keywords: PKA، پروتئین کیناز A; PDPN, Podoplanin; PKA, Protein Kinase A; CDK5, Cyclin dependent Kinase 5Podoplanin; Serine phosphorylation; Protein Kinase A; Cyclin dependent Kinase 5; Cell migration
Imbalance of HCN1 and HCN2 expression in hippocampal CA1 area impairs spatial learning and memory in rats with chronic morphine exposure
Keywords: PKA، پروتئین کیناز A; HCN channels, Hyperpolarization-activated cyclic-nucleotide-gated non-selective cation channels; CA1, Cornu ammonis 1; LTP, Long-term potentiation; TRIP8b, TPR containing Rab8b interacting protein; PKA, Protein kinase A; AP2, Adaptor protein 2; CNS, Centr
Nicotinamide ameliorates palmitate-induced ER stress in hepatocytes via cAMP/PKA/CREB pathway-dependent Sirt1 upregulation
Keywords: PKA، پروتئین کیناز A; NAM, nicotinamide; PKA, protein kinase A; CREB, cyclic AMP response-element-binding protein; Nampt, nicotinamide phosphoribosyltransferase; NMN, nicotinamide mononucleotide; PDE, phosphodiesteraseNicotinamide; Sirt1; NAD+; Deacetylation; CAMP; PKA
Effects of naturally occurring arginine 14 deletion on phospholamban conformational dynamics and membrane interactions
Keywords: PKA، پروتئین کیناز A; DCM, dilated cardiomyopathy; LOF, loss of function; PKA, protein kinase A; PLNAFA, phospholamban monomer bearing mutations C36A C41F C46A; PLNWT, wild type phospholamban pentamer; pSer, phosphoserine; SERCA, sarco(endo)plasmic reticulum Ca2 + ATPase; R14d
How do voltage-gated sodium channels enhance migration and invasiveness in cancer cells?
Keywords: PKA، پروتئین کیناز A; AKAP, A kinase anchoring protein; GPCR, G protein-coupled receptors; NCX, sodium-calcium exchanger; NHE-1, type 1 Na +/H + exchanger; PKA, protein kinase A; PKC, protein kinase C; TTX, tetrodotoxin; VGSC, voltage-gated sodium channel, pore forming α subun
Emerging Roles for Maf1 beyond the Regulation of RNA Polymerase III Activity
Keywords: PKA، پروتئین کیناز A; rRNA, ribosomal RNA; NLS, nuclear localization sequences; PTM, posttranslational modification; PKA, protein kinase A; CK2, casein kinase 2; TBP, TATA binding proteinRNA polymerase III; Caenorhabditis elegans; Drosophila melanogaster; mouse; human
Activation of D1-like receptor-dependent phosphatidylinositol signal pathway by SKF83959 inhibits voltage-gated sodium channels in cultured striatal neurons
Keywords: PKA، پروتئین کیناز A; DA, dopamine; DAG, diacylglycerol; IP3, inositol-1,4,5-phosphate 3; PI, phosphatidylinositol; PKA, protein kinase A; PKC, protein kinase C; PLC, phospholipase C; SPNs, spiny projection neurons; TTX, tetrodotoxin; VGSCs, voltage-gated sodium channelsSKF839
Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease
Keywords: PKA، پروتئین کیناز A; AMPK, AMP Kinase; cAMP, cyclic adenosine 3’5’-monophosphate; COX, Cyclooxygenase; PAF, Platelet activating factor; PG, Prostaglandin; DP, Prostaglandin D2 receptor; EP, Prostaglandin E2 receptor; PKA, Protein Kinase A; Tx, ThromboxaneAntiplatelet agent; p
Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cell
Keywords: PKA، پروتئین کیناز A; cAMP, cyclic AMP; EP receptor, E-type prostanoid receptor; PI3K, phosphatidylinositol 3-kinase; ERKs, extracellular signal-regulated kinases; PKA, protein kinase A; ICL, intracellular loop; PGE2, prostaglandin E2; COX-2, cyclooxygenase-2; EGF, epidermal g
PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner
Keywords: PKA، پروتئین کیناز A; PDE4, Phosphodiesterase 4; SMC, Smooth muscle cell; CAM, Cell adhesion molecule; VCAM-1, Vascular cell adhesion molecule-1; ICAM-1, Intercellular adhesion molecule 1; PKA, Protein kinase A; Epac1, Exchange protein directly activated by cAMP; H3K4me2, Hist
Mimicking the phosphorylation of Rsp5 in PKA site T761 affects its function and cellular localization
Keywords: PKA، پروتئین کیناز A; Yeast; Rsp5 Ubiquitin ligase; Phosphorylation; Protein kinase AAZC, Lazetidine-2-carboxylate; CFU, colony forming units; H2-DCFDA, 2′,7′-dichloro dihydrofluorescein diacetate; PKA, protein kinase A; ROS, reactive oxygen species; TCA, trichloroacetic acid;
Structure-Function Studies of the bHLH Phosphorylation Domain of TWIST1 in Prostate Cancer Cells 12
Keywords: PKA، پروتئین کیناز A; EMT, epithelial-mesenchymal transition; bHLH, basic helix-loop-helix; T-T, TWIST1-TWIST1; E12/E47, E2A proteins; T-E, TWIST1-E12; IHC, immunohistochemistry; PI, propidium iodide; PKA, protein kinase A
Understanding the mechanism of glucose-induced relief of Rgt1-mediated repression in yeast
Keywords: PKA، پروتئین کیناز A; Yeast; HXT; Rgt1; Glucose; DNA-bindingChIP, chromatin immunoprecipitation; ECL, enhanced chemiluminescence; IP, immunoprecipitation; PKA, protein kinase A
The laxative effect of emodin is attributable to increased aquaporin 3 expression in the colon of mice and HT-29 cells
Keywords: PKA، پروتئین کیناز A; AQP, aquaporin; cAMP, cyclic adenosine monophosphate; PKA, protein kinase A; p-CREB, phosphorylated cAMP response element-binding proteinEmodin; Laxative; Aquaporin 3; Colon
PLIN1 deficiency affects testicular gene expression at the meiotic stage in the first wave of spermatogenesis
Keywords: PKA، پروتئین کیناز A; P21, postnatal day 21; PAS, periodic acid-Schiff; Prm1, Protamine 1; Tnp2, transition protein 2; Wbp2nl, WW Domain-Binding Protein 2-Like; Fscn3, fascin homolog 3; LDs, lipid droplets; PKA, protein kinase A; HSL, hormone-sensitive lipase; BSA, albumin fro
Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening
Keywords: PKA، پروتئین کیناز A; ANT, adenine nucleotide transporter; BLM, black-lipid membrane; CsA, cyclosporin A; CyP-D, cyclophilin D; DCCD, dicyclocarbodiimide; DOC-Na, sodium deoxycholate; mPTP, mitochondrial permeability transition pore; PKA, protein kinase A; RLM, rat liver mitoc
Multidrug resistance protein 4 (MRP4/ABCC4) regulates thrombus formation in vitro and in vivo
Keywords: PKA، پروتئین کیناز A; cPLA2, cytosolic phospholipase A2; ESR, electron spin resonance; HO, hydroxyl radical; MRP4, multidrug resistance protein 4; PKA, protein Kinase A; PKC, protein kinase C; PKG, protein kinase G; PRP, platelet-rich plasma; PGE1, prostaglandin E1; ROS, react
Investigation of cAMP microdomains as a path to novel cancer diagnostics
Keywords: PKA، پروتئین کیناز A; cAMP, Cyclic adenosine monophosphate; sAC, Soluble adenylyl cyclase; tmAC, Transmembrane adenylyl cyclase; PDE, Phosphodiesterase; PKA, Protein kinase A; AKAP, A kinase anchoring protein; EPAC, Exchange protein activated by cAMP; GEF, Guanine nucleotide e
Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3β,5α,8α-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19)
