Keywords: اتصال پروتئین پلاسما; BGE; background electrolyte; CD; circular dichroism; CDEKC; cyclodextrin modified electrokinetic chromatography; CSEI; cation-selective exhaustive injection; EOF; electroosmotic flow; HCB; high conductivity buffer; LCB; low conductivity buffer; LVSS; larg
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Keywords: اتصال پروتئین پلاسما; Plasma protein binding; Nonlinearity; Atypical concentration dependence; Proposed mechanisms; Pharmacokinetic, pharmacodynamic and clinical implications;
Keywords: اتصال پروتئین پلاسما; plasma protein binding; fraction unbound; drug-drug interaction; AUC; area under the curve; AUCR; area under the curve ratio; AAG; alpha 1-acid glycoprotein; CYP; cytochrome P450; BSA; bovine serum albumin; CRO; contract research organization; CV; coeffic
Keywords: اتصال پروتئین پلاسما; Pyrethroids; Deltamethrin; Blood-brain barrier; Plasma protein binding; Brain uptake; Developmental neurotoxicity;
Enhancement in recovery of drugs with high protein binding efficiency from human plasma using magnetic nanoparticles
Keywords: اتصال پروتئین پلاسما; BA; bioanalytical; BE; bioequivalence; LC/MS; MS liquid chromatography-tandem mass spectrometry; SPE; solid phase extraction; LLE; liquid-liquid extraction; PP; protein precipitation; HPLC; high performance liquid chromatography; FDA; food and drug admi
Capillary electrophoresis in the context of drug discovery
Keywords: اتصال پروتئین پلاسما; ACE; affinity capillary electrophoresis; AGP; α-acid glycoprotein; AH; adrenaline hydrochloride; AIμEA; automatic micro-enzyme assay; AL; amlodipine; AT; antithrombin III; Bag3; Bcl2-associated anthanogene 3; BGE; background electrolyte; CM; chylomicron
Keywords: اتصال پروتئین پلاسما; 3-Arylpropionylhydroxamic acid; H. pylori urease inhibitor; Plasma protein binding; Kinetics study; Non-linear fitting;
Keywords: اتصال پروتئین پلاسما; Pharmacokinetics; Cefquinome; Flubendiamide; Buffalo calves; Plasma protein binding
Keywords: اتصال پروتئین پلاسما; Geniposide; UHPLC–ESI-MS/MS; Pharmacokinetic; Absolute oral bioavailability; Plasma protein binding
Keywords: اتصال پروتئین پلاسما; Plasma protein binding; Hollow fiber centrifugal ultrafiltration; Acetone; Protein binding displacer; Coumarins; HPLC;
Keywords: اتصال پروتئین پلاسما; Plasma protein binding; Human serum albumin; α1-Acid glycoprotein; In silico predictions; Ligand based modeling; Structure based modeling;
Keywords: اتصال پروتئین پلاسما; Free concentration; Plasma protein binding; Organic cations; Mixed-mode SPME; Ionized pharmaceuticals; Cation exchange;
Keywords: اتصال پروتئین پلاسما; Aβ; amyloid-β-peptide; AD; Alzheimer's disease; BR; bilirubin; BV; biliverdin; BVR; biliverdin reductase; CAT; catalase; CCNA2; gene encoding for cyclin-A2; CCNB1; gene encoding for G2/mitotic-specific cyclin-B1; CEP2; centrosomal protein 2; Cmax; pea
Keywords: اتصال پروتئین پلاسما; Hepatic clearance; Plasma protein binding; Steady-state equations; Fraction unbound; Dissociation/association; Active efflux rate constants;
Pharmacokinetics, tissue distribution and plasma protein binding study of SM-1, a novel PAC-1 derivative
Keywords: اتصال پروتئین پلاسما; Anti-tumour drugs; Pharmacokinetics; Plasma protein binding; SM-1; Tissue distribution;
Determination of total and free ceftolozane and tazobactam in human plasma and interstitial fluid by HPLC-UV
Keywords: اتصال پروتئین پلاسما; Cephalosporin; Beta-Lactamase inhibitor; Plasma protein binding; Tissue; Ultrafiltration; Microdialysis;
Elucidation of pharmacokinetics of novel DNA ligase I inhibitor, S012-1332 in rats: Integration of in vitro and in vivo findings
Keywords: اتصال پروتئین پلاسما; S012-1332; LC-ESI-MS/MS; Preclinical pharmacokinetics; Plasma protein binding; In vitro metabolism;
Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4
Keywords: اتصال پروتئین پلاسما; ABC; Activated B Cell-like; BTK; Bruton's Tyrosine Kinase; CD79; Cluster of Differentiation 79; CDK; Cyclin Dependent Kinase; CLK; CDC-Like Kinase; DCM; dichloromethane; DDQ; 2,3-Dichloro-5,6-DicyanobenzoQuinone; DIPEA; N,N-diisopropylethylamine; DLBCL;
The plasma protein binding of the endogenous glucocorticosteroids is of vital importance for the concentrations in hair and saliva
Keywords: اتصال پروتئین پلاسما; Cortisol; Cortisone; Plasma protein binding; Hair; Saliva; LC-MS/MS;
