کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5560784 | 1562032 | 2017 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Brain uptake of deltamethrin in rats as a function of plasma protein binding and blood-brain barrier maturation
ترجمه فارسی عنوان
جذب مغز از دالتمترین در موش های صحرایی به عنوان عملکردی از اتصال پروتئین های پلاسما و بلوغ گلودرد خونریزی
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کلمات کلیدی
پریتروئید، دالتمترین، مانع خون مغزی، اتصال پروتئین پلاسما، جذب مغز، عصبی رشدی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Pyrethroids, including permethrin and deltamethrin (DLM), are very widely used of insecticides. It was hypothesized that lower plasma binding and increased blood-brain barrier (BBB) penetration of DLM in immature rats contribute to the higher brain concentrations of DLM and more pronounced neurotoxicity reported in this age group. The left brain of anesthetized adult rats was perfused for 2 min via a carotid artery with 1 μM 14C-DLM in: 2-5% human serum albumin (HSA); plasma from adult and 15- and 21-d-old rats; and plasma from human donors of: birth-1 week, 1-4 weeks, 4 weeks-1 year, 1-3 years and adults. The fraction of DLM bound and brain uptake of DLM did not vary significantly with the HSA concentration nor with the age of rat or human plasma donors. One, 10 and 50 μM 14C-DLM were perfused into the left-brain of anesthetized adult, 15- and 21-d-old rats. DLM deposition in the brain was linear over this range of concentrations and inversely related to age. The results of this investigation indicate that increased BBB permeability in the youngest rats enhances brain deposition of the insecticide. Plasma protein binding of DLM in immature rats and humans is not sufficiently diminished to impact its brain uptake.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 62, September 2017, Pages 24-29
Journal: NeuroToxicology - Volume 62, September 2017, Pages 24-29
نویسندگان
Manoj Amaraneni, Jing Pang, Tanzir B. Mortuza, Srinivasa Muralidhara, Brian S. Cummings, Catherine A. White, Charles V. Vorhees, Jason Zastre, James V. Bruckner,