Keywords: PKA، پروتئین کیناز A; cAMP, intracellular cylic AMP; CREB, cAMP response element-binding protein; MAPK, mitogen-activated protein kinase; PI3K, phosphoinositide 3-kinase; PKA, protein kinase A; FSH, follicle-stimulating hormone; PGE2, prostaglandin E2; ELISA, enzyme-linked imm
Sarcoplasmic reticulum Ca2 + cycling protein phosphorylation in a physiologic Ca2 + milieu unleashes a high-power, rhythmic Ca2 + clock in ventricular myocytes: Relevance to arrhythmias and bio-pacemaker design
Keywords: PKA، پروتئین کیناز A; AP, action potential; β-ARs, β-adrenergic receptor stimulation; Ca2 +, calcium; IBMX, isobutyl-1-methylxanthine; LCR, local Ca2 + releases; PDE, phosphodiesterase; PKA, protein kinase A; PLB, phospholamban; PP, protein phosphatases; RyRs, ryanodine recept
Glutathione initiates the development of Dictyostelium discoideum through the regulation of YakA
Keywords: PKA، پروتئین کیناز A; GSH, reduced glutathione; GSSG, oxidized glutathione; PSF, prestarvation factor; CMF, conditioned medium factor; cAR1, cAMP receptor; ACA, adenylyl cyclase; PKA, protein kinase A; DTT, dithiothreitol; NAC, N-acetylcysteine; mBBr, monobromobimane; NEM, N-e
Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
Keywords: PKA، پروتئین کیناز A; Fru-2,6-P2, fructose-2,6-bisphosphate; PFK-2/FBPase-2, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; FL, fetal liver; AS, alternative splicing; PKA, protein kinase A; Bp, base pairsPfkfb1; 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase; Fruc
α-Tocopherol (vitamin E) stimulates cyclic AMP production in human peripheral mononuclear cells and alters immune function
Keywords: PKA، پروتئین کیناز A; cAMP, 3′5′ cyclic adenosine monophosphate; IL, interleukin; RANTES, Normal T cell Expressed and Secreted; PBMC, peripheral blood mononuclear cell; GPCR, G-protein coupled receptor; AC, adenylyl cyclase; PKA, protein kinase A; NK, natural killer; Th, T hel
Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis
Keywords: PKA، پروتئین کیناز A; CART, cocaine- and amphetamine-regulated transcript; HSL, hormone sensitive lipase; PDE3B, phosphodiesterase-3B; PKA, protein kinase A; PKB, protein kinase B; T2D, type 2 diabetes; WAT, white adipose tissueAdipocytes; Cocaine- and amphetamine-regulated tr
The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides
Keywords: PKA، پروتئین کیناز A; RSK, ribosomal S6 kinase; NTKD, N-terminal kinase domain; CTKD, C-terminal kinase domain; PKA, protein kinase A; AMPPNP, 5′-adenylyl-imidodiphosphateRSK kinase; SL0101; Quercitrin; Flavonol; Induced fit; Conformational selection
Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy
Keywords: PKA، پروتئین کیناز A; CaMKII, Ca2+/calmodulin-dependent protein kinase II; CaSpF, Ca2+ spark frequency; DMD, Duchenne muscular dystrophy; PES, programmed electrical stimulation; PKA, protein kinase A; RyR2, type 2 ryanodine receptor; SCaW, spontaneous Ca2+ wave; SOICR, store o
Protein kinase A regulates the long-term potentiation of intrinsic excitability in neonatal trigeminal motoneurons
Keywords: PKA، پروتئین کیناز A; TMNs, trigeminal motoneurons; PKA, protein kinase A; PKC, protein kinase C; CaMKII, calcium/calmodulin-dependent protein kinase IITrigeminal motoneuron; Long-term potentiation; Protein kinase A