Scaffold-based novel SHP2 allosteric inhibitors design using Receptor-Ligand pharmacophore model, virtual screening and molecular dynamics
Keywords: اتصال پروتئین پلاسما; SPB; structure based pharmacophore; ADMET; absorption, distribution, metabolism, excretion, and toxicity; TCPTP; T cell protein-tyrosinephosphatase; PTP1B; protein tyrosine phosphatase 1B; NS; Noonan Syndrome; JMML; juvenile myelomonocytic leukemia; AML;
Expanding LogP: Present possibilities
Keywords: اتصال پروتئین پلاسما; BBB; blood brain barrier; ClogP; calculated logP; CNS; central nerve system; CNSpos; drugs penetrating the blood brain barrier; CNSneg; drugs showing no significant brain uptake or pharmacological effects or side effects in CNS; DRUGefflux; drugs interact
Radiosynthesis of [18F]AV1451 in pharmaceutical conditions and its biological characteristics
Keywords: اتصال پروتئین پلاسما; TAU protein; Radiopharmaceutical drug; Plasma protein binding; Neurodegeneration;
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes
Keywords: اتصال پروتئین پلاسما; ADME; absorption, distribution, metabolism and excretion; Clint; intrinsic clearance; Clp; plasma clearance; Clu; unbound clearance; DCM; dichloromethane; DHEP; dog hepatocytes; DLM; dog liver microsomes; DMAc; dimethylacetamide; DMF; dimethylformamide; D
Insight into stereoselective disposition of enantiomers of a potent antithrombotic agent, S002-333 following administration of the racemic compound to mice
Keywords: اتصال پروتئین پلاسما; S002-333; Stereoselective pharmacokinetics; Tissue distribution; Plasma protein binding; In vitro metabolism; Enantiomer-enantiomer interaction;
Stereoselective protein binding studies of 2-(2-hydroxypropanamido) benzoic acid enantiomers in rat, beagle dog and human plasma
Keywords: اتصال پروتئین پلاسما; 2-(2-Hydroxypropanamido) benzoic acid; Enantiomers; Plasma protein binding; Species difference; UHPLC-MS/MS; Molecular docking;
ADME properties evaluation in drug discovery: Prediction of plasma protein binding using NSGA-II combining PLS and consensus modeling
Keywords: اتصال پروتئین پلاسما; Plasma protein binding; ADME; QSAR; NSGA-II; Consensus model;
Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes
Keywords: اتصال پروتئین پلاسما; GPR142; g-protein coupled receptor 142; HTS; high throughput screen; PPB; plasma protein binding; CYP; cytochrome P450; GPR142; Diabetes; Wild-type knock-out study;
Pharmacokinetics, tissue distribution, and plasma protein binding study of chicoric acid by HPLC–MS/MS
Keywords: اتصال پروتئین پلاسما; Chicoric acid; HPLC–MS/MS; Pharmacokinetics; Tissue distribution; Plasma protein binding
Application of a UPLC–MS/MS method to the protein binding study of TM-2 in rat, human and beagle dog plasma
Keywords: اتصال پروتئین پلاسما; TM-2; Plasma protein binding; UPLC–MS/MS
Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis
Keywords: اتصال پروتئین پلاسما; Nitroimidazole; Antiparasitic agent; Giardia lamblia; Entamoeba histolytica; Plasma protein binding; Metabolism; MtzS; metronidazole sensitive; MtzR; metronidazole resistant; MIC; minimum inhibition concentration;
PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data
Keywords: اتصال پروتئین پلاسما; AIC; Akaike information criterion; BSV; between subject variability; BLQ; below the limit of quantification; CV; cardiovascular; ECG; electrocardiogram; hERG; human ether-a-go-go-related gene channel; hCav1.2; human cardiac calcium channel; hNav1.5; human
Modification of a PAMPA model to predict passive gastrointestinal absorption and plasma protein binding
Keywords: اتصال پروتئین پلاسما; Alpha-1-acid glycoprotein; AGP; Human serum albumin; HSA; PAMPA; Passive permeability; Plasma protein binding; PPB
Pharmacokinetic and protein binding profile of peptidomimetic DPP-4 inhibitor – Teneligliptin in rats using liquid chromatography–tandem mass spectrometry
Keywords: اتصال پروتئین پلاسما; Teneligliptin; DPP-4 inhibitors; Pharmacokinetics; Plasma protein binding; LC–MS; Ultra-filtration
Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (−)-[18 F]Flubatine in humans
Keywords: اتصال پروتئین پلاسما; Flubatine; Plasma protein binding; Metabolism; Clinical trial; PET; Fluorine-18
A novel GC-MS method for determination of chrysophanol in rat plasma and tissues: Application to the pharmacokinetics, tissue distribution and plasma protein binding studies
Keywords: اتصال پروتئین پلاسما; Chrysophanol; GC/MS; Pharmacokinetics; Tissue distribution; Plasma protein binding;
GSSG/GSH ratios in cryopreserved rat and human hepatocytes as a biomarker for drug induced oxidative stress
Keywords: اتصال پروتئین پلاسما; CE; collision energy; CM; carboxymethyl; CsA; cyclosporin A; CXP; collision cell exit potential; DMSO; dimethyl sulphoxide; DP; declustering potential; DTNB or Ellman's reagent; 5,5â²-dithiobis-(2-nitrobenzoic acid); ESI; electrospray ionization; FBS;
Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models
Keywords: اتصال پروتئین پلاسما; ADME; absorption distribution metabolism and excretion; AEDs; antiepileptic drugs; AUC; area under the plasma drug concentration-time curve; BBB; blood-brain barrier; CBZ; carbamazepine; CBZ-E; carbamazepine-10,11-epoxide; Cmax; maximum peak concentra
2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists
Keywords: اتصال پروتئین پلاسما; CRTh2; Prostaglandin D2; Antagonist; Pyrazole; Plasma protein binding
Simultaneous determination of human plasma protein binding of bioactive flavonoids in Polygonum orientale by equilibrium dialysis combined with UPLC–MS/MS
Keywords: اتصال پروتئین پلاسما; Polygonum orientale; Plasma protein binding; Bioactive compounds; Equilibrium dialysis; UPLC–ESI-MS/MS
Pharmacokinetic changes of unbound theophylline are due to plasma protein binding displacement and CYP1A2 activity inhibition by baicalin in rats
Keywords: اتصال پروتئین پلاسما; Baicalin; Theophylline; Pharmacokinetics; Plasma protein binding; CYP1A2
Mutant prevention concentration and PK–PD relationships of enrofloxacin for Pasteurella multocida in buffalo calves
Keywords: اتصال پروتئین پلاسما; Buffalo calves; Enrofloxacin; Mutant prevention concentration; PK–PD modeling; Plasma protein binding
Impact of Recovery on Fraction Unbound Using Equilibrium Dialysis
Keywords: اتصال پروتئین پلاسما; plasma protein binding; brain homogenate binding; equilibrium dialysis; recovery; stability; nonspecific binding; simulation; ADME;
A kinetic method for the determination of plasma protein binding of compounds unstable in plasma: Specific application to enalapril
Keywords: اتصال پروتئین پلاسما; Plasma protein binding; Initial rates; Charcoal binding; Plasma instability; Enalapril
Plasma protein binding of polyphenols from maritime pine bark extract (USP)
Keywords: اتصال پروتئین پلاسما; Maritime pine bark extract; High performance affinity chromatography; Ultrafiltration; Plasma protein binding; Human
Use of unbound volumes of drug distribution in pharmacokinetic calculations
Keywords: اتصال پروتئین پلاسما; Volume of distribution; Plasma protein binding; Displacement of drug from plasma proteins; Pharmacokinetic modeling
QSAR Analysis of Blood-Brain Distribution: The Influence of Plasma and Brain Tissue Binding
Keywords: اتصال پروتئین پلاسما; QSAR; in silico modeling; nonlinear regression; computational ADME; blood-brain barrier; CNS; passive diffusion; drug transport; plasma protein binding; tissue binding;
Plasma protein binding of tetrodotoxin in the marine puffer fish Takifugu rubripes
Keywords: اتصال پروتئین پلاسما; Tetrodotoxin; Plasma protein binding; Equilibrium dialysis; Marine puffer fish Takifugu rubripes; Greenling Hexagrammos otakii; Bovine serum albumin; Bovine alpha-1-acid glycoprotein; Pharmacokinetics
Pre-clinical pharmacokinetics evaluation of an anticonvulsant candidate benzaldehyde semicarbazone free and included in β-cyclodextrin
Keywords: اتصال پروتئین پلاسما; Anticonvulsant; Benzaldehyde semicarbazone; Cyclodextrin; Pharmacokinetics; Tissue distribution; Plasma protein binding
Retention of structurally diverse drugs in human serum albumin chromatography and its potential to simulate plasma protein binding
Keywords: اتصال پروتئین پلاسما; Biomimetic chromatography; Human serum albumin stationary phase; Plasma protein binding; Lipophilicity; Charged species; Linear free energy relationships
Application of PAMPA-models to predict BBB permeability including efflux ratio, plasma protein binding and physicochemical parameters
Keywords: اتصال پروتئین پلاسما; Permeability; Solubility; PAMPA; Caco-2; Efflux-ratio; LogBB; Blood–brain barrier; Plasma protein binding