Levo-tetrahydropalmatine decreases ethanol drinking and antagonizes dopamine D2 receptor-mediated signaling in the mouse dorsal striatum
Keywords: PKA، پروتئین کیناز A; L-THP, levo-tetrahydropalmatine; PKA, protein kinase A; AKT, AKT8 virus oncogene cellular homolog; ERK, extracellular signal-regulated kinase; DMSO, dimethyl sulfoxide; ANOVA, analysis of variance; NAc, nucleus accumbens; CPu, caudate putamen; CeA, centra
Threat bias in mice with inactivating mutations of Prkar1a
Keywords: PKA، پروتئین کیناز A; ANOVA, analysis of variance; bp, base pair; BLA, basolateral amygdala; CA, central amygdala; LTP, long-term potentiation; MA, medial amygdala; OFC, orbitofrontal cortex; olf, olfactory bulb; PKA, protein kinase A; PTSD, post-traumatic stress disorder; PVH
Protective effect of puerarin on lead-induced mouse cognitive impairment via altering activities of acetyl cholinesterase, monoamine oxidase and nitric oxide synthase
Keywords: PKA، پروتئین کیناز A; AChE, acetyl cholinesterase; Akt, protein kinase B; eNOS, endothelial nitric oxide synthase; iNOS, inducible nitric oxide synthase; nNOS, neuronal nitric oxide synthase; MAO, monoamine oxidase; NO, nitric oxide; Pb, lead; PKA, protein kinase A; PU, puerar
Bicarbonate-sensitive soluble and transmembrane adenylyl cyclases in peripheral chemoreceptors
Keywords: PKA، پروتئین کیناز A; CB, carotid body; CA, carbonic anhydrase; IH, isohydric hypercapnia; CSN, carotid sinus nerve; PG, petrosal ganglion; sAC, soluble adenylyl cyclase; tmAC, transmembrane adenylyl cyclase; HCO3−, bicarbonate ion; PKA, protein kinase A; SD rats, Sprague-Dawl
The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses
Keywords: PKA، پروتئین کیناز A; aTregs, activated regulatory T cells; BCR, B cell receptor; cpf T cells, cytokine-producing FoxP3+ T cells; CSK, C-terminal SRC kinase; LYP, lymphoid tyrosine phosphatase; PKA, protein kinase A; PTP, protein tyrosine phosphatase; rTregs, resting regulator
c-Jun N-terminal kinase 2 phosphorylates endothelial nitric oxide synthase at serine 116 and regulates nitric oxide production
Keywords: PKA، پروتئین کیناز A; NO, nitric oxide; eNOS, endothelial NO synthase; BAEC, bovine aortic endothelial cell(s); JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; AMPK, AMP-activated protein kinase; PKA, protein kinase A; CDK, cyclin-dependent kinase; dn, do
Two novel N-terminal coding exons of Prkar1b gene of mouse: Identified using a novel approach of in silico and molecular biology techniques
Keywords: PKA، پروتئین کیناز A; PKA, Protein kinase A; AKAPs, A Kinase Anchoring Proteins; C, Catalytic subunit; R, Regulatory subunit; RT-PCR, Reverse transcriptase polymerase chain reaction; EST, Expressed sequence tags; PN, Postnatal; R1β, Regulatory type 1 beta subunitPrediction; N-
Inhibition of PKA attenuates memory deficits induced by β-amyloid (1–42), and decreases oxidative stress and NF-κB transcription factors
Keywords: PKA، پروتئین کیناز A; AD, Alzheimer's disease; Aβ, amyloid β; PKA, protein kinase A; NFκB, nuclear factor-κB; γ-GCS, glutamylcysteine synthetase; HO-1, hemeoxygenase-1; GSH, glutathione; SOD, superoxide dismutase; MAPK, mitogen-activated protein kinase; MWM, Morris water maze;